CA2895791A1 - Methods, compositions, kits, and systems for selective enrichment of target cells - Google Patents

Methods, compositions, kits, and systems for selective enrichment of target cells Download PDF

Info

Publication number
CA2895791A1
CA2895791A1 CA2895791A CA2895791A CA2895791A1 CA 2895791 A1 CA2895791 A1 CA 2895791A1 CA 2895791 A CA2895791 A CA 2895791A CA 2895791 A CA2895791 A CA 2895791A CA 2895791 A1 CA2895791 A1 CA 2895791A1
Authority
CA
Canada
Prior art keywords
cell
cells
target cell
subpopulation
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2895791A
Other languages
English (en)
French (fr)
Inventor
James Lim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xcell Biosciences Inc
Original Assignee
Xcell Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xcell Biosciences Inc filed Critical Xcell Biosciences Inc
Priority to CA3106271A priority Critical patent/CA3106271A1/en
Publication of CA2895791A1 publication Critical patent/CA2895791A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Sustainable Development (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2895791A 2013-01-25 2014-01-24 Methods, compositions, kits, and systems for selective enrichment of target cells Abandoned CA2895791A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3106271A CA3106271A1 (en) 2013-01-25 2014-01-24 Methods, compositions, kits, and systems for selective enrichment of target cells

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361756993P 2013-01-25 2013-01-25
US61/756,993 2013-01-25
US201361760626P 2013-02-04 2013-02-04
US61/760,626 2013-02-04
PCT/US2014/013048 WO2014117021A2 (en) 2013-01-25 2014-01-24 Methods, compositions, kits, and systems for selective enrichment of target cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3106271A Division CA3106271A1 (en) 2013-01-25 2014-01-24 Methods, compositions, kits, and systems for selective enrichment of target cells

Publications (1)

Publication Number Publication Date
CA2895791A1 true CA2895791A1 (en) 2014-07-31

Family

ID=51223330

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2895791A Abandoned CA2895791A1 (en) 2013-01-25 2014-01-24 Methods, compositions, kits, and systems for selective enrichment of target cells
CA3106271A Abandoned CA3106271A1 (en) 2013-01-25 2014-01-24 Methods, compositions, kits, and systems for selective enrichment of target cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3106271A Abandoned CA3106271A1 (en) 2013-01-25 2014-01-24 Methods, compositions, kits, and systems for selective enrichment of target cells

Country Status (8)

Country Link
US (2) US9857360B2 (https=)
EP (1) EP2948776B8 (https=)
JP (1) JP6509745B2 (https=)
CN (2) CN104956226B (https=)
AU (1) AU2014209218B2 (https=)
CA (2) CA2895791A1 (https=)
GB (1) GB2516196B (https=)
WO (1) WO2014117021A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109738309A (zh) * 2019-01-31 2019-05-10 河北超威电源有限公司 基于数值分析的铅炭动力电池极板检测方法

