CA2916980C - Regulation of glucose metabolism using anti-cgrp antibodies - Google Patents
Regulation of glucose metabolism using anti-cgrp antibodies Download PDFInfo
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- CA2916980C CA2916980C CA2916980A CA2916980A CA2916980C CA 2916980 C CA2916980 C CA 2916980C CA 2916980 A CA2916980 A CA 2916980A CA 2916980 A CA2916980 A CA 2916980A CA 2916980 C CA2916980 C CA 2916980C
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Classifications
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Hematology (AREA)
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- Gastroenterology & Hepatology (AREA)
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- Genetics & Genomics (AREA)
- Biophysics (AREA)
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- Mycology (AREA)
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- Emergency Medicine (AREA)
- Zoology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Developing Agents For Electrophotography (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US201361842745P | 2013-07-03 | 2013-07-03 | |
| US61/842,745 | 2013-07-03 | ||
| US201461982611P | 2014-04-22 | 2014-04-22 | |
| US61/982,611 | 2014-04-22 | ||
| PCT/US2014/045389 WO2015003122A2 (en) | 2013-07-03 | 2014-07-03 | Regulation of glucose metabolism using anti-cgrp antibodies |
Publications (2)
| Publication Number | Publication Date |
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| CA2916980A1 CA2916980A1 (en) | 2015-01-08 |
| CA2916980C true CA2916980C (en) | 2023-02-21 |
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| Country | Link |
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| US (1) | US20150017166A1 (enExample) |
| EP (1) | EP3016684B1 (enExample) |
| JP (4) | JP6502337B2 (enExample) |
| KR (1) | KR102476907B1 (enExample) |
| AU (2) | AU2014285052B2 (enExample) |
| CA (1) | CA2916980C (enExample) |
| ES (1) | ES2911690T3 (enExample) |
| IL (1) | IL243355B2 (enExample) |
| MX (1) | MX374612B (enExample) |
| NZ (1) | NZ754427A (enExample) |
| SG (2) | SG11201510618YA (enExample) |
| TW (2) | TWI712419B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| MX374612B (es) * | 2013-07-03 | 2025-03-06 | H Lundbeck As Star | Regulacion del metabolismo de glucosa usando anticuerpos anti-cgrp. |
| US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| HRP20240159T1 (hr) | 2014-03-21 | 2024-04-12 | Teva Pharmaceuticals International Gmbh | Antagonistička protutijela usmjerena protiv peptida povezanog s genom kalcitonina i postupci koji ih koriste |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| WO2018055574A1 (en) | 2016-09-23 | 2018-03-29 | Teva Pharmaceuticals International Gmbh | Treating refractory migraine |
| AU2020202454A1 (en) | 2020-04-06 | 2021-10-21 | H. Lundbeck A/S | Treatment of most bothersome symptom (MBS) associated with migraine using anti-CGRP antibodies |
| EP4196611A1 (en) * | 2020-08-15 | 2023-06-21 | Regeneron Pharmaceuticals, Inc. | Treatment of obesity in subjects having variant nucleic acid molecules encoding calcitonin receptor (calcr) |
| WO2023026245A1 (en) | 2021-08-27 | 2023-03-02 | H. Lundbeck A/S | Treatment of cluster headache using anti-cgrp antibodies |
Family Cites Families (28)
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| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| GB8720115D0 (en) | 1987-08-26 | 1987-09-30 | Cooper G J S | Treatment of diabetes mellitus |
| GB8725529D0 (en) | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
| US5266561A (en) | 1988-01-11 | 1993-11-30 | Amylin Pharmaceuticals, Inc. | Treatment of type 2 diabetes mellitus |
| WO1989006135A1 (en) * | 1988-01-11 | 1989-07-13 | Amylin Corporation | Treatment of type 2 diabetes mellitus |
| US5364841A (en) * | 1988-01-11 | 1994-11-15 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and essential hypertension and related disorders |
| US5175145A (en) | 1988-08-26 | 1992-12-29 | Amylin Pharmaceuticals, Inc. | Treatment of diabetes mellitus with amylin agonists |
| JP2989002B2 (ja) | 1988-12-22 | 1999-12-13 | キリン―アムジエン・インコーポレーテツド | 化学修飾顆粒球コロニー刺激因子 |
| DE68923790T2 (de) * | 1989-01-03 | 1996-05-15 | Motorola Inc | Verfahren zum herstellen von löthöckern hoher dichte und ein substratsockel für löthöcker hoher dichte. |
