CA2898047A1 - Procedes et dispositifs pour la preparation de nanoparticules lipidiques - Google Patents
Procedes et dispositifs pour la preparation de nanoparticules lipidiques Download PDFInfo
- Publication number
- CA2898047A1 CA2898047A1 CA2898047A CA2898047A CA2898047A1 CA 2898047 A1 CA2898047 A1 CA 2898047A1 CA 2898047 A CA2898047 A CA 2898047A CA 2898047 A CA2898047 A CA 2898047A CA 2898047 A1 CA2898047 A1 CA 2898047A1
- Authority
- CA
- Canada
- Prior art keywords
- lipid
- solution
- aqueous solution
- lnp
- inlet ports
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
- Y10S977/907—Liposome
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Dispersion Chemistry (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361791054P | 2013-03-15 | 2013-03-15 | |
US61/791,054 | 2013-03-15 | ||
US14/209,187 US9693958B2 (en) | 2013-03-15 | 2014-03-13 | Methods and devices for preparation of lipid nanoparticles |
US14/209,187 | 2014-03-13 | ||
PCT/US2014/027064 WO2014152200A1 (fr) | 2013-03-15 | 2014-03-14 | Procédés et dispositifs pour la préparation de nanoparticules lipidiques |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2898047A1 true CA2898047A1 (fr) | 2014-09-25 |
Family
ID=51581146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2898047A Abandoned CA2898047A1 (fr) | 2013-03-15 | 2014-03-14 | Procedes et dispositifs pour la preparation de nanoparticules lipidiques |
Country Status (9)
Country | Link |
---|---|
US (2) | US9693958B2 (fr) |
EP (1) | EP2968193B1 (fr) |
JP (1) | JP6450742B2 (fr) |
KR (1) | KR20150127580A (fr) |
CN (1) | CN105188685B (fr) |
AU (1) | AU2014240013B2 (fr) |
CA (1) | CA2898047A1 (fr) |
MX (1) | MX2015011072A (fr) |
WO (1) | WO2014152200A1 (fr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9693958B2 (en) * | 2013-03-15 | 2017-07-04 | Cureport, Inc. | Methods and devices for preparation of lipid nanoparticles |
AU2015280499B2 (en) | 2014-06-25 | 2020-03-19 | Acuitas Therapeutics Inc. | Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids |
JP2018507227A (ja) * | 2015-03-03 | 2018-03-15 | キュアポート インコーポレイテッド | 二薬搭載リポソーム医薬製剤 |
EP3265059A4 (fr) * | 2015-03-03 | 2018-08-29 | Cureport Inc. | Formulations pharmaceutiques liposomales en combinaison |
US10799456B2 (en) | 2015-06-15 | 2020-10-13 | University Of Washington | Multiple drug lipid nanoparticle composition and related methods for extended drug levels in blood and lymph tissue |
PL3718565T3 (pl) | 2015-10-22 | 2022-09-19 | Modernatx, Inc. | Szczepionki przeciwko wirusom układu oddechowego |
FI3368507T3 (fi) | 2015-10-28 | 2023-03-21 | Acuitas Therapeutics Inc | Uusia lipidejä ja lipidinanopartikkeliformulaatioita nukleiinihappojen annostelemiseksi |
US11286478B2 (en) | 2016-04-19 | 2022-03-29 | The Broad Institute, Inc. | Cpf1 complexes with reduced indel activity |
SG10202010311SA (en) | 2016-04-19 | 2020-11-27 | Broad Inst Inc | Novel Crispr Enzymes and Systems |
WO2017189308A1 (fr) | 2016-04-19 | 2017-11-02 | The Broad Institute Inc. | Nouvelles enzymes crispr et systèmes associés |
US11352647B2 (en) | 2016-08-17 | 2022-06-07 | The Broad Institute, Inc. | Crispr enzymes and systems |
US20200283743A1 (en) | 2016-08-17 | 2020-09-10 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
WO2018191657A1 (fr) | 2017-04-13 | 2018-10-18 | Acuitas Therapeutics, Inc. | Lipides pour administration d'agents actifs |
