CA2943254C - Bioassay system and method for detecting analytes in body fluids - Google Patents

Bioassay system and method for detecting analytes in body fluids Download PDF

Info

Publication number
CA2943254C
CA2943254C CA2943254A CA2943254A CA2943254C CA 2943254 C CA2943254 C CA 2943254C CA 2943254 A CA2943254 A CA 2943254A CA 2943254 A CA2943254 A CA 2943254A CA 2943254 C CA2943254 C CA 2943254C
Authority
CA
Canada
Prior art keywords
target analyte
antibody
resonance
grating structure
coupled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2943254A
Other languages
English (en)
French (fr)
Other versions
CA2943254A1 (en
Inventor
Josef Kerimo
Hansong Zeng
Ron Scharlack
Gert Blankenstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Werfen North America
Original Assignee
Instrumentation Laboratory Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instrumentation Laboratory Co filed Critical Instrumentation Laboratory Co
Publication of CA2943254A1 publication Critical patent/CA2943254A1/en
Application granted granted Critical
Publication of CA2943254C publication Critical patent/CA2943254C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Materials Engineering (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CA2943254A 2014-03-24 2015-03-20 Bioassay system and method for detecting analytes in body fluids Active CA2943254C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461969371P 2014-03-24 2014-03-24
US61/969,371 2014-03-24
PCT/US2015/021651 WO2015148290A1 (en) 2014-03-24 2015-03-20 Bioassay system and method for detecting analytes in body fluids

Publications (2)

Publication Number Publication Date
CA2943254A1 CA2943254A1 (en) 2015-10-01
CA2943254C true CA2943254C (en) 2021-05-04

Family

ID=52991948

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2943254A Active CA2943254C (en) 2014-03-24 2015-03-20 Bioassay system and method for detecting analytes in body fluids

Country Status (8)

Country Link
US (1) US20150268237A1 (https=)
EP (1) EP3123172B1 (https=)
JP (1) JP6606509B2 (https=)
CN (1) CN106461559B (https=)
AU (1) AU2015236470B2 (https=)
CA (1) CA2943254C (https=)
ES (1) ES2854352T3 (https=)
WO (1) WO2015148290A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108713144B (zh) * 2016-02-09 2021-08-13 积水化学工业株式会社 检测用器具、检测装置和检测方法
JP6633978B2 (ja) * 2016-06-17 2020-01-22 積水化学工業株式会社 検査キット及び検査方法
US10877192B2 (en) 2017-04-18 2020-12-29 Saudi Arabian Oil Company Method of fabricating smart photonic structures for material monitoring
US10401155B2 (en) 2017-05-12 2019-09-03 Saudi Arabian Oil Company Apparatus and method for smart material analysis
CN107356570B (zh) * 2017-06-08 2020-10-27 大连海事大学 一种固态上转换荧光探针及其制备方法与应用
ES2832880T3 (es) * 2017-06-08 2021-06-11 Lumito Ab Un método de análisis de una muestra para al menos un analito
US10746534B2 (en) 2017-07-03 2020-08-18 Saudi Arabian Oil Company Smart coating device for storage tank monitoring and calibration
CA3069148A1 (en) * 2017-07-11 2019-01-17 Aviana Molecular Technologies, Llc Signal amplification in biosensor device
CN108163802B (zh) * 2017-12-06 2020-02-07 北京纳百生物科技有限公司 一种抗原检测材料及其制备方法和应用
JP7345782B2 (ja) * 2018-07-31 2023-09-19 積水化学工業株式会社 検査方法、検査用器具及び検査装置
CN108957839B (zh) * 2018-08-09 2022-09-30 京东方科技集团股份有限公司 显示装置、显示面板、彩膜基板及彩膜
CN109470652A (zh) * 2018-10-24 2019-03-15 北京邮电大学 基于Fano谐振的椭圆空气孔部分刻蚀型光子晶体传感器
US11391730B2 (en) * 2019-12-31 2022-07-19 Robert Bosch Gmbh Sensor refresh systems
TW202440035A (zh) 2022-12-15 2024-10-16 美商阿達普提克斯生物科學公司 分析物偵測之系統及方法
WO2025100392A1 (ja) * 2023-11-06 2025-05-15 公立大学法人大阪 光学センサ、被検出物質の検出システムおよび光学センサの製造方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208479A (en) * 1977-07-14 1980-06-17 Syva Company Label modified immunoassays
DK0723146T3 (da) * 1992-09-14 2004-08-30 Stanford Res Inst Int Opkonverterende reportermolekyler til biologiske og andre assays ved anvendelse af laser-excitationsteknikker
JP2001116699A (ja) * 1999-10-21 2001-04-27 Ngk Insulators Ltd 遺伝子診断方法
US6951715B2 (en) * 2000-10-30 2005-10-04 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US6560020B1 (en) * 2001-01-16 2003-05-06 Holotek, Llc Surface-relief diffraction grating
US7008559B2 (en) * 2001-06-06 2006-03-07 Nomadics, Inc. Manganese doped upconversion luminescence nanoparticles
DE602004021685D1 (de) * 2003-03-27 2009-08-06 Corning Inc Markierungsfreier nachweis biologischer und chemischer stoffe mittels evaneszenzfeld
JP2007240361A (ja) * 2006-03-09 2007-09-20 Sekisui Chem Co Ltd 局在プラズモン増強センサ
EP1912067A1 (en) * 2006-10-12 2008-04-16 Eppendorf Array Technologies S.A. Method for quantification of a target compound obtained from a biological sample upon chips
CA2747942C (en) * 2008-12-22 2016-12-06 F. Hoffmann-La Roche Ag Armet as a marker for cancer
CN102375060B (zh) * 2010-08-19 2014-12-31 中国人民解放军军事医学科学院微生物流行病研究所 一种基于上转换发光十通道免疫层析的食源性致病菌检测试纸盘
WO2013095302A1 (en) * 2011-12-19 2013-06-27 Nanyang Technological University Synthesis of upconvension nanocomposites for photodynamic therapy
JP5975480B2 (ja) * 2012-01-31 2016-08-23 国立研究開発法人産業技術総合研究所 バイオチップ、バイオアッセイ用キット、及びバイオアッセイ方法
WO2014011118A1 (en) * 2012-07-12 2014-01-16 National University Of Singapore An upconversion fluorescent nanoparticle

