CA2909701C - Immunosuppressive tgf-.beta. signal converter - Google Patents
Immunosuppressive tgf-.beta. signal converter Download PDFInfo
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- CA2909701C CA2909701C CA2909701A CA2909701A CA2909701C CA 2909701 C CA2909701 C CA 2909701C CA 2909701 A CA2909701 A CA 2909701A CA 2909701 A CA2909701 A CA 2909701A CA 2909701 C CA2909701 C CA 2909701C
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Classifications
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- C07K2319/00—Fusion polypeptide
-
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361812917P | 2013-04-17 | 2013-04-17 | |
| US61/812,917 | 2013-04-17 | ||
| PCT/US2014/034570 WO2014172584A1 (en) | 2013-04-17 | 2014-04-17 | IMMUNOSUPPRESSIVE TGF-β SIGNAL CONVERTER |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2909701A1 CA2909701A1 (en) | 2014-10-23 |
| CA2909701C true CA2909701C (en) | 2022-12-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2909701A Active CA2909701C (en) | 2013-04-17 | 2014-04-17 | Immunosuppressive tgf-.beta. signal converter |
Country Status (6)
| Country | Link |
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| US (2) | US10584158B2 (OSRAM) |
| EP (2) | EP2986636B1 (OSRAM) |
| JP (1) | JP6578271B2 (OSRAM) |
| CN (1) | CN105452287A (OSRAM) |
| CA (1) | CA2909701C (OSRAM) |
| WO (1) | WO2014172584A1 (OSRAM) |
Families Citing this family (76)
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| CA2909701C (en) * | 2013-04-17 | 2022-12-06 | Baylor College Of Medicine | Immunosuppressive tgf-.beta. signal converter |
| HK1225740A1 (zh) | 2013-08-22 | 2017-09-15 | Acceleron Pharma Inc. | TGF-β受体II型变体及其用途 |
| EP3805371A1 (en) | 2014-05-15 | 2021-04-14 | National University of Singapore | Modified natural killer cells and uses thereof |
| WO2016014535A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Treatment of cancer using a cll-1 chimeric antigen receptor |
| JP7054622B2 (ja) | 2014-07-21 | 2022-04-14 | ノバルティス アーゲー | ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置 |
| JP6831777B2 (ja) | 2014-07-21 | 2021-02-17 | ノバルティス アーゲー | Ｃｄ３３キメラ抗原受容体を使用する癌の処置 |
| MA41538A (fr) * | 2014-10-17 | 2017-12-26 | Baylor College Medicine | Cellules immunitaires bipartites et tripartites de signalisation |
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| US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11000548B2 (en) | 2015-02-18 | 2021-05-11 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| SG10201908203SA (en) | 2015-03-05 | 2019-10-30 | Hutchinson Fred Cancer Res | Immunomodulatory Fusion Proteins And Uses Thereof |
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| WO2017024440A1 (zh) * | 2015-08-07 | 2017-02-16 | 深圳市体内生物医药科技有限公司 | 含Toll样受体胞内结构域的嵌合抗原受体 |
| EP3368571B1 (en) | 2015-10-30 | 2022-12-07 | The Regents of The University of California | Transforming growth factor-beta-responsive polypeptides and their methods for use |
| CN109072194B (zh) | 2015-12-09 | 2022-12-27 | 纪念斯隆-凯特林癌症中心 | 免疫细胞组合物及其使用方法 |
| EP3416661A4 (en) | 2016-02-18 | 2020-03-04 | Enlivex Therapeutics Ltd. | COMBINATION OF IMMUNOTHERAPY AND CYTOKINE CONTROL THERAPY FOR THE TREATMENT OF CANCER |
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| KR20180131557A (ko) * | 2016-04-05 | 2018-12-10 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 면역요법에서의 tgf베타의 억제 |
| ES2933961T3 (es) | 2016-04-15 | 2023-02-15 | Memorial Sloan Kettering Cancer Center | Células T transgénicas y composiciones de células T de receptor de antígeno quimérico y métodos relacionados |
| WO2017184901A1 (en) * | 2016-04-20 | 2017-10-26 | Fred Hutchinson Cancer Research Center | Immunomodulatory il2r fusion proteins and uses thereof |
| US12102652B2 (en) * | 2016-08-26 | 2024-10-01 | Baylor College Of Medicine | Constitutively active cytokine receptors for cell therapy |
| EP3507361A1 (en) * | 2016-08-30 | 2019-07-10 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of use for treating viral and other infections |
| WO2018075541A1 (en) * | 2016-10-17 | 2018-04-26 | Bluebird Bio, Inc. | TGFβR2 ENDONUCLEASE VARIANTS, COMPOSITIONS, AND METHODS OF USE |
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| WO2018170475A1 (en) | 2017-03-17 | 2018-09-20 | Fred Hutchinson Cancer Research Center | Immunomodulatory fusion proteins and uses thereof |
