CA2960830C - Detection of misfolded proteins - Google Patents

Detection of misfolded proteins Download PDF

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Publication number
CA2960830C
CA2960830C CA2960830A CA2960830A CA2960830C CA 2960830 C CA2960830 C CA 2960830C CA 2960830 A CA2960830 A CA 2960830A CA 2960830 A CA2960830 A CA 2960830A CA 2960830 C CA2960830 C CA 2960830C
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Prior art keywords
protein
misfolded
soluble
incubation mixture
incubation
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CA2960830A
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English (en)
French (fr)
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CA2960830A1 (en
Inventor
Claudio Soto JARA
Mohammad Shahnawaz
Russell M. Lebovitz
Benedikt K. VOLLRATH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Amprion Inc
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University of Texas System
Amprion Inc
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Publication of CA2960830A1 publication Critical patent/CA2960830A1/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
CA2960830A 2014-09-11 2015-09-11 Detection of misfolded proteins Active CA2960830C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462049306P 2014-09-11 2014-09-11
US62/049,306 2014-09-11
PCT/US2015/049844 WO2016040907A1 (en) 2014-09-11 2015-09-11 Detection of misfolded proteins

Publications (2)

Publication Number Publication Date
CA2960830A1 CA2960830A1 (en) 2016-03-17
CA2960830C true CA2960830C (en) 2023-09-05

Family

ID=55454515

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2960830A Active CA2960830C (en) 2014-09-11 2015-09-11 Detection of misfolded proteins

Country Status (15)

Country Link
US (1) US20160077112A1 (https=)
EP (2) EP3191599B1 (https=)
JP (2) JP6980953B2 (https=)
KR (1) KR102448128B1 (https=)
CN (1) CN107208125A (https=)
AU (1) AU2015314783B2 (https=)
BR (1) BR112017004899A2 (https=)
CA (1) CA2960830C (https=)
ES (1) ES2953855T3 (https=)
HR (1) HRP20231232T1 (https=)
IL (2) IL251052B (https=)
MX (1) MX2017003269A (https=)
PL (1) PL3191599T3 (https=)
SG (2) SG11201701953RA (https=)
WO (1) WO2016040907A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016040905A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded alpha synuclein protein
GB201611840D0 (en) * 2016-07-07 2016-08-24 Univ Court Of The Univ Of Edinburgh The Alpha-synuclein detection assay
CN110506057B (zh) 2017-02-17 2023-09-29 百时美施贵宝公司 Alpha突触核蛋白抗体及其应用
TW201901153A (zh) * 2017-05-16 2019-01-01 美商安培恩股份有限公司 折疊錯誤之ｔａｕ蛋白的檢測及檢測折疊錯誤之ｔａｕ蛋白的套組
WO2019070480A1 (en) 2017-10-02 2019-04-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services ASSAY FOR DETECTION OF ALPHA-SYNUCLEIN SELF-ACTIVATION ACTIVITY ASSOCIATED WITH SYNUCLEINOPATHIES
GB201720975D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Anti-alpha synuclein antibodies
GB201720970D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Antibodies
WO2019121952A1 (en) * 2017-12-21 2019-06-27 H. Lundbeck A/S Assay, method and treatment of alpha-synucleinopathies
CN108088816A (zh) * 2018-01-23 2018-05-29 深圳市国赛生物技术有限公司 小型特定蛋白分析仪
GB201803553D0 (en) 2018-03-06 2018-04-18 Univ Newcastle Detection of pathological protein aggregation
WO2019222554A2 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of brain injury or neurological disease using tau protein
EP4404104A3 (en) 2018-09-21 2024-10-16 DeepMind Technologies Limited Machine learning for determining protein structures
JP7376040B2 (ja) * 2019-09-03 2023-11-08 国立大学法人京都工芸繊維大学 神経変性疾患におけるバイオマーカー分子の検出方法
WO2021046174A1 (en) * 2019-09-04 2021-03-11 Amprion, Inc. Alpha-synuclein detection using beads
KR102277871B1 (ko) * 2019-12-17 2021-07-15 원광대학교산학협력단 소변의 알파-씨누클레인 중합체 측정에 의한 파킨슨병 진단 정보의 수집방법 및 그 키트
WO2021198098A1 (en) 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample
CN116057382A (zh) * 2020-05-18 2023-05-02 安培里翁公司 α-突触核蛋白底物及其制备和使用方法
IL303096A (en) * 2020-11-21 2023-07-01 Shuwen Biotech Co Ltd Apparatus and method for detecting misfolded protein in biological sample
US20240192230A1 (en) * 2021-04-15 2024-06-13 The Brigham And Women’S Hospital, Inc. Digital Protein Misfolding Assays
CN114199875B (zh) * 2022-02-18 2022-05-20 之江实验室 一种蛋白质多聚体是否可作为力缓冲剂的判断方法及装置

