CA2946877C - Methods and systems for point-of-care coagulation assays by optical detection - Google Patents
Methods and systems for point-of-care coagulation assays by optical detection Download PDFInfo
- Publication number
- CA2946877C CA2946877C CA2946877A CA2946877A CA2946877C CA 2946877 C CA2946877 C CA 2946877C CA 2946877 A CA2946877 A CA 2946877A CA 2946877 A CA2946877 A CA 2946877A CA 2946877 C CA2946877 C CA 2946877C
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- optical
- reaction chamber
- sample
- optical reference
- fluorescence
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
- G01N21/534—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke by measuring transmission alone, i.e. determining opacity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/59—Transmissivity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/062—LED's
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/063—Illuminating optical parts
- G01N2201/0636—Reflectors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461986475P | 2014-04-30 | 2014-04-30 | |
| US61/986,475 | 2014-04-30 | ||
| PCT/US2015/027715 WO2015167983A1 (en) | 2014-04-30 | 2015-04-27 | Methods and systems for point-of-care coagulation assays by optical detection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2946877A1 CA2946877A1 (en) | 2015-11-05 |
| CA2946877C true CA2946877C (en) | 2021-02-09 |
Family
ID=53053143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2946877A Active CA2946877C (en) | 2014-04-30 | 2015-04-27 | Methods and systems for point-of-care coagulation assays by optical detection |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11079325B2 (enExample) |
| EP (1) | EP3137878A1 (enExample) |
| JP (2) | JP6567549B2 (enExample) |
| CN (2) | CN110554007A (enExample) |
| AU (1) | AU2015253478C1 (enExample) |
| CA (1) | CA2946877C (enExample) |
| WO (1) | WO2015167983A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110554007A (zh) * | 2014-04-30 | 2019-12-10 | 仪器实验室公司 | 用于通过光检测进行定点照护凝固测定的方法及系统 |
| EP3191836B1 (en) | 2014-09-09 | 2022-11-23 | Perosphere Technologies Inc. | Microfluid chip-based, universal coagulation assay |
| WO2021195120A1 (en) * | 2020-03-24 | 2021-09-30 | In Diagnostics, Inc. | Clinical spectrophotometer for general chemistry, immuno-assay and nucleic acid detection |
| WO2022054921A1 (en) * | 2020-09-11 | 2022-03-17 | Atonarp Inc. | System including auto-alignment |
| US12036344B2 (en) * | 2020-11-13 | 2024-07-16 | Fresenius Medical Care Holdings, Inc. | Systems and methods for analyzing spent dialysate |
| CN115201498A (zh) * | 2021-04-13 | 2022-10-18 | 基蛋生物科技股份有限公司 | 一种用于凝血检测的试剂卡及检测仪器 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2383444A1 (fr) | 1977-03-11 | 1978-10-06 | Laborgeraete Analysensyst Gmbh | Mesure du temps de coagulation de sang |
| US5114860A (en) * | 1984-10-09 | 1992-05-19 | Toa Medical Electronics Co., Ltd. | Device of measuring a blood coagulating time |
| CA2069537A1 (en) * | 1991-06-07 | 1992-12-08 | Thomas A. Cook | Multiple output referencing system for evanescent wave sensor |
| JP2002514308A (ja) * | 1997-06-11 | 2002-05-14 | ネルコ ケミカル カンパニー | 半導体蛍光光度計およびその使用方法 |
| US6830934B1 (en) * | 1999-06-15 | 2004-12-14 | Lifescan, Inc. | Microdroplet dispensing for a medical diagnostic device |
| DE69941563D1 (de) | 1999-02-23 | 2009-12-03 | Asulab Sa | Elektrochemisches System zur Bestimmung der Blutgerinnungszeit |
| GB9906929D0 (en) * | 1999-03-26 | 1999-05-19 | Univ Glasgow | Assay system |
| US6252664B1 (en) * | 1999-10-15 | 2001-06-26 | Biocrystal Ltd. | Fluorescence filter cube for fluorescence detection and imaging |
