CA2928866C - Methods for diagnosing infectious diseases using adsorption media - Google Patents

Methods for diagnosing infectious diseases using adsorption media Download PDF

Info

Publication number
CA2928866C
CA2928866C CA2928866A CA2928866A CA2928866C CA 2928866 C CA2928866 C CA 2928866C CA 2928866 A CA2928866 A CA 2928866A CA 2928866 A CA2928866 A CA 2928866A CA 2928866 C CA2928866 C CA 2928866C
Authority
CA
Canada
Prior art keywords
mannose
pathogen
adsorption media
pathogens
virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2928866A
Other languages
English (en)
French (fr)
Other versions
CA2928866A1 (en
Inventor
Robert S. Ward
Keith R. Mccrea
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exthera Medical Corp
Original Assignee
Exthera Medical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exthera Medical Corp filed Critical Exthera Medical Corp
Publication of CA2928866A1 publication Critical patent/CA2928866A1/en
Application granted granted Critical
Publication of CA2928866C publication Critical patent/CA2928866C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/24—Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56905—Protozoa
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43552—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from insects
    • G01N2333/43556—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from insects from ticks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/44—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from protozoa
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/44—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from protozoa
    • G01N2333/445—Plasmodium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA2928866A 2013-11-08 2014-11-06 Methods for diagnosing infectious diseases using adsorption media Active CA2928866C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361902070P 2013-11-08 2013-11-08
US61/902,070 2013-11-08
PCT/US2014/064419 WO2015069942A1 (en) 2013-11-08 2014-11-06 Methods for diagnosing infectious diseases using adsorption media

Publications (2)

Publication Number Publication Date
CA2928866A1 CA2928866A1 (en) 2015-05-14
CA2928866C true CA2928866C (en) 2021-11-09

Family

ID=53042095

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2928866A Active CA2928866C (en) 2013-11-08 2014-11-06 Methods for diagnosing infectious diseases using adsorption media
CA2998767A Pending CA2998767A1 (en) 2013-11-08 2016-10-14 Methods for diagnosing infectious diseases using adsorption media

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2998767A Pending CA2998767A1 (en) 2013-11-08 2016-10-14 Methods for diagnosing infectious diseases using adsorption media

Country Status (10)

Country Link
US (3) US10487350B2 (enExample)
EP (2) EP3065796B1 (enExample)
JP (2) JP6806563B2 (enExample)
CN (2) CN105705177B (enExample)
AU (2) AU2014346668C1 (enExample)
BR (1) BR112016009827B1 (enExample)
CA (2) CA2928866C (enExample)
ES (1) ES2799398T3 (enExample)
MX (2) MX382486B (enExample)
WO (3) WO2015069942A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE029958T2 (en) 2005-12-13 2017-04-28 Exthera Medical Corp A method for removing extracellular microbes, inflammatory cells or inflammatory proteins from the body
WO2008155683A1 (en) 2007-06-18 2008-12-24 Firmenich Sa Malodor counteracting compositions and method for their use
JP5925693B2 (ja) 2009-12-01 2016-05-25 エクステラ・メディカル・コーポレーション 表面固定した多糖類を用いた、血液からのサイトカイン除去法
WO2012112724A1 (en) 2011-02-15 2012-08-23 Exthera Medical, Llc Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines
DK2861273T3 (da) 2012-06-13 2017-11-27 Exthera Medical Corp Anvendelse af heparin og kulhydrater til behandling af cancer.
EP3013445B1 (en) 2013-06-24 2019-11-06 ExThera Medical Corporation Blood filtration system containing mannose coated substrate
JP6806563B2 (ja) * 2013-11-08 2021-01-06 エクステラ・メディカル・コーポレーション 吸着媒体を使用する感染症の診断法
KR20170020749A (ko) 2014-04-24 2017-02-24 엑스테라 메디컬 코퍼레이션 고유속을 이용한 혈액으로부터 세균의 제거방법
JP7100454B2 (ja) 2014-09-22 2022-07-13 エクスセラ メディカル コーポレイション 装着型血液潅流デバイス
WO2017151797A1 (en) 2016-03-02 2017-09-08 Exthera Medical Corporation Method for treating drug intoxication
US11911551B2 (en) 2016-03-02 2024-02-27 Exthera Medical Corporation Method for treating drug intoxication
EP3735281B1 (en) 2018-01-05 2024-11-27 Path Ex, Inc. Device for the capture and removal of disease material from fluids
KR20220009400A (ko) 2019-05-16 2022-01-24 엑스테라 메디컬 코퍼레이션 내피 글리코칼릭스 구조의 조절 방법
WO2020236626A1 (en) * 2019-05-17 2020-11-26 Herzlinger George A Methods and systems for treating microbial disease
BR112022001265A8 (pt) * 2019-07-23 2022-10-18 Snapdna Sistema e método para detectar e o monitorar patógenos
FR3102773B1 (fr) * 2019-10-31 2024-04-05 Microbs Sas Dispositif contenant des billes de verre fonctionnalisées, et leur utilisation pour capter les micro-organismes
JP2023001488A (ja) * 2021-06-21 2023-01-06 三菱重工業株式会社 核酸抽出方法

