CA2946877C - Methods and systems for point-of-care coagulation assays by optical detection - Google Patents

Methods and systems for point-of-care coagulation assays by optical detection Download PDF

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Publication number
CA2946877C
CA2946877C CA2946877A CA2946877A CA2946877C CA 2946877 C CA2946877 C CA 2946877C CA 2946877 A CA2946877 A CA 2946877A CA 2946877 A CA2946877 A CA 2946877A CA 2946877 C CA2946877 C CA 2946877C
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CA
Canada
Prior art keywords
optical
reaction chamber
sample
optical reference
fluorescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2946877A
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English (en)
French (fr)
Other versions
CA2946877A1 (en
Inventor
Josef Kerimo
Hansong Zeng
Ron Scharlack
Gert Blankenstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Werfen North America
Original Assignee
Instrumentation Laboratory Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instrumentation Laboratory Co filed Critical Instrumentation Laboratory Co
Publication of CA2946877A1 publication Critical patent/CA2946877A1/en
Application granted granted Critical
Publication of CA2946877C publication Critical patent/CA2946877C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
    • G01N21/534—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke by measuring transmission alone, i.e. determining opacity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/59—Transmissivity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/063—Illuminating optical parts
    • G01N2201/0636—Reflectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CA2946877A 2014-04-30 2015-04-27 Methods and systems for point-of-care coagulation assays by optical detection Active CA2946877C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461986475P 2014-04-30 2014-04-30
US61/986,475 2014-04-30
PCT/US2015/027715 WO2015167983A1 (en) 2014-04-30 2015-04-27 Methods and systems for point-of-care coagulation assays by optical detection

Publications (2)

Publication Number Publication Date
CA2946877A1 CA2946877A1 (en) 2015-11-05
CA2946877C true CA2946877C (en) 2021-02-09

Family

ID=53053143

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2946877A Active CA2946877C (en) 2014-04-30 2015-04-27 Methods and systems for point-of-care coagulation assays by optical detection

Country Status (7)

Country Link
US (2) US11079325B2 (enExample)
EP (1) EP3137878A1 (enExample)
JP (2) JP6567549B2 (enExample)
CN (2) CN106605144B (enExample)
AU (1) AU2015253478C1 (enExample)
CA (1) CA2946877C (enExample)
WO (1) WO2015167983A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015167983A1 (en) * 2014-04-30 2015-11-05 Instrumentation Laboratory Company Methods and systems for point-of-care coagulation assays by optical detection
BR112017004506B1 (pt) 2014-09-09 2023-12-19 Perosphere Technologies Inc Microchip de ensaio para a medição de coagulação em uma amostra de sangue ou plasma, dispositivo de microensaio para a medição de coagulação em uma amostra de sangue ou plasma de um indíviduo e método para medição de tempo de coagulação
WO2021195120A1 (en) * 2020-03-24 2021-09-30 In Diagnostics, Inc. Clinical spectrophotometer for general chemistry, immuno-assay and nucleic acid detection
US11906435B2 (en) 2020-09-11 2024-02-20 Atonarp Inc. System including auto-alignment
US12036344B2 (en) * 2020-11-13 2024-07-16 Fresenius Medical Care Holdings, Inc. Systems and methods for analyzing spent dialysate
CN115201498A (zh) * 2021-04-13 2022-10-18 基蛋生物科技股份有限公司 一种用于凝血检测的试剂卡及检测仪器

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US5114860A (en) * 1984-10-09 1992-05-19 Toa Medical Electronics Co., Ltd. Device of measuring a blood coagulating time
CA2069537A1 (en) * 1991-06-07 1992-12-08 Thomas A. Cook Multiple output referencing system for evanescent wave sensor
MY132154A (en) * 1997-06-11 2007-09-28 Nalco Chemical Co Solid-state fluorometer and methods of use therefor
US6830934B1 (en) * 1999-06-15 2004-12-14 Lifescan, Inc. Microdroplet dispensing for a medical diagnostic device
EP2042610A1 (fr) 1999-02-23 2009-04-01 Asulab S.A. Système électrochimique pour la détermination d'un temps de coagulation du sang
GB9906929D0 (en) * 1999-03-26 1999-05-19 Univ Glasgow Assay system
US6252664B1 (en) * 1999-10-15 2001-06-26 Biocrystal Ltd. Fluorescence filter cube for fluorescence detection and imaging
US20030180191A1 (en) 2000-09-18 2003-09-25 Hideyuki Suzuki Micro well array and method of sealing liquid using the micro well array
JP2002221485A (ja) * 2000-11-22 2002-08-09 Minolta Co Ltd マイクロチップ
JP4680422B2 (ja) 2001-05-29 2011-05-11 嘉之 山海 血栓計測装置
AU2003282351A1 (en) * 2002-11-12 2004-06-03 Inverness Medical Switzerland Gmbh Photometric determination of coagulation time in undiluted whole blood
DE10350880A1 (de) * 2003-10-31 2005-06-02 Roche Diagnostics Gmbh Verfahren zur Bestimmung eines Analyten mittels einer Extraktionsschicht
US20050101025A1 (en) * 2003-11-12 2005-05-12 Ho Winston Z. Apparatus for proteins and nucleic acids analysis
EP1775574B1 (en) * 2004-07-27 2018-03-14 LSI Medience Corporation Method for automatic determination of sample
EP1846738A2 (en) * 2005-02-09 2007-10-24 Inlight Solutions, Inc. Methods and apparatus for noninvasive determinations of analytes
WO2006115161A1 (ja) 2005-04-21 2006-11-02 Matsushita Electric Industrial Co., Ltd. 光ヘッド装置及び光情報装置
US7919328B2 (en) * 2006-03-10 2011-04-05 Corning Incorporated Fluorescent ion doped glass and method for using the fluorescent ion doped glass to enhance fluorescence imaging techniques
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WO2015118843A1 (ja) * 2014-02-04 2015-08-13 パナソニックＩｐマネジメント株式会社 試料検出プレート、これを用いた蛍光検出システム及び蛍光検出方法
US10113999B2 (en) * 2014-03-07 2018-10-30 City University Of Hong Kong Method and a device for detecting a substance
WO2015167983A1 (en) * 2014-04-30 2015-11-05 Instrumentation Laboratory Company Methods and systems for point-of-care coagulation assays by optical detection

Also Published As

Publication number Publication date
JP2019194622A (ja) 2019-11-07
JP2017519189A (ja) 2017-07-13
EP3137878A1 (en) 2017-03-08
US20220018765A1 (en) 2022-01-20
US20150316533A1 (en) 2015-11-05
WO2015167983A1 (en) 2015-11-05
JP6567549B2 (ja) 2019-08-28
US11079325B2 (en) 2021-08-03
CA2946877A1 (en) 2015-11-05
CN110554007A (zh) 2019-12-10
AU2015253478C1 (en) 2019-01-17
US12571732B2 (en) 2026-03-10
CN106605144B (zh) 2019-09-27
CN106605144A (zh) 2017-04-26
AU2015253478A1 (en) 2016-11-17
AU2015253478B2 (en) 2018-04-26

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