SG10201707377XA - Nanoscale artificial antigen presenting cells - Google Patents
Nanoscale artificial antigen presenting cellsInfo
- Publication number
- SG10201707377XA SG10201707377XA SG10201707377XA SG10201707377XA SG10201707377XA SG 10201707377X A SG10201707377X A SG 10201707377XA SG 10201707377X A SG10201707377X A SG 10201707377XA SG 10201707377X A SG10201707377X A SG 10201707377XA SG 10201707377X A SG10201707377X A SG 10201707377XA
- Authority
- SG
- Singapore
- Prior art keywords
- presenting cells
- antigen presenting
- artificial antigen
- nanoscale artificial
- nanoscale
- Prior art date
Links
- 210000000612 antigen-presenting cell Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/44—Antibodies bound to carriers
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361786135P | 2013-03-14 | 2013-03-14 | |
US201461942797P | 2014-02-21 | 2014-02-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201707377XA true SG10201707377XA (en) | 2017-10-30 |
Family
ID=51625342
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201507506RA SG11201507506RA (en) | 2013-03-14 | 2014-03-13 | Nanoscale artificial antigen presenting cells |
SG10201707377XA SG10201707377XA (en) | 2013-03-14 | 2014-03-13 | Nanoscale artificial antigen presenting cells |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201507506RA SG11201507506RA (en) | 2013-03-14 | 2014-03-13 | Nanoscale artificial antigen presenting cells |
Country Status (12)
Country | Link |
---|---|
US (2) | US10435668B2 (en) |
EP (1) | EP2970907B1 (en) |
JP (1) | JP6632072B2 (en) |
KR (1) | KR102164405B1 (en) |
CN (1) | CN105431523B (en) |
AU (1) | AU2014244119B2 (en) |
CA (1) | CA2906514C (en) |
ES (1) | ES2782002T3 (en) |
IL (1) | IL241627B (en) |
MX (1) | MX2015012920A (en) |
SG (2) | SG11201507506RA (en) |
WO (1) | WO2014160132A1 (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10435668B2 (en) | 2013-03-14 | 2019-10-08 | The Johns Hopkins University | Nanoscale artificial antigen presenting cells |
MX2015017959A (en) * | 2013-06-24 | 2018-03-01 | Neximmune Inc | Compositions and methods for immunotherapy. |
CA3017170C (en) | 2014-09-17 | 2021-03-23 | The Johns Hopkins University | Reagents and methods for identifying, enriching, and/or expanding antigen-specific t cells |
ES2897707T3 (en) * | 2014-12-24 | 2022-03-02 | Neximmune Inc | Nanoparticle compositions and methods for immunotherapy |
WO2017013170A1 (en) * | 2015-07-22 | 2017-01-26 | F. Hoffmann-La Roche Ag | Identification of antigen epitopes and immune sequences recognizing the antigens |
US10539564B2 (en) | 2015-07-22 | 2020-01-21 | Roche Sequencing Solutions, Inc. | Identification of antigen epitopes and immune sequences recognizing the antigens |
WO2017161092A1 (en) * | 2016-03-16 | 2017-09-21 | Neximmune, Inc. | Production of antigen-specific t-cells |
JP7185530B2 (en) | 2016-06-13 | 2022-12-07 | トルク セラピューティクス, インコーポレイテッド | Methods and compositions for promoting immune cell function |
CN109952106B (en) | 2016-07-21 | 2022-08-05 | 伯克利之光生命科技公司 | Sorting T lymphocytes in a microfluidic device |
US10294454B2 (en) | 2016-08-24 | 2019-05-21 | General Electric Company | Methods and kits for cell activation |
TWI788307B (en) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion |
CN110381989A (en) * | 2016-12-21 | 2019-10-25 | 丹麦技术大学 | Antigen presentation bracket for immunocyte operation |
US11285196B2 (en) | 2017-03-13 | 2022-03-29 | Eslam Abbas Baseuny | Multivalent biologic constructs for inducing a therapeutic modulation of cellular response and uses thereof |
CN109306340B (en) * | 2017-07-27 | 2023-06-06 | 上海细胞治疗研究院 | Artificial antigen presenting cell for efficiently amplifying whole T cells and application thereof |
CN109337872B (en) * | 2017-07-27 | 2023-06-23 | 上海细胞治疗研究院 | Artificial antigen presenting cell for efficiently amplifying CAR-T cells and application thereof |
CN111432836A (en) | 2017-09-05 | 2020-07-17 | 转矩医疗股份有限公司 | Therapeutic protein compositions and methods of making and using same |
GB201801902D0 (en) * | 2018-02-06 | 2018-03-21 | Stichting Katholieke Univ | Immunomodulatory nanofilaments |
