CA2956000C - Anticorps monoclonal anti-ctla4 ou fragment de celui-ci se liant a l'antigene, composition medicinale et son utilisation - Google Patents
Anticorps monoclonal anti-ctla4 ou fragment de celui-ci se liant a l'antigene, composition medicinale et son utilisation Download PDFInfo
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Abstract
Cette invention relève des domaines du traitement des tumeurs et l'immunologie moléculaire et concerne un anticorps monoclonal anti-CTLA4 ou un fragment de celui-ci se liant à l'antigène, une composition médicinale le contenant, et son utilisation. L'anticorps monoclonal selon l'invention bloque la liaison de CTLA4 au B7, ce qui permet d'éliminer l'effet immunosuppresseur de CTLA4 sur l'hôte et d'activer les lymphocytes T.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN201410377352.9A CN105296433B (zh) | 2014-08-01 | 2014-08-01 | 一种ctla4抗体、其药物组合物及其用途 |
CN201410377352.9 | 2014-08-01 | ||
PCT/CN2015/085721 WO2016015675A1 (fr) | 2014-08-01 | 2015-07-31 | Anticorps monoclonal anti-ctla4 ou fragment de celui-ci se liant à l'antigène, composition médicinale et son utilisation |
Publications (2)
Publication Number | Publication Date |
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CA2956000A1 CA2956000A1 (fr) | 2016-02-04 |
CA2956000C true CA2956000C (fr) | 2022-09-27 |
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ID=55194268
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Application Number | Title | Priority Date | Filing Date |
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CA2956000A Active CA2956000C (fr) | 2014-08-01 | 2015-07-31 | Anticorps monoclonal anti-ctla4 ou fragment de celui-ci se liant a l'antigene, composition medicinale et son utilisation |
Country Status (40)
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105296433B (zh) * | 2014-08-01 | 2018-02-09 | 中山康方生物医药有限公司 | 一种ctla4抗体、其药物组合物及其用途 |
CN113603784A (zh) | 2015-05-29 | 2021-11-05 | 艾吉纳斯公司 | 抗-ctla-4抗体及其使用方法 |
EP3344656A1 (fr) | 2015-09-01 | 2018-07-11 | Agenus Inc. | Anticorps anti-pd1 et méthodes d'utilisation de ceux-ci |
US11760803B2 (en) | 2016-03-24 | 2023-09-19 | Takeda Pharmaceutical Company Limited | Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments |
TW201735949A (zh) | 2016-03-24 | 2017-10-16 | 千禧製藥公司 | 治療抗ctla4及抗pd-1組合治療中的胃腸道免疫相關不良事件之方法 |
CN107400166A (zh) * | 2016-05-19 | 2017-11-28 | 苏州康宁杰瑞生物科技有限公司 | 针对ctla4的单域抗体及其衍生蛋白 |
AU2017281830B2 (en) | 2016-06-20 | 2023-04-06 | Kymab Limited | Anti-PD-L1 antibodies |
CN106967172B (zh) * | 2016-08-23 | 2019-01-08 | 康方药业有限公司 | 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途 |
WO2018035710A1 (fr) | 2016-08-23 | 2018-03-01 | Akeso Biopharma, Inc. | Anticorps anti-ctla4 |
EP3522922A4 (fr) * | 2016-10-10 | 2020-06-10 | Crown Bioscience, Inc. (Taicang) | Nouveaux anticorps anti-ctla4 |
CN110023337B (zh) | 2016-10-11 | 2024-01-05 | 艾吉纳斯公司 | 抗lag-3抗体及其使用方法 |
US11013802B2 (en) | 2016-12-07 | 2021-05-25 | Agenus Inc. | Anti-CTLA-4 antibodies and methods of use thereof |
JP2020513819A (ja) * | 2017-03-15 | 2020-05-21 | スージョウ ギャラクシー バイオファーマ カンパニー リミテッド | Ctla4抗体、医薬組成物およびその使用 |
WO2018183408A1 (fr) * | 2017-03-31 | 2018-10-04 | Merck Sharp & Dohme Corp. | Compositions et procédés de traitement du cancer avec une combinaison d'un antagoniste de pd-1 et d'un anticorps anti-ctla4 |
SG11201910134SA (en) * | 2017-05-02 | 2019-11-28 | Merck Sharp & Dohme | Stable formulations of anti-ctla4 antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
RU2019138507A (ru) | 2017-05-02 | 2021-06-02 | Мерк Шарп И Доум Корп. | Составы антител против lag3 и совместные составы антител против lag3 и антител против pd-1 |
AR111760A1 (es) | 2017-05-19 | 2019-08-14 | Novartis Ag | Compuestos y composiciones para el tratamiento de tumores sólidos mediante administración intratumoral |
CN108948194B (zh) * | 2017-05-19 | 2023-02-17 | 上海药明生物技术有限公司 | 一种新的ctla-4单克隆抗体 |
EP3625255A4 (fr) * | 2017-05-19 | 2021-02-24 | Wuxi Biologics (Shanghai) Co. Ltd. | Nouveaux anticorps monoclonaux dirigés contre la protéine 4 associée aux lymphocytes t cytotoxiques (ctla-4) |
CN107325181A (zh) * | 2017-07-05 | 2017-11-07 | 无锡傲锐东源生物科技有限公司 | 抗ctla4蛋白单克隆抗体及其用途 |
CN111511762A (zh) | 2017-08-21 | 2020-08-07 | 天演药业公司 | 抗cd137分子及其用途 |
SG11202001604UA (en) * | 2017-09-21 | 2020-04-29 | Eucure Beijing Biopharma Co Ltd | Anti-ctla4 antibodies and uses thereof |
WO2019148444A1 (fr) * | 2018-02-02 | 2019-08-08 | Adagene Inc. | Anticorps anti-ctla4 et leurs procédés de fabrication et d'utilisation |
WO2019148445A1 (fr) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Anticorps activables dépendant de la précision/du contexte, et leurs procédés de fabrication et d'utilisation |
CN111727056A (zh) * | 2018-02-13 | 2020-09-29 | 默沙东公司 | 用抗pd-1抗体和抗ctla-4抗体治疗癌症的方法 |
CN112218892B (zh) * | 2018-03-19 | 2023-04-25 | 上海药明生物技术有限公司 | 新型抗ctla-4抗体多肽 |
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