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102012213838A1 (de) * 2012-08-03 2014-02-06 Katharina Pachmann Verfahren zur Kultivierung einer Subpopulation zirkulierender epithelialer Tumorzellen aus einer Körperflüssigkeit
WO2016081554A1 (en) * 2014-11-18 2016-05-26 Neostem Oncology, Llc Immunogenic compositions prepared from tumor cells derived from peripheral blood and originating from a solid tumor and their use
US11319523B2 (en) 2015-03-31 2022-05-03 Thrive Bioscience, Inc. Automated cell culture incubator
US10696937B2 (en) 2015-03-31 2020-06-30 Thrive Bioscience, Inc. Cell culture incubators with integrated cell manipulation systems
WO2016168687A1 (en) * 2015-04-17 2016-10-20 Xcell Biosciences, Inc. Cancer cell enrichment system
AU2016331926B2 (en) 2015-10-01 2021-12-09 Berkeley Lights, Inc. Well-plate incubator
AU2016341938B2 (en) * 2015-10-20 2022-12-01 Celcuity Inc. Methods of preparing a primary cell sample
CN105842444A (zh) * 2015-11-22 2016-08-10 李静 一种子宫内膜癌特异性检测的试剂盒
CN108884445A (zh) 2016-03-09 2018-11-23 北京智康博药肿瘤医学研究有限公司 肿瘤细胞悬浮培养物和相关方法
JP6485783B2 (ja) * 2016-09-29 2019-03-20 住友ゴム工業株式会社 医療用検査装置及び細胞検査方法
US10941374B2 (en) 2016-09-29 2021-03-09 Sumitomo Rubber Industries, Ltd. Medical analysis device and cell analysis method
JP6779483B2 (ja) 2016-09-29 2020-11-04 住友ゴム工業株式会社 医療用検査装置及び細胞検査方法
WO2018218485A1 (en) * 2017-05-31 2018-12-06 Beijing Percans Oncology Co. Ltd. Epithelial tumor cell cultures
WO2018090375A1 (en) * 2016-11-21 2018-05-24 Beijing Percans Oncology Co. Ltd. Epithelial tumor cell cultures
CA3045898A1 (en) * 2016-12-01 2018-06-07 Berkeley Lights, Inc. Well-plate incubator
IT201700024609A1 (it) * 2017-03-06 2018-09-06 Mollace Vincenzo Metodo e kit per la diagnosi e/o prognosi di tumori non ematologici
TWI616526B (zh) * 2017-05-15 2018-03-01 Cell separation and purification device
WO2019040646A2 (en) * 2017-08-24 2019-02-28 Nano Global Corp. DETECTION OF BIOLOGICAL CELLS OR BIOLOGICAL SUBSTANCES
KR101996218B1 (ko) * 2017-09-05 2019-10-01 주식회사 싸이토젠 Axl 기반 암환자 스크리닝 방법
JP7110360B2 (ja) 2017-10-09 2022-08-01 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー 凍結乾燥方法
WO2019090355A1 (en) * 2017-11-06 2019-05-09 Children's National Medical Center Cells expressing antibodies and methods of treatment using the same