Family Cites Families (168)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3782382A (en) 1972-02-03 1974-01-01 K N Enterprises Inc Means for blood administration and the like
US4103685A (en) 1976-01-05 1978-08-01 Lupien Paul J Method and apparatus for extravascular treatment of blood
JPS54127493U (enExample) 1978-02-25 1979-09-05
JPS6040926B2 (ja) 1979-07-24 1985-09-13 三菱重工業株式会社 マンドレルバ−の自動サポ−ト装置
US4430496A (en) 1980-01-17 1984-02-07 Varian Associates, Inc. Strong anion exchange composition and methods
US4415665A (en) 1980-12-12 1983-11-15 Pharmacia Fine Chemicals Ab Method of covalently binding biologically active organic substances to polymeric substances
JPS5853757A (ja) 1981-09-25 1983-03-30 Denki Kagaku Kogyo Kk 免疫アフイニテイクロマトグラフイ−用吸着体及びその製法
SE8200751L (sv) 1982-02-09 1983-08-10 Olle Larm Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter
JPS58146354A (ja) 1982-02-26 1983-08-31 日機装株式会社 体液浄化器の製造法
US4820302A (en) 1982-04-22 1989-04-11 Sterling Drug Inc. Bio compatible and blood compatible materials and methods
CA1221307A (en) 1982-12-02 1987-05-05 Nobutaka Tani Adsorbent and process for preparing the same
GB2141554A (en) 1983-06-15 1984-12-19 Philips Electronic Associated A slit imaging system using two concave mirrors
DE3609021A1 (de) 1985-03-25 1986-09-25 Bio-Rad Laboratories, Inc., Richmond, Calif. Chromatographisches trennmedium fuer die schnelle analyse von kleinen proben
DE3519011A1 (de) 1985-05-25 1986-11-27 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung eines materials zur affinitaetschromatographie
CA1327963C (en) 1987-09-08 1994-03-22 Ryuichi Yokohari Autoantibody adsorbent and apparatus for removing autoantibodies using the same
DE3853219T2 (de) 1987-11-20 1995-06-29 Kanegafuchi Chemical Ind Methode zur Entfernung von Serum-Amyloid-Protein.
US4955870A (en) * 1988-08-23 1990-09-11 Ridderheim Kristen A Hypodermic syringe with retractable needle
WO1991004086A1 (en) 1989-09-18 1991-04-04 Cuno, Incorporated Filter media and use for pyrogen removal
JPH0489500A (ja) 1990-07-31 1992-03-23 Kirin Brewery Co Ltd アフィニティクロマトグラフィーによる物質の精製法および精製装置
SE469256B (sv) 1991-02-18 1993-06-14 Medscand Ab Rengoeringsprodukt
AU648655B2 (en) 1991-03-26 1994-04-28 Otsuka Pharmaceutical Factory, Inc. Adsorbed cellular fibronectin and process for separating and purifying fibronectins
US5211850A (en) 1991-07-26 1993-05-18 Research Medical, Inc. Plasma filter sorbent system for removal of components from blood
DE4217917A1 (de) 1992-05-30 1993-12-02 Job Prof Dr Med Harenberg Immobilisation von chemisch kovalent gebundenem Heparin an Polymere mit Arylresten im Polymer
DE4331358A1 (de) 1992-10-12 1994-04-14 Braun Melsungen Ag Verfahren zur quantitativen selektiven Entfernung oder präparativen Gewinnung von Tumor-Nekrose-Faktor (TNF) oder/und Lipopolysacchariden (LPS) aus wäßrigen Flüssigkeiten
US5344455A (en) 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
US5437861A (en) 1993-03-16 1995-08-01 Applied Immune Sciences, Inc. Removal of selected factors from whole blood or its components; and prevention and treatment of septic shock syndrome
JP2643823B2 (ja) 1993-03-25 1997-08-20 有限会社 エンゼル総合研究所 吸着材料及びその製造方法
NO931809L (no) 1993-05-19 1994-11-21 Norsk Hydro As Hemofilter
US5447859A (en) 1993-07-16 1995-09-05 Viagene Method for the purification or removal of retroviruses using sulfated cellulose
