CA2903031C - Polyethylene glycol cleansers useful for removing irritating compounds from bodily surfaces - Google Patents
Polyethylene glycol cleansers useful for removing irritating compounds from bodily surfaces Download PDFInfo
- Publication number
- CA2903031C CA2903031C CA2903031A CA2903031A CA2903031C CA 2903031 C CA2903031 C CA 2903031C CA 2903031 A CA2903031 A CA 2903031A CA 2903031 A CA2903031 A CA 2903031A CA 2903031 C CA2903031 C CA 2903031C
- Authority
- CA
- Canada
- Prior art keywords
- capsaicin
- composition
- percent
- peg
- cleansing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229920001223 polyethylene glycol Polymers 0.000 title claims abstract description 85
- 239000002202 Polyethylene glycol Substances 0.000 title claims abstract description 80
- 230000000622 irritating effect Effects 0.000 title abstract description 25
- 150000001875 compounds Chemical class 0.000 title description 11
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 claims abstract description 347
- 239000000203 mixture Substances 0.000 claims abstract description 256
- 229960002504 capsaicin Drugs 0.000 claims abstract description 152
- 235000017663 capsaicin Nutrition 0.000 claims abstract description 152
- 239000002562 thickening agent Substances 0.000 claims abstract description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 43
- 229920000058 polyacrylate Polymers 0.000 claims abstract description 34
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims description 21
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims description 20
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims description 20
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims description 20
- 230000003444 anaesthetic effect Effects 0.000 claims description 16
- 229920000642 polymer Polymers 0.000 claims description 16
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 3
- 230000008719 thickening Effects 0.000 claims description 2
- 239000000126 substance Substances 0.000 abstract description 29
- 230000001354 painful effect Effects 0.000 abstract description 19
- 239000004094 surface-active agent Substances 0.000 abstract description 8
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- 229920002556 Polyethylene Glycol 300 Polymers 0.000 description 34
- 238000000034 method Methods 0.000 description 28
- -1 e.g. Polymers 0.000 description 21
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical class OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 20
- 238000009472 formulation Methods 0.000 description 20
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- 239000006210 lotion Substances 0.000 description 14
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- 230000036407 pain Effects 0.000 description 12
- 210000001508 eye Anatomy 0.000 description 10
- 238000004806 packaging method and process Methods 0.000 description 9
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 8
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- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
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- METKIMKYRPQLGS-GFCCVEGCSA-N (R)-atenolol Chemical compound CC(C)NC[C@@H](O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-GFCCVEGCSA-N 0.000 description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 3
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Landscapes
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- Adhesives Or Adhesive Processes (AREA)
