CA2907915C - Immunomodulatory nanoparticle compositions comprising a plurality of nanoparticles comprising biodegradable or biocompatible polymers and hydrophilic and hydrophobic cellular components - Google Patents
Immunomodulatory nanoparticle compositions comprising a plurality of nanoparticles comprising biodegradable or biocompatible polymers and hydrophilic and hydrophobic cellular components Download PDFInfo
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- CA2907915C CA2907915C CA2907915A CA2907915A CA2907915C CA 2907915 C CA2907915 C CA 2907915C CA 2907915 A CA2907915 A CA 2907915A CA 2907915 A CA2907915 A CA 2907915A CA 2907915 C CA2907915 C CA 2907915C
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| US9597385B2 (en) | 2012-04-23 | 2017-03-21 | Allertein Therapeutics, Llc | Nanoparticles for treatment of allergy |
| US9492535B2 (en) | 2013-03-14 | 2016-11-15 | Aimmune Therapeutics, Inc. | Peanut formulations and uses thereof |
| EP3760223A1 (en) | 2013-04-03 | 2021-01-06 | N-Fold Llc | Nanoparticle composition for desensitizing a subject to peanut allergens |
| JP6554493B2 (ja) | 2014-06-24 | 2019-07-31 | ザ・トラスティーズ・オブ・プリンストン・ユニバーシティＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｐｒｉｎｃｅｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ | 可溶性生物製剤、治療薬およびイメージング剤をカプセル化するためのプロセス |
| CA2916117C (en) * | 2014-12-22 | 2023-02-28 | Nishil Mohammed | Pristine and surface functionalized cellulose nanocrystals (cncs) incorporated hydrogel beads and uses thereof |
| CN104689772B (zh) * | 2015-03-06 | 2017-08-11 | 天津大学 | 多酚化学启发制备高分子微囊的方法 |
| US11103461B2 (en) | 2015-12-22 | 2021-08-31 | The Trustees Of Princeton University | Process for encapsulating soluble biologics, therapeutics, and imaging agents |
| CN106913520A (zh) * | 2015-12-25 | 2017-07-04 | 上海医药集团股份有限公司 | 艾沙康唑的微粒给药组合物 |
| JP6977206B2 (ja) * | 2016-03-31 | 2021-12-08 | 富山県 | 自然免疫を活性化する粘膜ワクチン用アジュバント |
| EP3525760A4 (en) * | 2016-10-14 | 2020-06-24 | Icahn School of Medicine at Mount Sinai | TREATMENT OF IMMUNOLOGICAL DISEASES WITH BERBERIN NANOPARTICLES |
| WO2019055539A1 (en) | 2017-09-12 | 2019-03-21 | Prudhomme Robert K | CELLULOSIC POLYMER NANOPARTICLES AND METHODS OF FORMING THE SAME |
| CN109692327B (zh) * | 2017-10-23 | 2022-04-08 | 华中科技大学 | 一种运载蜂毒肽的纳米颗粒的应用 |
| JP2021501753A (ja) | 2017-11-03 | 2021-01-21 | ザ・トラスティーズ・オブ・プリンストン・ユニバーシティＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｐｒｉｎｃｅｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ | 徐放性ナノキャリア製剤を形成するための疎水性イオン対化およびフラッシュナノ沈殿 |
| KR102095355B1 (ko) | 2018-01-12 | 2020-03-31 | 주식회사 엠디헬스케어 | 모르가넬라 속 세균 유래 나노소포 및 이의 용도 |
| US12186436B2 (en) | 2018-07-19 | 2025-01-07 | The Trustees Of Princeton University | Triblock copolymer stabilizers for the formation of nanoparticles encapsulating soluble biologics, therapeutics, and imaging agents |
| US11731099B2 (en) | 2018-07-20 | 2023-08-22 | The Trustees Of Princeton University | Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation |
| EP3836801A4 (en) | 2018-08-16 | 2022-05-18 | Société des Produits Nestlé S.A. | Peanut oral immunotherapy with maintenance dose |
| JP7169837B2 (ja) * | 2018-10-03 | 2022-11-11 | 三菱鉛筆株式会社 | 筆記具用水性インク組成物 |
| CN109776478B (zh) * | 2018-12-04 | 2022-10-14 | 福州大学 | 源于草酸青霉的iso-Penicillixanthone A及在宫颈癌方面的应用 |
| CN113891722A (zh) * | 2018-12-20 | 2022-01-04 | 爱沐疗法公司 | 用于漏服剂量的花生口服免疫疗法给药计划表 |
| WO2020136657A1 (en) * | 2018-12-28 | 2020-07-02 | Ramot At Tel-Aviv University Ltd. | Polymeric nanovaccines and uses thereof |
