CA2929715A1 - Methods for inhibiting tie2 kinase useful in the treatment of cancer - Google Patents
Methods for inhibiting tie2 kinase useful in the treatment of cancer Download PDFInfo
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- CA2929715A1 CA2929715A1 CA2929715A CA2929715A CA2929715A1 CA 2929715 A1 CA2929715 A1 CA 2929715A1 CA 2929715 A CA2929715 A CA 2929715A CA 2929715 A CA2929715 A CA 2929715A CA 2929715 A1 CA2929715 A1 CA 2929715A1
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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Landscapes
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- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2013/069005 WO2015069266A1 (en) | 2013-11-07 | 2013-11-07 | Methods for inhibiting tie2 kinase useful in the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2929715A1 true CA2929715A1 (en) | 2015-05-14 |
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| CA2929715A Abandoned CA2929715A1 (en) | 2013-11-07 | 2013-11-07 | Methods for inhibiting tie2 kinase useful in the treatment of cancer |
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| EP (1) | EP3065549A4 (zh) |
| JP (1) | JP6568093B2 (zh) |
| KR (2) | KR20160070188A (zh) |
| CN (2) | CN105873440B (zh) |
| AU (3) | AU2013404949B2 (zh) |
| CA (1) | CA2929715A1 (zh) |
| WO (1) | WO2015069266A1 (zh) |
Families Citing this family (22)
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| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| KR20160070188A (ko) * | 2013-11-07 | 2016-06-17 | 데시페라 파마슈티칼스, 엘엘씨. | 암치료에 유용한 tie2 키나아제의 억제 방법 |
| ES2710211T3 (es) | 2014-02-04 | 2019-04-23 | Pfizer | Combinación de un antagonista de PD-1 y un inhibidor de VEGFR para tratar el cáncer |
| RU2714233C2 (ru) | 2015-02-26 | 2020-02-13 | Мерк Патент Гмбх | Ингибиторы pd-1 / pd-l1 для лечения рака |
| WO2016191401A1 (en) * | 2015-05-27 | 2016-12-01 | Albert Einstein College Of Medicine, Inc. | Tmem active test and uses thereof in diagnosis, prognosis and treatment of tumors |
| CA2989586A1 (en) | 2015-06-16 | 2016-12-22 | Pfizer, Inc. | Pd-l1 antagonist combination treatments |
| CN114191428A (zh) | 2016-03-02 | 2022-03-18 | 卫材研究发展管理有限公司 | 基于艾日布林的抗体-药物偶联物和使用方法 |
| US10690673B2 (en) | 2016-03-29 | 2020-06-23 | Mayo Foundation For Medical Education And Research | Method of treating cancer metastasis by CDK 4/6 inhibitors |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| KR20190062515A (ko) | 2016-10-06 | 2019-06-05 | 화이자 인코포레이티드 | 암의 치료를 위한 아벨루맙의 투약 용법 |
| US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| CN106822128A (zh) * | 2017-02-24 | 2017-06-13 | 南华大学附属第医院 | 酪氨酸激酶抑制剂dcc‑2036的新应用 |
| CN111818915B (zh) | 2018-01-31 | 2024-05-24 | 德西费拉制药有限责任公司 | 治疗胃肠道间质瘤的组合疗法 |
| CN110003181B (zh) * | 2019-05-22 | 2020-08-28 | 北京凯恩梅格医药科技有限公司 | 一种基于克唑替尼结构的c-Met/HDAC双靶点抑制剂及其合成方法与应用 |
| TW202122085A (zh) * | 2019-08-12 | 2021-06-16 | 美商迪賽孚爾製藥公司 | 治療血管畸形之方法 |
| KR20220045189A (ko) | 2019-08-12 | 2022-04-12 | 데시페라 파마슈티칼스, 엘엘씨. | 위장관 기질 종양을 치료하는 방법 |
