CA2930324C - Aminopyridine derivatives as tam family kinase inhibitors - Google Patents
Aminopyridine derivatives as tam family kinase inhibitors Download PDFInfo
- Publication number
- CA2930324C CA2930324C CA2930324A CA2930324A CA2930324C CA 2930324 C CA2930324 C CA 2930324C CA 2930324 A CA2930324 A CA 2930324A CA 2930324 A CA2930324 A CA 2930324A CA 2930324 C CA2930324 C CA 2930324C
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- CA
- Canada
- Prior art keywords
- pyrazol
- pyridin
- amine
- compound
- oxadiazol
- Prior art date
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- -1 aralkynyl Chemical group 0.000 claims description 149
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 98
- 239000001257 hydrogen Substances 0.000 claims description 98
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 98
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 84
- 125000003118 aryl group Chemical group 0.000 claims description 75
- 125000001072 heteroaryl group Chemical group 0.000 claims description 75
- 125000000623 heterocyclic group Chemical group 0.000 claims description 75
- 125000000217 alkyl group Chemical group 0.000 claims description 61
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
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- Reproductive Health (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (5)
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| US201361909830P | 2013-11-27 | 2013-11-27 | |
| US201361909828P | 2013-11-27 | 2013-11-27 | |
| US61/909,828 | 2013-11-27 | ||
| US61/909,830 | 2013-11-27 | ||
| PCT/US2014/067709 WO2015081257A2 (en) | 2013-11-27 | 2014-11-26 | Aminopyridine derivatives as tam family kinase inhibitors |
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| CA2930324A1 CA2930324A1 (en) | 2015-06-04 |
| CA2930324C true CA2930324C (en) | 2022-01-18 |
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| WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
| JP7366031B2 (ja) | 2017-09-22 | 2023-10-20 | カイメラ セラピューティクス， インコーポレイテッド | タンパク質分解剤およびそれらの使用 |
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| WO2019140380A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
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| US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
| US20220356185A1 (en) * | 2018-07-06 | 2022-11-10 | Kymera Therapeutics, Inc. | Mertk degraders and uses thereof |
| EP3817822A4 (en) | 2018-07-06 | 2022-07-27 | Kymera Therapeutics, Inc. | PROTEIN DEGRADANTS AND USES THEREOF |
| AU2019343044B2 (en) * | 2018-09-18 | 2025-03-06 | Signalchem Lifesciences Corporation | Combination therapy for treating blood cancer |
| KR20250167680A (ko) | 2018-11-30 | 2025-12-01 | 카이메라 쎄라퓨틱스 인코포레이티드 | Irak 분해제 및 이의 용도 |
| US11591332B2 (en) | 2019-12-17 | 2023-02-28 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| WO2021127190A1 (en) | 2019-12-17 | 2021-06-24 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| AU2020412780A1 (en) | 2019-12-23 | 2022-07-21 | Kymera Therapeutics, Inc. | SMARCA degraders and uses thereof |
| KR20230005160A (ko) | 2020-03-19 | 2023-01-09 | 카이메라 쎄라퓨틱스 인코포레이티드 | Mdm2 분해제 및 이의 용도 |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| CN112707898A (zh) * | 2020-12-21 | 2021-04-27 | 徐新杰 | 一种杂芳基取代的吡嗪衍生物及其应用 |
| JP2024503300A (ja) | 2020-12-30 | 2024-01-25 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ分解剤およびそれらの使用 |
| EP4284368B1 (en) * | 2021-02-01 | 2024-12-11 | SignalChem Lifesciences Corporation | Use of the axl inhibitor slc-391 as antiviral therapeutic agent |
| TW202245788A (zh) | 2021-02-15 | 2022-12-01 | 美商凱麥拉醫療公司 | Irak4降解劑及其用途 |
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| PT2114955E (pt) | 2006-12-29 | 2013-04-18 | Rigel Pharmaceuticals Inc | Triazoles substituídos com arilo bicíclico em ponte ou heteroarilo bicíclico em ponte úteis como inibidores de axl |
| ES2607065T3 (es) | 2006-12-29 | 2017-03-29 | Rigel Pharmaceuticals, Inc. | Triazoles N3-heteroaril sustituidos y triazoles N5-heteroaril sustituidos útiles como inhibidores de axl |
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| WO2008128072A2 (en) | 2007-04-13 | 2008-10-23 | Supergen, Inc. | Axl kinase inhibitors useful for the treatment of cancer or hyperproliferative disorders |
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| GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
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| EP2328888B1 (en) * | 2008-07-09 | 2012-11-07 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
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2014
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- 2014-11-26 CN CN201480065032.8A patent/CN105764514B/zh active Active
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- 2014-11-26 BR BR112016012146-5A patent/BR112016012146B1/pt active IP Right Grant
- 2014-11-26 CN CN201910548630.5A patent/CN110156770B/zh active Active
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- 2014-11-26 EP EP14819178.6A patent/EP3074390B1/en active Active
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- 2014-11-26 KR KR1020167016444A patent/KR102398473B1/ko active Active
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| US20170022189A1 (en) | 2017-01-26 |
| JP6496731B2 (ja) | 2019-04-03 |
| BR112016012146A8 (pt) | 2018-01-30 |
| CN105764514B (zh) | 2019-07-12 |
| EP3074390A2 (en) | 2016-10-05 |
| CA2930324A1 (en) | 2015-06-04 |
| KR102398473B1 (ko) | 2022-05-16 |
| JP2017501981A (ja) | 2017-01-19 |
| CN110156770B (zh) | 2022-10-04 |
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| US10233176B2 (en) | 2019-03-19 |
| US20190152965A1 (en) | 2019-05-23 |
| US11034686B2 (en) | 2021-06-15 |
| KR20160091358A (ko) | 2016-08-02 |
| US11034685B2 (en) | 2021-06-15 |
| AU2014354711B2 (en) | 2018-10-25 |
| US10723725B2 (en) | 2020-07-28 |
| IL245660A0 (en) | 2016-06-30 |
| CN105764514A (zh) | 2016-07-13 |
| IL245660B (en) | 2020-01-30 |
| WO2015081257A2 (en) | 2015-06-04 |
| BR112016012146A2 (pt) | 2017-08-08 |
| MX373365B (es) | 2020-05-26 |
| US20200299288A1 (en) | 2020-09-24 |
| AU2014354711A1 (en) | 2016-06-02 |
| MX2016006815A (es) | 2016-12-02 |
| EP3074390B1 (en) | 2020-07-08 |
| US20200299287A1 (en) | 2020-09-24 |
| WO2015081257A3 (en) | 2015-07-02 |
| BR112016012146B1 (pt) | 2022-11-01 |
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