EP3065549A4 - Méthodes d'inhibition de la kinase tie2 utiles dans le traitement du cancer - Google Patents

Méthodes d'inhibition de la kinase tie2 utiles dans le traitement du cancer Download PDF

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Publication number
EP3065549A4
EP3065549A4 EP13896951.4A EP13896951A EP3065549A4 EP 3065549 A4 EP3065549 A4 EP 3065549A4 EP 13896951 A EP13896951 A EP 13896951A EP 3065549 A4 EP3065549 A4 EP 3065549A4
Authority
EP
European Patent Office
Prior art keywords
cancer
treatment
methods
tie2 kinase
kinase useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP13896951.4A
Other languages
German (de)
English (en)
Other versions
EP3065549A1 (fr
Inventor
Daniel L. Flynn
Michael D. Kaufman
Bryan Smith
Marc S. RUDOLTZ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deciphera Pharmaceuticals LLC
Original Assignee
Deciphera Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deciphera Pharmaceuticals LLC filed Critical Deciphera Pharmaceuticals LLC
Publication of EP3065549A1 publication Critical patent/EP3065549A1/fr
Publication of EP3065549A4 publication Critical patent/EP3065549A4/fr
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP13896951.4A 2013-11-07 2013-11-07 Méthodes d'inhibition de la kinase tie2 utiles dans le traitement du cancer Ceased EP3065549A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2013/069005 WO2015069266A1 (fr) 2013-11-07 2013-11-07 Méthodes d'inhibition de la kinase tie2 utiles dans le traitement du cancer

Publications (2)

Publication Number Publication Date
EP3065549A1 EP3065549A1 (fr) 2016-09-14
EP3065549A4 true EP3065549A4 (fr) 2017-05-24

Family

ID=53041876

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13896951.4A Ceased EP3065549A4 (fr) 2013-11-07 2013-11-07 Méthodes d'inhibition de la kinase tie2 utiles dans le traitement du cancer

Country Status (7)

Country Link
EP (1) EP3065549A4 (fr)
JP (1) JP6568093B2 (fr)
KR (2) KR20160070188A (fr)
CN (2) CN108464981B (fr)
AU (3) AU2013404949B2 (fr)
CA (1) CA2929715A1 (fr)
WO (1) WO2015069266A1 (fr)