| AU2001286262A1 (en) * | 2000-09-18 | 2002-04-02 | Center For Advanced Science And Technology Incubation, Ltd. (Casti) | Micro well array and method of sealing liquid using the micro well array |
| JP2002221485A (ja) * | 2000-11-22 | 2002-08-09 | Minolta Co Ltd | マイクロチップ |
| JP4680422B2 (ja) | 2001-05-29 | 2011-05-11 | 嘉之 山海 | 血栓計測装置 |
| US20060110283A1 (en) * | 2002-11-12 | 2006-05-25 | Inverness Medical Switzerland Gmbh | Photometric determination of coagulation time in undiluted whole blood |
| DE10350880A1 (de) * | 2003-10-31 | 2005-06-02 | Roche Diagnostics Gmbh | Verfahren zur Bestimmung eines Analyten mittels einer Extraktionsschicht |
| US20050101025A1 (en) * | 2003-11-12 | 2005-05-12 | Ho Winston Z. | Apparatus for proteins and nucleic acids analysis |
| EP1775574B1 (en) * | 2004-07-27 | 2018-03-14 | LSI Medience Corporation | Method for automatic determination of sample |
| JP2008537897A (ja) * | 2005-02-09 | 2008-10-02 | インライト ソリューションズ，インク． | 非侵襲的に検体を判定する方法及び装置 |
| CN101194309A (zh) | 2005-04-21 | 2008-06-04 | 松下电器产业株式会社 | 光学头装置及光信息装置 |
| US7919328B2 (en) * | 2006-03-10 | 2011-04-05 | Corning Incorporated | Fluorescent ion doped glass and method for using the fluorescent ion doped glass to enhance fluorescence imaging techniques |
| EP1969997A1 (en) * | 2007-03-12 | 2008-09-17 | Radiometer Basel AG | Sensor system |
| US9176049B2 (en) * | 2007-10-30 | 2015-11-03 | Arkray Inc | Method of optical analysis using reference cell and base plate correction and apparatus thereof |
| KR101022769B1 (ko) * | 2008-10-20 | 2011-03-17 | 삼성전자주식회사 | 바이오칩용 광검출 장치 |
| JP2010101835A (ja) * | 2008-10-27 | 2010-05-06 | Toshiba Corp | 蛍光基準部材、及び蛍光基準部材を備える蛍光検知装置 |
| JP4659146B2 (ja) * | 2009-07-03 | 2011-03-30 | シスメックス株式会社 | 血液分析装置及び血液分析方法 |
| JP5367509B2 (ja) | 2009-08-27 | 2013-12-11 | 株式会社東芝 | 光検出装置、及びこの光検出装置を備える紙葉類処理装置 |
| US20130301051A1 (en) * | 2010-06-18 | 2013-11-14 | Andrew Pogosyan | Scattering light source multi-wavelength photometer |
| WO2012096566A1 (en) | 2010-12-14 | 2012-07-19 | Stichting Katholieke Universiteit | Chemiluminescence-based haemostasis assay |
| SG194064A1 (en) | 2011-04-08 | 2013-11-29 | Panasonic Corp | Diagnosis kit and method of using the same |
| JP6244556B2 (ja) | 2012-04-25 | 2017-12-13 | パナソニックＩｐマネジメント株式会社 | 試料保持担体およびそれを用いた蛍光検出装置 |
| EP3104167A4 (en) * | 2014-02-04 | 2017-01-25 | Panasonic Intellectual Property Management Co., Ltd. | Sample detection plate, and fluorescence detection system and fluorescence detection method using same |
| US10113999B2 (en) * | 2014-03-07 | 2018-10-30 | City University Of Hong Kong | Method and a device for detecting a substance |
| CN110554007A (zh) * | 2014-04-30 | 2019-12-10 | 仪器实验室公司 | 用于通过光检测进行定点照护凝固测定的方法及系统 |
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2015
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- 2015-04-27 AU AU2015253478A patent/AU2015253478C1/en active Active
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| CN106605144B (zh) | 2019-09-27 |
| CA2946877A1 (en) | 2015-11-05 |
| AU2015253478B2 (en) | 2018-04-26 |
| AU2015253478A1 (en) | 2016-11-17 |
| AU2015253478C1 (en) | 2019-01-17 |
| CN110554007A (zh) | 2019-12-10 |
| US20150316533A1 (en) | 2015-11-05 |
| JP2017519189A (ja) | 2017-07-13 |
| JP6567549B2 (ja) | 2019-08-28 |
| CN106605144A (zh) | 2017-04-26 |
| EP3137878A1 (en) | 2017-03-08 |
| US20220018765A1 (en) | 2022-01-20 |
| US11079325B2 (en) | 2021-08-03 |
| JP2019194622A (ja) | 2019-11-07 |
| WO2015167983A1 (en) | 2015-11-05 |
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