US5753227A (en) 1993-07-23 1998-05-19 Strahilevitz; Meir Extracorporeal affinity adsorption methods for the treatment of atherosclerosis, cancer, degenerative and autoimmune diseases
WO1995005400A1 (en) 1993-08-19 1995-02-23 Minnesota Mining And Manufacturing Company Heparin functional affinity supports
JPH07178161A (ja) 1993-12-24 1995-07-18 Terumo Corp 医療器具
JP3901216B2 (ja) 1995-02-16 2007-04-04 株式会社カネカ 腫瘍壊死因子−αの吸着剤、吸着除去方法および前記吸着剤を用いた吸着器
SE9501056D0 (sv) 1995-03-23 1995-03-23 Probi Ab Epithelial adherent lactobacilli
US6312907B1 (en) 1995-04-24 2001-11-06 The Texas A & M University System DbpA compositions and methods of use
US6544727B1 (en) 1995-06-07 2003-04-08 Cerus Corporation Methods and devices for the removal of psoralens from blood products
EP0840781B1 (en) 1995-06-07 2009-12-09 Cerus Corporation Methods and devices for the removal of psoralens from blood products
WO1997000969A1 (de) * 1995-06-20 1997-01-09 Johannes Schumacher Verfahren und vorrichtung zur bestimmung der aktivität von enzymen in flüssigkeiten, beziehungsweise der konzentration und/oder aktivität von inhibitoren in flüssigkeiten
AU1085697A (en) * 1995-11-21 1997-06-11 Pall Corporation Inactivation method and system in biological fluids
DE69722491T2 (de) 1996-03-18 2004-05-19 Kaneka Corp. Adsorbens und Verfahren zur Entfernung von Chemokinen des CC-Subtyps aus Körperflüssigkeiten
RU2089283C1 (ru) 1996-03-23 1997-09-10 Научно-исследовательская фирма "Ультрасан" Био-, гемосовместимые сорбенты на основе сверхсшитых полимеров стирола с модифицированной поверхностью, способ их получения (варианты) и способ получения матрицы сорбента
SE507028C2 (sv) 1996-08-06 1998-03-16 Medicarb Ab Ny medicinsk användning
AU5811498A (en) * 1996-12-31 1998-07-31 Robert L. Stephon Microsphere-enhanced immunoassay for the detection of veterinary diseases
US20010018179A1 (en) 1998-01-06 2001-08-30 Derek J. Hei Batch devices for the reduction of compounds from biological compositions containing cells and methods of use
US20010009756A1 (en) 1998-01-06 2001-07-26 Derek Hei Flow devices for the reduction of compounds from biological compositions and methods of use
KR20060015703A (ko) 1997-03-25 2006-02-17 카네카 코포레이션 Ｃ형 간염 바이러스 제거용 흡착재, 흡착장치 및 흡착방법
ES2251090T3 (es) 1997-05-27 2006-04-16 Sanofi-Aventis Dispositivo y metodo para aplicar articulos planos.
US6465170B2 (en) * 1997-06-13 2002-10-15 Baxter Aktiengesellschaft Method for depleting viral and molecular pathogens in a biological material
US6197568B1 (en) 1997-07-29 2001-03-06 The Regents Of The University Of Michigan Method and compositions for isolation, diagnosis and treatment of polyanion-binding microorganisms
US20020197250A1 (en) 2001-04-10 2002-12-26 Renal Tech International Biocompatible devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood
US20020197249A1 (en) 2001-04-10 2002-12-26 Renal Tech International Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood products
US20020159995A1 (en) 1997-07-30 2002-10-31 Renal Tech International Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood, generated as a result of extracorporeal blood processing
US6053894A (en) * 1997-08-04 2000-04-25 Shadd, Jr.; Daniel L. Hypodermic syringe
CH692321A5 (de) 1997-11-03 2002-05-15 Mepha Ag Pharmazeutisch wirksame Zusammensetzung, welche eine gegen Malariaparasiten wirksame Substanz enthält.
US7611831B2 (en) 1998-01-06 2009-11-03 Cerus Corporation Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
