EP3065549A4 - Methods for inhibiting tie2 kinase useful in the treatment of cancer - Google Patents
Methods for inhibiting tie2 kinase useful in the treatment of cancer Download PDFInfo
- Publication number
- EP3065549A4 EP3065549A4 EP13896951.4A EP13896951A EP3065549A4 EP 3065549 A4 EP3065549 A4 EP 3065549A4 EP 13896951 A EP13896951 A EP 13896951A EP 3065549 A4 EP3065549 A4 EP 3065549A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- cancer
- treatment
- methods
- tie2 kinase
- kinase useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2013/069005 WO2015069266A1 (en) | 2013-11-07 | 2013-11-07 | Methods for inhibiting tie2 kinase useful in the treatment of cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3065549A1 EP3065549A1 (en) | 2016-09-14 |
EP3065549A4 true EP3065549A4 (en) | 2017-05-24 |
Family
ID=53041876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13896951.4A Ceased EP3065549A4 (en) | 2013-11-07 | 2013-11-07 | Methods for inhibiting tie2 kinase useful in the treatment of cancer |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP3065549A4 (zh) |
JP (1) | JP6568093B2 (zh) |
KR (2) | KR20160070188A (zh) |
CN (2) | CN105873440B (zh) |
AU (3) | AU2013404949B2 (zh) |
CA (1) | CA2929715A1 (zh) |
WO (1) | WO2015069266A1 (zh) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
KR20160070188A (ko) * | 2013-11-07 | 2016-06-17 | 데시페라 파마슈티칼스, 엘엘씨. | 암치료에 유용한 tie2 키나아제의 억제 방법 |
ES2710211T3 (es) | 2014-02-04 | 2019-04-23 | Pfizer | Combinación de un antagonista de PD-1 y un inhibidor de VEGFR para tratar el cáncer |
RU2714233C2 (ru) | 2015-02-26 | 2020-02-13 | Мерк Патент Гмбх | Ингибиторы pd-1 / pd-l1 для лечения рака |
WO2016191401A1 (en) * | 2015-05-27 | 2016-12-01 | Albert Einstein College Of Medicine, Inc. | Tmem active test and uses thereof in diagnosis, prognosis and treatment of tumors |
CA2989586A1 (en) | 2015-06-16 | 2016-12-22 | Pfizer, Inc. | Pd-l1 antagonist combination treatments |
CN114191428A (zh) | 2016-03-02 | 2022-03-18 | 卫材研究发展管理有限公司 | 基于艾日布林的抗体-药物偶联物和使用方法 |
US10690673B2 (en) | 2016-03-29 | 2020-06-23 | Mayo Foundation For Medical Education And Research | Method of treating cancer metastasis by CDK 4/6 inhibitors |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
KR20190062515A (ko) | 2016-10-06 | 2019-06-05 | 화이자 인코포레이티드 | 암의 치료를 위한 아벨루맙의 투약 용법 |
US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
CN106822128A (zh) * | 2017-02-24 | 2017-06-13 | 南华大学附属第医院 | 酪氨酸激酶抑制剂dcc‑2036的新应用 |
CN111818915B (zh) | 2018-01-31 | 2024-05-24 | 德西费拉制药有限责任公司 | 治疗胃肠道间质瘤的组合疗法 |
CN110003181B (zh) * | 2019-05-22 | 2020-08-28 | 北京凯恩梅格医药科技有限公司 | 一种基于克唑替尼结构的c-Met/HDAC双靶点抑制剂及其合成方法与应用 |
TW202122085A (zh) * | 2019-08-12 | 2021-06-16 | 美商迪賽孚爾製藥公司 | 治療血管畸形之方法 |
KR20220045189A (ko) | 2019-08-12 | 2022-04-12 | 데시페라 파마슈티칼스, 엘엘씨. | 위장관 기질 종양을 치료하는 방법 |
TW202122082A (zh) | 2019-08-12 | 2021-06-16 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
CN112812109B (zh) * | 2019-11-18 | 2022-06-21 | 中国科学院微生物研究所 | 化合物DaP-01及其制备方法和应用 |
JP2023509628A (ja) | 2019-12-30 | 2023-03-09 | デシフェラ・ファーマシューティカルズ,エルエルシー | 1-(4-ブロモ-5-(1-エチル-7-(メチルアミノ)-2-オキソ-1,2-ジヒドロ-1,6-ナフチリジン-3-イル)-2-フルオロフェニル)-3-フェニル尿素の組成物 |
EP4327827A3 (en) | 2019-12-30 | 2024-05-29 | Deciphera Pharmaceuticals, LLC | Amorphous kinase inhibitor formulations and methods of use thereof |
