CA2901493A1 - Tricyclic heterocycles as anticancer agents - Google Patents
Tricyclic heterocycles as anticancer agents Download PDFInfo
- Publication number
- CA2901493A1 CA2901493A1 CA2901493A CA2901493A CA2901493A1 CA 2901493 A1 CA2901493 A1 CA 2901493A1 CA 2901493 A CA2901493 A CA 2901493A CA 2901493 A CA2901493 A CA 2901493A CA 2901493 A1 CA2901493 A1 CA 2901493A1
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- Prior art keywords
- compound according
- formula
- substituted
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002246 antineoplastic agent Substances 0.000 title claims description 16
- 125000000169 tricyclic heterocycle group Chemical group 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 137
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- 201000011510 cancer Diseases 0.000 claims abstract description 18
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- 238000000034 method Methods 0.000 claims description 48
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 38
- -1 cyano, amino Chemical group 0.000 claims description 38
- 125000000217 alkyl group Chemical group 0.000 claims description 34
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 34
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 27
- 125000001424 substituent group Chemical group 0.000 claims description 27
- 201000010099 disease Diseases 0.000 claims description 25
- 125000000623 heterocyclic group Chemical group 0.000 claims description 23
- 239000007787 solid Substances 0.000 claims description 22
- 210000004027 cell Anatomy 0.000 claims description 21
- 238000011282 treatment Methods 0.000 claims description 21
- 125000003118 aryl group Chemical group 0.000 claims description 19
- 229910052739 hydrogen Inorganic materials 0.000 claims description 14
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- 125000004442 acylamino group Chemical group 0.000 claims description 2
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Landscapes
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361766387P | 2013-02-19 | 2013-02-19 | |
| US61/766,387 | 2013-02-19 | ||
| PCT/US2014/017127 WO2014130534A1 (en) | 2013-02-19 | 2014-02-19 | Tricyclic heterocycles as anticancer agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2901493A1 true CA2901493A1 (en) | 2014-08-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA2901493A Abandoned CA2901493A1 (en) | 2013-02-19 | 2014-02-19 | Tricyclic heterocycles as anticancer agents |
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| US (2) | US9796717B2 (enExample) |
| EP (1) | EP2958565A4 (enExample) |
| JP (1) | JP2016508521A (enExample) |
| KR (1) | KR20150119390A (enExample) |
| CN (1) | CN105073117A (enExample) |
| AU (1) | AU2014219042A1 (enExample) |
| BR (1) | BR112015019818A2 (enExample) |
| CA (1) | CA2901493A1 (enExample) |
| IL (1) | IL240612A0 (enExample) |
| MX (1) | MX2015010407A (enExample) |
| RU (1) | RU2015139700A (enExample) |
| SG (1) | SG11201506450RA (enExample) |
| WO (1) | WO2014130534A1 (enExample) |
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| WO2015138500A1 (en) | 2014-03-11 | 2015-09-17 | Icahn School Of Medicine At Mount Sinai | Sulfonamides derived from tricyclyl-2-aminocycloalkanols as anticancer agents |
| EP3116857B1 (en) | 2014-03-11 | 2019-02-06 | Icahn School of Medicine at Mount Sinai | Constrained tricyclic sulfonamides |
| WO2017044575A1 (en) * | 2015-09-09 | 2017-03-16 | Icahn School Of Medicine At Mount Sinai | Constrained benzhydryl sulfonamides as anticancer and neuroprotective agents |
| CA2997769A1 (en) | 2015-09-09 | 2017-03-16 | Icahn School Of Medicine At Mount Sinai | Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents |
| CN108349961B (zh) * | 2015-09-09 | 2022-02-18 | 西奈山伊坎医学院 | 杂环受限三环磺酰胺作为抗癌试剂 |
| WO2023164940A1 (zh) * | 2022-03-04 | 2023-09-07 | 中国福利会国际和平妇幼保健院 | 氮杂吩噻嗪类化合物及其在制备治疗子宫内膜癌的药物中的应用 |