Also Published As

Publication number Publication date
CN106461559B (zh) 2020-07-03
JP6606509B2 (ja) 2019-11-13
WO2015148290A1 (en) 2015-10-01
US20150268237A1 (en) 2015-09-24
AU2015236470A1 (en) 2016-10-06
AU2015236470B2 (en) 2019-03-07
CN106461559A (zh) 2017-02-22
EP3123172A1 (en) 2017-02-01
EP3123172B1 (en) 2021-01-13
CA2943254A1 (en) 2015-10-01
JP2017508975A (ja) 2017-03-30
ES2854352T3 (es) 2021-09-21

Similar Documents

Publication Publication Date Title
CA2943254C (en) Bioassay system and method for detecting analytes in body fluids
CN102165305B (zh) 检测系统与方法
CN106959370B (zh) 一种基于耦合光栅的荧光生物传感器及检测方法
JP2009511896A (ja) 全ポリマー光導波路センサ
JP2010518389A (ja) エバネセント導波管及び集積センサを用いるバイオセンサ
KR101799163B1 (ko) 바이오 센서용 광학 표지자, 이를 포함하는 광학 바이오센서 및 상기 바이오 센서용 광학 표지자의 제조방법
AU2010206657A1 (en) Apparatus and methods for detecting inflammation using quantum dots
CN108474741A (zh) 流体中粒子的光学检测
WO2010134592A1 (ja) Ｓｐｆｓ－ｌｐｆｓ系による測定方法に供するプラズモン励起センサおよびアッセイ法
EP4094072A1 (en) Digital microfluidic (dmf) system, dmf cartridge, and method including integrated optical fiber sensing
JP4885019B2 (ja) 表面プラズモン増強蛍光センサ
WO2009078511A1 (en) Fluorescence microscope using surface plasmon resonance
JP2010145272A (ja) プラズモン励起センサを用いたアッセイ法
EP2060904A1 (en) Plasmon grating biosensor
JP5315381B2 (ja) 蛍光検出装置、蛍光検出用の試料セルおよび蛍光検出方法
EP3218717B1 (en) Dynamic switching biosensor
JP2009080011A (ja) 蛍光検出方法
WO2021131331A1 (ja) 蛍光検出用生体分子検査チップ
JP6913966B2 (ja) センサチップ、目的物質検出装置及び目的物質検出方法
WO2014007134A1 (ja) センサーチップ
JP2011127991A (ja) プラズモン励起センサおよび該センサを用いたアッセイ法
JP2014025879A (ja) センサーチップおよびこのセンサーチップを備えた光学式検体検出装置
US7701579B2 (en) Fluorescence sensor
JP2011169609A (ja) プラズモン励起センサを用いたアッセイ法
Wang Development of nanophotonic biosensor platform towards on-chip liquid biopsy

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180122

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 10TH ANNIV.) - STANDARD

Year of fee payment: 10

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250314

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20250314