WO2018191750A2 (fr) | 2017-04-14 | 2018-10-18 | The Broad Institute Inc. | Nouvelle distribution de grandes charges utiles |
EP3638215A4 (fr) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | Formulations d'arn |
AU2017423053A1 (en) * | 2017-07-10 | 2020-01-23 | Immunovaccine Technologies Inc. | Pharmaceutical compositions, methods for preparation using lipid vesicle particles of defined size, and uses thereof |
WO2019023873A1 (fr) * | 2017-07-31 | 2019-02-07 | 江苏竞诺择生物医药科技有限公司 | Composition de microparticules nano-lipidiques et composition pharmaceutique pour le traitement de maladies prolifératives du système hématopoïétique |
US12065396B2 (en) | 2017-08-17 | 2024-08-20 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
AU2018326799A1 (en) | 2017-08-31 | 2020-02-27 | Modernatx, Inc. | Methods of making lipid nanoparticles |
US12018080B2 (en) | 2017-11-13 | 2024-06-25 | The Broad Institute, Inc. | Methods and compositions for treating cancer by targeting the CLEC2D-KLRB1 pathway |
CN113164623A (zh) | 2018-09-18 | 2021-07-23 | 维恩维纽克公司 | 基于arc的衣壳及其用途 |
WO2020061426A2 (fr) * | 2018-09-21 | 2020-03-26 | Acuitas Therapeutics, Inc. | Systèmes et procédés pour la fabrication de nanoparticules lipidiques et de liposomes |
CA3125485A1 (fr) | 2019-01-11 | 2020-07-16 | Acuitas Therapeutics, Inc. | Lipides pour l'administration de nanoparticules lipidiques d'agents actifs |
WO2020186213A1 (fr) | 2019-03-14 | 2020-09-17 | The Broad Institute, Inc. | Nouveaux modificateurs d'acide nucléique |
WO2020191102A1 (fr) | 2019-03-18 | 2020-09-24 | The Broad Institute, Inc. | Systèmes et protéines crispr de type vii |
US20220220469A1 (en) | 2019-05-20 | 2022-07-14 | The Broad Institute, Inc. | Non-class i multi-component nucleic acid targeting systems |
WO2021055855A1 (fr) | 2019-09-20 | 2021-03-25 | The Broad Institute, Inc. | Compositions et procédés d'administration de charge à une cellule cible |
EP3915544A1 (fr) * | 2020-05-25 | 2021-12-01 | Leon-Nanodrugs GmbH | Procédé de production d'une dispersion de liposomes |
EP3915673A1 (fr) * | 2020-05-25 | 2021-12-01 | Leon-Nanodrugs GmbH | Procédé de vérification de la fonctionnalité d'une installation de fabrication de nanoparticules par remplissage ciblé à partir de solutions sursaturées |
CA3189338A1 (fr) | 2020-07-16 | 2022-01-20 | Acuitas Therapeutics, Inc. | Lipides cationiques destines a etre utilises dans des nanoparticules lipidiques |
DE102020214601A1 (de) * | 2020-11-19 | 2022-05-19 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein | Verfahren und Vorrichtung zur Herstellung einer Flüssigkeit enthaltend Liposomen und hergestellte Flüssigkeit |
WO2022225368A1 (fr) * | 2021-04-22 | 2022-10-27 | (주)인벤티지랩 | Méthode de préparation de nanoparticules lipidiques et appareil de préparation associé |
US20240216278A1 (en) * | 2021-05-05 | 2024-07-04 | Leon-Nanodrugs Gmbh | Methods for producing nanoparticle dispersions |
WO2023196818A1 (fr) | 2022-04-04 | 2023-10-12 | The Regents Of The University Of California | Compositions et procédés de complémentation génétique |
KR102475540B1 (ko) * | 2022-04-26 | 2022-12-08 | 주식회사 무진메디 | 약물이 담지된 지질 나노입자 제조 방법 및 제조 장치 |
KR102474542B1 (ko) | 2022-06-17 | 2022-12-06 | 다온 주식회사 | 무선중계기를 위한 sspa 전력증폭장치 |
WO2024133600A1 (fr) | 2022-12-20 | 2024-06-27 | Nanocell Therapeutics B.V. | Vecteurs viraux à intégration et à auto-inactivation et constructions et utilisations de ceux-ci |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
