SG10201707377XA - Nanoscale artificial antigen presenting cells - Google Patents

Nanoscale artificial antigen presenting cells

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Publication number
SG10201707377XA
SG10201707377XA SG10201707377XA SG10201707377XA SG10201707377XA SG 10201707377X A SG10201707377X A SG 10201707377XA SG 10201707377X A SG10201707377X A SG 10201707377XA SG 10201707377X A SG10201707377X A SG 10201707377XA SG 10201707377X A SG10201707377X A SG 10201707377XA
Authority
SG
Singapore
Prior art keywords
presenting cells
antigen presenting
artificial antigen
nanoscale artificial
nanoscale
Prior art date
Application number
SG10201707377XA
Inventor
Jonathan Schneck
Mathias Oelke
Karlo Perica
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Publication of SG10201707377XA publication Critical patent/SG10201707377XA/en

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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0635B lymphocytes
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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    • A61K39/44Antibodies bound to carriers
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    • A61K39/4622Antigen presenting cells
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SG10201707377XA 2013-03-14 2014-03-13 Nanoscale artificial antigen presenting cells SG10201707377XA (en)

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US201361786135P 2013-03-14 2013-03-14
US201461942797P 2014-02-21 2014-02-21

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US (2) US10435668B2 (en)
EP (1) EP2970907B1 (en)
JP (1) JP6632072B2 (en)
KR (1) KR102164405B1 (en)
CN (1) CN105431523B (en)
AU (1) AU2014244119B2 (en)
CA (1) CA2906514C (en)
ES (1) ES2782002T3 (en)
IL (1) IL241627B (en)
MX (1) MX2015012920A (en)
SG (2) SG11201507506RA (en)
WO (1) WO2014160132A1 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10435668B2 (en) 2013-03-14 2019-10-08 The Johns Hopkins University Nanoscale artificial antigen presenting cells
MX2015017959A (en) * 2013-06-24 2018-03-01 Neximmune Inc Compositions and methods for immunotherapy.
CA3017170C (en) 2014-09-17 2021-03-23 The Johns Hopkins University Reagents and methods for identifying, enriching, and/or expanding antigen-specific t cells
ES2897707T3 (en) * 2014-12-24 2022-03-02 Neximmune Inc Nanoparticle compositions and methods for immunotherapy
WO2017013170A1 (en) * 2015-07-22 2017-01-26 F. Hoffmann-La Roche Ag Identification of antigen epitopes and immune sequences recognizing the antigens
US10539564B2 (en) 2015-07-22 2020-01-21 Roche Sequencing Solutions, Inc. Identification of antigen epitopes and immune sequences recognizing the antigens
WO2017161092A1 (en) * 2016-03-16 2017-09-21 Neximmune, Inc. Production of antigen-specific t-cells
JP7185530B2 (en) 2016-06-13 2022-12-07 トルク セラピューティクス, インコーポレイテッド Methods and compositions for promoting immune cell function
CN109952106B (en) 2016-07-21 2022-08-05 伯克利之光生命科技公司 Sorting T lymphocytes in a microfluidic device
US10294454B2 (en) 2016-08-24 2019-05-21 General Electric Company Methods and kits for cell activation
TWI788307B (en) 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion
CN110381989A (en) * 2016-12-21 2019-10-25 丹麦技术大学 Antigen presentation bracket for immunocyte operation
US11285196B2 (en) 2017-03-13 2022-03-29 Eslam Abbas Baseuny Multivalent biologic constructs for inducing a therapeutic modulation of cellular response and uses thereof
CN109306340B (en) * 2017-07-27 2023-06-06 上海细胞治疗研究院 Artificial antigen presenting cell for efficiently amplifying whole T cells and application thereof
CN109337872B (en) * 2017-07-27 2023-06-23 上海细胞治疗研究院 Artificial antigen presenting cell for efficiently amplifying CAR-T cells and application thereof
CN111432836A (en) 2017-09-05 2020-07-17 转矩医疗股份有限公司 Therapeutic protein compositions and methods of making and using same
GB201801902D0 (en) * 2018-02-06 2018-03-21 Stichting Katholieke Univ Immunomodulatory nanofilaments
US20200390807A1 (en) * 2018-02-20 2020-12-17 University Of Florida Research Foundation, Incorporated Composition and method for targeting natural killer cells in immunotherapy to overcome tumor suppression with manganese dioxide nanoparticles
CN108588020B (en) * 2018-03-30 2021-09-14 中国科学院苏州纳米技术与纳米仿生研究所 New application of near-infrared II-region quantum dots containing selenium element
CN110464848B (en) * 2018-05-11 2022-07-05 中国医学科学院肿瘤医院 Artificial antigen presenting cell and preparation method and application thereof
CA3100576A1 (en) * 2018-06-20 2019-12-26 Danmarks Tekniske Universitet Scaffolds with stabilized mhc molecules for immune-cell manipulation
JP2022512714A (en) * 2018-10-18 2022-02-07 バークレー ライツ,インコーポレイテッド Proto-antigen presentation synthetic surface, activated T cells and their use
MX2021005372A (en) 2018-11-08 2021-09-14 Neximmune Inc T cell compositions with improved phenotypic properties.
US20220331415A1 (en) * 2019-09-18 2022-10-20 The Regents Of The University Of California Immunoactive microparticles and uses thereof
MX2019015508A (en) 2019-12-18 2021-06-21 Univ Guadalajara Nanoparticles for treating cancer.
CN111172146B (en) * 2020-01-15 2023-09-12 苏州朴衡科技有限公司 Nanoscale artificial antigen presenting cell alpha CD3-Origami aAPC, preparation method and application thereof
CN115176015A (en) 2020-02-28 2022-10-11 国立大学法人金泽大学 Immunomodulating method, nucleic acid composition for immunomodulation and use thereof
CN112517035A (en) * 2020-12-16 2021-03-19 兰州交通大学 Preparation and application of metal atom doped hollow MXene quantum dot
WO2023033124A1 (en) * 2021-09-01 2023-03-09 国立大学法人金沢大学 Immunoregulatory method, nucleic acid composition for immunoregulation, and use thereof
WO2023060123A1 (en) * 2021-10-05 2023-04-13 The Johns Hopkins University Mhc ii artificial antigen presenting cells harness the effector and helper functions of antigen-specific cd4+ t cells
WO2023210661A1 (en) * 2022-04-25 2023-11-02 国立大学法人金沢大学 COMPOSITION FOR REGULATING CAR-T CELL ACTIVATION, HEMATOPOIETIC STEM CELL PROLIFERATION, AND iPS CELL DIFFERENTIATION, AND USE THEREOF