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US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
WO2015069266A1 (fr) * 2013-11-07 2015-05-14 Flynn Daniel L Méthodes d'inhibition de la kinase tie2 utiles dans le traitement du cancer
JP6591428B2 (ja) 2014-02-04 2019-10-16 ファイザー・インコーポレイテッド 癌治療のためのｐｄ−１拮抗薬およびｖｅｇｆｒ阻害剤の組み合わせ
CN107405401B (zh) 2015-02-26 2022-02-01 默克专利股份公司 用于治疗癌症的pd-1/pd-l1抑制剂
WO2016191401A1 (fr) * 2015-05-27 2016-12-01 Albert Einstein College Of Medicine, Inc. Test actif tmem et ses utilisations pour le diagnostic, le pronostic et le traitement de tumeurs
RU2766890C2 (ru) 2015-06-16 2022-03-16 Мерк Патент Гмбх Комбинированные способы лечения антагонистами pd-l1
KR102702620B1 (ko) 2016-03-02 2024-09-05 에자이 알앤드디 매니지먼트 가부시키가이샤 에리불린-기반 항체-약물 콘주게이트 및 사용 방법
WO2017172734A1 (fr) 2016-03-29 2017-10-05 Mayo Foundation For Medical Education And Research Traitement de métastases cancéreuses
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
JP2019530704A (ja) 2016-10-06 2019-10-24 ファイザー・インコーポレイテッド がんの処置のためのアベルマブの投与レジメン
EP3571200B8 (fr) 2017-01-17 2022-08-03 HepaRegeniX GmbH Inhibiteurs de protéine kinase pour favoriser la régénération du foie, ou pour réduire ou prévenir la mort des hépatocytes
CN106822128A (zh) * 2017-02-24 2017-06-13 南华大学附属第医院 酪氨酸激酶抑制剂dcc‑2036的新应用
KR20240140187A (ko) 2018-01-31 2024-09-24 데시페라 파마슈티칼스, 엘엘씨. 비만 세포증의 치료를 위한 병용 요법
CN118416236A (zh) 2018-01-31 2024-08-02 德西费拉制药有限责任公司 治疗胃肠道间质瘤的组合疗法
CN110003181B (zh) * 2019-05-22 2020-08-28 北京凯恩梅格医药科技有限公司 一种基于克唑替尼结构的c-Met/HDAC双靶点抑制剂及其合成方法与应用
BR112022002609A2 (pt) 2019-08-12 2022-08-09 Deciphera Pharmaceuticals Llc Métodos de tratamento de tumores estromais gastrointestinais
CN114746093A (zh) * 2019-08-12 2022-07-12 德西费拉制药有限责任公司 治疗血管畸形的方法
TW202122082A (zh) 2019-08-12 2021-06-16 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法
CN112812109B (zh) * 2019-11-18 2022-06-21 中国科学院微生物研究所 化合物DaP-01及其制备方法和应用
CA3163051A1 (fr) 2019-12-30 2021-07-08 Michael D. Kaufman Compositions de 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro -1,6-naphthyridine-3-yl)-2-fluorophenyl)-3-phenyluree
LT4084778T (lt) 2019-12-30 2024-01-25 Deciphera Pharmaceuticals, Llc Amorfinės kinazės inhibitoriaus vaistinės formos ir jų panaudojimo būdai
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130023587A1 (en) * 2010-04-01 2013-01-24 Duke University Compositions and methods for the treatment of cancer
WO2011150198A1 (fr) * 2010-05-27 2011-12-01 Ambit Biosciences Corporation Composés azolyle urée et leurs procédés d'utilisation
KR20140053836A (ko) * 2011-01-11 2014-05-08 글락소스미스클라인 엘엘씨 조합물
CA2843417C (fr) * 2011-07-29 2018-08-21 Medivation Prostate Therapeutics, Inc. Traitement du cancer du sein
WO2013036232A2 (fr) * 2011-09-08 2013-03-14 Deciphera Pharmaceuticals, Llc Méthodes et compositions pouvant être utilisées en vue du traitement de maladies myéloprolifératives et d'autres maladies prolifératives
US20130071403A1 (en) * 2011-09-20 2013-03-21 Vical Incorporated Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
WO2015069266A1 (fr) * 2013-11-07 2015-05-14 Flynn Daniel L Méthodes d'inhibition de la kinase tie2 utiles dans le traitement du cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BRYAN D SMITH ET AL: "Abstract B78: Rebastinib, a small molecule TIE2 kinase inhibitor, prevents primary tumor growth and lung metastasis in the PyMT breast cancer model", February 2013 (2013-02-01), XP002769061, Retrieved from the Internet <URL:http://cancerres.aacrjournals.org/content/73/3_Supplement/B78> [retrieved on 20170410] *
JAVIER CORTES ET AL: "Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study", THE LANCET, vol. 377, no. 9769, 1 March 2011 (2011-03-01), pages 914 - 923, XP055030961, ISSN: 0140-6736, DOI: 10.1016/S0140-6736(11)60070-6 *
KARLAN BETH Y. ET AL: "Randomized, Double-Blind, Placebo-Controlled Phase II Study of AMG 386 Combined With Weekly Paclitaxel in Patients With Recurrent Ovarian Cancer", JOURNAL OF CLINICAL ONCOLOGY, vol. 30, no. 4, 1 February 2012 (2012-02-01), US, pages 362 - 371, XP055890024, ISSN: 0732-183X, DOI: 10.1200/JCO.2010.34.3178 *
See also references of WO2015069266A1 *

Also Published As

Publication number Publication date
CA2929715A1 (fr) 2015-05-14
AU2013404949A1 (en) 2016-05-26
AU2021200113A1 (en) 2021-03-04
JP2017500371A (ja) 2017-01-05
KR20160070188A (ko) 2016-06-17
CN105873440A (zh) 2016-08-17
AU2019200261A1 (en) 2019-01-31
CN105873440B (zh) 2018-06-01
CN108464981B (zh) 2022-06-24
CN108464981A (zh) 2018-08-31
WO2015069266A1 (fr) 2015-05-14
KR20210063475A (ko) 2021-06-01
JP6568093B2 (ja) 2019-08-28
EP3065549A1 (fr) 2016-09-14
AU2013404949B2 (en) 2018-10-18

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