| WO2020150623A1 (en) * | 2019-01-18 | 2020-07-23 | University Of Georgia Research Foundation, Inc. | Salt nanoparticles and compositions and methods of use thereof |
| US10398744B1 (en) | 2019-02-08 | 2019-09-03 | King Saud University | Synthesis of mustard seed nanoparticles |
| EP3965815A4 (en) | 2019-05-10 | 2023-05-31 | Société des Produits Nestlé S.A. | METHOD OF IMPROVING THE QUALITY OF LIFE IN A PEANUT ALLERGY PATIENT |
| US20220387316A1 (en) * | 2019-11-13 | 2022-12-08 | The Regents Of The University Of Michigan | Nanoemulsion compositions for treating aeroallergen associated allergy and inflammation |
| WO2021102186A1 (en) * | 2019-11-20 | 2021-05-27 | Aimmune Therapeutics, Inc. | Methods and systems for managing distribution and treatment of a food allergy oral immunotherapy drug |
| EP4149513A4 (en) * | 2020-05-11 | 2025-02-26 | The University Of Southern California | Oral delivery of nanoparticles for kidney disease |
| AU2022256497A1 (en) * | 2021-04-16 | 2023-11-30 | Cour Pharmaceuticals Development Company Inc. | Treatment of peanut allergy with tolerizing nanoparticles |
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| WO2024006870A2 (en) * | 2022-06-29 | 2024-01-04 | Massachusetts Institute Of Technology | Structured nucleic acid templated architectures |
| CN120282796A (zh) * | 2022-10-19 | 2025-07-08 | 库尔制药开发公司 | 用耐受性纳米颗粒治疗花生过敏 |
| US12431000B2 (en) * | 2024-02-27 | 2025-09-30 | International Business Machines Corporation | Detecting allergens using internet of things |
| WO2025212530A1 (en) | 2024-04-01 | 2025-10-09 | N-Fold Llc | Nanoparticle manufacturing |
Family Cites Families (191)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3977794A (en) | 1974-07-15 | 1976-08-31 | Coulter Electronics, Inc. | Universal cell holder |
| DE2650306A1 (de) | 1976-11-02 | 1978-05-03 | Merck Patent Gmbh | Antibakteriell wirkender wundverband und verfahren zu seiner herstellung |
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| US4316885A (en) | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
| EP0056782B1 (en) | 1981-01-09 | 1984-08-01 | Sandoz Ag | Novel cyclosporins |
| US4894366A (en) | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| US5254562A (en) | 1984-12-03 | 1993-10-19 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| AU98530S (en) | 1985-06-20 | 1987-11-05 | Novartis Ag | Subdivided membrane controlled transdermal device |
| US4650803A (en) | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
| US4886499A (en) | 1986-12-18 | 1989-12-12 | Hoffmann-La Roche Inc. | Portable injection appliance |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US4798823A (en) | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US5227467A (en) | 1987-08-03 | 1993-07-13 | Merck & Co., Inc. | Immunosuppressive fluorinated cyclosporin analogs |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
| US5284826A (en) | 1989-07-24 | 1994-02-08 | Sandoz Ltd. | 0-hydroxyethyl and acyloxyethyl derivatives of [ser]8 cyclosporins |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5225194A (en) * | 1989-11-13 | 1993-07-06 | Ldc Research Corporation | Aqueous diafiltration process for preparing acellular vaccines, against selected bacterial diseases |
| US5208228A (en) | 1989-11-13 | 1993-05-04 | Merck & Co., Inc. | Aminomacrolides and derivatives having immunosuppressive activity |
