CA2951391C - Apelin polypeptides - Google Patents

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Publication number

CA2951391C

CA2951391C CA2951391A CA2951391A CA2951391C CA 2951391 C CA2951391 C CA 2951391C CA 2951391 A CA2951391 A CA 2951391A CA 2951391 A CA2951391 A CA 2951391A CA 2951391 C CA2951391 C CA 2951391C

Authority

CA

Canada

Prior art keywords

aeea

harg

nle

oic

ac4abu

Prior art date

2014-06-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 108010052412 Apelin Proteins 0.000 title description 140
• 102000018746 Apelin Human genes 0.000 title description 123
• 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 366
• 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 292
• 229920001184 polypeptide Polymers 0.000 claims abstract description 257
• 230000001965 increasing effect Effects 0.000 claims abstract description 48
• 206010019280 Heart failures Diseases 0.000 claims abstract description 46
• 102400000252 Apelin-13 Human genes 0.000 claims abstract description 13
• 108010040480 apelin-13 peptide Proteins 0.000 claims abstract description 13
• ODKSFYDXXFIFQN-UHFFFAOYSA-N Arginine Chemical compound OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 907
• 229920001223 polyethylene glycol Polymers 0.000 claims description 184
• 239000002202 Polyethylene glycol Substances 0.000 claims description 166
• -1 Tridecanoyl Chemical group 0.000 claims description 132
• 150000001413 amino acids Chemical group 0.000 claims description 77
• 230000021615 conjugation Effects 0.000 claims description 64
• 108060003951 Immunoglobulin Proteins 0.000 claims description 41
• 102000018358 immunoglobulin Human genes 0.000 claims description 41
• 229920000642 polymer Polymers 0.000 claims description 40
• 125000000628 margaroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 31
• 125000001924 fatty-acyl group Chemical group 0.000 claims description 30
• 230000002526 effect on cardiovascular system Effects 0.000 claims description 28
• 239000008194 pharmaceutical composition Substances 0.000 claims description 28
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 28
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• 125000003104 hexanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 17
• XXCCRHIAIBQDPX-PEWBXTNBSA-N apelin-13 Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCC(N)=O)C1=CN=CN1 XXCCRHIAIBQDPX-PEWBXTNBSA-N 0.000 claims description 15
• 230000000747 cardiac effect Effects 0.000 claims description 15
• 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 15
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