CN111630604A (zh) * 2017-11-20 2020-09-04 纳诺全球公司 基于生物细胞或生物物质的检测的数据收集和分析
CN107858433B (zh) * 2017-12-15 2019-01-25 武汉迈特维尔生物科技有限公司 一种用于检测精原细胞瘤的试剂盒
US11365390B2 (en) 2017-12-19 2022-06-21 Xcell Biosciences, Inc. Methods of modulating cell phenotype by way of regulating the gaseous environment
JP7109719B2 (ja) 2018-02-14 2022-08-01 住友ゴム工業株式会社 特定細胞捕捉方法
CN108641956A (zh) * 2018-06-19 2018-10-12 张起 一种贴壁型细胞培养系统
CN109593720A (zh) * 2018-11-20 2019-04-09 叶春玲 一种永生化人鳞状乳头型颅咽管瘤细胞株及其应用
US12220465B2 (en) * 2018-11-28 2025-02-11 Washington University Compositions and methods for targeted treatment and imaging of cancer or tumors
US20220023255A1 (en) * 2018-12-07 2022-01-27 The Johns Hopkins University Methods, compositions and kits for treating multiple sclerosis and other disorders
CN109652376B (zh) * 2019-01-08 2021-10-15 创芯国际生物科技(广州)有限公司 一种用于卵巢癌组织3d培养的培养基
US11614440B2 (en) 2019-01-24 2023-03-28 Sumitomo Rubber Industries, Ltd. Specific cell fractionating and capturing methods
WO2020159879A2 (en) * 2019-01-28 2020-08-06 Nano Global Corp. Amelioration based on detection of biological cells or biological substances
CN111487404B (zh) * 2019-01-28 2024-01-05 猎源（上海）生物医药科技有限公司 体液肿瘤细胞dna提取试剂盒
CN113614477B (zh) 2019-03-14 2023-04-28 泰尔茂比司特生物技术有限公司 冷冻干燥装载托盘组件及系统
CN111751543A (zh) * 2019-03-27 2020-10-09 南方医科大学南方医院 一种稀有肿瘤细胞富集方法及试剂盒
EP3962604A4 (en) * 2019-04-30 2023-02-08 Xcell Biosciences Inc. SYSTEMS AND METHODS FOR MODULATION OF A CELL PHENOTYPE
TWI790399B (zh) * 2019-08-30 2023-01-21 長庚大學 循環腫瘤細胞資訊評估方法及其分析方法
DE112021001571T5 (de) * 2020-03-12 2022-12-29 eXo Cell, LLC Verfahren und Systeme für Transport und Kultivierung von schwimmfähigem Gewebe
KR102400263B1 (ko) * 2020-04-08 2022-05-20 이엔셀 주식회사 줄기세포 초기 수율 촉진을 위한 줄기세포 배양 방법
CN111754457B (zh) * 2020-05-15 2023-08-18 中山大学 一种基于角膜共聚焦图像的菌丝筛查系统
CN113025712A (zh) * 2021-02-09 2021-06-25 中国人民解放军海军军医大学 一种检测肿瘤干细胞中遗传和表观遗传变化的方法
CN113981148A (zh) * 2021-11-18 2022-01-28 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 一种鉴别rv感染以及鉴定病毒基因型的方法及其应用
CN115170848B (zh) * 2022-06-08 2025-12-19 皖南医学院第一附属医院（皖南医学院弋矶山医院） 一种基于骨髓活检图像的造血组织比例确定方法
CN117448270B (zh) * 2023-12-22 2024-07-26 上海元戊医学技术有限公司 一种高效诱导多能干细胞分化为中脑多巴胺能神经前体细胞的方法

