CA2990088C - Hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them - Google Patents
Hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them Download PDFInfo
- Publication number
- CA2990088C CA2990088C CA2990088A CA2990088A CA2990088C CA 2990088 C CA2990088 C CA 2990088C CA 2990088 A CA2990088 A CA 2990088A CA 2990088 A CA2990088 A CA 2990088A CA 2990088 C CA2990088 C CA 2990088C
- Authority
- CA
- Canada
- Prior art keywords
- group
- formula
- phenyl
- compound
- pyrimidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1555752 | 2015-06-23 | ||
| FR1555752A FR3037957B1 (fr) | 2015-06-23 | 2015-06-23 | Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| PCT/EP2016/064433 WO2016207225A1 (en) | 2015-06-23 | 2016-06-22 | New hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2990088A1 CA2990088A1 (en) | 2016-12-29 |
| CA2990088C true CA2990088C (en) | 2021-04-13 |
Family
ID=54608634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2990088A Active CA2990088C (en) | 2015-06-23 | 2016-06-22 | Hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them |
Country Status (43)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3037956B1 (fr) * | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037959B1 (fr) * | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037958B1 (fr) * | 2015-06-23 | 2019-01-25 | Les Laboratoires Servier | Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2018015526A1 (en) | 2016-07-22 | 2018-01-25 | Les Laboratoires Servier | Combination of a bcl-2 inhibitor and a mcl-1 inhibitor, uses and pharmaceutical compositions thereof |
| EP3567043B1 (en) * | 2017-01-05 | 2023-12-06 | Henan Genuine Biotech Co., Ltd. | 2-[[5-[(4-hydroxy-3-chloro-2-methyl)-phenyl]-thieno[2,3-d]pyrimidin-4-yl]oxy]-3-(2-methoxybenzene)propanoic acid derivatives as mcl-1 and bcl-2 inhibitors for treating cancer |
| UY37560A (es) | 2017-01-06 | 2018-07-31 | Servier Lab | Combinación de un inhibidor de mcl-1 y un compuesto taxano, usos y composiciones farmacéuticas de ésta |
| CN110381937A (zh) * | 2017-01-06 | 2019-10-25 | 法国施维雅药厂 | Mcl-1抑制剂和紫杉烷化合物的组合及其用途和药物组合物 |
| TWI753178B (zh) * | 2017-06-22 | 2022-01-21 | 法商施維雅藥廠 | Mcl-1抑制劑與血液癌症標準療法之組合，其用途及醫藥組合物 |
| AU2018317828A1 (en) * | 2017-08-15 | 2020-04-02 | AbbVie Deutschland GmbH & Co. KG | Macrocyclic MCL-1 inhibitors and methods of use |
| CN111818917A (zh) | 2017-08-15 | 2020-10-23 | 艾伯维公司 | 大环mcl-1抑制剂和使用方法 |
| WO2019101144A1 (zh) * | 2017-11-23 | 2019-05-31 | 北京赛林泰医药技术有限公司 | Mcl-1选择性抑制剂及其制备和用途 |
| CN108424417B (zh) * | 2017-12-21 | 2019-09-20 | 河南真实生物科技有限公司 | 噻吩并嘧啶衍生物、其制备方法及在制备抗肿瘤药物中的应用 |
| CN110964034B (zh) * | 2018-09-29 | 2022-04-12 | 江苏恒瑞医药股份有限公司 | 嘧啶并噻吩类衍生物、其制备方法及其在医药上的应用 |
| TWI849001B (zh) | 2018-11-14 | 2024-07-21 | 法商施維雅藥廠 | Mcl-1抑制劑及米哚妥林(midostaurin)之組合，其用途及醫藥組合物 |
| CN111187277B (zh) * | 2018-11-14 | 2022-04-12 | 江苏恒瑞医药股份有限公司 | 噻吩并嘧啶类衍生物、其制备方法及其在医药上的应用 |
| AU2019391329B2 (en) * | 2018-12-06 | 2024-09-26 | Les Laboratoires Servier | New crystalline forms of a MCL-1 inhibitor, a process for their preparation and pharmaceutical compositions containing them. |
| KR20220024106A (ko) | 2019-05-20 | 2022-03-03 | 노파르티스 아게 | Mcl-1 억제제 항체-약물 접합체 및 사용 방법 |
| AR119156A1 (es) | 2019-06-17 | 2021-11-24 | Servier Lab | Combinación de un inhibidor de mcl-1 y un tratamiento estándar de atención médica para cáncer de mama, usos y composiciones farmacéuticas de la misma |
| US20230116602A1 (en) * | 2019-10-03 | 2023-04-13 | California Institute Of Technology | Mcl1 inhibitors and uses thereof |
| US20240042051A1 (en) | 2020-11-24 | 2024-02-08 | Francesca Rocchetti | Mcl-1 inhibitor antibody-drug conjugates and methods of use |
| WO2022216946A1 (en) * | 2021-04-07 | 2022-10-13 | California Institute Of Technology | Mcl1 inhibitors and uses thereof |
| JP7673255B2 (ja) | 2021-06-11 | 2025-05-08 | ギリアード サイエンシーズ， インコーポレイテッド | Ｍｃｌ－１阻害剤と抗体薬物コンジュゲートとの組み合わせ |
| TWI910028B (zh) | 2021-06-11 | 2025-12-21 | 美商基利科學股份有限公司 | Mcl-1抑制劑與抗癌劑之組合 |
| CN113651663B (zh) * | 2021-08-20 | 2024-03-29 | 浙大宁波理工学院 | 一种氘代芳香羰基类化合物的制备方法 |
| EP4413165A1 (en) | 2021-10-06 | 2024-08-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting and improving the efficacy of mcl-1 inhibitor therapy |
| CN120787162A (zh) | 2022-05-20 | 2025-10-14 | 诺华股份有限公司 | 抗肿瘤化合物的抗体-药物缀合物及其使用方法 |
