CA2925417C - Interleukin-4 receptor-binding fusion proteins and uses thereof - Google Patents

Interleukin-4 receptor-binding fusion proteins and uses thereof Download PDF

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Publication number
CA2925417C
CA2925417C CA2925417A CA2925417A CA2925417C CA 2925417 C CA2925417 C CA 2925417C CA 2925417 A CA2925417 A CA 2925417A CA 2925417 A CA2925417 A CA 2925417A CA 2925417 C CA2925417 C CA 2925417C
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Prior art keywords
fusion protein
cell
protein
nucleic acid
cells
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CA2925417A
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English (en)
French (fr)
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CA2925417A1 (en
Inventor
Fahar Merchant
Raj K. Puri
Bharatkumar H. Joshi
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Medicenna Therapeutics Inc
US Department of Health and Human Services
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Medicenna Therapeutics Inc
US Department of Health and Human Services
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Priority to CA3180148A priority Critical patent/CA3180148A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1761—Apoptosis related proteins, e.g. Apoptotic protease-activating factor-1 (APAF-1), Bax, Bax-inhibitory protein(s)(BI; bax-I), Myeloid cell leukemia associated protein (MCL-1), Inhibitor of apoptosis [IAP] or Bcl-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2026—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2086—IL-13 to IL-16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5437—IL-13
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/48—Regulators of apoptosis

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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CA2925417A 2013-09-24 2014-09-24 Interleukin-4 receptor-binding fusion proteins and uses thereof Active CA2925417C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3180148A CA3180148A1 (en) 2013-09-24 2014-09-24 Interleukin-4 receptor-binding fusion proteins and uses thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361881930P 2013-09-24 2013-09-24
US61/881,930 2013-09-24
PCT/CA2014/050915 WO2015042705A1 (en) 2013-09-24 2014-09-24 Interleukin-4 receptor-binding fusion proteins and uses thereof

Related Child Applications (1)

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CA3180148A Division CA3180148A1 (en) 2013-09-24 2014-09-24 Interleukin-4 receptor-binding fusion proteins and uses thereof

Publications (2)

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CA2925417A1 CA2925417A1 (en) 2015-04-02
CA2925417C true CA2925417C (en) 2023-10-24

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CA2925417A Active CA2925417C (en) 2013-09-24 2014-09-24 Interleukin-4 receptor-binding fusion proteins and uses thereof
CA3180148A Pending CA3180148A1 (en) 2013-09-24 2014-09-24 Interleukin-4 receptor-binding fusion proteins and uses thereof
CA2930074A Pending CA2930074A1 (en) 2013-09-24 2014-09-24 Interleukin-4 receptor-binding fusion proteins and uses thereof

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CA2930074A Pending CA2930074A1 (en) 2013-09-24 2014-09-24 Interleukin-4 receptor-binding fusion proteins and uses thereof

Country Status (6)

Country Link
US (6) US10093708B2 (de)
EP (3) EP3049525B1 (de)
JP (4) JP6936934B2 (de)
CN (4) CN105764926A (de)
CA (3) CA2925417C (de)
WO (2) WO2015042705A1 (de)

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EP3049525B1 (de) * 2013-09-24 2025-07-23 Medicenna Therapeutics, Inc. Interleukin-4 rezeptor-bindende fusionsproteine und verwendungen davon
CN105722860A (zh) * 2013-09-24 2016-06-29 梅迪塞纳医疗股份有限公司 白介素-2融合蛋白及其应用
PT3145946T (pt) 2014-05-21 2019-11-20 Universita¿T Basel Distribuição de proteínas à base de bactérias
KR101741594B1 (ko) * 2015-06-30 2017-05-30 경북대학교 산학협력단 암세포 및 종양관련 대식세포를 동시에 표적하는 융합 펩타이드를 유효성분으로 포함하는 항암 및 암 전이 억제용 약학적 조성물
WO2017001568A1 (en) 2015-07-01 2017-01-05 Universitat De Lleida Treatment and prevention of amyotrophic lateral sclerosis
EP3325505B1 (de) * 2015-07-23 2020-08-19 Modernatx, Inc. Boten-ribonukleinsäuren (mrna) zur herstellung intrazellulärer bindungspolypeptide und verfahren zur verwendung davon
HRP20201792T1 (hr) * 2015-11-19 2020-12-25 Universität Basel Isporuka proteina na bazi bakterija
KR102736981B1 (ko) 2015-11-19 2024-12-02 우니페르시테트 바젤 악성 고형 종양 치료를 위한 병독성 약독화된 박테리아
EP3559022B1 (de) 2016-12-20 2021-06-30 Universität Basel Virulenzabgeschwächte bakterienbasierte proteinabgabe
WO2019052562A1 (zh) * 2017-09-15 2019-03-21 科济生物医药（上海）有限公司 Il-4r的融合蛋白及其应用
US12274735B2 (en) 2017-10-10 2025-04-15 Medicenna Therapeutics Inc. IL-4-fusion formulations for treatment of central nervous system (CNS) tumors
US12404497B2 (en) 2018-06-01 2025-09-02 Medicenna Therapeutics Inc. Uses and methods for oncolytic virus targeting of IL-4/IL-13 and fusions thereof
WO2020212598A1 (en) 2019-04-19 2020-10-22 Synerkine Pharma B.V. A fusion protein comprising il13
CN114457024A (zh) * 2020-10-30 2022-05-10 未来智人再生医学研究院(广州)有限公司 一种表达IL-4Rα阻断物的多能干细胞或其衍生物及应用
KR20250004954A (ko) * 2022-03-08 2025-01-09 메디세나 테라퓨틱스, 인크. Il-2, il-13, 및 il-4 시토킨 이작용성 분자의 용도 및 방법
CN121532418A (zh) * 2023-07-17 2026-02-13 南京传奇生物科技有限公司 融合蛋白及其使用方法

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