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034062A (en) 1975-03-20 1977-07-05 Borden, Inc. Removal of oxygen from gas stream with copper catalyst
US5330915A (en) 1991-10-18 1994-07-19 Endotronics, Inc. Pressure control system for a bioreactor
US6322989B1 (en) 1991-11-25 2001-11-27 Yoreh Biotechnologies, Ltd. Whole blood/mitogen assay for the early detection of a subject with ovarian or breast cancer and kit
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US5922687A (en) 1995-05-04 1999-07-13 Board Of Trustees Of The Leland Stanford Junior University Intracellular delivery of nucleic acids using pressure
US5882914A (en) * 1995-06-06 1999-03-16 The Johns Hopkins University School Of Medicine Nucleic acids encoding the hypoxia inducible factor-1
US20040072722A1 (en) 2002-10-10 2004-04-15 Kornblith Paul L. Methods for assessing efficacy of chemotherapeutic agents
AU1198599A (en) 1997-10-24 1999-05-17 Neorx Corporation Delivery vehicles for bioactive agents and uses thereof
US7282350B2 (en) 1998-02-12 2007-10-16 Immunivest Corporation Labeled cell sets for use as functional controls in rare cell detection assays
WO1999041613A1 (en) 1998-02-12 1999-08-19 Immunivest Methods and reagents for the rapid and efficient isolation of circulating cancer cells
WO1999047922A2 (en) 1998-03-18 1999-09-23 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
US6184035B1 (en) * 1998-11-18 2001-02-06 California Institute Of Technology Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells
US6610540B1 (en) * 1998-11-18 2003-08-26 California Institute Of Technology Low oxygen culturing of central nervous system progenitor cells
US8131053B2 (en) 1999-01-25 2012-03-06 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
US6656683B1 (en) 2000-07-05 2003-12-02 Board Of Regents, The University Of Texas System Laser scanning cytology with digital image capture
CA2422162C (en) 2000-09-09 2012-10-23 The Research Foundation Of State University Of New York Method and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof
US20040151705A1 (en) 2002-03-22 2004-08-05 Shuichi Mizuno Neo-cartilage constructs and a method for preparation thereof
US7863012B2 (en) 2004-02-17 2011-01-04 Veridex, Llc Analysis of circulating tumor cells, fragments, and debris
US20030092178A1 (en) 2001-11-15 2003-05-15 Biospherix, Ltd. Cell culture incubator with dynamic oxygen control
US20050244843A1 (en) 2001-11-16 2005-11-03 Wen-Tien Chen Blood test prototypes and methods for the detection of circulating tumor and endothelial cells
US7435587B2 (en) * 2002-03-01 2008-10-14 Memorial Sloan-Kettering Cancer Center Apparatus for growing cells under variable hydrostatic pressures
AU2003242815A1 (en) 2002-03-13 2003-09-22 Biomerieux Method for the characterisation of circulating tumour cells stemming from solid cancers
JP2004180675A (ja) 2002-11-19 2004-07-02 Sanyo Electric Co Ltd インキュベータ
US7367550B2 (en) 2003-11-18 2008-05-06 Massachusetts Institute Of Technology Peristaltic mixing and oxygenation system
US8106258B2 (en) 2003-12-23 2012-01-31 Monsanto Technology Llc Use of a low-oxygen environment in plant transformation
GB0403611D0 (en) 2004-02-18 2004-03-24 Univ Glasgow Analysis of cell morphology and motility
PT1773978E (pt) 2004-05-19 2014-05-29 Massachusetts Inst Technology Modelo de doença com células/tecidos tri-dimensionais perfundidos
US7629128B2 (en) 2004-08-30 2009-12-08 Prolx Pharmaceuticals Corp. Methods of identifying respondents to hypoxia inducible factor 1-α inhibitors
US20060094109A1 (en) 2004-11-02 2006-05-04 Immunivest Corporation Device and method for analytical cell imaging
JP4913727B2 (ja) 2005-03-18 2012-04-11 株式会社日本触媒 酸素除去触媒および当該触媒を用いた酸素除去方法
US7476541B1 (en) 2005-03-29 2009-01-13 Timothy F. Dutra Bioreactor system and method for the production and collection of blood cells from engineered bone marrow tissue
US20070026417A1 (en) 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
WO2006108229A1 (en) * 2005-04-12 2006-10-19 Angioblast Systems, Inc. Isolation of adult multipotential cells by tissue non-specific alkaline phosphatase
JP4744187B2 (ja) 2005-05-10 2011-08-10 オリンパス株式会社 細胞観察装置
WO2007012071A1 (en) 2005-07-20 2007-01-25 Government Of The United States Of America, As Represented By The Secretary, Department Of Health Bioreactor device, and method and system for fabricating tissues in the bioreactor device
EP1984030B1 (en) 2006-01-30 2013-05-08 The Scripps Research Institute Methods for detection of circulating tumor cells and methods of diagnosis of cancer in a mammalian subject