| PY24103486A (es) | 2023-11-22 | 2025-06-06 | Servier Lab | Conjugados de anticuerpo anti-cd74-fármaco y métodos de uso de los mismos |
| TW202540186A (zh) | 2023-11-22 | 2025-10-16 | 瑞士商諾華公司 | 抗ｃｄ７抗體藥物結合物及其使用方法 |
| TW202530255A (zh) | 2023-12-15 | 2025-08-01 | 法商亞維西亞有限公司 | 抗ｉｌ－１ｒａｐ結合結構域及其抗體－藥物偶聯物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2217956B1 (es) * | 2003-01-23 | 2006-04-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo. |
| EA009920B1 (ru) * | 2003-08-29 | 2008-04-28 | Вернэлис (Кембридж) Лимитед | Соединения пиримидотиофена |
| BRPI0908573A2 (pt) * | 2008-03-05 | 2012-12-25 | Methylgene Inc | inibidores da atividade de proteÍna tirosina quinase |
| CN102464667B (zh) * | 2010-11-03 | 2014-06-04 | 中国科学院上海药物研究所 | 一类五元杂环并嘧啶类化合物及其制备方法和用途 |
| AR090037A1 (es) * | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
| FR3015483B1 (fr) * | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037958B1 (fr) * | 2015-06-23 | 2019-01-25 | Les Laboratoires Servier | Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037956B1 (fr) * | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037959B1 (fr) * | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2015
- 2015-06-23 FR FR1555752A patent/FR3037957B1/fr not_active Expired - Fee Related
-
2016
- 2016-06-16 UY UY0001036736A patent/UY36736A/es unknown
- 2016-06-22 GE GEAP201614678A patent/GEP20207074B/en unknown
- 2016-06-22 TN TNP/2017/000511A patent/TN2017000511A1/en unknown
- 2016-06-22 PE PE2017002534A patent/PE20180742A1/es unknown
- 2016-06-22 US US15/737,479 patent/US10227358B2/en active Active
- 2016-06-22 CU CUP2017000160A patent/CU20170160A7/xx unknown
- 2016-06-22 MX MX2017016997A patent/MX372716B/es active IP Right Grant
- 2016-06-22 HU HUE16733379A patent/HUE047889T2/hu unknown
- 2016-06-22 EA EA201890125A patent/EA033266B1/ru unknown
- 2016-06-22 CR CR20170564A patent/CR20170564A/es unknown
- 2016-06-22 PT PT167333798T patent/PT3313851T/pt unknown
- 2016-06-22 RS RS20200136A patent/RS59904B1/sr unknown
- 2016-06-22 ES ES16733379T patent/ES2759480T3/es active Active
- 2016-06-22 MY MYPI2017704877A patent/MY190561A/en unknown
- 2016-06-22 JP JP2017566271A patent/JP6741697B2/ja active Active
- 2016-06-22 MD MDE20180444T patent/MD3313851T2/ro unknown
- 2016-06-22 EP EP16733379.8A patent/EP3313851B1/en active Active
- 2016-06-22 GE GEAP201914678A patent/GEAP201914678A/en unknown
- 2016-06-22 UA UAA201800618A patent/UA122228C2/uk unknown
- 2016-06-22 RU RU2018102365A patent/RU2734418C2/ru active
- 2016-06-22 BR BR112017027414-0A patent/BR112017027414B1/pt active IP Right Grant
- 2016-06-22 CA CA2990088A patent/CA2990088C/en active Active
- 2016-06-22 TW TW105119605A patent/TWI604844B/zh not_active IP Right Cessation
- 2016-06-22 MA MA42239A patent/MA42239B1/fr unknown
- 2016-06-22 DK DK16733379.8T patent/DK3313851T3/da active
- 2016-06-22 HR HRP20200107TT patent/HRP20200107T1/hr unknown
- 2016-06-22 KR KR1020187002033A patent/KR102718253B1/ko active Active
- 2016-06-22 HK HK18109026.9A patent/HK1249506A1/zh unknown
- 2016-06-22 CN CN201680036383.5A patent/CN107709333B/zh active Active
- 2016-06-22 WO PCT/EP2016/064433 patent/WO2016207225A1/en not_active Ceased
- 2016-06-22 JO JOP/2016/0128A patent/JO3675B1/ar active
- 2016-06-22 PL PL16733379T patent/PL3313851T3/pl unknown
- 2016-06-22 SI SI201630625T patent/SI3313851T1/sl unknown
- 2016-06-22 AU AU2016282836A patent/AU2016282836B2/en active Active
- 2016-06-23 AR ARP160101881A patent/AR105103A1/es unknown
-
2017
- 2017-12-07 PH PH12017502246A patent/PH12017502246B1/en unknown
- 2017-12-12 IL IL256270A patent/IL256270A/en active IP Right Grant
- 2017-12-12 SV SV2017005587A patent/SV2017005587A/es unknown
- 2017-12-12 EC ECIEPI201781744A patent/ECSP17081744A/es unknown
- 2017-12-13 CO CONC2017/0012786A patent/CO2017012786A2/es unknown
- 2017-12-13 ZA ZA2017/08460A patent/ZA201708460B/en unknown
- 2017-12-18 CL CL2017003258A patent/CL2017003258A1/es unknown
-
2019
- 2019-01-15 US US16/247,614 patent/US10711010B2/en active Active
-
2020
- 2020-01-31 CY CY20201100083T patent/CY1122542T1/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20171219 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 9TH ANNIV.) - STANDARD Year of fee payment: 9 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20241227 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT Effective date: 20241227 |