CA2913550A1 - Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (pcsk9) - Google Patents
Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (pcsk9) Download PDFInfo
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- CA2913550A1 CA2913550A1 CA2913550A CA2913550A CA2913550A1 CA 2913550 A1 CA2913550 A1 CA 2913550A1 CA 2913550 A CA2913550 A CA 2913550A CA 2913550 A CA2913550 A CA 2913550A CA 2913550 A1 CA2913550 A1 CA 2913550A1
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- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Landscapes
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| US14/290,544 US10111953B2 (en) | 2013-05-30 | 2014-05-29 | Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9) |
| PCT/US2014/040163 WO2014194168A2 (en) | 2013-05-30 | 2014-05-30 | Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (pcsk9) |
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| US20130064834A1 (en) | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| CN110711248A (zh) | 2011-01-28 | 2020-01-21 | 赛诺菲生物技术公司 | 包含针对pcsk9的人抗体的药物组合物 |
| CN112812184A (zh) | 2011-02-25 | 2021-05-18 | 中外制药株式会社 | FcγRIIb特异性Fc抗体 |
| AR087329A1 (es) | 2011-06-17 | 2014-03-19 | Regeneron Pharma | Anticuerpos humanos contra proteina 3 de tipo angiopoietina humana |
| CN109517059B (zh) | 2011-06-30 | 2023-03-28 | 中外制药株式会社 | 异源二聚化多肽 |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| ES2992345T3 (es) | 2011-09-16 | 2024-12-11 | Regeneron Pharma | Métodos para reducir los niveles de lipoproteína(a) mediante la administración de un inhibidor de la proproteína convertasa subtilisina kexina-9 (PCSK9) |
| WO2013047748A1 (ja) | 2011-09-30 | 2013-04-04 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| KR20230143201A (ko) | 2011-11-30 | 2023-10-11 | 추가이 세이야쿠 가부시키가이샤 | 면역 복합체를 형성하는 세포내로의 운반체（캐리어）를 포함하는 의약 |
| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| WO2014030728A1 (ja) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | FcγRIIb特異的Fc領域改変体 |
| US10058630B2 (en) | 2012-10-22 | 2018-08-28 | Concievalve, Llc | Methods for inhibiting stenosis, obstruction, or calcification of a stented heart valve or bioprosthesis |
| DK2940135T5 (da) | 2012-12-27 | 2021-09-20 | Chugai Pharmaceutical Co Ltd | Heterodimeriseret polypeptid |
| CN113621057A (zh) | 2013-04-02 | 2021-11-09 | 中外制药株式会社 | Fc区变体 |
| AU2014274844B2 (en) | 2013-06-07 | 2019-11-28 | Regeneron Pharmaceuticals, Inc. | Methods for inhibiting atherosclerosis by administering an inhibitor of PCSK9 |
| EP3068803B1 (en) | 2013-11-12 | 2021-01-20 | Sanofi Biotechnology | Dosing regimens for use with pcsk9 inhibitors |
| US9914769B2 (en) | 2014-07-15 | 2018-03-13 | Kymab Limited | Precision medicine for cholesterol treatment |
| US8883157B1 (en) | 2013-12-17 | 2014-11-11 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
| US9139648B1 (en) | 2014-07-15 | 2015-09-22 | Kymab Limited | Precision medicine by targeting human NAV1.9 variants for treatment of pain |
| RU2735521C2 (ru) | 2014-07-16 | 2020-11-03 | Санофи Байотекнолоджи | Способы лечения пациентов с гетерозиготной семейной гиперхолестеринемией (hefh) |
| TW201628649A (zh) | 2014-10-09 | 2016-08-16 | 再生元醫藥公司 | 減少醫藥調配物中微可見顆粒之方法 |
| IL278014B2 (en) | 2014-12-19 | 2023-10-01 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variable FC regions and methods of use |
| SG10201907215QA (en) | 2015-02-05 | 2019-09-27 | Chugai Pharmaceutical Co Ltd | Antibodies Comprising An Ion Concentration Dependent Antigen-Binding Domain, Fc Region Variants, Il-8-Binding Antibodies, And Uses Therof |
| JP2018516624A (ja) * | 2015-04-15 | 2018-06-28 | コンシーヴァルブ エルエルシー | 自然心臓弁、ステント装着された心臓弁またはバイオプロテーゼの狭窄、閉塞または石灰化を抑制するためのデバイスおよび方法 |