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| US4634766A (en) | 1983-10-31 | 1987-01-06 | Merck Frosst Canada, Inc. | 1,4-diaza-phenothiazines |
| GB8510680D0 (en) | 1985-04-26 | 1985-06-05 | Smith Kline French Lab | Pyridine derivatives |
| US4882351A (en) | 1987-10-14 | 1989-11-21 | Roussel Uclaf | Tricyclic compounds |
| US5834462A (en) | 1993-07-26 | 1998-11-10 | Eisai Co., Ltd. | Tricyclic heterocyclic sulfonamide and sulfonic ester derivatives |
| EP0881220A4 (en) | 1996-02-15 | 1999-04-21 | Mitsubishi Chem Corp | DIARYLSULTAME DERIVATIVES |
| US6333322B1 (en) * | 1996-03-13 | 2001-12-25 | Eisai Co., Ltd. | Nitrogen-containing tricyclic compounds and drugs containing the same |
| CN1267290A (zh) * | 1997-06-17 | 2000-09-20 | 先灵公司 | 新的法呢基－蛋白转移酶的三环磺酰胺抑制剂 |
| AU2641899A (en) | 1998-02-27 | 1999-09-15 | Eisai Co. Ltd. | Heterocycle-fused benzothiazine derivatives |
| ES2311544T3 (es) * | 2000-09-20 | 2009-02-16 | Schering Corp | Imidazoles sustituidos como agonistas o antagonistas duales de histamina h1 y h3. |
| TW200400816A (en) * | 2002-06-26 | 2004-01-16 | Lilly Co Eli | Tricyclic steroid hormone nuclear receptor modulators |
| IT1362675B (it) | 2005-03-15 | 2009-06-25 | Menarini Internat Operations Luxembourg Sa | N-idrossiammidi -sostituiti con gruppi triciclici come inibitori dell'istone deacelitasi,loro preparazione ed impiego in formulazioni farmaceutiche |
| KR20080000665A (ko) | 2005-04-22 | 2008-01-02 | 알란토스 파마슈티컬즈 홀딩, 인코포레이티드 | 디펩티딜 펩티다아제-ⅳ 억제제 |
| GB0508992D0 (en) | 2005-05-03 | 2005-06-08 | Novartis Ag | Organic compounds |
| WO2013025882A2 (en) * | 2011-08-16 | 2013-02-21 | Mt. Sinai School Of Medicine | Tricyclic compounds as anticancer agents |
| CA2882826A1 (en) | 2012-08-24 | 2014-02-27 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| CN102942562B (zh) | 2012-12-05 | 2014-10-01 | 天津市斯芬克司药物研发有限公司 | 一种苯并咪唑衍生物及其制备方法和应用 |
| WO2015138500A1 (en) | 2014-03-11 | 2015-09-17 | Icahn School Of Medicine At Mount Sinai | Sulfonamides derived from tricyclyl-2-aminocycloalkanols as anticancer agents |
| EP3116857B1 (en) | 2014-03-11 | 2019-02-06 | Icahn School of Medicine at Mount Sinai | Constrained tricyclic sulfonamides |
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2014
- 2014-02-19 WO PCT/US2014/017127 patent/WO2014130534A1/en not_active Ceased
- 2014-02-19 EP EP14754200.5A patent/EP2958565A4/en not_active Withdrawn
- 2014-02-19 CA CA2901493A patent/CA2901493A1/en not_active Abandoned
- 2014-02-19 RU RU2015139700A patent/RU2015139700A/ru not_active Application Discontinuation
- 2014-02-19 JP JP2015558219A patent/JP2016508521A/ja active Pending
- 2014-02-19 BR BR112015019818A patent/BR112015019818A2/pt not_active IP Right Cessation
- 2014-02-19 SG SG11201506450RA patent/SG11201506450RA/en unknown
- 2014-02-19 AU AU2014219042A patent/AU2014219042A1/en not_active Abandoned
- 2014-02-19 CN CN201480009539.1A patent/CN105073117A/zh active Pending
- 2014-02-19 US US14/768,632 patent/US9796717B2/en active Active
- 2014-02-19 KR KR1020157025564A patent/KR20150119390A/ko not_active Withdrawn
- 2014-02-19 MX MX2015010407A patent/MX2015010407A/es unknown
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2015
- 2015-08-17 IL IL240612A patent/IL240612A0/en unknown
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2017
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2958565A1 (en) | 2015-12-30 |
| KR20150119390A (ko) | 2015-10-23 |
| AU2014219042A1 (en) | 2015-09-17 |
| US20150376191A1 (en) | 2015-12-31 |
| WO2014130534A1 (en) | 2014-08-28 |
| IL240612A0 (en) | 2015-10-29 |
| JP2016508521A (ja) | 2016-03-22 |
| CN105073117A (zh) | 2015-11-18 |
| US20180002339A1 (en) | 2018-01-04 |
| BR112015019818A2 (pt) | 2017-07-18 |
| MX2015010407A (es) | 2015-10-26 |
| RU2015139700A (ru) | 2017-03-27 |
| SG11201506450RA (en) | 2015-09-29 |
| US9796717B2 (en) | 2017-10-24 |
| EP2958565A4 (en) | 2016-07-27 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |
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