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US1920008A (en) | 1933-07-25 | of wilmington | ||
US5030453A (en) | 1983-03-24 | 1991-07-09 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
US4895452A (en) * | 1988-03-03 | 1990-01-23 | Micro-Pak, Inc. | Method and apparatus for producing lipid vesicles |
US5032457A (en) * | 1988-03-03 | 1991-07-16 | Micro Vesicular Systems, Inc. | Paucilamellar lipid vesicles using charge-localized, single chain, nonphospholipid surfactants |
IL91664A (en) | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
US5145256A (en) * | 1990-04-30 | 1992-09-08 | Environmental Equipment Corporation | Apparatus for treating effluents |
WO1992002244A1 (fr) | 1990-07-31 | 1992-02-20 | The Liposome Company, Inc. | Accumulation d'acides amines et de peptides dans des liposomes |
US5800833A (en) | 1995-02-27 | 1998-09-01 | University Of British Columbia | Method for loading lipid vesicles |
US5891467A (en) | 1997-01-31 | 1999-04-06 | Depotech Corporation | Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes |
BR0012624B1 (pt) | 1999-07-15 | 2011-08-09 | métodos para a preparação de agentes terapêuticos envolvidos por lipìdeos. | |
US6680068B2 (en) | 2000-07-06 | 2004-01-20 | The General Hospital Corporation | Drug delivery formulations and targeting |
EP1345597B1 (fr) | 2000-12-27 | 2007-10-03 | Ares Trading S.A. | Nanoparticules lipidiques amphiphiles destinees a l'incorporation de peptides et/ou proteines |
WO2002100435A1 (fr) | 2001-06-11 | 2002-12-19 | Centre Hospitalier Universitaire De Montreal | Compositions et methodes permettant de favoriser le transfert d'acide nucleique dans des cellules |
CA2456977C (fr) | 2001-08-16 | 2011-06-07 | The Trustees Of The University Of Pennsylvania | Synthese et utilisation de reactifs pour ameliorer la lipofection d'adn et/ou les therapies par medicaments et promedicaments a liberation lente |
EP2282214B1 (fr) | 2002-05-09 | 2022-10-05 | The University of Chicago | Dispositif et procédé pour le transport de bouchons commandés par pression et réaction |
EP1519714B1 (fr) * | 2002-06-28 | 2010-10-20 | Protiva Biotherapeutics Inc. | Appareil liposomal et procedes de fabrication |
KR20050084607A (ko) | 2002-09-28 | 2005-08-26 | 매사추세츠 인스티튜트 오브 테크놀로지 | 인플루엔자 치료제 |
US20040208921A1 (en) | 2003-01-14 | 2004-10-21 | Ho Rodney J. Y. | Lipid-drug formulations and methods for targeted delivery of lipid-drug complexes to lymphoid tissues |
ES2677868T3 (es) | 2003-10-16 | 2018-08-07 | Nestec S.A. | Composición nutricional frente a los efectos secundarios de la quimioterapia o de la radioterapia |
JP2006153677A (ja) * | 2004-11-30 | 2006-06-15 | Dainippon Screen Mfg Co Ltd | 差圧式流量計、流量制御装置および基板処理装置 |
AU2006227133A1 (en) | 2005-03-22 | 2006-09-28 | Georgetown University | Delivery systems and methods for diagnosing and treating cardiovascular diseases |
WO2007009164A1 (fr) * | 2005-07-15 | 2007-01-25 | Eiffel Technologies Limited | Procede de formation de particules |
US8304849B2 (en) * | 2005-12-29 | 2012-11-06 | Intel Corporation | Apparatus to send biological fluids through a printed wire board |
EP1973837B1 (fr) * | 2005-12-30 | 2017-04-19 | Dermazone Solutions, Inc. | Nanoparticules lipidiques |
US20080171078A1 (en) * | 2007-01-12 | 2008-07-17 | Mark Gray | Uniformly sized liposomes |
