CA2895077A1 - In vivo delivery of oligonucleotides - Google Patents
In vivo delivery of oligonucleotides Download PDFInfo
- Publication number
- CA2895077A1 CA2895077A1 CA2895077A CA2895077A CA2895077A1 CA 2895077 A1 CA2895077 A1 CA 2895077A1 CA 2895077 A CA2895077 A CA 2895077A CA 2895077 A CA2895077 A CA 2895077A CA 2895077 A1 CA2895077 A1 CA 2895077A1
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- oligonucleotide
- hes
- nucleic acid
- disease
- mirna
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| MX347361B (es) | 2011-07-19 | 2017-04-12 | Wave Life Sciences Ltd | Metodos para la sintesis de acidos nucleicos funcionalizados. |
| KR20140091688A (ko) | 2011-10-06 | 2014-07-22 | 미라젠 세러퓨틱스 인코포레이티드 | 마이크로rna 조절에 의한 전신 에너지 항상성의 제어 |
| CA2895077A1 (en) * | 2011-12-12 | 2013-06-20 | Beverly Packard | In vivo delivery of oligonucleotides |
| CA2876180C (en) | 2012-06-21 | 2019-11-19 | MiRagen Therapeutics, Inc. | Oligonucleotide-based inhibitors comprising locked nucleic acid motif |
| RU2674600C2 (ru) * | 2012-07-03 | 2018-12-11 | Просенса Текнолоджиз Б.В. | Олигонуклеотид для лечения пациентов с мышечной дистрофией |
| EP2872147B1 (en) | 2012-07-13 | 2022-12-21 | Wave Life Sciences Ltd. | Method for making chiral oligonucleotides |
| EP2872485B1 (en) | 2012-07-13 | 2020-12-16 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
| US10947543B2 (en) * | 2013-03-13 | 2021-03-16 | Yale University | Interferon production using short RNA duplexes |
| JP7011389B2 (ja) * | 2013-06-12 | 2022-01-26 | オンコイミューニン，インコーポレイティド | オリゴヌクレオチドの全身性イン－ビボ送達 |
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| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| CN106068325B (zh) | 2014-01-16 | 2021-07-09 | 波涛生命科学有限公司 | 手性设计 |
| US10119140B2 (en) | 2014-04-18 | 2018-11-06 | Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Reno | Methods for enhancing or decreasing the levels of MIR124 and MIR29 in subjects with muscular dystrophy |
| PL3143123T3 (pl) * | 2014-05-16 | 2020-07-13 | The Trustees Of The University Of Pennsylvania | Indukcja regeneracji serca za pomocą mikroRNA |
| SG11201705907XA (en) | 2015-01-20 | 2017-08-30 | Miragen Therapeutics Inc | Mir-92 inhibitors and uses thereof |
| JP7511326B2 (ja) * | 2015-10-09 | 2024-07-05 | ウェイブ ライフ サイエンシズ リミテッド | オリゴヌクレオチド組成物およびその方法 |
| WO2018065390A1 (en) * | 2016-10-04 | 2018-04-12 | Vib Vzw | Means and methods to treat inflammatory diseases |
| WO2019246450A1 (en) | 2018-06-20 | 2019-12-26 | Yale University | Rig-i agonists and treatments using same |
| WO2020181130A2 (en) * | 2019-03-05 | 2020-09-10 | MiRagen Therapeutics, Inc. | Polynucleotide conjugates and uses thereof |
| WO2020206115A2 (en) * | 2019-04-03 | 2020-10-08 | Bristol-Myers Squibb Company | Angptl2 antisense oligonucleotides and uses thereof |
| JP7692829B2 (ja) * | 2019-07-30 | 2025-06-16 | 塩野義製薬株式会社 | Ｍｕｒｆ１を標的とする核酸医薬 |
| JP2023509979A (ja) * | 2020-01-11 | 2023-03-10 | オンコイミューニン，インコーポレイティド | オリゴヌクレオチドの標的化及び局所インビボ送達 |
| US11786545B2 (en) | 2020-12-09 | 2023-10-17 | Yale University | Compositions and methods for treating SARS-CoV-2 infection |
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| WO2022232223A1 (en) * | 2021-04-28 | 2022-11-03 | The Johns Hopkins University | Treating cancer |
| CN113975397B (zh) * | 2021-10-26 | 2023-08-22 | 中南大学湘雅三医院 | 一种基因/小分子化合物纳米递药系统及其制备方法与应用 |
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| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US4500707A (en) | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US5132418A (en) | 1980-02-29 | 1992-07-21 | University Patents, Inc. | Process for preparing polynucleotides |
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US4668777A (en) | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
| US4973679A (en) | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
| US4415732A (en) | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
| US5023243A (en) | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
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| US7977321B2 (en) * | 2008-02-12 | 2011-07-12 | University Of Tennessee Research Foundation | Small interfering RNAs targeting feline herpes virus |
| EA037404B1 (ru) | 2008-11-10 | 2021-03-24 | Арбутус Биофарма Корпорэйшн | Липиды и композиции для доставки лекарственных средств |
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| CA3042927C (en) | 2009-05-05 | 2022-05-17 | Arbutus Biopharma Corporation | Lipid compositions for the delivery of therapeutic agents |
| AU2010324658A1 (en) * | 2009-11-26 | 2012-05-03 | Quark Pharmaceuticals, Inc. | siRNA compounds comprising terminal substitutions |
| WO2011072082A2 (en) * | 2009-12-09 | 2011-06-16 | Nitto Denko Corporation | Modulation of hsp47 expression |
| CA2895077A1 (en) * | 2011-12-12 | 2013-06-20 | Beverly Packard | In vivo delivery of oligonucleotides |
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2012
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- 2012-12-12 DK DK12858522.1T patent/DK2790736T3/en active
- 2012-12-12 EP EP12858522.1A patent/EP2790736B1/en active Active
- 2012-12-12 WO PCT/US2012/069294 patent/WO2013090457A2/en not_active Ceased
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2019
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2022
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2024
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| JP2015502365A (ja) | 2015-01-22 |
| US20240401040A1 (en) | 2024-12-05 |
| US20200109403A1 (en) | 2020-04-09 |
| EP2790736B1 (en) | 2018-01-31 |
| US20160040161A1 (en) | 2016-02-11 |
| US10557136B2 (en) | 2020-02-11 |
| WO2013090457A3 (en) | 2014-09-04 |
| DK2790736T3 (en) | 2018-05-07 |
| EP2790736A2 (en) | 2014-10-22 |
| EP2790736A4 (en) | 2015-09-23 |
| US11261443B2 (en) | 2022-03-01 |
| WO2013090457A2 (en) | 2013-06-20 |
| JP2019073548A (ja) | 2019-05-16 |
| US20220170017A1 (en) | 2022-06-02 |
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| FZDE | Discontinued |
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