US6136424A (en) 1998-02-06 2000-10-24 Renal Tech International, Llc Method of and material for purification of physiological liquids of organism, and method of producing the material
GB9804632D0 (en) 1998-03-05 1998-04-29 Cantab Pharma Res Virus preparations and methods
US8197430B1 (en) 1998-05-22 2012-06-12 Biopheresis Technologies, Inc. Method and system to remove cytokine inhibitor in patients
US6248127B1 (en) 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device
JP2000086688A (ja) 1998-09-04 2000-03-28 Ngk Insulators Ltd パルボウイルス吸着糖鎖リガンドおよびこれを利用したパルボウイルス除去装置
NO984143L (no) 1998-09-09 2000-03-10 Norsk Hydro As Ny prosess for å fremstille overflatemodifiserende stoffer
WO2000023792A1 (en) * 1998-10-19 2000-04-27 Cbd Technologies Ltd. Methods of concentrating microorganisms using affinity separation
EP1057529A4 (en) 1998-12-22 2004-08-25 Toray Industries MATERIALS FOR THE DISPOSAL OF BACTERIAL COMPONENTS
CA2322000C (en) 1998-12-24 2008-07-29 Toray Industries, Inc. Hemocathartic method and hemocathartic column
US6297272B1 (en) 1999-01-12 2001-10-02 Hauser, Inc. Artemisinin analogs having antimalarial antiproliferative and antitumor activities and chemoselective methods of making the same
JP2000217575A (ja) 1999-02-01 2000-08-08 Masashi Funayama 生理活性物質、ヒト血球分化細胞およびヒト細胞の吸着体。
IN191696B (enExample) 1999-02-12 2003-12-20 Council Scient Ind Res
DE19916352A1 (de) 1999-04-12 2000-10-19 Braun Melsungen Ag Entfernung von hüllehaltigen Viren aus Blut, Plasma oder Serum
ATE428495T1 (de) 1999-04-28 2009-05-15 Toray Industries Stoffe zur enternung von cannabinoiden und säulen mit diesen stoffen zur entfernung von cannabinoiden
WO2001018060A1 (fr) 1999-09-08 2001-03-15 Toray Industries, Inc. Materiaux de circulation extracorporelle, adsorbants de facteurs de complication diabetique, reservoirs servant a eliminer des facteurs de complication diabetique et procede d'elimination de facteurs de complication diabetique
SE515295C2 (sv) 1999-11-23 2001-07-09 Medicarb Ab Förfarande för framställning av konjugat av en biologiskt aktiv polysackarid och ett fast substrat, samt sådana konjugat
JP2001178817A (ja) 1999-12-24 2001-07-03 Terumo Corp 人工腎臓用装置およびこれを用いた品質評価装置ならびに流体回路
US7067060B2 (en) 2000-01-11 2006-06-27 Nephros, Inc. Ionic enhanced dialysis/diafiltration system
JP2001190273A (ja) * 2000-01-14 2001-07-17 Jsr Corp ウイルス濃縮用粒子、該粒子を使用するウイルス濃縮方法およびウイルス検出方法
GB0001450D0 (en) 2000-01-21 2000-03-08 Genpoint As Cell isolation method
DE60035127T2 (de) 2000-03-06 2008-02-14 Dade Behring Marburg Gmbh Mit polysacchariden beschichtete träger, deren herstellung und verwendung
US20020164644A1 (en) 2000-04-05 2002-11-07 Ikuro Maruyama Adsorbents for high mobility group proteins and column for purifying body fluid
US7181261B2 (en) 2000-05-15 2007-02-20 Silver James H Implantable, retrievable, thrombus minimizing sensors
DE10045434B4 (de) 2000-09-14 2005-07-14 Fresenius Hemocare Gmbh Adsorbens mit unterschiedlich modifizierten Oberflächenbereichen, Verfahren zu dessen Herstellung und Verwendung davon
JP4283430B2 (ja) 2000-09-26 2009-06-24 株式会社カネカ エンテロトキシンの吸着材、吸着除去方法および吸着器
US8153121B2 (en) 2000-10-06 2012-04-10 Los Angeles Biomedical Research Institute at Harbor—UCLA Medical Center Diagnosis and therapy of antibody-mediated inflammatory autoimmune disorders
US8178304B2 (en) 2000-10-06 2012-05-15 Smith Terry J Diagnostic methods relating to Graves' disease and other autoimmune disorders
US6509104B2 (en) 2000-12-05 2003-01-21 Michigan Biotechnology Institute Antithrombogenic polymer coating