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| SI1539124T1 (sl) * | 2002-09-05 | 2018-12-31 | Vanderbilt Royalty Sub L.P. | Sestavki in kompleti za odstranjevanje dražilnih spojin s telesnih površin |
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| PT1587506E (pt) * | 2002-12-18 | 2008-10-30 | Algorx | Administração de capasaicinóides |
| JP2006513267A (ja) * | 2002-12-18 | 2006-04-20 | アルゴルクス ファーマスーティカルズ，インク | カプサイシノイドの投与 |
| NZ542887A (en) * | 2003-04-08 | 2008-05-30 | Algorx Pharmaceuticals Inc | Preparation and purification of synthetic capsaicin |
| EP2907503A1 (en) | 2003-04-10 | 2015-08-19 | Neurogesx, Inc. | Methods and compositions for administration of TRPV1 agonists |
| DE102004009904A1 (de) * | 2004-02-26 | 2005-09-22 | Grünenthal GmbH | Kit aus einem gegebenenfalls wirkstoffhaltigen Pflaster und einem Hautirritationen verhindernden Mittel |
| KR20060040550A (ko) * | 2004-11-05 | 2006-05-10 | 마루이시세이야쿠가부시키가이샤 | 인슐린유사 성장인자-1 분비촉진제 |
| JP2006151971A (ja) * | 2004-11-05 | 2006-06-15 | Maruishi Pharmaceutical Co Ltd | インスリン様成長因子−１分泌促進剤 |
| CA2596194A1 (en) * | 2004-11-24 | 2006-06-01 | Algorx Pharmaceuticals, Inc. | Capsaicinoid gel formulation and uses thereof |
| US20070053965A1 (en) * | 2005-02-25 | 2007-03-08 | Gruenenthal Gmbh | Kit comprising a plaster, optionally containing an active substance, and an agent that at least partially reduces skin irritation |
| DE602006017345D1 (de) * | 2005-04-01 | 2010-11-18 | Neurogesx Inc | Öle von capsaicinoiden und verfahren zu ihrer herstellung und verwendung |
| US8057830B2 (en) * | 2006-03-21 | 2011-11-15 | Access Business Group International Llc | Cleansing compositions and methods of reducing skin irritation |
| US7282224B1 (en) | 2006-06-09 | 2007-10-16 | Guthy-Renker Corporation | Pain relief composition |
| US20080107747A1 (en) * | 2006-10-23 | 2008-05-08 | Roederer Joy E | Pain relief composition |
| WO2008075615A1 (en) * | 2006-12-21 | 2008-06-26 | Semiconductor Energy Laboratory Co., Ltd. | Light-emitting element and light-emitting device |
| WO2008103180A1 (en) | 2007-02-23 | 2008-08-28 | Hill's Pet Nutrition, Inc. | Compositions and methods for preventing or treating obesity in animals |
| US8404277B2 (en) | 2007-06-08 | 2013-03-26 | Samyang Biopharmaceuticals Corporation | Matrix-type transdermal drug delivery system and preparation method thereof |
| US8158682B2 (en) * | 2008-09-12 | 2012-04-17 | Vallinex, Inc. | Instillation administration of capsaicinoids for the treatment of pain |
| RU2010108361A (ru) * | 2010-03-09 | 2011-09-20 | Гаврилова Эмилия Евгеньевна (RU) | Набор лечебных средств |
| RU2582454C2 (ru) * | 2010-06-09 | 2016-04-27 | Као Корпорейшн | Парогенерирующее устройство обогрева |
| MX2017005046A (es) * | 2014-10-31 | 2017-07-04 | Avent Inc | Metodo y articulos para inhibir las contracciones vesicales. |
| MX389514B (es) | 2015-10-01 | 2025-03-20 | Firmenich Incorporated | Compuestos útiles como moduladores de canal receptor 8 de potencial transitorio de melastatina (trpm8). |
| JP7412871B2 (ja) * | 2017-06-27 | 2024-01-15 | 小林製薬株式会社 | 外用組成物 |
| JP7412870B2 (ja) * | 2017-06-27 | 2024-01-15 | 小林製薬株式会社 | 外用組成物 |
| EA031658B1 (ru) * | 2017-06-30 | 2019-02-28 | Акционерное Общество "Верофарм" | Антицеллюлитный косметический комплекс |
| EP3514538B1 (en) * | 2018-01-19 | 2021-08-04 | Nambu University Industry-Cooperation Group | Composition for controlling secretion of prostasomes and use thereof |
