CA2965745C - Cd3/cd38 t cell retargeting hetero-dimeric immunoglobulins and methods of their production - Google Patents
Cd3/cd38 t cell retargeting hetero-dimeric immunoglobulins and methods of their production Download PDFInfo
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
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- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2014/073738 | 2014-11-04 | ||
| PCT/EP2014/073738 WO2015063339A1 (en) | 2013-11-04 | 2014-11-04 | Production of t cell retargeting hetero-dimeric immunoglobulins |
| EP15167034.6 | 2015-05-08 | ||
| EP15167034 | 2015-05-08 | ||
| PCT/EP2015/075628 WO2016071355A1 (en) | 2014-11-04 | 2015-11-03 | Cd3/cd38 t cell retargeting hetero-dimeric immunoglobulins and methods of their production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2965745A1 CA2965745A1 (en) | 2016-05-12 |
| CA2965745C true CA2965745C (en) | 2023-12-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA2965745A Active CA2965745C (en) | 2014-11-04 | 2015-11-03 | Cd3/cd38 t cell retargeting hetero-dimeric immunoglobulins and methods of their production |
Country Status (20)
| Country | Link |
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| EP (1) | EP3215541A1 (zh) |
| JP (3) | JP2018501297A (zh) |
| KR (1) | KR20170078831A (zh) |
| CN (1) | CN107207596A (zh) |
| AU (1) | AU2015341884B2 (zh) |
| BR (1) | BR112017009263A2 (zh) |
| CA (1) | CA2965745C (zh) |
| CL (1) | CL2017001090A1 (zh) |
| CO (1) | CO2017005240A2 (zh) |
| EA (1) | EA039658B1 (zh) |
| HK (1) | HK1244014A1 (zh) |
| IL (1) | IL251848A0 (zh) |
| MA (1) | MA40894A (zh) |
| MX (1) | MX2017005814A (zh) |
| MY (1) | MY186929A (zh) |
| NZ (1) | NZ732019A (zh) |
| PE (1) | PE20171041A1 (zh) |
| PH (1) | PH12017500819A1 (zh) |
| SG (1) | SG11201703313SA (zh) |
| WO (1) | WO2016071355A1 (zh) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
| EP3620473A1 (en) | 2013-01-14 | 2020-03-11 | Xencor, Inc. | Novel heterodimeric proteins |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| CA2918795A1 (en) | 2013-07-25 | 2015-01-29 | Cytomx Therapeutics, Inc. | Multispecific antibodies, multispecific activatable antibodies and methods of using the same |
| NZ720161A (en) | 2013-11-04 | 2022-07-29 | Ichnos Sciences SA | Production of t cell retargeting hetero-dimeric immunoglobulins |
| UA119167C2 (uk) | 2014-03-28 | 2019-05-10 | Зенкор, Інк. | Біспецифічне антитіло, яке зв'язується з cd38 та cd3 |
| EP3172235A2 (en) * | 2014-07-25 | 2017-05-31 | Cytomx Therapeutics Inc. | Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same |
| US11773166B2 (en) | 2014-11-04 | 2023-10-03 | Ichnos Sciences SA | CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| EP3223845B1 (en) | 2014-11-26 | 2021-05-19 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cd20 |
| CN107406512A (zh) | 2014-11-26 | 2017-11-28 | Xencor公司 | 结合cd3和cd38的异二聚体抗体 |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Ｆｌｔ３及ｃｄ３抗體構築體 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Ｍｓｌｎ及ｃｄ３抗體構築體 |
| KR20180085800A (ko) | 2015-12-07 | 2018-07-27 | 젠코어 인코포레이티드 | Cd3 및 psma에 결합하는 이종이합체성 항체 |
| EA039859B1 (ru) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| MA45255A (fr) | 2016-06-14 | 2019-04-17 | Xencor Inc | Anticorps inhibiteurs de points de contrôle bispécifiques |
