CA2954522A1 - Treatment of leukemia with histone deacetylase inhibitors - Google Patents
Treatment of leukemia with histone deacetylase inhibitors Download PDFInfo
- Publication number
- CA2954522A1 CA2954522A1 CA2954522A CA2954522A CA2954522A1 CA 2954522 A1 CA2954522 A1 CA 2954522A1 CA 2954522 A CA2954522 A CA 2954522A CA 2954522 A CA2954522 A CA 2954522A CA 2954522 A1 CA2954522 A1 CA 2954522A1
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- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- subject
- alkyl
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Landscapes
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US9145412B2 (en) | 2012-11-02 | 2015-09-29 | Acetylon Pharmaceuticals, Inc. | Selective HDAC1 and HDAC2 inhibitors |
| JP6626437B2 (ja) | 2013-10-08 | 2019-12-25 | アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | ヒストンデアセチラーゼ阻害剤とＨｅｒ２阻害剤またはＰＩ３Ｋ阻害剤のいずれかの組み合わせ |
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| CN105939716A (zh) | 2013-12-03 | 2016-09-14 | 埃斯泰隆制药公司 | 组蛋白脱乙酰基酶抑制剂和免疫调节药物的组合 |
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| HK1251566A1 (zh) | 2014-12-12 | 2019-02-01 | Regenacy Pharmaceuticals, Llc | 作为hdac1/2抑制剂的呱啶衍生物 |
| EP3286310A4 (en) * | 2015-04-24 | 2019-01-09 | California Institute of Technology | REACTIVATION OF X-CHROMOSOME GENES |
| JP6816036B2 (ja) | 2015-06-08 | 2021-01-20 | アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | ヒストン脱アセチル化阻害剤の結晶形態 |
| WO2016200930A1 (en) | 2015-06-08 | 2016-12-15 | Acetylon Pharmaceuticals, Inc. | Methods of making protein deacetylase inhibitors |
| JP2019515909A (ja) | 2016-04-19 | 2019-06-13 | アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 慢性リンパ性白血病の治療を目的とするｈｄａｃ阻害剤単独またはｂｔｋ阻害剤との配合物 |
| TW201803594A (zh) * | 2016-06-09 | 2018-02-01 | 達納-法伯癌症協會 | Hdac抑制劑與bet抑制劑之使用方法及醫藥組合 |
| JP7100018B2 (ja) | 2016-08-08 | 2022-07-12 | アセチロン ファーマシューティカルズ インコーポレイテッド | ヒストンデアセチラーゼ６阻害剤及びｃｄ２０阻害抗体の薬学的組み合わせならびにその使用 |
| JP2019537427A (ja) | 2016-10-27 | 2019-12-26 | カリフォルニア インスティチュート オブ テクノロジー | Ｘ染色体の再活性化のためのｈｄａｃ阻害剤組成物 |
| JP7090611B2 (ja) | 2016-11-23 | 2022-06-24 | アセチロン ファーマシューティカルズ インコーポレイテッド | ヒストン脱アセチル化酵素阻害剤とプログラム細胞死リガンド１（ｐｄ－ｌ１）阻害剤とを含む医薬組み合わせ物及びその使用方法 |
| CN106810460A (zh) * | 2016-12-30 | 2017-06-09 | 苏州诚和医药化学有限公司 | 一种4‑[2‑(二甲基氨基)乙氧基]苄胺的制备方法 |
| US11709164B2 (en) | 2017-10-26 | 2023-07-25 | National University Of Singapore | Approach for universal monitoring of minimal residual disease in acute myeloid leukemia |
| JP7021503B2 (ja) * | 2017-11-02 | 2022-02-17 | 三菱瓦斯化学株式会社 | 脂肪族ジアミンの製造方法 |
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-
2015
- 2015-07-06 JP JP2017522324A patent/JP6952602B2/ja active Active
- 2015-07-06 WO PCT/US2015/039225 patent/WO2016007423A1/en not_active Ceased
- 2015-07-06 EA EA201790142A patent/EA201790142A1/ru unknown
- 2015-07-06 CN CN201580047830.2A patent/CN107205988A/zh active Pending
- 2015-07-06 SG SG11201700094TA patent/SG11201700094TA/en unknown
- 2015-07-06 US US14/792,046 patent/US9833466B2/en active Active
- 2015-07-06 EP EP15818585.0A patent/EP3166603B1/en active Active
- 2015-07-06 BR BR112017000301A patent/BR112017000301A2/pt not_active Application Discontinuation
- 2015-07-06 CA CA2954522A patent/CA2954522A1/en not_active Abandoned
- 2015-07-06 AU AU2015288060A patent/AU2015288060A1/en not_active Abandoned
- 2015-07-06 MX MX2017000307A patent/MX2017000307A/es unknown
- 2015-07-06 KR KR1020177003321A patent/KR20170044097A/ko not_active Withdrawn
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2017
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Also Published As
| Publication number | Publication date |
|---|---|
| CN107205988A (zh) | 2017-09-26 |
| JP2017524735A (ja) | 2017-08-31 |
| MX2017000307A (es) | 2017-11-23 |
| US20160030458A1 (en) | 2016-02-04 |
| AU2015288060A1 (en) | 2017-02-09 |
| EP3166603A1 (en) | 2017-05-17 |
| IL249935A0 (en) | 2017-03-30 |
| BR112017000301A2 (pt) | 2017-11-07 |
| EA201790142A1 (ru) | 2017-07-31 |
| WO2016007423A1 (en) | 2016-01-14 |
| EP3166603B1 (en) | 2020-02-12 |
| JP6952602B2 (ja) | 2021-10-20 |
| KR20170044097A (ko) | 2017-04-24 |
| SG11201700094TA (en) | 2017-02-27 |
| EP3166603A4 (en) | 2017-12-13 |
| US9833466B2 (en) | 2017-12-05 |
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