AU2014285052B2 - Regulation of glucose metabolism using anti-CGRP antibodies - Google Patents

Regulation of glucose metabolism using anti-CGRP antibodies Download PDF

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Publication number
AU2014285052B2
AU2014285052B2 AU2014285052A AU2014285052A AU2014285052B2 AU 2014285052 B2 AU2014285052 B2 AU 2014285052B2 AU 2014285052 A AU2014285052 A AU 2014285052A AU 2014285052 A AU2014285052 A AU 2014285052A AU 2014285052 B2 AU2014285052 B2 AU 2014285052B2
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Australia
Prior art keywords
seq
antibody
cgrp
sequence
fragments
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AU2014285052A
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AU2014285052A1 (en
Inventor
Brian Baker
John A. Latham
Jeffrey T.L. Smith
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H Lundbeck AS
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H Lundbeck AS
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Priority to AU2019279945A priority Critical patent/AU2019279945B2/en
Assigned to LUNDBECK SEATTLE BIOPHARMACEUTICALS, INC reassignment LUNDBECK SEATTLE BIOPHARMACEUTICALS, INC Request to Amend Deed and Register Assignors: ALDER BIOPHARMACEUTICALS, INC.
Assigned to H. LUNDBECK A/S. reassignment H. LUNDBECK A/S. Request for Assignment Assignors: LUNDBECK SEATTLE BIOPHARMACEUTICALS, INC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Developing Agents For Electrophotography (AREA)
AU2014285052A 2013-07-03 2014-07-03 Regulation of glucose metabolism using anti-CGRP antibodies Active AU2014285052B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2019279945A AU2019279945B2 (en) 2013-07-03 2019-12-10 Regulation of glucose metabolism using anti-CGRP antibodies

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361842745P 2013-07-03 2013-07-03
US61/842,745 2013-07-03
US201461982611P 2014-04-22 2014-04-22
US61/982,611 2014-04-22
PCT/US2014/045389 WO2015003122A2 (en) 2013-07-03 2014-07-03 Regulation of glucose metabolism using anti-cgrp antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2019279945A Division AU2019279945B2 (en) 2013-07-03 2019-12-10 Regulation of glucose metabolism using anti-CGRP antibodies

Publications (2)

Publication Number Publication Date
AU2014285052A1 AU2014285052A1 (en) 2016-02-11
AU2014285052B2 true AU2014285052B2 (en) 2019-09-12

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AU2014285052A Active AU2014285052B2 (en) 2013-07-03 2014-07-03 Regulation of glucose metabolism using anti-CGRP antibodies
AU2019279945A Active AU2019279945B2 (en) 2013-07-03 2019-12-10 Regulation of glucose metabolism using anti-CGRP antibodies

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Country Status (13)

Country Link
US (1) US20150017166A1 (enExample)
EP (1) EP3016684B1 (enExample)
JP (4) JP6502337B2 (enExample)
KR (1) KR102476907B1 (enExample)
AU (2) AU2014285052B2 (enExample)
CA (1) CA2916980C (enExample)
ES (1) ES2911690T3 (enExample)
IL (1) IL243355B2 (enExample)
MX (1) MX374612B (enExample)
NZ (1) NZ754427A (enExample)
SG (2) SG10201906172XA (enExample)
TW (2) TWI712419B (enExample)
WO (1) WO2015003122A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015003122A2 (en) * 2013-07-03 2015-01-08 Alder Biopharmaceuticals, Inc. Regulation of glucose metabolism using anti-cgrp antibodies
US10556945B2 (en) 2014-03-21 2020-02-11 Teva Pharmaceuticals International Gmbh Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
RS65360B1 (sr) 2014-03-21 2024-04-30 Teva Pharmaceuticals Int Gmbh Antagonistička antitela specifična za peptid genski srodan kalcitoninu i postupci njihove upotrebe
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
AU2017331593B2 (en) 2016-09-23 2022-04-28 Teva Pharmaceuticals International Gmbh Treating refractory migraine
SG10202003296VA (en) 2020-04-06 2021-11-29 H Lundbeck As Treatment of most bothersome symptom (mbs) associated with migraine using anti-cgrp antibodies
WO2022040035A1 (en) * 2020-08-15 2022-02-24 Regeneron Pharmaceuticals, Inc. Treatment of obesity in subjects having variant nucleic acid molecules encoding calcitonin receptor (calcr)
WO2023026245A1 (en) 2021-08-27 2023-03-02 H. Lundbeck A/S Treatment of cluster headache using anti-cgrp antibodies