| TW202122082A (zh) | 2019-08-12 | 2021-06-16 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| CN112812109B (zh) * | 2019-11-18 | 2022-06-21 | 中国科学院微生物研究所 | 化合物DaP-01及其制备方法和应用 |
| JP2023509628A (ja) | 2019-12-30 | 2023-03-09 | デシフェラ・ファーマシューティカルズ，エルエルシー | １－（４－ブロモ－５－（１－エチル－７－（メチルアミノ）－２－オキソ－１，２－ジヒドロ－１，６－ナフチリジン－３－イル）－２－フルオロフェニル）－３－フェニル尿素の組成物 |
| EP4327827A3 (en) | 2019-12-30 | 2024-05-29 | Deciphera Pharmaceuticals, LLC | Amorphous kinase inhibitor formulations and methods of use thereof |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (7)
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|---|---|---|---|---|
| US20130023587A1 (en) * | 2010-04-01 | 2013-01-24 | Duke University | Compositions and methods for the treatment of cancer |
| WO2011150198A1 (en) * | 2010-05-27 | 2011-12-01 | Ambit Biosciences Corporation | Azolyl urea compounds and methods of use thereof |
| WO2012097021A1 (en) * | 2011-01-11 | 2012-07-19 | Glaxosmithkline Llc | Combination |
| MX359664B (es) * | 2011-07-29 | 2018-10-05 | Univ Colorado Regents | Tratamiento de cáncer de mama. |
| WO2013036232A2 (en) * | 2011-09-08 | 2013-03-14 | Deciphera Pharmaceuticals, Llc | Methods and compositions for the treatment of myeloproliferative diseases and other proliferative diseases |
| US20130071403A1 (en) * | 2011-09-20 | 2013-03-21 | Vical Incorporated | Synergistic anti-tumor efficacy using alloantigen combination immunotherapy |
| KR20160070188A (ko) * | 2013-11-07 | 2016-06-17 | 데시페라 파마슈티칼스, 엘엘씨. | 암치료에 유용한 tie2 키나아제의 억제 방법 |
-
2013
- 2013-11-07 KR KR1020167014649A patent/KR20160070188A/ko active Application Filing
- 2013-11-07 CN CN201380081931.2A patent/CN105873440B/zh active Active
- 2013-11-07 CA CA2929715A patent/CA2929715A1/en not_active Abandoned
- 2013-11-07 JP JP2016552405A patent/JP6568093B2/ja active Active
- 2013-11-07 WO PCT/US2013/069005 patent/WO2015069266A1/en active Application Filing
- 2013-11-07 AU AU2013404949A patent/AU2013404949B2/en active Active
- 2013-11-07 KR KR1020217015635A patent/KR20210063475A/ko not_active Application Discontinuation
- 2013-11-07 CN CN201810436668.9A patent/CN108464981B/zh active Active
- 2013-11-07 EP EP13896951.4A patent/EP3065549A4/en not_active Ceased
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2019
- 2019-01-15 AU AU2019200261A patent/AU2019200261A1/en not_active Abandoned
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2021
- 2021-01-10 AU AU2021200113A patent/AU2021200113A1/en active Pending
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| AU2019200261A1 (en) | 2019-01-31 |
| KR20210063475A (ko) | 2021-06-01 |
| AU2013404949B2 (en) | 2018-10-18 |
| KR20160070188A (ko) | 2016-06-17 |
| WO2015069266A1 (en) | 2015-05-14 |
| EP3065549A4 (en) | 2017-05-24 |
| CN105873440B (zh) | 2018-06-01 |
| JP6568093B2 (ja) | 2019-08-28 |
| CN105873440A (zh) | 2016-08-17 |
| JP2017500371A (ja) | 2017-01-05 |
| CN108464981A (zh) | 2018-08-31 |
| AU2013404949A1 (en) | 2016-05-26 |
| EP3065549A1 (en) | 2016-09-14 |
| AU2021200113A1 (en) | 2021-03-04 |
| CN108464981B (zh) | 2022-06-24 |
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