CA2920720A1 - Tissue repair devices utilizing self-assembled materials - Google Patents

Tissue repair devices utilizing self-assembled materials Download PDF

Info

Publication number
CA2920720A1
CA2920720A1 CA2920720A CA2920720A CA2920720A1 CA 2920720 A1 CA2920720 A1 CA 2920720A1 CA 2920720 A CA2920720 A CA 2920720A CA 2920720 A CA2920720 A CA 2920720A CA 2920720 A1 CA2920720 A1 CA 2920720A1
Authority
CA
Canada
Prior art keywords
tissue
nonabsorbable
silk fibroin
hyaluronic acid
protective material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2920720A
Other languages
English (en)
French (fr)
Inventor
William D. Wagner
Nicole Levi
Rui Wang
Louis C. Argenta
Michael J. Morykwas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wake Forest University Health Sciences
Original Assignee
Wake Forest University Health Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wake Forest University Health Sciences filed Critical Wake Forest University Health Sciences
Publication of CA2920720A1 publication Critical patent/CA2920720A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H9/00—Pneumatic or hydraulic massage
    • A61H9/005—Pneumatic massage
    • A61H9/0057—Suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/02—Methods for coating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/06—Coatings containing a mixture of two or more compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/20—Materials or treatment for tissue regeneration for reconstruction of the heart, e.g. heart valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/90—Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
    • A61M1/91—Suction aspects of the dressing
    • A61M1/916—Suction aspects of the dressing specially adapted for deep wounds

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rehabilitation Therapy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Materials For Medical Uses (AREA)
CA2920720A 2013-08-20 2013-08-20 Tissue repair devices utilizing self-assembled materials Abandoned CA2920720A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2013/055730 WO2015026326A1 (en) 2013-08-20 2013-08-20 Tissue repair devices utilizing self-assembled materials

Publications (1)

Publication Number Publication Date
CA2920720A1 true CA2920720A1 (en) 2015-02-26

Family

ID=52483986

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2920720A Abandoned CA2920720A1 (en) 2013-08-20 2013-08-20 Tissue repair devices utilizing self-assembled materials

Country Status (5)

Country Link
US (1) US20160193106A1 (https=)
EP (1) EP3033117A4 (https=)
JP (1) JP6224248B2 (https=)
CA (1) CA2920720A1 (https=)
WO (1) WO2015026326A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106183508A (zh) * 2016-07-19 2016-12-07 南通纺织丝绸产业技术研究院 基于蚕丝蛋白的光学防伪标记及其制备方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11298453B2 (en) 2003-10-28 2022-04-12 Smith & Nephew Plc Apparatus and method for wound cleansing with actives
EP3677291B1 (en) 2013-05-10 2024-01-03 Smith & Nephew PLC Fluidic connector for irrigation and aspiration of wounds
US20150057685A1 (en) * 2013-08-22 2015-02-26 Allergan, Inc. Medical device with anti adhesive property
US20230190997A1 (en) 2017-06-26 2023-06-22 Evolved By Nature, Inc. Silk-hyaluronic acid based tissue filers and methods of using the same
AU2019405953B2 (en) 2018-12-19 2025-09-18 Evolved By Nature, Inc. Silk-hyaluronic acid tissue fillers and methods of making and using the same
WO2020197656A1 (en) * 2019-02-12 2020-10-01 Trustees Of Tufts College System and method for fabrication of large, porous drug-silk materials using cryogranulation
US20250295691A1 (en) * 2020-06-19 2025-09-25 Evolved By Nature, Inc. Silk-Hyaluronic Acid Compositions For Tissue Filling, Tissue Spacing, and Tissue Bulking