| JP2024117288A (ja) * | 2023-02-17 | 2024-08-29 | 能美防災株式会社 | 防護対象物に付着した延焼防止剤の除去方法 |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4239781A (en) * | 1979-05-03 | 1980-12-16 | Roy Edwards | Method for treating skin ailments |
| US4303066A (en) * | 1979-06-28 | 1981-12-01 | National Patent Development Corporation | Burn dressing |
| US4387107A (en) * | 1979-07-25 | 1983-06-07 | Dermik Laboratories, Inc. | Stable benzoyl peroxide composition |
| GB2075837B (en) * | 1980-05-14 | 1984-03-14 | Hisamitsu Pharmaceutical Co | Topical pharmaceutical gel containing anti-inflammatory analgesic agents |
| US4424205A (en) * | 1982-03-18 | 1984-01-03 | The Procter & Gamble Company | Hydroxyphenylacetamides having analgesic and anti-irritant activity |
| US4493848A (en) * | 1983-07-14 | 1985-01-15 | The Procter & Gamble Company | Compositions and methods useful for producing analgesia |
| US4681897A (en) * | 1984-01-16 | 1987-07-21 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
| GB8401206D0 (en) * | 1984-01-17 | 1984-02-22 | Allied Colloids Ltd | Polymers and aqueous solutions |
| GB8414950D0 (en) * | 1984-06-12 | 1984-07-18 | Allied Colloids Ltd | Cationic polyelectrolytes |
| CA1263606A (en) * | 1985-05-29 | 1989-12-05 | Jeffrey P. Gilbard | Non-toxic opthalmic preparations |
| GB8531118D0 (en) | 1985-12-18 | 1986-01-29 | Allied Colloids Ltd | Copolymers |
| GB8622797D0 (en) * | 1986-09-22 | 1986-10-29 | Allied Colloids Ltd | Polymeric particles |
| EP0262945B1 (en) * | 1986-10-01 | 1994-01-05 | Ciba Specialty Chemicals Water Treatments Limited | Water soluble polymeric compositions |
| US5202118A (en) * | 1987-12-18 | 1993-04-13 | Immunex Corporation | Method for promoting wound healing using IL-1 |
| US4939149A (en) * | 1988-10-24 | 1990-07-03 | The United States Of America As Represented By The Department Of Health And Human Services | Resiniferatoxin and analogues thereof to cause sensory afferent C-fiber and thermoregulatory desensitization |
| GB8909095D0 (en) * | 1989-04-21 | 1989-06-07 | Allied Colloids Ltd | Thickened aqueous compositions |
| US5721275A (en) * | 1989-06-07 | 1998-02-24 | Bazzano; Gail S. | Slow release vehicles for minimizing skin irritancy of topical compositions |
| US5633285A (en) * | 1991-03-01 | 1997-05-27 | Warner-Lambert Company | Cytoprotective wound healing compositions and methods for preparing and using same |
| WO1993007245A2 (en) * | 1991-10-07 | 1993-04-15 | Nephin | A solid cleansing bar |
| ATE156997T1 (de) * | 1992-06-17 | 1997-09-15 | Procter & Gamble | Nichtstechende zusammensetzungen mit kühleffekt |
| US5288814A (en) * | 1992-08-26 | 1994-02-22 | The B. F. Goodrich Company | Easy to disperse polycarboxylic acid thickeners |
| US5376732A (en) * | 1992-10-30 | 1994-12-27 | Research Corporation Technologies, Inc. | Polymers having oxidic functionality and derivatives thereof |
| US5910512A (en) * | 1994-04-18 | 1999-06-08 | Healthline Laboratories, Inc. | Topical analgesic using water soluble capsaicin |
| FR2721213B1 (fr) | 1994-06-15 | 1996-09-13 | Pf Medicament | Procédé de préparation d'un extrait de Capsicum, riche en capsaïcine et autres capsinoïdes. |
| US5624906A (en) * | 1994-12-08 | 1997-04-29 | Lever Brothers Company, Division Of Conopco, Inc. | Oral hygiene compositions comprising heteroatom containing alkyl aldonamide compounds |
| CA2222424C (en) * | 1995-05-27 | 2001-06-26 | The Procter & Gamble Company | Cleansing compositions |