EP1884274A1 (en) 2000-12-29 2008-02-06 Upfront Chromatography A/S Extracorporeal capturing of specific bio-macromolecular entities from extracellular body fluids
KR100804542B1 (ko) 2001-01-30 2008-02-20 가부시키가이샤 가네카 직접 혈액관류가 가능한 체액 처리기
DE10117043A1 (de) 2001-04-05 2002-11-07 Gerhard Puetz Verfahren zur Eliminierung von potentiell toxischen und/oder schädlichen Stoffen
US20020197252A1 (en) 2001-04-10 2002-12-26 Renal Tech International Selective adsorption devices and systems
US6773412B2 (en) 2001-04-13 2004-08-10 Chf Solutions, Inc. User interface for blood treatment device
US20040146500A1 (en) * 2001-05-09 2004-07-29 Takashi Miyata Biopolymer-containing gel
EP1435263A1 (en) 2001-10-10 2004-07-07 Noritake Co., Limited Photocatalytic material selectively inactivating biologically harmful substance and utilization thereof
JP2003128502A (ja) 2001-10-18 2003-05-08 Noritake Co Ltd 有害物質の処理材およびその製造方法
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US20030148017A1 (en) 2001-12-07 2003-08-07 Olli Tuominen Copolymer coating for a hydrophobic membrane
US6951846B2 (en) 2002-03-07 2005-10-04 The United States Of America As Represented By The Secretary Of The Army Artemisinins with improved stability and bioavailability for therapeutic drug development and application
WO2003078023A1 (en) 2002-03-14 2003-09-25 Baxter International Inc. Compound removal device
EP1507557A4 (en) 2002-04-23 2006-06-14 Meir Strahilevitz METHODS AND DEVICES FOR TARGETING A SITE IN A MAMMAL AND DETERMINING CHEMICAL SPECIES FROM A MAMMAL
WO2003090774A1 (en) * 2002-04-24 2003-11-06 The Council Of The Queensland Institute Of Medical Research Mannose binding lectin and uses thereof
US20050249724A1 (en) * 2002-07-11 2005-11-10 Upfront Chromatography A/S Extracorporeal stablised expanded bed adsorption method for the treatment of sepsis
ATE426808T1 (de) * 2002-07-24 2009-04-15 Bio Rad Laboratories Proteininteraktionsdifferenzabbildung
WO2005021799A2 (en) * 2003-08-15 2005-03-10 University Of South Florida Materials and methods for capture of pathogens and removal of aurintricarboxylic acid from a sample
US20040182783A1 (en) 2003-03-17 2004-09-23 Walker Kimberly A. Filter and concentrator device for treatment of blood
US7207964B2 (en) 2003-03-17 2007-04-24 Hemavation, Llc Apparatus and method for down-regulating immune system mediators in blood
CN1255106C (zh) 2003-09-26 2006-05-10 李国桥 复方青蒿素
US7399400B2 (en) 2003-09-30 2008-07-15 Nano-Proprietary, Inc. Nanobiosensor and carbon nanotube thin film transistors
WO2005051313A2 (en) 2003-11-19 2005-06-09 Chiron Corporation Methods and reagents for treating, preventing and diagnosing bunyavirus infection
WO2006009179A1 (ja) 2004-07-23 2006-01-26 Kaneka Corporation 水不溶性微粒子を除去した吸着材を充填した直接血液灌流用吸着器、および水不溶性微粒子を除去した直接血液灌流用吸着材の取得方法
US20060030027A1 (en) 2004-08-04 2006-02-09 Aspira Biosystems, Inc. Capture and removal of biomolecules from body fluids using partial molecular imprints
WO2006025371A1 (ja) 2004-08-30 2006-03-09 Kaneka Corporation 顆粒球吸着材
CN1300587C (zh) * 2004-12-20 2007-02-14 山东省医药生物技术研究中心 检测血液脑脊液病原体抗体的蛋白芯片及其制备方法与应用
US8445293B2 (en) * 2005-02-09 2013-05-21 Rapid Pathogen Screening, Inc. Method to increase specificity and/or accuracy of lateral flow immunoassays
FR2884715B1 (fr) 2005-04-20 2007-06-15 Sanofi Aventis Sa Association entre la ferroquine et un derive d'artemisinine pour le traitement du paludisme
GB0509433D0 (en) 2005-05-09 2005-06-15 Uni For Milj Og Biovitenskap Method