| US5122511A (en) | 1990-02-27 | 1992-06-16 | Merck & Co., Inc. | Immunosuppressive cyclosporin analogs with modified amino acids at position-8 |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| PT98990A (pt) | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
| US5143918A (en) | 1990-10-11 | 1992-09-01 | Merck & Co., Inc. | Halomacrolides and derivatives having immunosuppressive activity |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| US5120842A (en) | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
| US5100883A (en) | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
| US5118678A (en) | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
| US5250678A (en) | 1991-05-13 | 1993-10-05 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
| US5162334A (en) | 1991-05-13 | 1992-11-10 | Merck & Co., Inc. | Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity |
| US5262533A (en) | 1991-05-13 | 1993-11-16 | Merck & Co., Inc. | Amino O-aryl macrolides having immunosuppressive activity |
| US5565560A (en) | 1991-05-13 | 1996-10-15 | Merck & Co., Inc. | O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
| US5120725A (en) | 1991-05-29 | 1992-06-09 | American Home Products Corporation | Bicyclic rapamycins |
| US5120727A (en) | 1991-05-29 | 1992-06-09 | American Home Products Corporation | Rapamycin dimers |
| US5169851A (en) | 1991-08-07 | 1992-12-08 | American Home Products Corporation | Rapamycin analog as immunosuppressants and antifungals |
| US5202332A (en) | 1991-08-07 | 1993-04-13 | American Home Products Corporation | Rapamycin analog as immunosuppressant |
| US5189042A (en) | 1991-08-22 | 1993-02-23 | Merck & Co. Inc. | Fluoromacrolides having immunosuppressive activity |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| US5208241A (en) | 1991-09-09 | 1993-05-04 | Merck & Co., Inc. | N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| US5151413A (en) | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
| US6911220B1 (en) | 1992-02-19 | 2005-06-28 | The General Hospital Corporation | Allogeneic and xenogeneic transplantation |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| US6010715A (en) | 1992-04-01 | 2000-01-04 | Bertek, Inc. | Transdermal patch incorporating a polymer film incorporated with an active agent |
| US5284840A (en) | 1992-06-12 | 1994-02-08 | Merck & Co., Inc. | Alkylidene macrolides having immunosuppressive activity |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| US5258389A (en) | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
| US5558869A (en) | 1992-12-30 | 1996-09-24 | University Of Arkansas | Major peanut allergen ara h II |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| US5504091A (en) | 1993-04-23 | 1996-04-02 | American Home Products Corporation | Biotin esters of rapamycin |
| US5565215A (en) | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| JPH09504308A (ja) | 1993-07-23 | 1997-04-28 | マサチューセッツ インスティチュート オブ テクノロジー | 非直鎖状の親水性−疎水性マルチブロックコポリマーのナノ粒子およびマイクロ粒子 |
| US5830877A (en) | 1993-08-26 | 1998-11-03 | The Regents Of The University Of California | Method, compositions and devices for administration of naked polynucleotides which encode antigens and immunostimulatory |
| IT1261849B (it) | 1993-09-02 | 1996-06-03 | Avantgarde Spa | Dispositivo medico per la somministrazione di principi attivi o farmaci a bassissimo dosaggio, in particolare di farmaci omeopatici. |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| EP0772619B2 (en) | 1994-07-15 | 2010-12-08 | The University of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US6007845A (en) | 1994-07-22 | 1999-12-28 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
| US5837533A (en) | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
| US5693648A (en) | 1994-09-30 | 1997-12-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity |
| US5660854A (en) | 1994-11-28 | 1997-08-26 | Haynes; Duncan H | Drug releasing surgical implant or dressing material |
| EP0805678B1 (en) | 1995-01-05 | 2003-10-29 | THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN | Surface-modified nanoparticles and method of making and using same |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US6126936A (en) | 1995-03-10 | 2000-10-03 | Biohybrid Technologies Llc | Microcapsules and composite microreactors for immunoisolation of cells |
| KR100201352B1 (ko) | 1995-03-16 | 1999-06-15 | 성재갑 | 단일주사 백신 제형 |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| DK0752245T3 (da) | 1995-07-05 | 2002-09-09 | Europ Economic Community | Biokompatible og bionedbrydelige nanopartikler udviklet til absorption og afgivelse af proteinholdige lægemidler |
| DE19537012A1 (de) | 1995-10-04 | 1997-04-10 | Dietl Hans | Cyclosporin(e) enhaltende pharmazeutische Zubereitung zur oralen Applikation und Verfahren zu ihrer Herstellung |
| US6835824B1 (en) | 1995-12-29 | 2004-12-28 | University Of Arkansas | Peanut allergens and methods |
| JPH11507840A (ja) | 1995-12-29 | 1999-07-13 | ユニバーシティ オブ アーカンソー | ピーナッツアレルゲンおよび方法 |
| US20030202980A1 (en) | 1995-12-29 | 2003-10-30 | Caplan Michael J. | Methods and reagents for decreasing clinical reaction to allergy |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| AU734665B2 (en) | 1996-05-09 | 2001-06-21 | General Hospital Corporation, The | Mixed chimerism and tolerance |
| US5739432A (en) | 1996-05-30 | 1998-04-14 | The Regents Of The University Of California | Ultrasonic characterization of single drops of liquids |
| US5709797A (en) | 1996-06-05 | 1998-01-20 | Poli Industria Chimica S.P.A. | Method of isolating cyclosporins |
| US5774209A (en) | 1996-10-08 | 1998-06-30 | Spectronic Instruments, Inc. | Transmittance cell for spectrophotometer |
| ATE292980T1 (de) | 1996-10-11 | 2005-04-15 | Univ California | Immunostimulierende oligonucleotidekonjugate |
| EP1005368B1 (en) | 1997-03-10 | 2009-09-02 | Ottawa Hospital Research Institute | Use of nucleic acids containing unmethylated CpG dinucleotide in combination with alum as adjuvants |
| PL336596A1 (en) * | 1997-04-30 | 2000-07-03 | Guilford Pharm Inc | Biodegradable compositions with polycycloaliphatic phosphoesters, products containing them and methods of using them |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| US5948433A (en) | 1997-08-21 | 1999-09-07 | Bertek, Inc. | Transdermal patch |
| US6342507B1 (en) | 1997-09-05 | 2002-01-29 | Isotechnika, Inc. | Deuterated rapamycin compounds, method and uses thereof |
| US7399480B2 (en) | 1997-09-26 | 2008-07-15 | Abbott Laboratories | Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances using medical devices |
| DE69840586D1 (de) | 1997-10-08 | 2009-04-02 | Isotechnika Inc | Deuterierte Cyclosporin-analoga und ihre Verwendung als immunmodulierende Agenzien |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| DE69921773D1 (de) | 1998-01-16 | 2004-12-16 | Univ Johns Hopkins | Orale verabreichung von nukleinsäure-impstoffen durch partikelkomplexe |
| JP4292262B2 (ja) | 1998-01-30 | 2009-07-08 | アラタイン セラピューティクス， エルエルシー | 予後アレルギー試験または予後炎症試験 |