US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130023587A1 (en) * | 2010-04-01 | 2013-01-24 | Duke University | Compositions and methods for the treatment of cancer |
WO2011150198A1 (en) * | 2010-05-27 | 2011-12-01 | Ambit Biosciences Corporation | Azolyl urea compounds and methods of use thereof |
WO2012097021A1 (en) * | 2011-01-11 | 2012-07-19 | Glaxosmithkline Llc | Combination |
MX359664B (es) * | 2011-07-29 | 2018-10-05 | Univ Colorado Regents | Tratamiento de cáncer de mama. |
WO2013036232A2 (en) * | 2011-09-08 | 2013-03-14 | Deciphera Pharmaceuticals, Llc | Methods and compositions for the treatment of myeloproliferative diseases and other proliferative diseases |
US20130071403A1 (en) * | 2011-09-20 | 2013-03-21 | Vical Incorporated | Synergistic anti-tumor efficacy using alloantigen combination immunotherapy |
KR20160070188A (ko) * | 2013-11-07 | 2016-06-17 | 데시페라 파마슈티칼스, 엘엘씨. | 암치료에 유용한 tie2 키나아제의 억제 방법 |
-
2013
- 2013-11-07 KR KR1020167014649A patent/KR20160070188A/ko active Application Filing
- 2013-11-07 CN CN201380081931.2A patent/CN105873440B/zh active Active
- 2013-11-07 CA CA2929715A patent/CA2929715A1/en not_active Abandoned
- 2013-11-07 JP JP2016552405A patent/JP6568093B2/ja active Active
- 2013-11-07 WO PCT/US2013/069005 patent/WO2015069266A1/en active Application Filing
- 2013-11-07 AU AU2013404949A patent/AU2013404949B2/en active Active
- 2013-11-07 KR KR1020217015635A patent/KR20210063475A/ko not_active Application Discontinuation
- 2013-11-07 CN CN201810436668.9A patent/CN108464981B/zh active Active
- 2013-11-07 EP EP13896951.4A patent/EP3065549A4/en not_active Ceased
-
2019
- 2019-01-15 AU AU2019200261A patent/AU2019200261A1/en not_active Abandoned
-
2021
- 2021-01-10 AU AU2021200113A patent/AU2021200113A1/en active Pending
Non-Patent Citations (3)
Title |
---|
BRYAN D SMITH ET AL: "Abstract B78: Rebastinib, a small molecule TIE2 kinase inhibitor, prevents primary tumor growth and lung metastasis in the PyMT breast cancer model", February 2013 (2013-02-01), XP002769061, Retrieved from the Internet <URL:http://cancerres.aacrjournals.org/content/73/3_Supplement/B78> [retrieved on 20170410] * |
JAVIER CORTES ET AL: "Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study", THE LANCET, vol. 377, no. 9769, 1 March 2011 (2011-03-01), pages 914 - 923, XP055030961, ISSN: 0140-6736, DOI: 10.1016/S0140-6736(11)60070-6 * |
See also references of WO2015069266A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU2019200261A1 (en) | 2019-01-31 |
KR20210063475A (ko) | 2021-06-01 |
AU2013404949B2 (en) | 2018-10-18 |
KR20160070188A (ko) | 2016-06-17 |
WO2015069266A1 (en) | 2015-05-14 |
CN105873440B (zh) | 2018-06-01 |
JP6568093B2 (ja) | 2019-08-28 |
CN105873440A (zh) | 2016-08-17 |
JP2017500371A (ja) | 2017-01-05 |
CN108464981A (zh) | 2018-08-31 |
AU2013404949A1 (en) | 2016-05-26 |
CA2929715A1 (en) | 2015-05-14 |
EP3065549A1 (en) | 2016-09-14 |
AU2021200113A1 (en) | 2021-03-04 |
CN108464981B (zh) | 2022-06-24 |
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DAX | Request for extension of the european patent (deleted) | ||
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 31/357 20060101ALI20170411BHEP Ipc: A61P 35/00 20060101ALI20170411BHEP Ipc: A61K 31/337 20060101ALI20170411BHEP Ipc: A61K 31/4709 20060101AFI20170411BHEP Ipc: A61K 45/06 20060101ALI20170411BHEP |
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