CA2971672A1 - Means and methods for displaying cyclic peptides on bacteriophage particles - Google Patents
Means and methods for displaying cyclic peptides on bacteriophage particles Download PDFInfo
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- CA2971672A1 CA2971672A1 CA2971672A CA2971672A CA2971672A1 CA 2971672 A1 CA2971672 A1 CA 2971672A1 CA 2971672 A CA2971672 A CA 2971672A CA 2971672 A CA2971672 A CA 2971672A CA 2971672 A1 CA2971672 A1 CA 2971672A1
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- peptide
- cyclic peptide
- bacteriophage
- precursor
- enzyme
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
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- Virology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| EP14199588.6 | 2014-12-22 | ||
| EP14199588 | 2014-12-22 | ||
| PCT/EP2015/080738 WO2016102434A1 (en) | 2014-12-22 | 2015-12-21 | Novel methods for displaying cyclic peptides on bacteriophage particles |
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| CA2971672A1 true CA2971672A1 (en) | 2016-06-30 |
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| EP2603586B2 (en) | 2010-08-13 | 2025-02-26 | Miti Biosystems GmbH | Modified peptide display |
| CN106366168B (zh) * | 2016-08-26 | 2020-09-15 | 上海交通大学 | 羊毛硫肽类抗菌肽及其脱氢衍生物的制备方法 |
| CN109432399A (zh) * | 2018-12-27 | 2019-03-08 | 重庆市科学技术研究院 | 用于乙型肝炎的环肽药物及其应用 |
| EP3972625A4 (en) * | 2019-05-20 | 2023-04-12 | The Texas A&M University System | A genetically encoded, phage-displayed cyclic peptide library and methods of making the same |
| WO2022020380A1 (en) * | 2020-07-20 | 2022-01-27 | Massachusetts Institute Of Technology | M13 bacteriophage with a high cysteine content and genetically engineerable hydrogels |
| CN112851788B (zh) * | 2021-02-03 | 2022-11-01 | 河北省科学院生物研究所 | 一种羊毛硫肽LichencinA3及其制备方法和应用 |
| PL443378A1 (pl) * | 2022-12-31 | 2024-07-01 | Instytut Biotechnologii I Medycyny Molekularnej | 7 aminokwasowe sekwencje oraz klony fagowe wiążące selektywnie jony niklu |
| CN116790698B (zh) * | 2023-06-21 | 2024-06-18 | 南京大学 | 基于氧化脱羧酶的硫醛合成方法及其应用 |
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| DE3852304T3 (de) | 1987-03-02 | 1999-07-01 | Enzon Labs Inc., Piscataway, N.J. | Organismus als Träger für "Single Chain Antibody Domain (SCAD)". |
| AU4308689A (en) | 1988-09-02 | 1990-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| DE60020366T2 (de) | 1999-06-14 | 2006-02-02 | Genentech Inc., San Francisco | Strukturiertes peptidgerüst zur ausstellung von drehung-bibliotheken auf phage |
| US7785825B2 (en) * | 2004-01-12 | 2010-08-31 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for dehydration and cyclization of peptides, synthetic compounds, and lantibiotics |
| CA2594151C (en) | 2004-12-07 | 2013-02-19 | Applied Nanosystems B.V. | Methods for the production and secretion of modified peptides |
| BRPI0617191A2 (pt) * | 2005-10-12 | 2011-07-19 | Scripps Research Inst | modificação pós-traducional de polipeptìdeos expressos em fagos |
| ES2509959T5 (en) | 2008-02-05 | 2024-12-19 | Bicyclerd Ltd | Methods and compositions |
| EP2405008A1 (en) * | 2010-07-06 | 2012-01-11 | LanthioPep B.V. | Bacterial surface display of thioether-bridge-containing peptides |
| EP2603586B2 (en) * | 2010-08-13 | 2025-02-26 | Miti Biosystems GmbH | Modified peptide display |
| EP2578599A1 (en) | 2011-10-07 | 2013-04-10 | LanthioPep B.V. | Cyclic analogs of GLP-1 and GLP-1 related peptides |
| WO2016049656A1 (en) * | 2014-09-26 | 2016-03-31 | The Board Of Trustees Of The University Of Illinois | Biosynthesis and engineering of lanthipeptides |
-
2015
- 2015-12-21 DK DK15817300.5T patent/DK3237614T3/da active
- 2015-12-21 RU RU2017122176A patent/RU2702087C2/ru active
- 2015-12-21 CN CN201580069979.0A patent/CN107109403A/zh active Pending
- 2015-12-21 EP EP15817300.5A patent/EP3237614B1/en not_active Not-in-force
- 2015-12-21 KR KR1020177020523A patent/KR20170090509A/ko not_active Ceased
- 2015-12-21 MX MX2017008286A patent/MX2017008286A/es unknown
- 2015-12-21 CA CA2971672A patent/CA2971672A1/en active Pending
- 2015-12-21 JP JP2017533929A patent/JP6810041B2/ja not_active Expired - Fee Related
- 2015-12-21 US US15/537,910 patent/US10774323B2/en not_active Expired - Fee Related
- 2015-12-21 AU AU2015371172A patent/AU2015371172B2/en not_active Ceased
- 2015-12-21 WO PCT/EP2015/080738 patent/WO2016102434A1/en not_active Ceased
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2017
- 2017-07-11 ZA ZA2017/04674A patent/ZA201704674B/en unknown
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2020
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|---|---|
| AU2015371172B2 (en) | 2021-05-13 |
| MX2017008286A (es) | 2018-02-19 |
| KR20170090509A (ko) | 2017-08-07 |
| DK3237614T3 (da) | 2019-09-09 |
| AU2015371172A1 (en) | 2017-07-13 |
| WO2016102434A1 (en) | 2016-06-30 |
| JP6810041B2 (ja) | 2021-01-06 |
| EP3237614A1 (en) | 2017-11-01 |
| EP3237614B1 (en) | 2019-06-26 |
| ZA201704674B (en) | 2019-09-25 |
| RU2702087C2 (ru) | 2019-10-03 |
| JP2018500352A (ja) | 2018-01-11 |
| US20180051276A1 (en) | 2018-02-22 |
| US10774323B2 (en) | 2020-09-15 |
| RU2017122176A (ru) | 2019-01-24 |
| US20200385705A1 (en) | 2020-12-10 |
| CN107109403A (zh) | 2017-08-29 |
| RU2017122176A3 (enExample) | 2019-04-03 |
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