Citations (3)

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US5266561A (en) * 1988-01-11 1993-11-30 Amylin Pharmaceuticals, Inc. Treatment of type 2 diabetes mellitus
US5364841A (en) * 1988-01-11 1994-11-15 Amylin Pharmaceuticals, Inc. Treatment of obesity and essential hypertension and related disorders
US20120294797A1 (en) * 2011-05-20 2012-11-22 Brian Robert Kovacevich Anti-cgrp compositions and use thereof

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GB8725529D0 (en) 1987-10-30 1987-12-02 Delta Biotechnology Ltd Polypeptides
EP0348490B1 (en) * 1988-01-11 1995-09-27 Amylin Pharmaceuticals, Inc. Treatment of type 2 diabetes mellitus
US5175145A (en) 1988-08-26 1992-12-29 Amylin Pharmaceuticals, Inc. Treatment of diabetes mellitus with amylin agonists
CA2006596C (en) 1988-12-22 2000-09-05 Rika Ishikawa Chemically-modified g-csf
EP0403631B1 (en) * 1989-01-03 1995-08-09 Motorola, Inc. Method of making high density solder bumps and a substrate socket for high density solder bumps
US5766883A (en) 1989-04-29 1998-06-16 Delta Biotechnology Limited Polypeptides
AU620727B2 (en) * 1989-07-10 1992-02-20 Amylin Pharmaceuticals, Inc. Treatment of obesity and essential hypertension and related disorders
FR2650598B1 (fr) 1989-08-03 1994-06-03 Rhone Poulenc Sante Derives de l'albumine a fonction therapeutique
EP0542810A1 (en) 1990-08-02 1993-05-26 B.R. Centre Limited Methods for the production of proteins with a desired function
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
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Publication number Priority date Publication date Assignee Title
US5266561A (en) * 1988-01-11 1993-11-30 Amylin Pharmaceuticals, Inc. Treatment of type 2 diabetes mellitus
US5364841A (en) * 1988-01-11 1994-11-15 Amylin Pharmaceuticals, Inc. Treatment of obesity and essential hypertension and related disorders
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Also Published As

Publication number Publication date
KR20160029822A (ko) 2016-03-15
MX2016000220A (es) 2016-08-18
MX374612B (es) 2025-03-06
WO2015003122A2 (en) 2015-01-08
TWI753471B (zh) 2022-01-21
AU2014285052A1 (en) 2016-02-11
JP2020158525A (ja) 2020-10-01
EP3016684B1 (en) 2022-02-23
TWI712419B (zh) 2020-12-11
EP3016684A4 (en) 2017-06-07
CA2916980A1 (en) 2015-01-08
IL243355B1 (en) 2024-06-01
NZ715834A (en) 2021-11-26
JP2016528198A (ja) 2016-09-15
SG10201906172XA (en) 2019-08-27
WO2015003122A3 (en) 2015-03-19
NZ754427A (en) 2021-12-24
JP2018168186A (ja) 2018-11-01
AU2019279945B2 (en) 2022-01-20
SG11201510618YA (en) 2016-03-30
JP6502337B2 (ja) 2019-04-17
ES2911690T3 (es) 2022-05-20
IL243355A0 (en) 2016-03-31
JP2019112455A (ja) 2019-07-11
TW202106335A (zh) 2021-02-16
CN105492026A (zh) 2016-04-13
US20150017166A1 (en) 2015-01-15
TW201536316A (zh) 2015-10-01
KR102476907B1 (ko) 2022-12-13
EP3016684A2 (en) 2016-05-11
AU2019279945A1 (en) 2020-01-16
IL243355B2 (en) 2024-10-01
CA2916980C (en) 2023-02-21

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HB Alteration of name in register

Owner name: LUNDBECK SEATTLE BIOPHARMACEUTICALS, INC

Free format text: FORMER NAME(S): ALDER BIOPHARMACEUTICALS, INC.

PC Assignment registered

Owner name: H. LUNDBECK A/S.

Free format text: FORMER OWNER(S): LUNDBECK SEATTLE BIOPHARMACEUTICALS, INC