CA2896336C - Compositions and methods for transdermal delivery of non-steroidal anti-inflammatory agents - Google Patents

Compositions and methods for transdermal delivery of non-steroidal anti-inflammatory agents Download PDF

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Publication number
CA2896336C
CA2896336C CA2896336A CA2896336A CA2896336C CA 2896336 C CA2896336 C CA 2896336C CA 2896336 A CA2896336 A CA 2896336A CA 2896336 A CA2896336 A CA 2896336A CA 2896336 C CA2896336 C CA 2896336C
Authority
CA
Canada
Prior art keywords
composition
polymer
nsaid
polymer matrix
acrylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2896336A
Other languages
English (en)
French (fr)
Other versions
CA2896336A1 (en
Inventor
Keita Mori
Puchun Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noven Pharmaceuticals Inc
Original Assignee
Noven Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noven Pharmaceuticals Inc filed Critical Noven Pharmaceuticals Inc
Publication of CA2896336A1 publication Critical patent/CA2896336A1/en
Application granted granted Critical
Publication of CA2896336C publication Critical patent/CA2896336C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2896336A 2012-12-28 2013-12-27 Compositions and methods for transdermal delivery of non-steroidal anti-inflammatory agents Active CA2896336C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261747039P 2012-12-28 2012-12-28
US61/747,039 2012-12-28
PCT/US2013/077927 WO2014106009A1 (en) 2012-12-28 2013-12-27 Compositions and methods for transdermal delivery of non-steroidal anti-inflammatory agents

Publications (2)

Publication Number Publication Date
CA2896336A1 CA2896336A1 (en) 2014-07-03
CA2896336C true CA2896336C (en) 2021-10-19

Family

ID=49956516

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2896336A Active CA2896336C (en) 2012-12-28 2013-12-27 Compositions and methods for transdermal delivery of non-steroidal anti-inflammatory agents

Country Status (13)

Country Link
US (1) US20140188056A1 (enExample)
EP (1) EP2938334A1 (enExample)
JP (1) JP6550337B2 (enExample)
KR (1) KR20150103077A (enExample)
AR (1) AR094290A1 (enExample)
AU (1) AU2013370290A1 (enExample)
CA (1) CA2896336C (enExample)
HK (1) HK1216610A1 (enExample)
IL (1) IL239602A0 (enExample)
MX (1) MX2015008284A (enExample)
PH (1) PH12015501463A1 (enExample)
TW (1) TW201438767A (enExample)
WO (1) WO2014106009A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9314470B2 (en) 2012-12-28 2016-04-19 Noven Pharmaceuticals, Inc. Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol
EP2938335B1 (en) 2012-12-28 2021-03-17 Noven Pharmaceuticals, INC. Multi-polymer compositions for transdermal drug delivery
WO2014159582A1 (en) 2013-03-14 2014-10-02 Noven Pharmaceuticals, Inc Amphetamine transdermal compositions with acrylic block copolymer
AR095259A1 (es) 2013-03-15 2015-09-30 Noven Pharma Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria
AR095260A1 (es) 2013-03-15 2015-09-30 Noven Pharma Composiciones de anfetaminas transdérmicas estables y métodos de fabricación
EP3179989B1 (en) * 2014-07-31 2019-06-12 Noven Pharmaceuticals, INC. Silicone-containing acrylic polymers for transdermal drug delivery compositions
JP6807848B2 (ja) 2015-02-06 2021-01-06 ノーヴェン ファーマシューティカルズ インコーポレイテッド 経皮薬物送達のための感圧粘着剤
US10406116B2 (en) 2015-02-06 2019-09-10 Noven Pharmaceuticals, Inc. Pressure-sensitive adhesives for transdermal drug delivery
JP7531821B2 (ja) * 2015-11-16 2024-08-13 ノーヴェン ファーマシューティカルズ インコーポレイテッド 経皮薬物送達システムのための伸縮可能なバッキング層