| US5766883A (en) | 1989-04-29 | 1998-06-16 | Delta Biotechnology Limited | Polypeptides |
| JPH04500688A (ja) * | 1989-07-10 | 1992-02-06 | アミリン・コーポレイション | 肥満および本態性高血圧および関連疾患の治療 |
| FR2650598B1 (fr) | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | Derives de l'albumine a fonction therapeutique |
| WO1992002551A1 (en) | 1990-08-02 | 1992-02-20 | B.R. Centre Limited | Methods for the production of proteins with a desired function |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| WO1994021293A1 (en) | 1993-03-19 | 1994-09-29 | Duke University | Method of treatment of tumors with an antibody binding to tenascin |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| WO1996004925A1 (en) | 1994-08-12 | 1996-02-22 | Immunomedics, Inc. | Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells |
| US6653104B2 (en) | 1996-10-17 | 2003-11-25 | Immunomedics, Inc. | Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells |
| AU2002356469A1 (en) * | 2001-11-26 | 2003-06-10 | Protemix Corp Ltd | Methods of compositions for normalizing lipid levels in mammalian tissues |
| ES2630224T3 (es) | 2003-10-22 | 2017-08-18 | Keck Graduate Institute | Métodos para sintetizar polipéptidos heteromultiméricos en levadura con el uso de una estrategia de apareamiento haploide |
| EP2380592B1 (en) * | 2005-11-14 | 2018-03-07 | Teva Pharmaceuticals International GmbH | Antagonist antibody directed against calcitonin gene-related peptide |
| WO2008045140A1 (en) | 2006-05-19 | 2008-04-17 | Alder Biopharmaceuticals, Inc. | Culture method for obtaining a clonal population of antigen-specific b cells |
| TWI501976B (zh) | 2007-05-21 | 2015-10-01 | Alder Biopharmaceuticals Inc | 抗ＴＮＦ－α之抗體及其用途 |
| US9056905B2 (en) | 2007-05-21 | 2015-06-16 | Alderbio Holdings Llc | Antibodies to TNF-α and use thereof |
| KR101829776B1 (ko) | 2007-05-21 | 2018-02-19 | 앨더바이오 홀딩스 엘엘씨 | Ｉｌ-６에 대한 항체 및 이의 용도 |
| SG10201604040PA (en) * | 2011-05-20 | 2016-07-28 | Alderbio Holdings Llc | Anti-cgrp compositions and use thereof |
| CN103957935B (zh) * | 2011-05-20 | 2018-04-03 | 奥尔德生物控股有限责任公司 | 抗cgrp或抗cgrp‑r抗体或抗体片段用于治疗或预防慢性和急性形式的腹泻的用途 |
| MX374612B (es) * | 2013-07-03 | 2025-03-06 | H Lundbeck As Star | Regulacion del metabolismo de glucosa usando anticuerpos anti-cgrp. |
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2014
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- 2014-07-03 WO PCT/US2014/045389 patent/WO2015003122A2/en not_active Ceased
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- 2014-07-03 AU AU2014285052A patent/AU2014285052B2/en active Active
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- 2014-07-03 NZ NZ754427A patent/NZ754427A/en unknown
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- 2014-07-03 SG SG10201906172XA patent/SG10201906172XA/en unknown
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2018
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- 2019-12-10 AU AU2019279945A patent/AU2019279945B2/en active Active
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2020
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Also Published As
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| JP2019112455A (ja) | 2019-07-11 |
| KR20160029822A (ko) | 2016-03-15 |
| TW202106335A (zh) | 2021-02-16 |
| IL243355B2 (en) | 2024-10-01 |
| NZ754427A (en) | 2021-12-24 |
| WO2015003122A2 (en) | 2015-01-08 |
| IL243355A0 (en) | 2016-03-31 |
| ES2911690T3 (es) | 2022-05-20 |
| AU2019279945B2 (en) | 2022-01-20 |
| AU2014285052A1 (en) | 2016-02-11 |
| AU2019279945A1 (en) | 2020-01-16 |
| TWI712419B (zh) | 2020-12-11 |
| EP3016684A4 (en) | 2017-06-07 |
| CN105492026A (zh) | 2016-04-13 |
| SG11201510618YA (en) | 2016-03-30 |
| JP2018168186A (ja) | 2018-11-01 |
| AU2014285052B2 (en) | 2019-09-12 |
| CA2916980A1 (en) | 2015-01-08 |
| WO2015003122A3 (en) | 2015-03-19 |
| JP2016528198A (ja) | 2016-09-15 |
| TW201536316A (zh) | 2015-10-01 |
| TWI753471B (zh) | 2022-01-21 |
| SG10201906172XA (en) | 2019-08-27 |
| US20150017166A1 (en) | 2015-01-15 |
| KR102476907B1 (ko) | 2022-12-13 |
| EP3016684B1 (en) | 2022-02-23 |
| IL243355B1 (en) | 2024-06-01 |
| MX2016000220A (es) | 2016-08-18 |
| JP6502337B2 (ja) | 2019-04-17 |
| EP3016684A2 (en) | 2016-05-11 |
| JP2020158525A (ja) | 2020-10-01 |
| NZ715834A (en) | 2021-11-26 |
| MX374612B (es) | 2025-03-06 |
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