US20100291588A1 (en) 2005-06-24 2010-11-18 The Board Of Regents Of The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems
US20100239673A1 (en) 2005-08-01 2010-09-23 Linhardt Robert J Blood compatible nanomaterials and methods of making and using the same
US7776911B2 (en) 2005-11-07 2010-08-17 Indian Institute Of Science Antimalarial drug containing synergistic combination of curcumin and artemisinin
WO2007058592A1 (en) 2005-11-21 2007-05-24 Ge Healthcare Bio-Sciences Ab A method of chromatography using semi-synthetic heparin ligands
HUE029958T2 (en) 2005-12-13 2017-04-28 Exthera Medical Corp A method for removing extracellular microbes, inflammatory cells or inflammatory proteins from the body
WO2008057111A2 (en) * 2005-12-21 2008-05-15 Meso Scale Technologies, Llc Assay apparatuses, methods and reagents
US8211048B2 (en) 2006-02-22 2012-07-03 Henry Ford Health System System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits
US7763097B2 (en) 2006-06-08 2010-07-27 University of Pittsburgh—of the Commonwealth System of Higher Education Devices, systems and methods for reducing the concentration of a chemical entity in fluids
JP4934133B2 (ja) 2006-06-16 2012-05-16 テルモ株式会社 血液処理フィルターおよび血液処理回路
FR2902670B1 (fr) 2006-06-22 2009-04-24 Gambro Lundia Ab Utilisation d'une suspension pour traiter un support a usage medical, support a usage medical, echangeur et dispositif d'adsorption comprenant le support
WO2008147382A1 (en) 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
CA2667012A1 (en) 2006-10-26 2008-05-02 Abbott Laboratories Immunoassay of analytes in samples containing endogenous anti-analyte antibodies
GB0702183D0 (en) * 2007-02-05 2007-03-14 Iti Scotland Ltd Pathogen binding
WO2008128251A1 (en) 2007-04-17 2008-10-23 The Children's Hospital Of Philadelphia Humanized viral vectors and methods of use thereof
AU2008242142A1 (en) 2007-04-19 2008-10-30 C.G.M.3 Ltd Device system and method for monitoring and controlling blood analyte levels
CA2690401C (en) 2007-06-18 2016-10-18 Olle Larm Device and method for restoration of the condition of blood
WO2008155683A1 (en) 2007-06-18 2008-12-24 Firmenich Sa Malodor counteracting compositions and method for their use
JP4226050B1 (ja) 2007-09-12 2009-02-18 株式会社Ｒｅｉメディカル 体液浄化処理用吸着カラム
JP2011502703A (ja) 2007-11-16 2011-01-27 スミス アンド ネフュー インコーポレーテッド 環状リング移植片
WO2009086343A2 (en) * 2007-12-31 2009-07-09 3M Innovative Properties Company Microorganism-capturing compositions and methods
US11051733B2 (en) 2008-01-18 2021-07-06 Wake Forest University Health Sciences Isolating and purifying cells for therapy
FR2926993B1 (fr) 2008-02-06 2011-03-11 Sanofi Aventis Association entre un sel de bis-thiazolium ou l'un de ses precurseurs et l'artemisinine ou l'un de ses derives pour le traitement du paludisme
EP2087916A1 (en) 2008-02-11 2009-08-12 ICinnovation BV Electrosorption device for the purification of blood and other fluids
ES2821448T3 (es) 2008-06-23 2021-04-26 Temasek Polytechnic Sorbente para un dispositivo de diálisis
US20100021622A1 (en) * 2008-07-24 2010-01-28 National Chiao Tung University Apparatus and method for forming multilayer polymer thin film
US20100040546A1 (en) * 2008-08-13 2010-02-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Biological targeting compositions and methods of using the same
WO2010029317A2 (en) 2008-09-10 2010-03-18 Ibd Column Therapies International Ab Treating inflammatory conditions