US7850983B2 (en) * 2006-02-07 2010-12-14 Spinalcyte, Llc Methods and compositions for repair of cartilage using an in vivo bioreactor
JP2009529880A (ja) 2006-03-13 2009-08-27 ベリデックス・エルエルシー 原発細胞の増殖
US20090304644A1 (en) 2006-05-30 2009-12-10 Cytori Therapeutics, Inc. Systems and methods for manipulation of regenerative cells separated and concentrated from adipose tissue
MX2008015425A (es) 2006-06-02 2008-12-12 Pfizer Prod Inc Ensayo de celulas tumorales circulantes.
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
JP5254226B2 (ja) 2006-07-14 2013-08-07 エクセレレックス インク． 環境保護用収容システム
US7735670B2 (en) 2006-10-17 2010-06-15 Honeywell International Inc. Oxygen removal system
US20100216168A1 (en) 2007-03-23 2010-08-26 Precision Therapeutics, Inc. Methods for evaluating angiogenic potential in culture
EP2626416A3 (en) 2007-04-07 2013-12-18 The Whitehead Institute for Biomedical Research Reprogramming of somatic cells
US20100233694A1 (en) 2007-04-16 2010-09-16 On-O-ity, Inc Devices and methods for diagnosing, prognosing, or theranosing a condition by enriching rare cells
US10590391B2 (en) 2007-06-08 2020-03-17 Wake Forest University Health Sciences Selective cell therapy for the treatment of renal failure
WO2008156708A2 (en) 2007-06-15 2008-12-24 Massachusetts Institute Of Technology Methods and compositions for enhanced differentiation from embryonic stem cells
GB0713121D0 (en) 2007-07-06 2007-08-15 Univ Keele Refrigerated gas equilibration device
US8303522B2 (en) 2007-10-18 2012-11-06 The Curators Of The University Of Missouri Device for transfecting cells using shock waves generated by the ignition of nanoenergetic materials
US8071395B2 (en) 2007-12-12 2011-12-06 The Board Of Trustees Of The Leland Stanford Junior University Methods and apparatus for magnetic separation of cells
US20090186006A1 (en) * 2008-01-16 2009-07-23 Murphy Michael P Placental vascular lobule stem cells
WO2010013845A1 (en) 2008-07-30 2010-02-04 Kyoto University Method of efficiently establishing induced pluripotent stem cells
CA2736178A1 (en) 2008-09-05 2010-03-11 Peter Kuhn Methods for the detection of circulating tumor cells
KR102428795B1 (ko) * 2008-11-12 2022-08-04 인리젠 분리된 신장 세포 및 이의 용도
GB201111244D0 (en) * 2011-06-30 2011-08-17 Konink Nl Akademie Van Wetenschappen Knaw Culture media for stem cells
KR101109125B1 (ko) * 2009-03-24 2012-02-15 한국과학기술연구원 줄기세포를 혈관세포로 분화시키는 방법 및 이를 이용한 생체 내 혈관신생 유도
US20120100538A1 (en) 2009-03-24 2012-04-26 Biocept, Inc. Devices and methods of cell capture and analysis
US20120141547A1 (en) 2009-04-03 2012-06-07 Feng Zhao Methods of making cell sheets, tissue sheets and tissue engineered blood vessels
US8551425B2 (en) 2009-05-20 2013-10-08 California Institute Of Technology Method for cancer detection, diagnosis and prognosis
HRP20180594T1 (hr) 2009-07-10 2018-08-10 Histogen, Inc. Pripravci od kondicioniranog medija i izvanstaničnog matriksa iz stanica uzgajanih u hipoksičnim uvjetima
US8501397B2 (en) * 2009-07-24 2013-08-06 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Enrichment of stem cells from adult tissues
US8900860B2 (en) * 2009-11-30 2014-12-02 National Yang-Ming University Method for expanding mesenchymal stem cells in low-density and hypoxic culture
WO2011113036A2 (en) 2010-03-12 2011-09-15 Whitehead Institute For Biomedical Research Compositions and methods for expanding bfu-e cells
JP5703302B2 (ja) 2010-09-08 2015-04-15 株式会社島津製作所 細胞培養容器及びその容器を用いた細胞培養方法
EP2638149B1 (en) 2010-11-12 2019-05-15 Georgetown University Immortalization of epithelial cells and methods of use
US9404986B2 (en) * 2011-05-06 2016-08-02 The Regents Of The University Of California Measuring biological tissue parameters using diffusion magnetic resonance imaging
EP2809333B1 (en) 2012-02-03 2017-08-16 Technische Universität München - Klinikum Rechts der Isar Device-based methods for localised delivery of cell-free carriers with stress-induced cellular factors
RU2696071C2 (ru) 2012-04-24 2019-07-30 Виселл Терапеутикс, Инк. Получение плюрипотентных клеток de novo
US9447378B2 (en) 2012-04-27 2016-09-20 Massachusetts Institute Of Technology Method for differentiating human embryonic stem cells into β-cells for the treatment of type I diabetes
CN103014118B (zh) * 2013-01-10 2014-05-14 贵州大学 一种用于抗癌药物筛选的细胞共培养方法
CN103387963B (zh) * 2013-08-12 2015-05-20 厦门大学附属中山医院 一株Ming氏人膨胀型胃癌细胞系及其应用
US10428300B2 (en) 2013-10-15 2019-10-01 Hitachi, Ltd. Cell culturing device
US20150247112A1 (en) 2014-03-03 2015-09-03 Kiyatec Inc. 3D Tissue Culture Devices and Systems

