CA2909500C - Crystal form of cabazitaxel and preparation method thereof - Google Patents

Crystal form of cabazitaxel and preparation method thereof Download PDF

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Publication number
CA2909500C
CA2909500C CA2909500A CA2909500A CA2909500C CA 2909500 C CA2909500 C CA 2909500C CA 2909500 A CA2909500 A CA 2909500A CA 2909500 A CA2909500 A CA 2909500A CA 2909500 C CA2909500 C CA 2909500C
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CA
Canada
Prior art keywords
cabazitaxel
crystalline form
carbon atoms
mixture
hydrate
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Active
Application number
CA2909500A
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English (en)
French (fr)
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CA2909500A1 (en
Inventor
Jing Li
Quanxing Yao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chongqing Sintaho Pharmaceutical Co Ltd
Original Assignee
Chongqing Taihao Pharmaceutical Co Ltd
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Publication of CA2909500A1 publication Critical patent/CA2909500A1/en
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Publication of CA2909500C publication Critical patent/CA2909500C/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
CA2909500A 2012-07-25 2013-07-18 Crystal form of cabazitaxel and preparation method thereof Active CA2909500C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201210259595.3A CN102746258B (zh) 2012-07-25 2012-07-25 卡巴他赛的结晶形式及其制备方法
CN201210259595.3 2012-07-25
CA2870569A CA2870569A1 (en) 2012-07-25 2013-07-18 Crystal form of cabazitaxel and preparation method thereof
PCT/CN2013/079575 WO2014015760A1 (zh) 2012-07-25 2013-07-18 卡巴他赛的结晶形式及其制备方法
WOPCT/CN2013/079575 2013-07-18

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2870569A Division CA2870569A1 (en) 2012-07-25 2013-07-18 Crystal form of cabazitaxel and preparation method thereof

Publications (2)

Publication Number Publication Date
CA2909500A1 CA2909500A1 (en) 2014-01-30
CA2909500C true CA2909500C (en) 2018-01-09

Family

ID=47026807

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2909500A Active CA2909500C (en) 2012-07-25 2013-07-18 Crystal form of cabazitaxel and preparation method thereof
CA2870569A Abandoned CA2870569A1 (en) 2012-07-25 2013-07-18 Crystal form of cabazitaxel and preparation method thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2870569A Abandoned CA2870569A1 (en) 2012-07-25 2013-07-18 Crystal form of cabazitaxel and preparation method thereof

Country Status (8)

