AU2015371172B2 - Novel methods for displaying cyclic peptides on bacteriophage particles - Google Patents

Novel methods for displaying cyclic peptides on bacteriophage particles Download PDF

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Publication number
AU2015371172B2
AU2015371172B2 AU2015371172A AU2015371172A AU2015371172B2 AU 2015371172 B2 AU2015371172 B2 AU 2015371172B2 AU 2015371172 A AU2015371172 A AU 2015371172A AU 2015371172 A AU2015371172 A AU 2015371172A AU 2015371172 B2 AU2015371172 B2 AU 2015371172B2
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AU
Australia
Prior art keywords
peptide
cyclic peptide
bacteriophage
precursor
enzyme
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Ceased
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AU2015371172A
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English (en)
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AU2015371172A1 (en
Inventor
Tjibbe Bosma
Markus Andreas MOOSMEIER
Josef Prassler
Johannes Herbert URBAN
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LanthioPep BV
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LanthioPep BV
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Publication of AU2015371172A1 publication Critical patent/AU2015371172A1/en
Assigned to LANTHIOPEP B.V. reassignment LANTHIOPEP B.V. Request for Assignment Assignors: MORPHOSYS AG
Application granted granted Critical
Publication of AU2015371172B2 publication Critical patent/AU2015371172B2/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00021—Viruses as such, e.g. new isolates, mutants or their genomic sequences

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2015371172A 2014-12-22 2015-12-21 Novel methods for displaying cyclic peptides on bacteriophage particles Ceased AU2015371172B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14199588.6 2014-12-22
EP14199588 2014-12-22
PCT/EP2015/080738 WO2016102434A1 (en) 2014-12-22 2015-12-21 Novel methods for displaying cyclic peptides on bacteriophage particles

Publications (2)

Publication Number Publication Date
AU2015371172A1 AU2015371172A1 (en) 2017-07-13
AU2015371172B2 true AU2015371172B2 (en) 2021-05-13

Family

ID=52292661

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015371172A Ceased AU2015371172B2 (en) 2014-12-22 2015-12-21 Novel methods for displaying cyclic peptides on bacteriophage particles

Country Status (12)

Country Link
US (2) US10774323B2 (enExample)
EP (1) EP3237614B1 (enExample)
JP (1) JP6810041B2 (enExample)
KR (1) KR20170090509A (enExample)
CN (1) CN107109403A (enExample)
AU (1) AU2015371172B2 (enExample)
CA (1) CA2971672A1 (enExample)
DK (1) DK3237614T3 (enExample)
MX (1) MX2017008286A (enExample)
RU (1) RU2702087C2 (enExample)
WO (1) WO2016102434A1 (enExample)
ZA (1) ZA201704674B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2603586B2 (en) 2010-08-13 2025-02-26 Miti Biosystems GmbH Modified peptide display
CN106366168B (zh) * 2016-08-26 2020-09-15 上海交通大学 羊毛硫肽类抗菌肽及其脱氢衍生物的制备方法
CN109432399A (zh) * 2018-12-27 2019-03-08 重庆市科学技术研究院 用于乙型肝炎的环肽药物及其应用
EP3972625A4 (en) * 2019-05-20 2023-04-12 The Texas A&M University System A genetically encoded, phage-displayed cyclic peptide library and methods of making the same
WO2022020380A1 (en) * 2020-07-20 2022-01-27 Massachusetts Institute Of Technology M13 bacteriophage with a high cysteine content and genetically engineerable hydrogels
CN112851788B (zh) * 2021-02-03 2022-11-01 河北省科学院生物研究所 一种羊毛硫肽LichencinA3及其制备方法和应用
PL443378A1 (pl) * 2022-12-31 2024-07-01 Instytut Biotechnologii I Medycyny Molekularnej 7 aminokwasowe sekwencje oraz klony fagowe wiążące selektywnie jony niklu
CN116790698B (zh) * 2023-06-21 2024-06-18 南京大学 基于氧化脱羧酶的硫醛合成方法及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3852304T3 (de) 1987-03-02 1999-07-01 Enzon Labs Inc., Piscataway, N.J. Organismus als Träger für "Single Chain Antibody Domain (SCAD)".
AU4308689A (en) 1988-09-02 1990-04-02 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
US6660843B1 (en) * 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
DE60020366T2 (de) 1999-06-14 2006-02-02 Genentech Inc., San Francisco Strukturiertes peptidgerüst zur ausstellung von drehung-bibliotheken auf phage
US7785825B2 (en) * 2004-01-12 2010-08-31 The Board Of Trustees Of The University Of Illinois Compositions and methods for dehydration and cyclization of peptides, synthetic compounds, and lantibiotics
CA2594151C (en) 2004-12-07 2013-02-19 Applied Nanosystems B.V. Methods for the production and secretion of modified peptides
BRPI0617191A2 (pt) * 2005-10-12 2011-07-19 Scripps Research Inst modificação pós-traducional de polipeptìdeos expressos em fagos
ES2509959T5 (en) 2008-02-05 2024-12-19 Bicyclerd Ltd Methods and compositions
EP2405008A1 (en) * 2010-07-06 2012-01-11 LanthioPep B.V. Bacterial surface display of thioether-bridge-containing peptides
EP2603586B2 (en) * 2010-08-13 2025-02-26 Miti Biosystems GmbH Modified peptide display
EP2578599A1 (en) 2011-10-07 2013-04-10 LanthioPep B.V. Cyclic analogs of GLP-1 and GLP-1 related peptides
WO2016049656A1 (en) * 2014-09-26 2016-03-31 The Board Of Trustees Of The University Of Illinois Biosynthesis and engineering of lanthipeptides

Also Published As

Publication number Publication date
MX2017008286A (es) 2018-02-19
KR20170090509A (ko) 2017-08-07
DK3237614T3 (da) 2019-09-09
AU2015371172A1 (en) 2017-07-13
WO2016102434A1 (en) 2016-06-30
JP6810041B2 (ja) 2021-01-06
EP3237614A1 (en) 2017-11-01
EP3237614B1 (en) 2019-06-26
ZA201704674B (en) 2019-09-25
RU2702087C2 (ru) 2019-10-03
JP2018500352A (ja) 2018-01-11
US20180051276A1 (en) 2018-02-22
US10774323B2 (en) 2020-09-15
CA2971672A1 (en) 2016-06-30
RU2017122176A (ru) 2019-01-24
US20200385705A1 (en) 2020-12-10
CN107109403A (zh) 2017-08-29
RU2017122176A3 (enExample) 2019-04-03

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PC1 Assignment before grant (sect. 113)

Owner name: LANTHIOPEP B.V.

Free format text: FORMER APPLICANT(S): MORPHOSYS AG

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired