CA2906514A1 - Cellules presentant l'antigene artificielles a l'echelle nanometrique - Google Patents

Cellules presentant l'antigene artificielles a l'echelle nanometrique Download PDF

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CA2906514A1
CA2906514A1 CA2906514A CA2906514A CA2906514A1 CA 2906514 A1 CA2906514 A1 CA 2906514A1 CA 2906514 A CA2906514 A CA 2906514A CA 2906514 A CA2906514 A CA 2906514A CA 2906514 A1 CA2906514 A1 CA 2906514A1
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cells
aapc
nano
antigen
cell
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CA2906514C (fr
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Jonathan Schneck
Mathias Oelke
Karlo Perica
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Johns Hopkins University
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Johns Hopkins University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
    • A—HUMAN NECESSITIES
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    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A61K47/6939—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being a polysaccharide, e.g. starch, chitosan, chitin, cellulose or pectin
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0635—B lymphocytes
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
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    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

Cette invention concerne des cellules présentant l'antigène artificielles (CPAa) à l'échelle nanométrique, qui délivrent des signaux stimulateurs aux lymphocytes, notamment les lymphocytes cytotoxiques, destinées à être utilisées comme outil puissant en immunothérapie.
CA2906514A 2013-03-14 2014-03-13 Cellules presentant l'antigene artificielles a l'echelle nanometrique Active CA2906514C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361786135P 2013-03-14 2013-03-14
US61/786,135 2013-03-14
US201461942797P 2014-02-21 2014-02-21
US61/942,797 2014-02-21
PCT/US2014/025889 WO2014160132A1 (fr) 2013-03-14 2014-03-13 Cellules présentant l'antigène artificielles à l'échelle nanométrique

Publications (2)

Publication Number Publication Date
CA2906514A1 true CA2906514A1 (fr) 2014-10-02
CA2906514C CA2906514C (fr) 2021-07-27

Family

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Family Applications (1)

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CA2906514A Active CA2906514C (fr) 2013-03-14 2014-03-13 Cellules presentant l'antigene artificielles a l'echelle nanometrique

Country Status (12)

Country Link
US (2) US10435668B2 (fr)
EP (1) EP2970907B1 (fr)
JP (1) JP6632072B2 (fr)
KR (1) KR102164405B1 (fr)
CN (1) CN105431523B (fr)
AU (1) AU2014244119B2 (fr)
CA (1) CA2906514C (fr)
ES (1) ES2782002T3 (fr)
IL (1) IL241627B (fr)
MX (1) MX2015012920A (fr)
SG (2) SG11201507506RA (fr)
WO (1) WO2014160132A1 (fr)

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EP3995145B1 (fr) 2013-06-24 2024-10-16 NexImmune, Inc. Compositions et procédés pour immunothérapie
SG11201702191YA (en) * 2014-09-17 2017-04-27 Univ Johns Hopkins Reagents and methods for identifying, enriching, and/or expanding antigen-specific t cells
AU2015371265B2 (en) 2014-12-24 2021-06-03 Neximmune, Inc Nanoparticle compositions and methods for immunotherapy
EP3325646B1 (fr) * 2015-07-22 2020-08-19 F.Hoffmann-La Roche Ag Identification d'épitopes antigéniques et séquences immunitaires reconnaissant les antigènes
US10539564B2 (en) 2015-07-22 2020-01-21 Roche Sequencing Solutions, Inc. Identification of antigen epitopes and immune sequences recognizing the antigens
AU2017233035B2 (en) * 2016-03-16 2021-08-05 Neximmune, Inc. Production of antigen-specific T-cells
CA3029813A1 (fr) 2016-06-13 2017-12-21 Torque Therapeutics, Inc. Methodes et procedes pour favoriser la fonction des cellules immunitaires
EP3487510B1 (fr) 2016-07-21 2023-07-19 Berkeley Lights, Inc. Tri de lymphocytes t dans un dispositif microfluidique
US10294454B2 (en) 2016-08-24 2019-05-21 General Electric Company Methods and kits for cell activation
TWI788307B (zh) 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
EP3558346A1 (fr) 2016-12-21 2019-10-30 Danmarks Tekniske Universitet Échafaudages présentateurs d'antigènes servant à la manipulation de cellules immunitaires
CA3051481A1 (fr) * 2017-02-07 2018-08-16 Seattle Children's Hospital (dba Seattle Children's Research Institute) Agents de ciblage de tumeur a lymphocytes t car (ctct) d'ether de phospholipide (ple)
US11285196B2 (en) 2017-03-13 2022-03-29 Eslam Abbas Baseuny Multivalent biologic constructs for inducing a therapeutic modulation of cellular response and uses thereof
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