| DE69940805D1 (de) | 1998-01-31 | 2009-06-10 | Sinai School Medicine | Verfahren und reagenzien zur verminderung der klinischen reaktion zur allergie |
| US7879977B2 (en) | 1998-01-31 | 2011-02-01 | University Of Arkansas | Methods and reagents for decreasing clinical reaction to allergy |
| US5965154A (en) | 1998-03-17 | 1999-10-12 | Plc Holding, L.L.C. | Adhesive matrix type transdermal patch and method of manufacturing same |
| SE9801288D0 (sv) | 1998-04-14 | 1998-04-14 | Astra Ab | Vaccine delivery system and metod of production |
| US6299875B1 (en) | 1998-06-04 | 2001-10-09 | Panacea Pharmaceuticals, Llc | Methods to block IGE binding to cell surface receptors of mast cells |
| IL140899A0 (en) | 1998-07-17 | 2002-02-10 | Skyepharma Inc | Lipid/polymer containing pharmaceutical compositions and processes for the preparation thereof |
| FR2785812B1 (fr) | 1998-11-16 | 2002-11-29 | Commissariat Energie Atomique | Protheses bioactives, notamment a proprietes immunosuppressives, antistenose et antithrombose, et leur fabrication |
| US6551990B2 (en) | 1998-12-07 | 2003-04-22 | University Of Washington | Methods of inhibiting ectopic calcification |
| JP2004538237A (ja) | 1998-12-18 | 2004-12-24 | シーア ファーマスーティカルズ エルエルシー | 表面アレルゲンに対するアレルギー反応を減少させるための方法および組成物 |
| CA2357413A1 (en) | 1998-12-22 | 2000-06-29 | Panacea Pharmaceuticals, Llc | Sensitizing agents for the treatment of skin lesions |
| US20020009452A1 (en) | 1999-02-10 | 2002-01-24 | Michael Caplan | Method for altering undesirable immune responses to polypeptides |
| AU3760100A (en) | 1999-03-16 | 2000-10-04 | Panacea Pharmaceuticals, Llc | Immunostimulatory nucleic acids and antigens |
| US20020090381A1 (en) | 1999-04-09 | 2002-07-11 | H. Kim Bottomly | System for controlling immune system response to antigen |
| WO2001014855A1 (en) | 1999-08-20 | 2001-03-01 | Charles William Robertson | Liquid photometer using surface tension to contain sample |
| AU4139801A (en) | 1999-12-06 | 2001-06-12 | Board Of Trustees Of The University Of Arkansas, The | Controlled delivery of antigens |
| US8246945B2 (en) | 2000-04-06 | 2012-08-21 | University Of Arkansas | Methods and reagents for decreasing clinical reaction to allergy |
| ES2260078T3 (es) | 2000-04-06 | 2006-11-01 | Seer Pharmaceuticals, Llc. | Sistema de administracion microbiana. |
| AU6815901A (en) | 2000-06-02 | 2001-12-17 | Zycos Inc | Delivery systems for bioactive agents |
| WO2002030456A1 (en) | 2000-10-12 | 2002-04-18 | The University Of Tennessee Research Corporation | Targeting drug/gene carriers to irradiated tissue |
| US6676963B1 (en) | 2000-10-27 | 2004-01-13 | Barnes-Jewish Hospital | Ligand-targeted emulsions carrying bioactive agents |
| US6544543B1 (en) | 2000-12-27 | 2003-04-08 | Advanced Cardiovascular Systems, Inc. | Periodic constriction of vessels to treat ischemic tissue |
| US6809826B2 (en) | 2001-02-20 | 2004-10-26 | Charles William Robertson | Liquid photometer using surface tension to contain sample |
| AU2002233619A1 (en) | 2001-02-26 | 2002-09-12 | Zur Pierre Beserman | Systems devices and methods for intrabody targeted delivery and reloading of therapeutic agents |
| EP1379227A4 (en) | 2001-03-21 | 2007-12-12 | Univ Kentucky Res Found | MICROEMULSIONS AS PRECURSORS OF SOLID NANOPARTICLES |
| US20030153044A1 (en) | 2001-05-14 | 2003-08-14 | Monika Liljedahl | Tissues or organs for use in xenotransplantation |
| US20030003591A1 (en) | 2001-07-02 | 2003-01-02 | Ortho-Clinical Diagnostics, Inc. | Reaction vessel |
