CA2920457A1 - Anti-acne compositions comprising bile acid-fatty acid conjugates - Google Patents

Anti-acne compositions comprising bile acid-fatty acid conjugates Download PDF

Info

Publication number
CA2920457A1
CA2920457A1 CA2920457A CA2920457A CA2920457A1 CA 2920457 A1 CA2920457 A1 CA 2920457A1 CA 2920457 A CA2920457 A CA 2920457A CA 2920457 A CA2920457 A CA 2920457A CA 2920457 A1 CA2920457 A1 CA 2920457A1
Authority
CA
Canada
Prior art keywords
acid
composition
acne
fabac
fatty acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2920457A
Other languages
English (en)
French (fr)
Inventor
Nava Dayan
Allen BAHARAFF
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galmed Research and Development Ltd
Original Assignee
GALDERM THERAPEUTICS Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GALDERM THERAPEUTICS Ltd filed Critical GALDERM THERAPEUTICS Ltd
Publication of CA2920457A1 publication Critical patent/CA2920457A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
CA2920457A 2013-08-08 2014-08-07 Anti-acne compositions comprising bile acid-fatty acid conjugates Abandoned CA2920457A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361863454P 2013-08-08 2013-08-08
US61/863,454 2013-08-08
PCT/IL2014/050718 WO2015019359A1 (en) 2013-08-08 2014-08-07 Anti-acne compositions comprising bile acid-fatty acid conjugates

Publications (1)

Publication Number Publication Date
CA2920457A1 true CA2920457A1 (en) 2015-02-12

Family

ID=52460753

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2920457A Abandoned CA2920457A1 (en) 2013-08-08 2014-08-07 Anti-acne compositions comprising bile acid-fatty acid conjugates

Country Status (7)

Country Link
US (1) US20160175324A1 (enExample)
EP (1) EP3030229B1 (enExample)
JP (1) JP2016527307A (enExample)
CN (1) CN105611919A (enExample)
AU (1) AU2014304079A1 (enExample)
CA (1) CA2920457A1 (enExample)
WO (1) WO2015019359A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL227890A0 (en) * 2013-08-08 2014-01-30 Galderm Therapeutics Ltd Antiaging compounds containing bile acid and fatty acid conjugates
WO2016199137A1 (en) 2015-06-10 2016-12-15 Galmed Research And Development Ltd. Low dose compositions of aramchol salts
US11571431B2 (en) 2013-12-04 2023-02-07 Galmed Research And Development Ltd Aramchol salts
US10016456B2 (en) * 2014-07-18 2018-07-10 Dabney Patents, L.L.C. Methods for treating acne vulgaris
IL243707A0 (en) 2016-01-20 2016-05-01 Galmed Res And Dev Ltd Treatment to regulate the microbiota in the intestine
KR20180036580A (ko) 2016-09-30 2018-04-09 주식회사 유스바이오팜 수가용화(水加溶化)된 우르소데옥시콜산을 함유하는 염증성 피부질환 또는 중증 소양증 예방 또는 치료용 조성물
WO2018062922A1 (ko) * 2016-09-30 2018-04-05 주식회사 유스바이오팜 수가용화된 우르소데옥시콜산을 함유하는 염증성 피부질환 또는 중증 소양증 예방 또는 치료용 조성물
US11197870B2 (en) 2016-11-10 2021-12-14 Galmed Research And Development Ltd Treatment for hepatic fibrosis
WO2019044852A1 (ja) * 2017-08-31 2019-03-07 株式会社資生堂 レチノイドの副作用に対する感受性の決定方法
CN109503693B (zh) * 2018-12-12 2021-04-06 合肥工业大学 一种利用胆酸为原料合成Aramchol的工艺

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3860712A (en) * 1973-04-16 1975-01-14 Sterling Drug Inc Composition and method for treatment of acne or seborrhea
IT8167097A0 (it) * 1981-01-26 1981-01-26 Unilever Nv Composizione cosmetica per il trattamento della pelle o dei capelli
IL123998A (en) * 1998-04-08 2004-09-27 Galmed Int Ltd Conjugates of bile salts and pharmaceutical preparations containing them
US7759348B2 (en) * 2003-07-30 2010-07-20 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
ES2296463B1 (es) * 2005-07-13 2009-02-16 Universidade De Santiago Compostela Nuevos amidoderivados de acidos billares funcionalizados en la posicion 3 del anillo a. procedimientos para su obtencion y aplicaciones.
CN101821234B (zh) * 2007-08-08 2014-06-25 格里斯威医药有限责任公司 苯氧基吡咯烷衍生物及其应用和组合物
WO2009060452A2 (en) * 2007-11-08 2009-05-14 Galmed International Ltd. Methods and compositions for treating biliary cholesterol crystallization and related conditions
FR2940281B1 (fr) * 2008-12-22 2011-04-01 Fabre Pierre Dermo Cosmetique Ester de diol et d'acide gras polyinsature comme agent anti-acne
US8937194B2 (en) * 2008-12-31 2015-01-20 Nitromega Corp. Topical compositions containing nitro fatty acids
US20120157419A1 (en) * 2009-02-02 2012-06-21 Tuvia Gilat Methods and compositions for treating alzheimer's disease
IL227890A0 (en) * 2013-08-08 2014-01-30 Galderm Therapeutics Ltd Antiaging compounds containing bile acid and fatty acid conjugates

Also Published As

Publication number Publication date
JP2016527307A (ja) 2016-09-08
AU2014304079A1 (en) 2016-02-25
EP3030229A4 (en) 2017-03-22
US20160175324A1 (en) 2016-06-23
EP3030229B1 (en) 2019-03-13
WO2015019359A1 (en) 2015-02-12
EP3030229A1 (en) 2016-06-15
CN105611919A (zh) 2016-05-25

Similar Documents

Publication Publication Date Title
EP3030229B1 (en) Anti-acne compositions comprising bile acid-fatty acid conjugates
KR101443927B1 (ko) 헥사미딘류 및 레티노이드류를 함유하는 피부 개선 조성물
US20160175223A1 (en) Anti-aging compositions comprising bile acid-fatty acid conjugates
JP2007537214A (ja) 美容術及び皮膚科医学において有用なスポット適用配合物
US20150094370A1 (en) Pharmaceutical compositions comprising dgla, 15-ohepa, and/or 15-hetre and methods of reducing sebum production using same
WO2013057284A1 (en) Pharmaceutical compositions comprising dgla, 15-ohepa, and/or 15-hetre and methods of use thereof
CN102038672B (zh) 一种用于治疗痤疮的药物组合物
US20240225985A1 (en) Brightening compositions and methods of use
CA2798121C (en) Topical composition and use thereof for the prophylaxis and the treatment of defects connected to inflammatory dermopathies
EA038613B1 (ru) Смешанные составы
JP5578880B2 (ja) 抗マラセチア菌剤
CA2762394C (en) Topical retinoid solutions
HK1224943A1 (en) Anti-acne compositions comprising bile acid-fatty acid conjugates
JP2014144929A (ja) ビタミン類を含有するニキビの予防又は治療用組成物
CN103327957B (zh) 亮肤组合物

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20200831