CA2968010A1 - Combinations of prostaglandins and nitric oxide donors - Google Patents

Combinations of prostaglandins and nitric oxide donors Download PDF

Info

Publication number
CA2968010A1
CA2968010A1 CA2968010A CA2968010A CA2968010A1 CA 2968010 A1 CA2968010 A1 CA 2968010A1 CA 2968010 A CA2968010 A CA 2968010A CA 2968010 A CA2968010 A CA 2968010A CA 2968010 A1 CA2968010 A1 CA 2968010A1
Authority
CA
Canada
Prior art keywords
compound
nitrooxy
furan
hydroxyhexahydrofuro
bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2968010A
Other languages
English (en)
French (fr)
Inventor
Nicoletta Almirante
Laura Storoni
Elena Bastia
Francesco Impagnatiello
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nicox SA
Original Assignee
Nicox SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox SA filed Critical Nicox SA
Publication of CA2968010A1 publication Critical patent/CA2968010A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2968010A 2014-11-19 2015-11-17 Combinations of prostaglandins and nitric oxide donors Pending CA2968010A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14193883.7 2014-11-19
EP14193883 2014-11-19
PCT/EP2015/076865 WO2016079142A1 (en) 2014-11-19 2015-11-17 Combinations of prostaglandins and nitric oxide donors

Publications (1)

Publication Number Publication Date
CA2968010A1 true CA2968010A1 (en) 2016-05-26

Family

ID=51904805

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2968010A Pending CA2968010A1 (en) 2014-11-19 2015-11-17 Combinations of prostaglandins and nitric oxide donors

Country Status (7)

Country Link
US (1) US10610509B2 (enExample)
EP (1) EP3220905B1 (enExample)
JP (1) JP6820847B2 (enExample)
CN (1) CN106999452B (enExample)
CA (1) CA2968010A1 (enExample)
ES (1) ES2764654T3 (enExample)
WO (1) WO2016079142A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019121488A1 (en) * 2017-12-21 2019-06-27 Nicox S.A. Nitric oxide releasing hyaluronic esters
KR102836746B1 (ko) 2018-08-06 2025-07-21 니콕스 에스아 산화질소 방출 포스포디에스테라제 타입 5 억제제
JP7708771B2 (ja) * 2020-02-05 2025-07-15 ニコックス エス．エー． 緑内障及び高眼圧症の処置のための組成物
CN118084895B (zh) * 2024-02-28 2025-09-05 中国药科大学 一种一氧化氮供体型Omidenepag衍生物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002085372A1 (en) * 2001-04-19 2002-10-31 Teika Pharmaceutical Co., Ltd. Medicines and medicinal kits
WO2009098113A1 (en) * 2008-02-07 2009-08-13 Nicox S.A. Nitric oxide donor compounds
EP2911656B1 (en) * 2012-10-23 2020-12-02 Nicox SA Quinone based nitric oxide donating compounds for ophthalmic use

Also Published As

Publication number Publication date
US20170354634A1 (en) 2017-12-14
ES2764654T3 (es) 2020-06-04
US10610509B2 (en) 2020-04-07
WO2016079142A1 (en) 2016-05-26
EP3220905B1 (en) 2019-10-09
EP3220905A1 (en) 2017-09-27
JP2017534658A (ja) 2017-11-24
CN106999452A (zh) 2017-08-01
CN106999452B (zh) 2020-10-16
JP6820847B2 (ja) 2021-01-27

Similar Documents

Publication Publication Date Title
KR102196825B1 (ko) 녹내장 예방 또는 치료를 위한 약물 요법
AU2011282681B2 (en) Preservative free bimatoprost and timolol solutions
KR20130112728A (ko) 방부제 없는 프로스타글란딘계 비점성 용액의 고분자 전달 시스템
JP2011516537A (ja) 安定性のある眼科用の製剤
BRPI0908717A2 (pt) composições farmacêuticas tendo biodisponibilidade desejável
US20060111388A1 (en) Phenanthroline and derivatives thereof used to lower intraocular pressure in an affected eye
JP2017501224A (ja) 緑内障の治療用組成物及び方法
EP3220905B1 (en) Combinations of prostaglandins and nitric oxide donors
US20150099807A1 (en) Preservative free bimatoprost solutions
US10058560B2 (en) Preservative free bimatoprost and timolol solutions
JP2020172486A (ja) エピナスチン又はその塩を含有する水性医薬組成物
WO2019024433A1 (zh) 氨基金刚烷胺单硝酸酯类化合物眼用组合物及其制剂和应用
JP6963651B2 (ja) エピナスチン又はその塩を含有する水性組成物
HK1241269A1 (en) Combinations of prostaglandins and nitric oxide donors
HK1241269B (zh) 前列腺素类和一氧化氮供体的组合产品
US20120232139A1 (en) Composition for ocular topical administration treatment ocular hypertension and glaucoma
JP7118579B1 (ja) エピナスチン又はその塩を含有する水性組成物
WO2018123945A1 (ja) タフルプロストとクエン酸エステルとを含有するデポ剤
HK40003602B (en) Preservative free bimatoprost and timolol solutions
HK40003602A (en) Preservative free bimatoprost and timolol solutions
TR201606768A1 (tr) Oftalmi̇k farmasöti̇k terki̇pler

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20201116

EEER Examination request

Effective date: 20201116

EEER Examination request

Effective date: 20201116

EEER Examination request

Effective date: 20201116

EEER Examination request

Effective date: 20201116

EEER Examination request

Effective date: 20201116