| US7081489B2 (en) | 2001-08-09 | 2006-07-25 | Florida State University Research Foundation | Polymeric encapsulation of nanoparticles |
| US20040023897A1 (en) | 2001-11-13 | 2004-02-05 | Caplan Michael J. | Methods for preventing or treating disease mediated by toxin-secreting bacteria |
| AU2002358947A1 (en) | 2001-12-05 | 2003-06-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Nanoparticles containing polymeric nucleic acid homologs, pharmaceutical compositions and articles of manufacture containing same and methods of use thereof |
| US20030235619A1 (en) | 2001-12-21 | 2003-12-25 | Christine Allen | Polymer-lipid delivery vehicles |
| US20040038303A1 (en) | 2002-04-08 | 2004-02-26 | Unger Gretchen M. | Biologic modulations with nanoparticles |
| US7285289B2 (en) | 2002-04-12 | 2007-10-23 | Nagy Jon O | Nanoparticle vaccines |
| CA2516116A1 (en) | 2003-01-16 | 2004-08-05 | St. John's University | Nanoparticle based stabilization of ir fluorescent dyes |
| ATE371437T1 (de) | 2003-02-17 | 2007-09-15 | Peter Burkhard | Peptidische nanoteilchen als arzneimittelabgabe- und antigen-display-systeme |
| AU2004269405A1 (en) | 2003-09-02 | 2005-03-10 | University Of North Carolina At Chapel Hill | Biodegradable polymer-ligand conjugates and their uses in isolation of cellular subpopulations and in cryopreservation, culture and transplantation of cells |
| ES2246695B1 (es) | 2004-04-29 | 2007-05-01 | Instituto Cientifico Y Tecnologico De Navarra, S.A. | Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico. |
| WO2006052285A2 (en) | 2004-05-13 | 2006-05-18 | The Trustees Of Columbia University In The City Of New York | Polymeric nanoparticles and nanogels for extraction and release of compounds |
| EP1768692B8 (en) | 2004-07-01 | 2015-06-17 | Yale University | Targeted and high density drug loaded polymeric materials |
| JP5117191B2 (ja) | 2004-10-01 | 2013-01-09 | ミダテック リミテッド | 抗原及びアジュバントを含むナノ粒子、並びに免疫原性構造 |
| US7375815B2 (en) | 2004-10-12 | 2008-05-20 | Agilent Technologies, Inc. | Optical devices, systems and method for producing a collimated light path |
| US20060087650A1 (en) | 2004-10-21 | 2006-04-27 | Shen Thomas Y | Cuvette holder for spectrophotometers |
| US20060109468A1 (en) | 2004-11-24 | 2006-05-25 | Evans Richard W | Devices, methods, and systems for measuring an optical property of a sample |
| CA2597612C (en) | 2005-02-11 | 2010-11-02 | Nanodrop Technologies, Inc. | Apparatus and method for measuring the signal from a fluorescing nanodrop contained by surface tension |
| DE602006000381T2 (de) | 2005-04-28 | 2008-12-18 | Nipro Corp., Osaka | Bioabsorbierbare pharmazeutische Zusammensetzung enthaltend einen PLGA-Copolymer |
| US8252846B2 (en) | 2005-05-10 | 2012-08-28 | Emory University | Strategies for delivery of active agents using micelles and particles |
| CA2605551A1 (en) | 2005-05-10 | 2006-11-16 | Naomi Balaban | Compositions for administering rnaiii-inhibiting peptides |
| US20070026126A1 (en) | 2005-08-01 | 2007-02-01 | Bryan Hitchcock | Sterol fortified beverages |
| EP1973608A1 (en) | 2005-12-14 | 2008-10-01 | Cytos Biotechnology AG | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
| US8021689B2 (en) | 2006-02-21 | 2011-09-20 | Ecole Polytechnique Federale de Lausanne (“EPFL”) | Nanoparticles for immunotherapy |
| US9188594B2 (en) | 2006-12-06 | 2015-11-17 | Yale University | Nanoelectronic-enzyme linked immunosorbent assay system and method |
