CN106999452B - 前列腺素类和一氧化氮供体的组合产品 - Google Patents

前列腺素类和一氧化氮供体的组合产品 Download PDF

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Publication number
CN106999452B
CN106999452B CN201580062042.0A CN201580062042A CN106999452B CN 106999452 B CN106999452 B CN 106999452B CN 201580062042 A CN201580062042 A CN 201580062042A CN 106999452 B CN106999452 B CN 106999452B
Authority
CN
China
Prior art keywords
prostaglandin
nitric oxide
hydroxyhexahydrofuro
nitrooxy
furan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201580062042.0A
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English (en)
Chinese (zh)
Other versions
CN106999452A (zh
Inventor
N·阿尔米兰特
L·斯托洛尼
E·巴斯蒂亚
F·因派纳提洛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nicox SA
Original Assignee
Nicox SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox SA filed Critical Nicox SA
Publication of CN106999452A publication Critical patent/CN106999452A/zh
Application granted granted Critical
Publication of CN106999452B publication Critical patent/CN106999452B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201580062042.0A 2014-11-19 2015-11-17 前列腺素类和一氧化氮供体的组合产品 Expired - Fee Related CN106999452B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14193883.7 2014-11-19
EP14193883 2014-11-19
PCT/EP2015/076865 WO2016079142A1 (en) 2014-11-19 2015-11-17 Combinations of prostaglandins and nitric oxide donors

Publications (2)

Publication Number Publication Date
CN106999452A CN106999452A (zh) 2017-08-01
CN106999452B true CN106999452B (zh) 2020-10-16

Family

ID=51904805

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580062042.0A Expired - Fee Related CN106999452B (zh) 2014-11-19 2015-11-17 前列腺素类和一氧化氮供体的组合产品

Country Status (7)

Country Link
US (1) US10610509B2 (enExample)
EP (1) EP3220905B1 (enExample)
JP (1) JP6820847B2 (enExample)
CN (1) CN106999452B (enExample)
CA (1) CA2968010A1 (enExample)
ES (1) ES2764654T3 (enExample)
WO (1) WO2016079142A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019121488A1 (en) * 2017-12-21 2019-06-27 Nicox S.A. Nitric oxide releasing hyaluronic esters
CN112566670B (zh) 2018-08-06 2024-11-12 尼科斯股份有限公司 一氧化氮释放第5型磷酸二酯酶抑制剂
CN115038449A (zh) * 2020-02-05 2022-09-09 尼科斯股份有限公司 用于治疗青光眼和眼高压的组合物
CN118084895B (zh) * 2024-02-28 2025-09-05 中国药科大学 一种一氧化氮供体型Omidenepag衍生物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1503674A (zh) * 2001-04-19 2004-06-09 ������ҩ��ʽ���� 药物及药物试剂盒
CA2706082A1 (en) * 2008-02-07 2009-08-13 Nicox S.A. Nitric oxide donor compounds
WO2014063923A1 (en) * 2012-10-23 2014-05-01 Nicox S.A. Quinone based nitric oxide donating compounds for ophthalmic use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1503674A (zh) * 2001-04-19 2004-06-09 ������ҩ��ʽ���� 药物及药物试剂盒
CA2706082A1 (en) * 2008-02-07 2009-08-13 Nicox S.A. Nitric oxide donor compounds
WO2014063923A1 (en) * 2012-10-23 2014-05-01 Nicox S.A. Quinone based nitric oxide donating compounds for ophthalmic use

Also Published As

Publication number Publication date
US20170354634A1 (en) 2017-12-14
US10610509B2 (en) 2020-04-07
ES2764654T3 (es) 2020-06-04
CA2968010A1 (en) 2016-05-26
CN106999452A (zh) 2017-08-01
EP3220905A1 (en) 2017-09-27
WO2016079142A1 (en) 2016-05-26
EP3220905B1 (en) 2019-10-09
JP2017534658A (ja) 2017-11-24
JP6820847B2 (ja) 2021-01-27

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