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4112177A (en) * 1978-01-23 1978-09-05 Minnesota Mining And Manufacturing Company Porous adhesive tape
JPS5843368B2 (ja) * 1980-10-30 1983-09-27 日東電工株式会社 消炎鎮痛貼付剤
US5656286A (en) * 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5474783A (en) * 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
CA2115840A1 (en) * 1991-08-27 1993-03-04 Tsung-Min Hsu Transdermal formulation for administering prazosin
JP3542814B2 (ja) * 1993-03-09 2004-07-14 積水化学工業株式会社 消炎鎮痛貼付剤
AU6635294A (en) * 1993-04-22 1994-11-08 Minnesota Mining And Manufacturing Company Transdermal antiinflammatory composition
JPH08295624A (ja) * 1995-04-26 1996-11-12 Read Chem Kk プラスター基剤、その製造方法、該基剤を使用した外用貼 付剤
US5976566A (en) * 1997-08-29 1999-11-02 Macrochem Corporation Non-steroidal antiinflammtory drug formulations for topical application to the skin
DE19830649C2 (de) * 1998-07-09 2003-04-10 Lohmann Therapie Syst Lts Topisches Pflaster mit nichtsteroidalen Antirheumatika mit Säuregruppe
JP2000281570A (ja) * 1999-03-30 2000-10-10 Nichiban Co Ltd 経皮投与用貼付剤
US7063859B1 (en) * 1999-04-28 2006-06-20 Noven Pharmaceuticals, Inc. Barrier film lined backing layer composition and method for topical administration of active agents
DE10025890A1 (de) * 2000-05-25 2001-11-29 Euro Celtique Sa Dosierung von transdermalen Arzneimittelsystemen
ITMI20020798A1 (it) * 2002-04-15 2003-10-15 F T Holding S A Cerotti transdermici a matrice adesiva siliconica stabilizzati con copolimeri metacrilici
US20040202704A1 (en) * 2002-08-30 2004-10-14 Watson Pharmaceuticals, Inc. Transdermal delivery systems and methods
RS20060332A (sr) * 2003-10-28 2008-04-04 Noven Pharmaceuticals Inc., Kompozicije i postupci za kontrolisanje gubitka i oslobađanja leka u transdermalnim sistemima oslobađanja leka
US20060078602A1 (en) * 2004-10-08 2006-04-13 Noven Pharmaceuticals, Inc. Device for transdermal administration of drugs including acrylic polymers
ES2385737T3 (es) * 2004-11-10 2012-07-31 Hisamitsu Pharmaceutical Co., Inc. Fármaco para uso externo y parche adhesivo
KR100663163B1 (ko) * 2005-10-24 2007-01-02 (주)아모레퍼시픽 비스테로이드성 소염진통제를 함유하는 경피 투여 제제
US7989496B2 (en) * 2006-10-27 2011-08-02 Noven Pharmaceuticals, Inc. Transdermal delivery of ketoprofen polar derivatives
JP5318639B2 (ja) * 2009-04-08 2013-10-16 株式会社ウェーブロック・アドバンスト・テクノロジー 貼付剤用支持体、及び、貼付剤

Also Published As

Publication number Publication date
US20140188056A1 (en) 2014-07-03
CA2896336A1 (en) 2014-07-03
TW201438767A (zh) 2014-10-16
EP2938334A1 (en) 2015-11-04
AU2013370290A1 (en) 2015-07-16
AR094290A1 (es) 2015-07-22
PH12015501463A1 (en) 2015-09-21
HK1216610A1 (zh) 2016-11-25
MX2015008284A (es) 2015-12-03
JP2016504367A (ja) 2016-02-12
KR20150103077A (ko) 2015-09-09
JP6550337B2 (ja) 2019-07-24
WO2014106009A1 (en) 2014-07-03
IL239602A0 (en) 2015-08-31

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Effective date: 20181212