| EP3615571A1 (en) * | 2017-04-24 | 2020-03-04 | Ichnos Sciences SA | T cell redirecting bispecific antibodies for the treatment of egfr positive cancers |
| WO2018224441A1 (en) * | 2017-06-05 | 2018-12-13 | Numab Innovation Ag | Novel anti-cd3 antibodies |
| JP7247110B2 (ja) | 2017-06-05 | 2023-03-28 | ヌマブ セラピューティクス アクチェンゲゼルシャフト | 新規抗ｃｄ３抗体 |
| AU2018280868A1 (en) | 2017-06-08 | 2020-01-02 | Black Belt Therapeutics Limited | CD38 modulating antibody |
| CN110997723B (zh) * | 2017-06-08 | 2023-09-26 | 黑带医疗有限公司 | Cd38调节抗体 |
| KR102631281B1 (ko) * | 2017-08-10 | 2024-01-30 | 그리폴스 다이어그노스틱 솔루션즈 인크. | 재조합 인간 cd38-세포외 도메인을 포함하는 조성물, 방법 및/또는 키트 |
| US11236173B2 (en) | 2017-08-16 | 2022-02-01 | Black Belt Therapeutics Limited | CD38 antibody |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| US11542338B2 (en) | 2017-08-16 | 2023-01-03 | Black Belt Therapeutics Limited | CD38 modulating antibody |
| SG11202002384VA (en) | 2017-10-14 | 2020-04-29 | Cytomx Therapeutics Inc | Antibodies, activatable antibodies, bispecific antibodies, and bispecific activatable antibodies and methods of use thereof |
| JP2022502683A (ja) * | 2018-09-25 | 2022-01-11 | イクノス サイエンシズ エスエー | 生体試料中の抗体の定量化 |
| KR102353568B1 (ko) * | 2018-11-14 | 2022-01-20 | 주식회사 헬릭스미스 | 안정성이 향상된 항 c-Met 항체 또는 그의 항원 결합 단편 |
| AU2020211728A1 (en) * | 2019-01-23 | 2021-08-12 | Encefa | CD31 competitors and uses thereof |
| US20220177582A1 (en) * | 2019-03-13 | 2022-06-09 | Ichnos Sciences SA | Non-consensus glycosylation of bispecific antibodies |
| AU2020277489A1 (en) * | 2019-05-23 | 2021-11-25 | VelosBio Inc. | Anti-ROR1/anti-CD3 bispecific binding molecules |
| WO2020250940A1 (ja) * | 2019-06-11 | 2020-12-17 | 小野薬品工業株式会社 | 免疫抑制剤 |
| CN110551222B (zh) * | 2019-08-27 | 2023-06-06 | 重庆市畜牧科学院 | 一种新型双功能抗体及其用途 |
| WO2021063330A1 (zh) * | 2019-09-30 | 2021-04-08 | 和铂医药(苏州)有限公司 | 靶向cd3的抗体、双特异性抗体及其用途 |
| CN113493519B (zh) * | 2020-03-19 | 2022-12-27 | 浙江道尔生物科技有限公司 | 一种半衰期显著延长的治疗眼部血管新生疾病的融合蛋白 |
| US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
| WO2021254574A2 (en) * | 2020-06-17 | 2021-12-23 | Y-Mabs Therapeutics, Inc. | Cd38 antibodies for the treatment of human diseases |
| IL300666A (en) | 2020-08-19 | 2023-04-01 | Xencor Inc | ANTI–CD28 COMPOSITIONS |
| EP4305065A1 (en) | 2021-03-10 | 2024-01-17 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and gpc3 |
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| EP1720907B1 (en) * | 2004-02-06 | 2015-04-08 | MorphoSys AG | Anti-cd38 human antibodies and uses therefor |
| SI2567976T1 (sl) * | 2005-03-23 | 2017-11-30 | Genmab A/S | Protitelesa usmerjena proti cd38 za zdravljenje multiplega mieloma |
| AU2006301446B2 (en) * | 2005-10-12 | 2012-06-07 | Morphosys Ag | Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human CD38 |
| EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| MX2011014008A (es) * | 2009-06-26 | 2012-06-01 | Regeneron Pharma | Anticuerpos biespecificos facilmente aislados con formato de inmunoglobulina original. |
| SI2522724T1 (sl) * | 2009-12-25 | 2020-07-31 | Chuqai Seiyaku Kabushiki Kaisha | Postopek za spremembo polipeptida za čiščenje polipetidnih multimerov |
| LT2580243T (lt) * | 2010-06-09 | 2020-01-27 | Genmab A/S | Antikūnai prieš žmogaus cd38 |