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| IL269553B2 (en) | 2017-03-27 | 2025-10-01 | Nat Univ Singapore | Truncated NKG2D chimeric receptors and their uses in immunotherapy with natural killer cells |
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| CN108853144A (zh) * | 2017-05-16 | 2018-11-23 | 科济生物医药（上海）有限公司 | Toll样受体激动剂与免疫效应细胞的联用 |
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| CN118420783A (zh) * | 2017-12-06 | 2024-08-02 | 恺兴生命科技(上海)有限公司 | 嵌合蛋白、表达嵌合蛋白的免疫效应细胞及其应用 |
| US12258381B2 (en) | 2018-02-09 | 2025-03-25 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| EP3762410A4 (en) * | 2018-03-06 | 2022-04-06 | The Trustees of the University of Pennsylvania | CHEMICAL PROSTATE MEMBRANE SPECIFIC ANTIGEN SPECIFIC ANTIGEN RECEPTORS AND METHODS OF USE THEREOF |
| AU2019231791B2 (en) | 2018-03-09 | 2022-08-11 | Agenus Inc. | Anti-CD73 antibodies and methods of use thereof |
| CN112055717B (zh) | 2018-04-02 | 2024-04-26 | 新加坡国立大学 | 用在免疫细胞中表达的膜结合抗细胞因子非信号传导粘合剂中和人细胞因子 |
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| KR102821463B1 (ko) * | 2019-08-15 | 2025-06-16 | 난트바이오 인코포레이티드 | Tgf-베타 트랩 |
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| CN116490518A (zh) * | 2020-07-17 | 2023-07-25 | 西穆尔克斯股份有限公司 | 用于重定向免疫抑制信号传导的嵌合MyD88受体及相关组合物和方法 |
| CN112210543B (zh) * | 2020-07-30 | 2023-01-03 | 山东省成体细胞产业技术研究院有限公司 | 一种针对实体瘤克服TGF-β免疫抑制的CAR-T细胞 |
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| CN114525260A (zh) * | 2022-02-24 | 2022-05-24 | 深圳市先康达生命科学有限公司 | 一种同时表达融合蛋白及嵌合抗原受体的免疫细胞及其应用 |
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| KR20250008809A (ko) | 2022-04-08 | 2025-01-15 | 리제너론 파마슈티칼스 인코포레이티드 | 다분할 수용체 및 신호전달 복합체 |
| CN120981484A (zh) | 2023-01-23 | 2025-11-18 | 汉诺威医学院 | 抗entpd3嵌合抗原受体 |
| EP4403580A1 (en) | 2023-01-23 | 2024-07-24 | Medizinische Hochschule Hannover | Anti-entpd3 chimeric antigen receptor |
| US20250250542A1 (en) | 2023-02-07 | 2025-08-07 | Quell Therapeutics Limited | Culture method |
| WO2024175805A1 (en) | 2023-02-24 | 2024-08-29 | Medizinische Hochschule Hannover | Chimeric antigen receptor |
| EP4420676A1 (en) | 2023-02-24 | 2024-08-28 | Medizinische Hochschule Hannover | Chimeric antigen receptor |
| EP4434539A1 (en) | 2023-03-20 | 2024-09-25 | Medizinische Hochschule Hannover | Chimeric antigen receptor |
| WO2024194355A1 (en) | 2023-03-20 | 2024-09-26 | Medizinische Hochschule Hannover | Chimeric antigen receptor |
| CN118109416B (zh) * | 2023-03-30 | 2024-11-22 | 广州百吉生物制药有限公司 | 功能增强型工程化免疫细胞及其制备和应用 |
| EP4509522A1 (en) | 2023-08-16 | 2025-02-19 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | A tgfbeta switch receptor, a nucleic acid encoding it, cells and pharmaceutical compositions comprising the same |
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| GB9304200D0 (en) | 1993-03-02 | 1993-04-21 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US20090247520A1 (en) * | 2008-03-27 | 2009-10-01 | The Burnham Institute For Medical Research | INHIBITORS OF ANTIGEN RECEPTOR-INDUCED NF-kappa B ACTIVATION |
| EP3467101A3 (en) * | 2010-09-08 | 2019-06-19 | Baylor College of Medicine | Immunotherapy of brain tumor using geneticially engineered gd2-specific t cells |
| US10548921B2 (en) * | 2011-04-08 | 2020-02-04 | Baylor College Of Medicine | Reversing the effects of the tumor microenvironment using chimeric cytokine receptors |
| EA201490364A1 (ru) * | 2011-07-29 | 2014-08-29 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Костимулирующие рецепторы-переключатели |
| CA2909701C (en) * | 2013-04-17 | 2022-12-06 | Baylor College Of Medicine | Immunosuppressive tgf-.beta. signal converter |
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- 2014-04-17 CN CN201480034691.5A patent/CN105452287A/zh active Pending
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2020
- 2020-01-15 US US16/743,987 patent/US20200140520A1/en not_active Abandoned
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| US20160075755A1 (en) | 2016-03-17 |
| US20200140520A1 (en) | 2020-05-07 |
| WO2014172584A1 (en) | 2014-10-23 |
| EP3470423A1 (en) | 2019-04-17 |
| HK1220704A1 (en) | 2017-05-12 |
| CN105452287A (zh) | 2016-03-30 |
| EP3470423B1 (en) | 2021-10-06 |
| JP2016520302A (ja) | 2016-07-14 |
| EP2986636B1 (en) | 2018-11-14 |
| JP6578271B2 (ja) | 2019-09-18 |
| EP2986636A1 (en) | 2016-02-24 |
| US10584158B2 (en) | 2020-03-10 |
| CA2909701A1 (en) | 2014-10-23 |
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