| US5703026A (en) * | 1995-06-01 | 1997-12-30 | The Procter & Gamble Company | Skin cleansing bar soap compositions comprising particles of absorbent gellant materials |
| US5747052A (en) * | 1995-06-09 | 1998-05-05 | Anthony Rizzo | Aqueous composition to neutralize the irritating effect of capsaicin on eyes, skin and mucous membranes |
| US6239180B1 (en) * | 1995-11-08 | 2001-05-29 | The Regents Of The University Of California | Transdermal therapeutic device and method with capsaicin and capsaicin analogs |
| US6248788B1 (en) * | 1996-11-06 | 2001-06-19 | The Regents Of The University Of California | Therapeutic method with capsaicin and capasicin analogs |
| US5958436A (en) * | 1995-12-21 | 1999-09-28 | Cosmederm Technologies | Formulations and methods for reducing skin irritation |
| US5698191A (en) * | 1996-01-30 | 1997-12-16 | Nouveau Technologies, Inc. | Non-lethal bio-repellent compositions |
| US5856361A (en) | 1996-04-23 | 1999-01-05 | Medical Merchandising, Inc. | Pain reliever and method of use |
| JP2001515492A (ja) * | 1997-03-13 | 2001-09-18 | エヌ． キャンベル，ジェイムズ | カプサイシンまたはカプサイシンアナログを含有する組成物および局所麻酔 |
| US5922331A (en) * | 1997-03-26 | 1999-07-13 | Chanel, Inc. | Skin cream composition |
| US5827886A (en) * | 1997-05-07 | 1998-10-27 | Thione International, Inc. | Composition for relief of arthritis-induced symptoms |
| EP0999840B1 (en) * | 1997-06-16 | 2003-05-02 | Janssen Pharmaceutica N.V. | Use of a draflazine analogue for treating pain |
| TW460293B (en) * | 1997-10-28 | 2001-10-21 | Kao Corp | External skin-care composition |
| EP0916334A1 (en) | 1997-11-07 | 1999-05-19 | Unilever Plc | Detergent composition |
| US6113892A (en) * | 1997-12-23 | 2000-09-05 | Helene Curtis, Inc. | Compositions for cleansing, conditioning and moisturizing hair and skin |
| US6015763A (en) * | 1998-02-17 | 2000-01-18 | Dotolo Research Corp. | Cleaner impregnated towel |
| US6013270A (en) * | 1998-04-20 | 2000-01-11 | The Procter & Gamble Company | Skin care kit |
| JP3211027B2 (ja) * | 1998-11-13 | 2001-09-25 | 丸石製薬株式会社 | カプサイシン含有外用剤 |
| US6390291B1 (en) * | 1998-12-18 | 2002-05-21 | Smithkline Beecham Corporation | Method and package for storing a pressurized container containing a drug |
| JP2000191510A (ja) | 1998-12-28 | 2000-07-11 | Kao Corp | 皮膚洗浄剤組成物 |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US5994407A (en) * | 1999-06-16 | 1999-11-30 | Cuilty-Siller; Carlos | Procedure to prepare a solution with capsaicin |
| US7074747B1 (en) * | 1999-07-01 | 2006-07-11 | Johnson & Johnson Consumer Companies, Inc. | Cleansing compositions |
| AU5764800A (en) * | 1999-07-01 | 2001-01-22 | Johnson & Johnson Consumer Companies, Inc. | Cleansing compositions |
| HU225734B1 (en) * | 1999-07-28 | 2007-07-30 | Zoltan Dardai | Multilayer plaster for introducing peptidaceous pharmacons in living organisms and process for producing thereof |
| DE10009252A1 (de) * | 2000-03-01 | 2001-09-06 | Henkel Kgaa | Wärmendes Hautreinigungsgel |
| US6342470B1 (en) * | 2000-04-26 | 2002-01-29 | Unilever Home & Personal Care Usa | Bar comprising soap, fatty acid, polyalkylene glycol and protic acid salts in critical ratios and providing enhanced skin care benefits |
| US6774100B2 (en) * | 2000-12-06 | 2004-08-10 | Imaginative Research Associates, Inc. | Anhydrous creams, lotions and gels |
| US20030235549A1 (en) * | 2001-05-01 | 2003-12-25 | Parminder Singh | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