US8310415B2 (en) 2008-09-30 2012-11-13 Animas Corporation Medical devices using bistable displays
US8454547B2 (en) * 2009-02-25 2013-06-04 The Invention Science Fund I, Llc Device, system, and method for controllably reducing inflammatory mediators in a subject
US20140256761A1 (en) 2009-04-22 2014-09-11 Robert Lewis Steele Enhanced artemisinin-based combination therapy for treating parasitic mediated disease
US20140011830A1 (en) 2012-07-06 2014-01-09 Robert Lewis Steele Artemisinin-Based Combination Therapy For Treating Parasitic Mediated Disease
US20130071474A1 (en) 2009-04-22 2013-03-21 James Spencer COMBINATIONS OF BERBERINE, ARTEMISININ, Loperamide AND THEIR DERIVATIVES TO TREAT MALARIA, DIARRHEA, TRAVELERS' DIARRHEA, DYSENTERY, DENGUE FEVER, PARASITES, CHOLERA AND VIRUSES
US20130072513A1 (en) 2009-04-22 2013-03-21 James Spencer COMBINATIONS OF BERBERINE, ARTEMISININ, Loperamide AND THEIR DERIVATIVES TO TREAT MALARIA, DIARRHEA, TRAVELERS' DIARRHEA, DYSENTERY, DENGUE FEVER, PARASITES, CHOLERA AND VIRUSES
US8801922B2 (en) 2009-06-24 2014-08-12 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Dialysis system
KR20120079054A (ko) 2009-07-10 2012-07-11 에볼바 아게 디인 조성물
JP5925693B2 (ja) * 2009-12-01 2016-05-25 エクステラ・メディカル・コーポレーション 表面固定した多糖類を用いた、血液からのサイトカイン除去法
US8481757B2 (en) 2010-02-04 2013-07-09 Georgua Tech Research Corporation Compounds and compositions useful in the treatment of malaria
AU2011215942B8 (en) 2010-02-09 2014-02-13 Exthera Medical Corporation Removal of virulence factors through extracorporeal therapy
US20130102948A1 (en) 2010-04-19 2013-04-25 Ilan K. Reich Portable blood filtration devices, systems, and methods
CA2814586C (en) 2010-10-15 2024-01-30 Cytopherx, Inc. Cytopheretic cartridge and use thereof
WO2012099721A2 (en) * 2011-01-18 2012-07-26 The Regents Of The University Of California Real-time adaptive immune system and method
WO2012112724A1 (en) 2011-02-15 2012-08-23 Exthera Medical, Llc Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines
US20130131423A1 (en) 2011-04-12 2013-05-23 Tianxin Wang Methods to detect and treat diseases
DK2717941T3 (da) 2011-06-13 2020-07-13 Tla Targeted Immunotherapies Ab Behandling af cancer
EP3081937B1 (en) * 2011-07-18 2019-11-13 President and Fellows of Harvard College Engineered microbe-targeting molecules and uses thereof
EP2556849A1 (en) 2011-08-08 2013-02-13 Gambro Lundia AB Separation material
DK2861273T3 (da) 2012-06-13 2017-11-27 Exthera Medical Corp Anvendelse af heparin og kulhydrater til behandling af cancer.
US20140011829A1 (en) 2012-07-06 2014-01-09 Robert Lewis Steele Artemisinin-Based Combination Therapy For Treating Viral Mediated Disease
WO2014085713A1 (en) 2012-11-30 2014-06-05 The Methodist Hospital Research Institute Methods and compositions for detecting tuberculosis
EP3013445B1 (en) 2013-06-24 2019-11-06 ExThera Medical Corporation Blood filtration system containing mannose coated substrate
US9850203B2 (en) 2013-09-26 2017-12-26 Pharmakea, Inc. Autotaxin inhibitor compounds
JP6806563B2 (ja) 2013-11-08 2021-01-06 エクステラ・メディカル・コーポレーション 吸着媒体を使用する感染症の診断法
KR20170020749A (ko) 2014-04-24 2017-02-24 엑스테라 메디컬 코퍼레이션 고유속을 이용한 혈액으로부터 세균의 제거방법
JP7100454B2 (ja) 2014-09-22 2022-07-13 エクスセラ メディカル コーポレイション 装着型血液潅流デバイス
DE202016001950U1 (de) 2016-03-30 2017-07-03 Leybold Gmbh Vakuumpumpe
RU2756512C1 (ru) 2018-01-10 2021-10-01 ЭксДабл-ЮФАРМА ЛТД. Пролекарства кетамина, его композиции и применения