| US8889117B2 (en) | 2007-02-15 | 2014-11-18 | Yale University | Modular nanoparticles for adaptable vaccines |
| US10265407B2 (en) | 2007-02-15 | 2019-04-23 | Yale University | Modular nanodevices for smart adaptable vaccines |
| JP5443175B2 (ja) * | 2007-02-22 | 2014-03-19 | バクスター・インターナショナル・インコーポレイテッド | 疎水性タンパク質を精製する方法 |
| WO2008109347A2 (en) | 2007-03-02 | 2008-09-12 | Yale University | Methods for ex vivo administration of drugs to grafts using polymeric nanoparticles |
| WO2009038591A1 (en) | 2007-09-17 | 2009-03-26 | Yale University | Bile salt colloids and methods of making and using thereof |
| ES2376175T3 (es) * | 2007-09-28 | 2012-03-09 | Bind Biosciences, Inc. | Direccionamiento a células de c�?ncer usando nanopart�?culas. |
| BRPI0817664A2 (pt) * | 2007-10-12 | 2015-03-24 | Massachusetts Inst Technology | Nanopartículas, método para preparar nanopartículas e método para tratar terapeuticamente ou profilaticamente um indivíduo |
| GB0721081D0 (en) | 2007-10-26 | 2007-12-05 | Metcalfe Susan M | Immuno-modulatory composition |
| US8629098B2 (en) | 2008-01-15 | 2014-01-14 | Yale University | Compositions and methods for adoptive and active immunotherapy |
| US9737593B2 (en) | 2008-03-19 | 2017-08-22 | Yale University | Carbon nanotube compositions and methods of use thereof |
| AU2009266940A1 (en) | 2008-07-01 | 2010-01-07 | Emory University | Synergistic induction of humoral and cellular immunity by combinatorial activation of toll-like receptors |
| US20100031262A1 (en) | 2008-07-31 | 2010-02-04 | Baird-Gent Jill M | Program Schedule Sub-Project Network and Calendar Merge |
| US8323696B2 (en) | 2008-08-29 | 2012-12-04 | Ecole Polytechnique Federale De Lausanne | Nanoparticles for immunotherapy |
| US8343498B2 (en) * | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
| WO2010059253A2 (en) | 2008-11-24 | 2010-05-27 | Massachusets Institute Of Technology | Methods and compositions for localized agent delivery |
| CA2750098A1 (en) | 2009-01-20 | 2010-07-29 | Myelin Repair Foundation, Inc. | Compositions and methods for induction of antigen-specific tolerance |
| US8822065B2 (en) | 2009-03-11 | 2014-09-02 | Samsung Sdi Co., Ltd. | Rechargeable battery with current collector plate |
| US20120219545A1 (en) | 2009-07-31 | 2012-08-30 | Mount Sinai School Of Medicine | Materials and methods for diagnosing and treating shellfish allergy |
| EP3492922B1 (en) | 2009-09-14 | 2025-11-05 | Icahn School of Medicine at Mount Sinai | Methods for characterizing antibody binding affinity and epitope diversity in food allergy |
| US8727965B2 (en) | 2010-03-05 | 2014-05-20 | Tissue Genesis, Inc. | Methods and compositions to support tissue integration and inosculation of transplanted tissue and transplanted engineered penile tissue with adipose stromal cells |
| WO2011150235A1 (en) | 2010-05-27 | 2011-12-01 | Allertein Therapeutics, Llc | Methods and reagents for treating autoimmune disorders and/or graft rejection |
| JP2013531043A (ja) | 2010-07-16 | 2013-08-01 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 癌の免疫療法のための方法及び組成物 |
| JP5909745B2 (ja) | 2010-11-12 | 2016-04-27 | クール ファーマシューティカルズ ディベロップメント カンパニー | 炎症性疾患の治療薬、ならびにウイルスまたは細菌感染疾患の治療薬 |
| CN103501812A (zh) | 2011-04-29 | 2014-01-08 | 西莱克塔生物科技公司 | 用于过敏症治疗的致耐受性合成纳米载体 |
| US9446175B2 (en) | 2011-06-03 | 2016-09-20 | Yale University | Compositions and methods for treating and preventing neointimal stenosis |
| WO2013003157A1 (en) | 2011-06-28 | 2013-01-03 | Yale University | Cell-free tissued engineered vascular grafts |