| US6465022B1 (en) | 2001-06-19 | 2002-10-15 | New Mexico Tech Research Foundation | Method of providing an essential oil extract of capsicum, and the extract |
| US6428772B1 (en) * | 2001-06-25 | 2002-08-06 | Blistex Inc. | Acne treatment composition with cooling effect |
| JP3881871B2 (ja) * | 2001-11-13 | 2007-02-14 | 三菱重工業株式会社 | ガスタービンの燃料制御方法、及びそれに供する制御装置 |
| SI1539124T1 (sl) | 2002-09-05 | 2018-12-31 | Vanderbilt Royalty Sub L.P. | Sestavki in kompleti za odstranjevanje dražilnih spojin s telesnih površin |
| US20040131560A1 (en) * | 2002-10-04 | 2004-07-08 | The Procter & Gamble Company | Oral compositions and use thereof |
| WO2005027642A1 (en) | 2003-09-25 | 2005-03-31 | Darren Wayne Eade | Repellent preparations |
| US20060018845A1 (en) * | 2004-07-23 | 2006-01-26 | Edelstein Janette S | Tooth whitening |
| DE102011077796A1 (de) | 2011-06-20 | 2012-12-20 | Voith Patent Gmbh | Verfahren und System zur Wärmerückgewinnung für eine Trockenpartie einer Maschine zur Herstellung einer Materialbahn |
-
2003
- 2003-09-05 SI SI200332577T patent/SI1539124T1/sl unknown
- 2003-09-05 CA CA2903031A patent/CA2903031C/en not_active Expired - Lifetime
- 2003-09-05 ES ES03752011.1T patent/ES2687970T3/es not_active Expired - Lifetime
- 2003-09-05 US US10/655,911 patent/US20040126430A1/en not_active Abandoned
- 2003-09-05 WO PCT/US2003/027742 patent/WO2004021990A2/en not_active Ceased
- 2003-09-05 JP JP2004534582A patent/JP4279254B2/ja not_active Expired - Lifetime
- 2003-09-05 MX MXPA05002440A patent/MXPA05002440A/es not_active Application Discontinuation
- 2003-09-05 AU AU2003270325A patent/AU2003270325A1/en not_active Abandoned
- 2003-09-05 EP EP03752011.1A patent/EP1539124B1/en not_active Expired - Lifetime
- 2003-09-05 PT PT03752011T patent/PT1539124T/pt unknown
- 2003-09-05 HU HUE03752011A patent/HUE042241T2/hu unknown
- 2003-09-05 DK DK03752011.1T patent/DK1539124T3/en active
- 2003-09-05 EA EA200500442A patent/EA012367B1/ru not_active IP Right Cessation
- 2003-09-05 LT LTEP03752011.1T patent/LT1539124T/lt unknown
- 2003-09-05 CA CA2497771A patent/CA2497771C/en not_active Expired - Lifetime
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2004
- 2004-03-26 US US10/810,185 patent/US20040180081A1/en not_active Abandoned
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2006
- 2006-05-15 US US11/435,187 patent/US20060204563A1/en not_active Abandoned
- 2006-05-15 US US11/435,188 patent/US20060204564A1/en not_active Abandoned
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2008
- 2008-11-11 JP JP2008289299A patent/JP2009084289A/ja not_active Withdrawn
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2010
- 2010-07-06 US US12/830,997 patent/US8263059B2/en not_active Expired - Fee Related
-
2012
- 2012-08-28 US US13/596,773 patent/US8889113B2/en not_active Expired - Lifetime
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2014
- 2014-11-14 US US14/542,041 patent/US9549893B2/en not_active Expired - Fee Related
-
2016
- 2016-12-13 US US15/377,804 patent/US10463598B2/en not_active Expired - Lifetime
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2018
- 2018-09-18 CY CY181100958T patent/CY1120926T1/el unknown
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2019
- 2019-09-24 US US16/581,102 patent/US10869827B2/en not_active Expired - Fee Related
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2020
- 2020-11-13 US US17/098,131 patent/US11534388B2/en not_active Expired - Lifetime
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