Also Published As

Publication number Publication date
EP3362794B1 (en) 2023-06-07
AU2016338673B2 (en) 2023-02-02
EP3065796A4 (en) 2017-07-05
CN108139396A (zh) 2018-06-08
WO2015069942A1 (en) 2015-05-14
AU2014346668A1 (en) 2016-05-26
MX382486B (es) 2025-03-13
AU2014346668C1 (en) 2018-04-26
US10487350B2 (en) 2019-11-26
CA2928866A1 (en) 2015-05-14
US11306346B2 (en) 2022-04-19
US20170073727A1 (en) 2017-03-16
CN105705177A (zh) 2016-06-22
WO2018085113A1 (en) 2018-05-11
BR112016009827B1 (pt) 2021-10-26
EP3362794A1 (en) 2018-08-22
JP2017500014A (ja) 2017-01-05
JP2018532113A (ja) 2018-11-01
US20160084835A1 (en) 2016-03-24
CN105705177B (zh) 2019-10-22
US10457974B2 (en) 2019-10-29
AU2016338673A1 (en) 2018-04-26
AU2014346668B2 (en) 2017-11-02
EP3362794A4 (en) 2019-07-24
ES2799398T3 (es) 2020-12-17
EP3065796B1 (en) 2020-04-15
CA2998767A1 (en) 2017-04-20
EP3065796A1 (en) 2016-09-14
JP6806563B2 (ja) 2021-01-06
MX2016005959A (es) 2016-10-14
BR112016009827A2 (pt) 2017-08-01
WO2017066627A1 (en) 2017-04-20
BR112018006635A2 (pt) 2018-10-23
MX2018004206A (es) 2018-05-17
US20200056221A1 (en) 2020-02-20
JP6898923B2 (ja) 2021-07-07

Similar Documents

Publication Publication Date Title
CA2928866C (en) Methods for diagnosing infectious diseases using adsorption media
US20200182865A1 (en) Method and kit for capturing extracellular vesicles (evs) on a solid surface
US20120152847A1 (en) Sorbent for endotoxins
JP2017500014A5 (enExample)
CN103221079A (zh) 新颖的内毒素吸着剂
WO2008063663A2 (en) Poly (ethylene glycol) anti-body detection assays and kits for performing thereof
JP4621693B2 (ja) 相違する種間の相互作用を特性解析するための方法および装置
HK1228813A1 (en) Methods for diagnosing infectious diseases using adsorption media
HK1228813B (en) Methods for diagnosing infectious diseases using adsorption media
BR112018006635B1 (pt) Método in vitro para detectar um patógeno infeccioso
EP1867991B1 (en) Immunoassay method and immunoassay kit to be used therein
CN106267407A (zh) 母胎Rh血型不合血液净化治疗仪
Uzun et al. Poly (hydroxyethyl methacrylate) based affinity membranes for in vitro removal of anti-dsDNA antibodies from SLE plasma
JPH03287067A (ja) リンパ球の分離剤、分離装置および分離方法
JPH07502123A (ja) 抗原及び核酸の検出
Akande-Sholabi et al. Affinity binding macroporous monolithic cryogel as a matrix for extracorporeal apheresis medical devices
RU2684639C1 (ru) Способ удаления эндотоксинов из биологических жидкостей с помощью ковалентно иммобилизованного лизоцима в качестве лиганда
JP2007089788A (ja) ＣＤ４９ｄ強陽性細胞除去材料
JP2004101256A (ja) バイオマテリアルのスクリーニング方法
JPH04114662A (ja) リンパ球分離用吸着剤および分離装置

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20191010