| EP3939572B1 (en) | 2012-04-12 | 2024-03-27 | Yale University | Vehicles for controlled delivery of different pharmaceutical agents |
| US9597385B2 (en) | 2012-04-23 | 2017-03-21 | Allertein Therapeutics, Llc | Nanoparticles for treatment of allergy |
| US20150150996A1 (en) | 2012-06-06 | 2015-06-04 | Northwestern University | Compositions and methods for antigen-specific tolerance |
| KR20250052503A (ko) | 2012-06-21 | 2025-04-18 | 노쓰웨스턴유니버시티 | 펩티드 접합된 입자 |
| CA2921491C (en) | 2012-08-23 | 2022-06-21 | Susan Marie Metcalfe | Neurotherapeutic nanoparticle compositions and devices |
| HK1220368A1 (zh) | 2013-03-13 | 2017-05-05 | Cour Pharmaceuticals Development Company | 用於治疗炎症的免疫修饰性颗粒 |
| EP3760223A1 (en) | 2013-04-03 | 2021-01-06 | N-Fold Llc | Nanoparticle composition for desensitizing a subject to peanut allergens |
| JP6553033B2 (ja) | 2013-08-13 | 2019-07-31 | ノースウェスタン ユニバーシティ | ペプチドコンジュゲート粒子 |
| US20160228521A1 (en) | 2013-09-16 | 2016-08-11 | Allertein Therapeutics, Llc | Managing immune responses in transplantation |
| CN105848649B (zh) | 2013-11-01 | 2019-08-02 | 耶鲁大学 | 用于免疫疗法的模块化粒子 |
| US10898593B2 (en) | 2014-05-13 | 2021-01-26 | Yale University | Compositions for nanoconfinement induced contrast enhancement and methods of making and using thereof |
| WO2016057909A1 (en) | 2014-10-10 | 2016-04-14 | Cour Pharmaceuticals Development Company | Immune-modifying particles for the treatment of ebola virus |
| MX2017015127A (es) | 2015-05-27 | 2018-06-22 | Univ Northwestern | Particulas modificadas por carbohidratos y formulaciones en particulas para modular una respuesta inmunitaria. |
| WO2017075053A1 (en) | 2015-10-26 | 2017-05-04 | Cour Pharmaceuticals Development Company Inc. | Immune-modifying particles for the treatment of malaria |
| AU2016379413B2 (en) | 2015-12-23 | 2024-04-04 | Cour Pharmaceuticals Development Company Inc. | Covalent polymer-antigen conjugated particles |
| US20190365656A1 (en) | 2016-01-04 | 2019-12-05 | Cour Pharmaceuticals Development Company, Inc. | Particles encapsulating fusion proteins containing linked epitopes |
| JP2019504895A (ja) | 2016-02-09 | 2019-02-21 | クール ファーマシューティカルズ ディベロップメント カンパニー インコーポレイテッド | スギ花粉エピトープを封入するｔｉｍｐ（組織性メタロプロテアーゼ阻害因子） |
| US11484506B2 (en) | 2016-02-18 | 2022-11-01 | Cour Pharmaceuticals Development Company, Inc. | Process for the preparation of tolerizing immune-modulating particles |
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- 2014-04-03 JP JP2016506618A patent/JP2016516754A/ja not_active Ceased
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| HK1221165A1 (en) | 2017-05-26 |
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| CN105188741A (zh) | 2015-12-23 |
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| MX2015013894A (es) | 2015-12-11 |
| BR112015022506A2 (pt) | 2017-10-24 |
| JP6756810B2 (ja) | 2020-09-16 |
| US9539217B2 (en) | 2017-01-10 |
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| ZA201508106B (en) | 2018-12-19 |
| KR102233251B1 (ko) | 2021-03-26 |
| JP2016516754A (ja) | 2016-06-09 |
| EP2981285A4 (en) | 2016-11-09 |
| SG11201508113SA (en) | 2015-10-29 |
| AU2014248090B2 (en) | 2018-08-02 |
| WO2014165679A1 (en) | 2014-10-09 |
| JP2019073525A (ja) | 2019-05-16 |
| CA2907915A1 (en) | 2014-10-09 |
| US20160113881A1 (en) | 2016-04-28 |
| KR20150138857A (ko) | 2015-12-10 |
| IL241807B (en) | 2019-08-29 |
| EP2981285B1 (en) | 2020-06-03 |
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