US20200390807A1 (en) * | 2018-02-20 | 2020-12-17 | University Of Florida Research Foundation, Incorporated | Composition and method for targeting natural killer cells in immunotherapy to overcome tumor suppression with manganese dioxide nanoparticles |
CN108588020B (en) * | 2018-03-30 | 2021-09-14 | 中国科学院苏州纳米技术与纳米仿生研究所 | New application of near-infrared II-region quantum dots containing selenium element |
CN110464848B (en) * | 2018-05-11 | 2022-07-05 | 中国医学科学院肿瘤医院 | Artificial antigen presenting cell and preparation method and application thereof |
CA3100576A1 (en) * | 2018-06-20 | 2019-12-26 | Danmarks Tekniske Universitet | Scaffolds with stabilized mhc molecules for immune-cell manipulation |
JP2022512714A (en) * | 2018-10-18 | 2022-02-07 | バークレー ライツ,インコーポレイテッド | Proto-antigen presentation synthetic surface, activated T cells and their use |
MX2021005372A (en) | 2018-11-08 | 2021-09-14 | Neximmune Inc | T cell compositions with improved phenotypic properties. |
US20220331415A1 (en) * | 2019-09-18 | 2022-10-20 | The Regents Of The University Of California | Immunoactive microparticles and uses thereof |
MX2019015508A (en) | 2019-12-18 | 2021-06-21 | Univ Guadalajara | Nanoparticles for treating cancer. |
CN111172146B (en) * | 2020-01-15 | 2023-09-12 | 苏州朴衡科技有限公司 | Nanoscale artificial antigen presenting cell alpha CD3-Origami aAPC, preparation method and application thereof |
CN115176015A (en) | 2020-02-28 | 2022-10-11 | 国立大学法人金泽大学 | Immunomodulating method, nucleic acid composition for immunomodulation and use thereof |
CN112517035A (en) * | 2020-12-16 | 2021-03-19 | 兰州交通大学 | Preparation and application of metal atom doped hollow MXene quantum dot |
WO2023033124A1 (en) * | 2021-09-01 | 2023-03-09 | 国立大学法人金沢大学 | Immunoregulatory method, nucleic acid composition for immunoregulation, and use thereof |
WO2023060123A1 (en) * | 2021-10-05 | 2023-04-13 | The Johns Hopkins University | Mhc ii artificial antigen presenting cells harness the effector and helper functions of antigen-specific cd4+ t cells |
WO2023210661A1 (en) * | 2022-04-25 | 2023-11-02 | 国立大学法人金沢大学 | COMPOSITION FOR REGULATING CAR-T CELL ACTIVATION, HEMATOPOIETIC STEM CELL PROLIFERATION, AND iPS CELL DIFFERENTIATION, AND USE THEREOF |
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---|---|---|---|---|
US6458354B1 (en) | 1996-03-28 | 2002-10-01 | The Johns Hopkins University | Molecular complexes which modify immune responses |
US7973137B1 (en) | 1996-03-28 | 2011-07-05 | Johns Hopkins University | Cell compositions comprising molecular complexes that modify immune responses |
CA2250166A1 (en) | 1996-03-28 | 1997-10-02 | The Johns Hopkins University | Soluble divalent and multivalent heterodimeric analogs of proteins |
US6140113A (en) | 1996-03-28 | 2000-10-31 | The Johns Hopkins University | Polynucleotides encoding molecular complexes which modify immune responses |
US6268411B1 (en) | 1997-09-11 | 2001-07-31 | The Johns Hopkins University | Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses |
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US7541184B2 (en) * | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
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US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
CA2410510A1 (en) | 2000-06-02 | 2001-12-13 | Memorial Sloan-Kettering Cancer Center | Artificial antigen presenting cells and methods of use thereof |
CA2493081C (en) | 2002-07-12 | 2013-04-23 | The Johns Hopkins University | Reagents and methods for engaging unique clonotypic lymphocyte receptors |
MXPA05012080A (en) * | 2003-05-08 | 2006-02-22 | Xcyte Therapies Inc | Generation and isolation of antigen-specific t cells. |
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KR20150132196A (en) * | 2013-02-26 | 2015-11-25 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | Combined organ and hematopoietic cells for transplantation tolerance of grafts |
US10435668B2 (en) | 2013-03-14 | 2019-10-08 | The Johns Hopkins University | Nanoscale artificial antigen presenting cells |
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