| US10772956B2 (en) | 2015-08-18 | 2020-09-15 | Regeneron Pharmaceuticals, Inc. | Methods for reducing or eliminating the need for lipoprotein apheresis in patients with hyperlipidemia by administering alirocumab |
| EP3394098A4 (en) | 2015-12-25 | 2019-11-13 | Chugai Seiyaku Kabushiki Kaisha | ANTI-MYOSTATIN ANTIBODIES AND METHODS OF USE |
| MA43734A (fr) * | 2016-03-03 | 2018-11-28 | Regeneron Pharma | Procédés de traitement de patients atteints d'hyperlipidémie par administration d'un inhibiteur de pcsk9 en combinaison avec un inhibiteur d'angptl3 |
| CN109689099B (zh) | 2016-08-05 | 2023-02-28 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| US11020686B2 (en) | 2016-08-16 | 2021-06-01 | Regeneron Pharmaceuticals, Inc. | Methods for quantitating individual antibodies from a mixture |
| BR112019006689A2 (pt) | 2016-10-25 | 2019-06-25 | Regeneron Pharma | métodos e sistemas para análise de dados de cromatografia |
| EP3609532A1 (en) | 2017-04-13 | 2020-02-19 | Cadila Healthcare Limited | Novel peptide based pcsk9 vaccine |
| US12042538B2 (en) | 2017-09-19 | 2024-07-23 | Regeneron Pharmaceuticals, Inc. | Methods of reducing particle formation and compositions formed thereby |
| EP4640703A2 (en) | 2017-11-14 | 2025-10-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-c1s antibodies and methods of use |
| WO2019118187A1 (en) | 2017-12-13 | 2019-06-20 | Regeneron Pharmaceuticals, Inc. | Devices and systems for chromatography column bed support management and related methods |
| TWI814812B (zh) | 2018-05-02 | 2023-09-11 | 美商里珍納龍藥品有限公司 | 用於評估生化過濾器的適合性的方法 |
| TWI853823B (zh) | 2018-07-02 | 2024-09-01 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
| MX2021001431A (es) | 2018-08-10 | 2021-05-12 | Chugai Pharmaceutical Co Ltd | Molecula de union al antigeno anti grupo de diferenciacion 137 (cd137) y su uso. |
| EP4470609A3 (en) | 2019-01-18 | 2025-03-12 | Astrazeneca AB | Pcsk9 inhibitors and methods of use thereof |
| KR20220016865A9 (ko) | 2019-05-15 | 2022-02-21 | 추가이 세이야쿠 가부시키가이샤 | 항원 결합 분자, 약학 조성물, 및 방법 |
| US20220331373A1 (en) * | 2019-06-25 | 2022-10-20 | Ezcol B.V. | Rhodospirillum rubrum cells that lower plasma cholesterol while leaving other serum protein levels unaffected |
| CA3161347A1 (en) * | 2019-12-10 | 2021-06-17 | Shazia ALI | Use of a pcsk9 inhibitor to treat homozygous familial hypercholesterolemia |
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- 2014-05-29 US US14/290,544 patent/US10111953B2/en active Active
- 2014-05-30 CA CA2913550A patent/CA2913550A1/en not_active Abandoned
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- 2014-05-30 AU AU2014274046A patent/AU2014274046B2/en not_active Ceased
- 2014-05-30 WO PCT/US2014/040163 patent/WO2014194168A2/en not_active Ceased
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- 2014-05-30 EP EP14733889.1A patent/EP3003361B1/en active Active
- 2014-05-30 CN CN201480030575.6A patent/CN105473161A/zh active Pending
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|---|---|
| US20140356371A1 (en) | 2014-12-04 |
| EA201592302A1 (ru) | 2016-04-29 |
| KR20160013047A (ko) | 2016-02-03 |
| JP2016520616A (ja) | 2016-07-14 |
| JP6549102B2 (ja) | 2019-07-24 |
| US10111953B2 (en) | 2018-10-30 |
| EP3003361A2 (en) | 2016-04-13 |
| AU2014274046B2 (en) | 2019-04-11 |
| HK1216841A1 (en) | 2016-12-09 |
| MX2015016097A (es) | 2016-03-21 |
| MX367325B (es) | 2019-08-15 |
| EP3003361B1 (en) | 2019-07-03 |
| AU2014274046A1 (en) | 2015-11-19 |
| CN105473161A (zh) | 2016-04-06 |
| WO2014194168A2 (en) | 2014-12-04 |
| EA034379B1 (ru) | 2020-01-31 |
| IL242250B (en) | 2019-11-28 |
| WO2014194168A3 (en) | 2015-10-29 |
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