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109738309A (zh) * 2019-01-31 2019-05-10 河北超威电源有限公司 基于数值分析的铅炭动力电池极板检测方法
CN109738309B (zh) * 2019-01-31 2021-07-20 河北超威电源有限公司 基于数值分析的铅炭动力电池极板检测方法

Also Published As

Publication number Publication date
GB201419892D0 (en) 2014-12-24
GB2516196A8 (en) 2015-02-18
AU2014209218B2 (en) 2018-06-07
US9857360B2 (en) 2018-01-02
WO2014117021A3 (en) 2014-10-09
EP2948776B1 (en) 2019-12-04
EP2948776A2 (en) 2015-12-02
CN104956226B (zh) 2018-02-02
US20180267025A1 (en) 2018-09-20
CN108165603A (zh) 2018-06-15
WO2014117021A2 (en) 2014-07-31
GB2516196A (en) 2015-01-14
JP2016514950A (ja) 2016-05-26
AU2014209218A1 (en) 2015-07-02
JP6509745B2 (ja) 2019-05-08
EP2948776B8 (en) 2020-02-26
CA3106271A1 (en) 2014-07-31
US20140212895A1 (en) 2014-07-31
EP2948776A4 (en) 2016-08-24
CN104956226A (zh) 2015-09-30
GB2516196B (en) 2015-09-09

Similar Documents

Publication Publication Date Title
EP2948776B1 (en) Methods, compositions, kits, and systems for selective enrichment of target cells
Visan et al. Comparative analysis of tangential flow filtration and ultracentrifugation, both combined with subsequent size exclusion chromatography, for the isolation of small extracellular vesicles
Faruqu et al. Preparation of exosomes for siRNA delivery to cancer cells
Wu et al. Immune tolerance of embryo implantation and pregnancy: the role of human decidual stromal cell-and embryonic-derived extracellular vesicles
Wong et al. Orchestrated intron retention regulates normal granulocyte differentiation
Lock et al. Macrophages enhance contractile force in iPSC-derived human engineered cardiac tissue
Han et al. Extracellular vesicles in the tumor microenvironment: Therapeutic resistance, clinical biomarkers, and targeting strategies
Mao et al. The molecular mechanisms of HLA-G regulatory function on immune cells during early pregnancy
Gorczyca et al. The Molecular Quality and Mitochondrial Activity of Porcine Cumulus–Oocyte Complexes Are Affected by Their Exposure to Three Endocrine-Active Compounds under 3D In Vitro Maturation Conditions
Rahbari et al. Exosomes: novel implications in diagnosis and treatment of gastrointestinal cancer
KR20130024904A (ko) 암 조직 유래 세포괴 또는 암 세포 응집괴의 약제 또는 방사선 감수성 평가 방법
Wang et al. Diagnosis of invasive nonfunctional pituitary adenomas by serum extracellular vesicles
Moccia et al. Extracellular vesicles in veterinary medicine
Liao et al. Stereo-cell: Spatial enhanced-resolution single-cell sequencing with high-density DNA nanoball-patterned arrays
Xie et al. Differential expression pattern of goat uterine fluids extracellular vesicles miRNAs during peri-implantation
Smieszek et al. Obesity affects the proliferative potential of equine endometrial progenitor cells and modulates their molecular phenotype associated with mitochondrial metabolism
Clausen et al. Guidelines for mouse and human DC functional assays
Sani et al. Unveiling exosomes: cutting‐edge isolation techniques and their therapeutic potential
Makowiecka et al. Changes in biomechanical properties of A375 cells due to the silencing of TMSB4X expression are not directly correlated with alterations in their stemness features
EP3425043A1 (en) Regularly arranged spheroids having uniform size, and use thereof
JP5809782B2 (ja) 癌組織由来細胞塊または癌細胞凝集塊の薬剤または放射線感受性評価方法
Huang et al. Busulfan Chemotherapy Downregulates TAF7/TNF-α Signaling in Male Germ Cell Dysfunction
US10012647B2 (en) Depletion of mouse cells for isolation of human cells
Palethorpe et al. An optimized explant Organoid Method for Preclinical Brain Tumor Research
US20260055431A1 (en) Methods of delivering components to microorganospheres

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20190122

FZDE Discontinued

Effective date: 20220118