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6408901A (en) 2000-07-07 2002-01-21 Applied Research Systems Early diagnosis of conformational diseases
EP1366368A2 (en) 2001-01-03 2003-12-03 Ortho-Mcneil Pharmaceutical, Inc. Alpha synuclein aggregation assays
GB0203446D0 (en) * 2002-02-14 2002-04-03 Univ Lancaster Detection and/or monitoring of synuclein-related diseases
EP1820806A1 (en) * 2006-02-16 2007-08-22 Crossbeta Biosciences B.V. Affinity regions
EP1853915B1 (en) * 2005-02-15 2011-10-12 Adlyfe, Inc. Method for detecting misfolded proteins and prions
EP2392583A1 (en) * 2006-05-19 2011-12-07 Alnylam Europe AG. RNAi modulation of Aha and therapeutic uses thereof
WO2008030973A2 (en) * 2006-09-06 2008-03-13 The Board Of Regents Of The University Of Texas System Methods and compositions for the detection of protein folding disorders
JP2010043865A (ja) * 2006-12-12 2010-02-25 Olympus Corp 異常型プリオンの検出方法
WO2011064225A1 (en) * 2009-11-24 2011-06-03 Probiodrug Ag Novel diagnostic method for the diagnosis of alzheimer's disease or mild cgnitive impairment
US9133343B2 (en) * 2009-11-30 2015-09-15 Enzo Biochem, Inc. Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications
EP2666020A1 (en) * 2011-01-18 2013-11-27 The United States of America, as represented by The Secretary, Department of Health and Human Services Methods for amplification and detection of prions
US9534044B2 (en) 2013-02-28 2017-01-03 United Arab Emirates University Alpha-synuclein antibodies and uses thereof
WO2016040903A1 (en) * 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded amyloid beta protein

Also Published As

Publication number Publication date
WO2016040907A1 (en) 2016-03-17
CN107208125A (zh) 2017-09-26
US20160077112A1 (en) 2016-03-17
JP2022000629A (ja) 2022-01-04
JP6980953B2 (ja) 2021-12-15
PL3191599T3 (pl) 2023-12-27
HRP20231232T1 (hr) 2024-01-19
ES2953855T3 (es) 2023-11-16
BR112017004899A2 (pt) 2017-12-12
EP4292654A2 (en) 2023-12-20
EP3191599B1 (en) 2023-08-02
EP3191599A4 (en) 2018-03-14
EP3191599C0 (en) 2023-08-02
CA2960830A1 (en) 2016-03-17
SG10202008464UA (en) 2020-10-29
KR20170103741A (ko) 2017-09-13
JP2017530373A (ja) 2017-10-12
IL251052B (en) 2022-05-01
KR102448128B1 (ko) 2022-09-27
IL251052A0 (en) 2017-04-30
AU2015314783B2 (en) 2021-10-21
MX2017003269A (es) 2017-12-04
EP3191599A1 (en) 2017-07-19
JP7104943B2 (ja) 2022-07-22
IL291809A (en) 2022-06-01
AU2015314783A1 (en) 2017-04-27
SG11201701953RA (en) 2017-04-27
IL291809B2 (en) 2023-06-01
EP4292654A3 (en) 2024-01-03

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