| JOP20210044A1 (ar) * | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| CN108285488B (zh) * | 2011-03-25 | 2023-01-24 | 伊克诺斯科学公司 | 异二聚体免疫球蛋白 |
| AU2013322710A1 (en) * | 2012-09-25 | 2015-04-16 | Glenmark Pharmaceuticals S.A. | Purification of hetero-dimeric immunoglobulins |
| EP2914302B1 (en) * | 2012-11-05 | 2017-01-04 | MorphoSys AG | Radiolabelled antibody and uses thereof |
| NZ720161A (en) * | 2013-11-04 | 2022-07-29 | Ichnos Sciences SA | Production of t cell retargeting hetero-dimeric immunoglobulins |
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2015
- 2015-11-02 MA MA040894A patent/MA40894A/fr unknown
- 2015-11-03 MY MYPI2017701499A patent/MY186929A/en unknown
- 2015-11-03 SG SG11201703313SA patent/SG11201703313SA/en unknown
- 2015-11-03 CN CN201580072196.8A patent/CN107207596A/zh active Pending
- 2015-11-03 AU AU2015341884A patent/AU2015341884B2/en active Active
- 2015-11-03 KR KR1020177015252A patent/KR20170078831A/ko not_active Application Discontinuation
- 2015-11-03 MX MX2017005814A patent/MX2017005814A/es unknown
- 2015-11-03 EA EA201790961A patent/EA039658B1/ru unknown
- 2015-11-03 EP EP15790129.9A patent/EP3215541A1/en not_active Withdrawn
- 2015-11-03 PE PE2017000802A patent/PE20171041A1/es unknown
- 2015-11-03 BR BR112017009263-8A patent/BR112017009263A2/pt active Search and Examination
- 2015-11-03 NZ NZ732019A patent/NZ732019A/en unknown
- 2015-11-03 CA CA2965745A patent/CA2965745C/en active Active
- 2015-11-03 WO PCT/EP2015/075628 patent/WO2016071355A1/en active Application Filing
- 2015-11-03 JP JP2017542319A patent/JP2018501297A/ja active Pending
-
2017
- 2017-04-23 IL IL251848A patent/IL251848A0/en unknown
- 2017-05-02 CL CL2017001090A patent/CL2017001090A1/es unknown
- 2017-05-03 PH PH12017500819A patent/PH12017500819A1/en unknown
- 2017-05-26 CO CONC2017/0005240A patent/CO2017005240A2/es unknown
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2018
- 2018-03-12 HK HK18103440.0A patent/HK1244014A1/zh unknown
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2019
- 2019-07-23 JP JP2019135318A patent/JP2019214582A/ja active Pending
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2021
- 2021-08-02 JP JP2021126392A patent/JP7403505B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MY186929A (en) | 2021-08-26 |
| JP2018501297A (ja) | 2018-01-18 |
| MA40894A (fr) | 2017-09-12 |
| IL251848A0 (en) | 2017-06-29 |
| PH12017500819A1 (en) | 2017-10-02 |
| EA039658B1 (ru) | 2022-02-22 |
| BR112017009263A2 (pt) | 2018-01-30 |
| HK1244014A1 (zh) | 2018-07-27 |
| CL2017001090A1 (es) | 2018-01-05 |
| WO2016071355A1 (en) | 2016-05-12 |
| EP3215541A1 (en) | 2017-09-13 |
| CO2017005240A2 (es) | 2017-10-31 |
| NZ732019A (en) | 2022-07-29 |
| CA2965745A1 (en) | 2016-05-12 |
| AU2015341884A1 (en) | 2017-06-08 |
| MX2017005814A (es) | 2017-08-02 |
| JP2021184722A (ja) | 2021-12-09 |
| KR20170078831A (ko) | 2017-07-07 |
| EA201790961A1 (ru) | 2017-10-31 |
| PE20171041A1 (es) | 2017-07-19 |
| AU2015341884B2 (en) | 2020-09-17 |
| JP2019214582A (ja) | 2019-12-19 |
| SG11201703313SA (en) | 2017-05-30 |
| CN107207596A (zh) | 2017-09-26 |
| JP7403505B2 (ja) | 2023-12-22 |
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