Country Link
US (1) US9353076B2 (https=)
EP (2) EP2835369B1 (https=)
JP (1) JP6329135B2 (https=)
CN (1) CN102746258B (https=)
AU (2) AU2013295924B2 (https=)
CA (2) CA2909500C (https=)
IN (1) IN2014MN01962A (https=)
WO (1) WO2014015760A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103764637A (zh) 2011-04-12 2014-04-30 普拉斯化学品有限公司 卡巴他赛的固态形式及其制备方法
US9394266B2 (en) 2012-03-08 2016-07-19 IVAX International GmbH Solid state forms of cabazitaxel and processes for preparation thereof
CN102746258B (zh) * 2012-07-25 2015-02-04 重庆泰濠制药有限公司 卡巴他赛的结晶形式及其制备方法
CN103804323A (zh) * 2012-11-14 2014-05-21 上海希迈医药科技有限公司 一种卡巴他赛溶剂化物及其制备方法和应用
CN103819428B (zh) * 2012-11-19 2016-01-13 齐鲁制药有限公司 7β,10β-二甲氧基多西紫杉醇的溶剂化物的晶型及其制备方法
CN103058960B (zh) * 2012-12-12 2014-12-10 江苏奥赛康药业股份有限公司 卡巴他赛多晶型形式及其制备方法
KR101429543B1 (ko) 2012-12-13 2014-08-14 주식회사 삼양바이오팜 카바지탁셀의 신규 결정형 및 그 제조방법
CN103044364B (zh) * 2013-01-07 2016-01-20 重庆泰濠制药有限公司 一种卡巴他赛无定形晶及其制备方法
WO2014128728A2 (en) * 2013-02-25 2014-08-28 Laurus Labs Private Limited Solid forms of cabazitaxel and processes for preparation thereof
CN103450119B (zh) * 2013-09-24 2015-06-17 天津炜捷制药有限公司 一种卡巴他赛晶型w及其制备方法
EP2865674A1 (en) * 2013-10-23 2015-04-29 INDENA S.p.A. Crystalline solvate forms of Cabazitaxel
CN105461664A (zh) * 2014-08-21 2016-04-06 中国医学科学院药物研究所 卡巴他赛晶n5型物质及制备方法和其组合物与用途
CN105461665A (zh) * 2014-08-21 2016-04-06 中国医学科学院药物研究所 卡巴他赛晶n6型物质及制备方法和其组合物与用途
JP2019501953A (ja) 2016-01-15 2019-01-24 珠海貝海生物技術有限公司Ｚｈｕｈａｉ Ｂｅｉｈａｉ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． カバジタキセル及びヒト血清アルブミンを含む組成物及び製剤
WO2018047074A1 (en) * 2016-09-07 2018-03-15 Cadila Healthcare Limited Sterile injectable compositions comprising drug micelles
US11413265B2 (en) 2018-04-20 2022-08-16 Zhuhai Beihai Biotech Co., Ltd. Formulations and compositions of Cabazitaxel
CN113429369B (zh) * 2021-07-23 2022-12-02 无锡紫杉药业有限公司 一种高效的卡巴他赛纯化方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1248869A2 (en) 2000-01-07 2002-10-16 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
FR2926551A1 (fr) * 2008-01-17 2009-07-24 Aventis Pharma Sa Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation
CN101525321B (zh) * 2008-03-06 2012-03-07 上海希迪制药有限公司 多烯紫杉醇倍半水结晶体及其制备方法
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
CN102060815B (zh) * 2010-12-24 2012-09-26 重庆泰濠制药有限公司 一种紫杉烷类化合物的制备方法
CN103764637A (zh) 2011-04-12 2014-04-30 普拉斯化学品有限公司 卡巴他赛的固态形式及其制备方法
TWI526437B (zh) 2011-09-09 2016-03-21 台灣神隆股份有限公司 卡巴他賽之結晶型
CN102336726B (zh) * 2011-09-30 2014-11-26 重庆泰濠制药有限公司 一种卡巴他赛的制备方法
CN104395759B (zh) * 2011-09-30 2017-10-13 生命技术公司 用于图像分析识别的方法和系统
CN102503913B (zh) * 2011-10-20 2014-03-26 江苏红豆杉生物科技股份有限公司 直接用于x射线单晶衍射分析的二甲氧基紫杉烷类化合物单晶晶体的制备方法
DE112012004569T5 (de) * 2011-11-01 2014-08-14 Fresenius Kabi Oncology Ltd. Amorphe Form von Cabazitaxel und Verfahren zum Herstellen davon
ES2716799T3 (es) * 2011-11-28 2019-06-17 Fresenius Kabi Oncology Ltd Forma cristalina de cabazitaxel y proceso para la preparación de la misma
EP2791122B1 (en) * 2011-12-13 2019-01-23 Aventis Pharma S.A. Crystalline form of cabazitaxel and process for preparing the same
US9394266B2 (en) * 2012-03-08 2016-07-19 IVAX International GmbH Solid state forms of cabazitaxel and processes for preparation thereof
CN102746258B (zh) * 2012-07-25 2015-02-04 重庆泰濠制药有限公司 卡巴他赛的结晶形式及其制备方法
WO2014022237A1 (en) * 2012-07-31 2014-02-06 Yung Shin Pharm. Ind. Co., Ltd. Amorphous cabazitaxel
CN102898406B (zh) * 2012-11-02 2014-12-03 上海金和生物技术有限公司 一种卡巴他赛晶体及其制备方法
CN103058960B (zh) * 2012-12-12 2014-12-10 江苏奥赛康药业股份有限公司 卡巴他赛多晶型形式及其制备方法

Also Published As

Publication number Publication date
AU2016200343A1 (en) 2016-02-11
US20150141674A1 (en) 2015-05-21
WO2014015760A1 (zh) 2014-01-30
CA2870569A1 (en) 2014-01-30
CN102746258A (zh) 2012-10-24
EP3067348A1 (en) 2016-09-14
AU2013295924A1 (en) 2014-10-23
EP2835369A1 (en) 2015-02-11
US9353076B2 (en) 2016-05-31
AU2016200343B2 (en) 2017-03-30
EP2835369A4 (en) 2015-12-02
CA2909500A1 (en) 2014-01-30
EP2835369B1 (en) 2019-04-03
IN2014MN01962A (https=) 2015-07-10
AU2013295924B2 (en) 2016-02-18
CN102746258B (zh) 2015-02-04
JP6329135B2 (ja) 2018-05-23
JP2015518012A (ja) 2015-06-25

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