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7198046B1 (en) * 1991-11-14 2007-04-03 Wake Forest University Health Sciences Wound treatment employing reduced pressure
US20040110722A1 (en) * 1999-05-27 2004-06-10 Ornberg Richard L. Modified hyaluronic acid polymers
US7763769B2 (en) * 2001-02-16 2010-07-27 Kci Licensing, Inc. Biocompatible wound dressing
US7700819B2 (en) * 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
US20040058056A1 (en) * 2001-07-06 2004-03-25 Shigemasa Osaki Drug diffusion coatings, applications and methods
GB2382305B (en) * 2001-11-23 2004-12-15 Johnson & Johnson Medical Ltd Absorbent wound dressings containing a hydrogel layer
US6960617B2 (en) * 2002-04-22 2005-11-01 Purdue Research Foundation Hydrogels having enhanced elasticity and mechanical strength properties
GB2415382A (en) * 2004-06-21 2005-12-28 Johnson & Johnson Medical Ltd Wound dressings for vacuum therapy
US8349349B2 (en) * 2006-02-28 2013-01-08 Covidien Lp Tissue adhesives and sealants and method for their use
US7779625B2 (en) * 2006-05-11 2010-08-24 Kalypto Medical, Inc. Device and method for wound therapy
US8192760B2 (en) * 2006-12-04 2012-06-05 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
EP3513820B1 (en) * 2007-03-14 2025-06-18 The Board of Trustees of the Leland Stanford Junior University Devices for application of reduced pressure therapy
CN103990184A (zh) * 2008-01-09 2014-08-20 韦克福里斯特大学健康科学院 用于治疗中枢神经系统病理的装置和方法
GB0816496D0 (en) * 2008-09-10 2008-10-15 Zhao Xiaobin Hyaluronic acid cryogel
WO2010038231A1 (en) * 2008-10-02 2010-04-08 L.R.R.& D. Ltd. Interface layer wound dressing
US20110189292A1 (en) * 2009-04-20 2011-08-04 Allergan, Inc. Dermal fillers comprising silk fibroin hydrogels and uses thereof
EP2421551B2 (en) * 2009-04-20 2020-07-15 Allergan, Inc. Silk fibroin hydrogels and uses thereof
CN101700409A (zh) * 2009-11-20 2010-05-05 佘振定 一种由纯天然材料制备的创伤用材料
JP5754612B2 (ja) * 2010-10-06 2015-07-29 日立化成株式会社 創傷被覆材
CA3065694A1 (en) * 2010-11-10 2012-05-18 Inregen Methods of forming injectable formulations for providing regenerative effects to an organ such as a kidney
US20140315828A1 (en) * 2013-04-22 2014-10-23 Allergan, Inc. Cross-linked silk-hyaluronic acid compositions

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106183508A (zh) * 2016-07-19 2016-12-07 南通纺织丝绸产业技术研究院 基于蚕丝蛋白的光学防伪标记及其制备方法
CN106183508B (zh) * 2016-07-19 2018-11-02 南通纺织丝绸产业技术研究院 基于蚕丝蛋白的光学防伪标记及其制备方法

Also Published As

Publication number Publication date
EP3033117A1 (en) 2016-06-22
JP6224248B2 (ja) 2017-11-01
US20160193106A1 (en) 2016-07-07
WO2015026326A1 (en) 2015-02-26
EP3033117A4 (en) 2017-04-19
JP2016528007A (ja) 2016-09-15

Similar Documents

Publication Publication Date Title
US20160193106A1 (en) Tissue repair devices utilizing self-assembled materials
Zhang et al. Layered nanofiber sponge with an improved capacity for promoting blood coagulation and wound healing
CN106029361B (zh) 替代组织的多层基体及其用途
KR101102308B1 (ko) 세포외기질 성분과 생체적합성 고분자를 포함하는 복합 필름 및 그 제조방법
Shevach et al. Omentum ECM-based hydrogel as a platform for cardiac cell delivery
Salehi et al. Kaolin-loaded chitosan/polyvinyl alcohol electrospun scaffold as a wound dressing material: In vitro and in vivo studies
CN101773689B (zh) 外科修复补片
CN103480042B (zh) 一种人工硬脊膜及其制备方法和使用方法
CN111793899B (zh) 仿生纳米纤维材料及其制备方法与应用
CN104055795B (zh) 一种可注射植入剂及其制备方法
RS56189B1 (sr) Postupci, cev i uređaj za dobijanje kompozicije za zarastanje rana
CN104117096A (zh) 一种新型复合生物硬脑膜
Liu et al. A tough and mechanically stable adhesive hydrogel for non-invasive wound repair
TR201911079T4 (tr) Kolajen ve fibrinin karıştırıldığı doku yapıştırıcısı ve bunun hazırlanmasına yönelik yöntem.
Wen et al. Astragalus polysaccharides driven stretchable nanofibrous membrane wound dressing for joint wound healing
Flanagan et al. Development of a sutureless dural substitute from Bombyx mori silk fibroin
Yang et al. Double-cross-linked hydrogel with long-lasting underwater adhesion: enhancement of maxillofacial in situ and onlay bone retention
Cheng et al. Highly absorbent silk fibroin protein xerogel
CN113727740A (zh) 医用黏合剂及其制备方法和用途
Maghdouri-White et al. Biomanufacturing organized collagen-based microfibers as a Tissue ENgineered Device (TEND) for tendon regeneration
CN111317867A (zh) 一种神经导管及其制备方法
CN102743796A (zh) 用聚乙烯醇制成的丝素蛋白多孔支架及其制备方法和用途
CN102813961A (zh) 一种含有亚微米级透明质酸微球的注射凝胶与制备方法
CN101856515B (zh) 以壳聚糖和贝壳粉末为原料制备人工骨的方法
Teng et al. Biomimetic and wound microenvironment-modulating PEGylated glycopolypeptide hydrogels for arterial massive hemorrhage and wound prohealing

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180814

FZDE Discontinued

Effective date: 20210831