AU2015253478C1 - Methods and systems for point-of-care coagulation assays by optical detection - Google Patents

Methods and systems for point-of-care coagulation assays by optical detection Download PDF

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Publication number
AU2015253478C1
AU2015253478C1 AU2015253478A AU2015253478A AU2015253478C1 AU 2015253478 C1 AU2015253478 C1 AU 2015253478C1 AU 2015253478 A AU2015253478 A AU 2015253478A AU 2015253478 A AU2015253478 A AU 2015253478A AU 2015253478 C1 AU2015253478 C1 AU 2015253478C1
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Australia
Prior art keywords
optical
reaction chamber
fluorescence
excitation light
assay system
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AU2015253478A
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English (en)
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AU2015253478B2 (en
AU2015253478A1 (en
Inventor
Gert Blankenstein
Josef Kerimo
Ron Scharlack
Hansong Zeng
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Werfen North America
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Instrumentation Laboratory Co
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Publication of AU2015253478B2 publication Critical patent/AU2015253478B2/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/49Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/53Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
    • G01N21/534Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke by measuring transmission alone, i.e. determining opacity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • G01N33/4905Determining clotting time of blood
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/59Transmissivity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6408Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6486Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/06Illumination; Optics
    • G01N2201/062LED's
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/06Illumination; Optics
    • G01N2201/063Illuminating optical parts
    • G01N2201/0636Reflectors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
AU2015253478A 2014-04-30 2015-04-27 Methods and systems for point-of-care coagulation assays by optical detection Active AU2015253478C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461986475P 2014-04-30 2014-04-30
US61/986,475 2014-04-30
PCT/US2015/027715 WO2015167983A1 (en) 2014-04-30 2015-04-27 Methods and systems for point-of-care coagulation assays by optical detection

Publications (3)

Publication Number Publication Date
AU2015253478A1 AU2015253478A1 (en) 2016-11-17
AU2015253478B2 AU2015253478B2 (en) 2018-04-26
AU2015253478C1 true AU2015253478C1 (en) 2019-01-17

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Family Applications (1)

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AU2015253478A Active AU2015253478C1 (en) 2014-04-30 2015-04-27 Methods and systems for point-of-care coagulation assays by optical detection

Country Status (7)

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US (2) US11079325B2 (enExample)
EP (1) EP3137878A1 (enExample)
JP (2) JP6567549B2 (enExample)
CN (2) CN110554007A (enExample)
AU (1) AU2015253478C1 (enExample)
CA (1) CA2946877C (enExample)
WO (1) WO2015167983A1 (enExample)

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CN110554007A (zh) * 2014-04-30 2019-12-10 仪器实验室公司 用于通过光检测进行定点照护凝固测定的方法及系统
EP3191836B1 (en) 2014-09-09 2022-11-23 Perosphere Technologies Inc. Microfluid chip-based, universal coagulation assay
WO2021195120A1 (en) * 2020-03-24 2021-09-30 In Diagnostics, Inc. Clinical spectrophotometer for general chemistry, immuno-assay and nucleic acid detection
WO2022054921A1 (en) * 2020-09-11 2022-03-17 Atonarp Inc. System including auto-alignment
US12036344B2 (en) * 2020-11-13 2024-07-16 Fresenius Medical Care Holdings, Inc. Systems and methods for analyzing spent dialysate
CN115201498A (zh) * 2021-04-13 2022-10-18 基蛋生物科技股份有限公司 一种用于凝血检测的试剂卡及检测仪器

Citations (2)

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Publication number Priority date Publication date Assignee Title
US5114860A (en) * 1984-10-09 1992-05-19 Toa Medical Electronics Co., Ltd. Device of measuring a blood coagulating time
US20080096285A1 (en) * 2004-07-27 2008-04-24 Atsushi Koyata Method for Automatic Determination of Sample

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JP2002514308A (ja) * 1997-06-11 2002-05-14 ネルコ ケミカル カンパニー 半導体蛍光光度計およびその使用方法
US6830934B1 (en) * 1999-06-15 2004-12-14 Lifescan, Inc. Microdroplet dispensing for a medical diagnostic device
DE69941563D1 (de) 1999-02-23 2009-12-03 Asulab Sa Elektrochemisches System zur Bestimmung der Blutgerinnungszeit
GB9906929D0 (en) * 1999-03-26 1999-05-19 Univ Glasgow Assay system
US6252664B1 (en) * 1999-10-15 2001-06-26 Biocrystal Ltd. Fluorescence filter cube for fluorescence detection and imaging
AU2001286262A1 (en) * 2000-09-18 2002-04-02 Center For Advanced Science And Technology Incubation, Ltd. (Casti) Micro well array and method of sealing liquid using the micro well array
JP2002221485A (ja) * 2000-11-22 2002-08-09 Minolta Co Ltd マイクロチップ
JP4680422B2 (ja) 2001-05-29 2011-05-11 嘉之 山海 血栓計測装置
US20060110283A1 (en) * 2002-11-12 2006-05-25 Inverness Medical Switzerland Gmbh Photometric determination of coagulation time in undiluted whole blood
DE10350880A1 (de) * 2003-10-31 2005-06-02 Roche Diagnostics Gmbh Verfahren zur Bestimmung eines Analyten mittels einer Extraktionsschicht
US20050101025A1 (en) * 2003-11-12 2005-05-12 Ho Winston Z. Apparatus for proteins and nucleic acids analysis
JP2008537897A (ja) * 2005-02-09 2008-10-02 インライト ソリューションズ,インク. 非侵襲的に検体を判定する方法及び装置
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US5114860A (en) * 1984-10-09 1992-05-19 Toa Medical Electronics Co., Ltd. Device of measuring a blood coagulating time
US20080096285A1 (en) * 2004-07-27 2008-04-24 Atsushi Koyata Method for Automatic Determination of Sample

Also Published As

Publication number Publication date
CA2946877C (en) 2021-02-09
CN106605144B (zh) 2019-09-27
CA2946877A1 (en) 2015-11-05
AU2015253478B2 (en) 2018-04-26
AU2015253478A1 (en) 2016-11-17
CN110554007A (zh) 2019-12-10
US20150316533A1 (en) 2015-11-05
JP2017519189A (ja) 2017-07-13
JP6567549B2 (ja) 2019-08-28
CN106605144A (zh) 2017-04-26
EP3137878A1 (en) 2017-03-08
US20220018765A1 (en) 2022-01-20
US11079325B2 (en) 2021-08-03
JP2019194622A (ja) 2019-11-07
WO2015167983A1 (en) 2015-11-05

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