US7985058B2 (en) * | 2007-01-12 | 2011-07-26 | Mark Gray | Method and apparatus for making uniformly sized particles |
US8067390B2 (en) | 2007-03-02 | 2011-11-29 | The Board Of Regents Of The University Of Texas System | Therapeutic targeting of interleukins using siRNA in neutral liposomes |
FR2916974B1 (fr) | 2007-06-11 | 2010-11-26 | Univ Angers | Procede de preparation de nanoparticules lipidiques |
US20110038941A1 (en) | 2007-12-27 | 2011-02-17 | The Ohio State University Research Foundation | Lipid Nanoparticle Compositions and Methods of Making and Using the Same |
KR20110009128A (ko) * | 2008-04-04 | 2011-01-27 | 로버트 쇼어 | 미세소관-상호작용 제제를 위한 지질-오일-물 나노에멀젼 전달 시스템 |
JP2010069476A (ja) * | 2008-08-20 | 2010-04-02 | Yunifiido Engineering:Kk | 液体混合装置 |
JP2010075914A (ja) * | 2008-08-25 | 2010-04-08 | National Institute Of Advanced Industrial Science & Technology | 高温高圧マイクロ混合デバイス |
CA2747182C (fr) * | 2008-12-17 | 2014-11-18 | Robert A. Dupuit | Procede de fabrication de petits liposomes |
NO329468B1 (no) * | 2009-01-07 | 2010-10-25 | Framo Eng As | Anordning for tilveiebringelse av en kontrollerbar trykkreduksjon. |
WO2010091192A2 (fr) | 2009-02-04 | 2010-08-12 | The Brigham And Women's Hospital, Inc. | Composés du platine à échelle nanométrique et leurs procédés d'utilisation |
US20100221347A1 (en) * | 2009-02-18 | 2010-09-02 | Ritman Erik L | Enhancing solute transport within a tissue scaffold |
WO2010099884A1 (fr) * | 2009-03-06 | 2010-09-10 | Ehrfeld Mikrotechnik Bts Gmbh | Mélangeur statique compact coaxial et son utilisation |
FR2948035B1 (fr) | 2009-07-20 | 2015-04-24 | Centre Nat Rech Scient | Procede de fabrication de capsules, capsules ainsi obtenues et utilisation desdites capsules |
JP5558883B2 (ja) * | 2010-03-30 | 2014-07-23 | 畑村 洋太郎 | 混合装置、グラデーション混合物及び混合物製造方法 |
EP2558074B1 (fr) * | 2010-04-08 | 2018-06-06 | The Trustees of Princeton University | Préparation de nanoparticules de lipide |
US9693958B2 (en) | 2013-03-15 | 2017-07-04 | Cureport, Inc. | Methods and devices for preparation of lipid nanoparticles |
-
2014
- 2014-03-13 US US14/209,187 patent/US9693958B2/en active Active
- 2014-03-14 WO PCT/US2014/027064 patent/WO2014152200A1/fr active Application Filing
- 2014-03-14 CA CA2898047A patent/CA2898047A1/fr not_active Abandoned
- 2014-03-14 CN CN201480012955.7A patent/CN105188685B/zh active Active
- 2014-03-14 MX MX2015011072A patent/MX2015011072A/es unknown
- 2014-03-14 EP EP14769279.2A patent/EP2968193B1/fr active Active
- 2014-03-14 AU AU2014240013A patent/AU2014240013B2/en active Active
- 2014-03-14 KR KR1020157021385A patent/KR20150127580A/ko not_active Application Discontinuation
- 2014-03-14 JP JP2016502326A patent/JP6450742B2/ja active Active
-
2017
- 2017-06-15 US US15/623,983 patent/US11497715B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2014152200A4 (fr) | 2014-11-13 |
JP6450742B2 (ja) | 2019-01-09 |
US20140348900A1 (en) | 2014-11-27 |
CN105188685A (zh) | 2015-12-23 |
EP2968193A1 (fr) | 2016-01-20 |
AU2014240013A1 (en) | 2015-08-13 |
WO2014152200A1 (fr) | 2014-09-25 |
US11497715B2 (en) | 2022-11-15 |
EP2968193B1 (fr) | 2021-09-01 |
MX2015011072A (es) | 2015-10-22 |
JP2016517423A (ja) | 2016-06-16 |
AU2014240013B2 (en) | 2018-07-12 |
CN105188685B (zh) | 2021-06-15 |
KR20150127580A (ko) | 2015-11-17 |
US9693958B2 (en) | 2017-07-04 |
US20180000735A1 (en) | 2018-01-04 |
EP2968193A4 (fr) | 2016-06-01 |
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