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458354B1 (en) 1996-03-28 2002-10-01 The Johns Hopkins University Molecular complexes which modify immune responses
US7973137B1 (en) 1996-03-28 2011-07-05 Johns Hopkins University Cell compositions comprising molecular complexes that modify immune responses
CA2250166A1 (en) 1996-03-28 1997-10-02 The Johns Hopkins University Soluble divalent and multivalent heterodimeric analogs of proteins
US6140113A (en) 1996-03-28 2000-10-31 The Johns Hopkins University Polynucleotides encoding molecular complexes which modify immune responses
US6268411B1 (en) 1997-09-11 2001-07-31 The Johns Hopkins University Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses
US7572631B2 (en) * 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
US7541184B2 (en) * 2000-02-24 2009-06-02 Invitrogen Corporation Activation and expansion of cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
WO2001062895A2 (en) 2000-02-24 2001-08-30 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
CA2410510A1 (en) 2000-06-02 2001-12-13 Memorial Sloan-Kettering Cancer Center Artificial antigen presenting cells and methods of use thereof
CA2493081C (en) 2002-07-12 2013-04-23 The Johns Hopkins University Reagents and methods for engaging unique clonotypic lymphocyte receptors
MXPA05012080A (en) * 2003-05-08 2006-02-22 Xcyte Therapies Inc Generation and isolation of antigen-specific t cells.
US8629098B2 (en) * 2008-01-15 2014-01-14 Yale University Compositions and methods for adoptive and active immunotherapy
WO2010099205A1 (en) * 2009-02-24 2010-09-02 The Trustees Of The University Of Pennsylvania Methods for treating progressive multifocal leukoencephalopathy (pml)
ES2564841T3 (en) 2010-05-14 2016-03-29 The General Hospital Corporation Compositions and methods to identify tumor-specific neoantigens
WO2014127220A1 (en) 2013-02-15 2014-08-21 The Johns Hopkins University Antigen-specific t cell redirectors
KR20150132196A (en) * 2013-02-26 2015-11-25 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 Combined organ and hematopoietic cells for transplantation tolerance of grafts
US10435668B2 (en) 2013-03-14 2019-10-08 The Johns Hopkins University Nanoscale artificial antigen presenting cells
CA3017170C (en) * 2014-09-17 2021-03-23 The Johns Hopkins University Reagents and methods for identifying, enriching, and/or expanding antigen-specific t cells
WO2020041968A1 (en) * 2018-08-28 2020-03-05 华为技术有限公司 Surface wave conversion coupling device and surface wave communication system

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