CA2889770A1 - Trans-clomiphene for use in cancer therapy - Google Patents
Trans-clomiphene for use in cancer therapy Download PDFInfo
- Publication number
- CA2889770A1 CA2889770A1 CA2889770A CA2889770A CA2889770A1 CA 2889770 A1 CA2889770 A1 CA 2889770A1 CA 2889770 A CA2889770 A CA 2889770A CA 2889770 A CA2889770 A CA 2889770A CA 2889770 A1 CA2889770 A1 CA 2889770A1
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- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| US201261722013P | 2012-11-02 | 2012-11-02 | |
| US61/722,013 | 2012-11-02 | ||
| PCT/US2013/066141 WO2014070523A1 (en) | 2012-11-02 | 2013-10-22 | Trans-clomiphene for use in cancer therapy |
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| CA2889770A1 true CA2889770A1 (en) | 2014-05-08 |
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| CA2889770A Abandoned CA2889770A1 (en) | 2012-11-02 | 2013-10-22 | Trans-clomiphene for use in cancer therapy |
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| US (1) | US9687458B2 (enExample) |
| EP (1) | EP2914294A1 (enExample) |
| JP (3) | JP2015535283A (enExample) |
| CN (1) | CN104994877A (enExample) |
| AU (1) | AU2013338311A1 (enExample) |
| CA (1) | CA2889770A1 (enExample) |
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| IL (1) | IL238453A0 (enExample) |
| MX (1) | MX2015005160A (enExample) |
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Cited By (1)
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| WO2017081171A1 (en) | 2015-11-10 | 2017-05-18 | Paracrine Therapeutics Ab | Treatment of er-negative breast cancer with an pdgf-cc inhibitor and an anti estrogen |
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| WO2016022325A1 (en) * | 2014-08-05 | 2016-02-11 | The Penn State Research Foundation | Novel triarylethylene compounds and methods using same |
| JP2018002619A (ja) * | 2016-06-29 | 2018-01-11 | 国立大学法人 東京大学 | オートファジー阻害剤 |
| EP3515424A4 (en) * | 2016-09-26 | 2020-05-06 | Repros Therapeutics Inc. | ANTI-ESTROGEN AND / OR AROMATASE INHIBITORS FOR USE IN THE TREATMENT OF ADIPOSITAS AND RELATED SYMPTOMS |
| CN108420806A (zh) * | 2017-02-15 | 2018-08-21 | 武汉华杰世纪生物医药有限公司 | 具有靶向性的抗肿瘤药物 |
| WO2019236209A2 (en) * | 2018-04-27 | 2019-12-12 | Jin Byung Ju | Methods for high-content drug screening |
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| US2914563A (en) | 1957-08-06 | 1959-11-24 | Wm S Merrell Co | Therapeutic composition |
| IT951631B (it) | 1971-03-18 | 1973-07-10 | Richardson Merrell Spa | Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi |
| US4061733A (en) | 1976-10-15 | 1977-12-06 | Narayan Vishwanath Gunjikar | Veterinary compositions for inducing estrus in animals and method |
| US4729999A (en) | 1984-10-12 | 1988-03-08 | Bcm Technologies | Antiestrogen therapy for symptoms of estrogen deficiency |
| EP0206021B1 (de) | 1985-06-08 | 1988-08-10 | ASTA Pharma AG | Neue Derivate des 1,1,2,2-Tetramethyl-1,2-bis-(2-fluor-4-hydroxyphenyl)-ethans |
| US4820736A (en) | 1987-03-20 | 1989-04-11 | Yale University | Use of clomiphene to predict fertility in a human female |
| US5681585A (en) | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| ES2112994T3 (es) | 1992-09-15 | 1998-04-16 | Merrell Pharma Inc | Analogos de clomifeno no metabolizables utilizados en el tratamiento de tumores resistentes al tamoxifeno. |
| US5776923A (en) | 1993-01-19 | 1998-07-07 | Endorecherche, Inc. | Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone |
| GB9405304D0 (en) | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| JPH10501814A (ja) | 1994-06-17 | 1998-02-17 | ユニバーシティ・オブ・ネブラスカ・ボード・オブ・リージェンツ | 生物的作用物質用のイン・シツゲル形成デリバリービヒクルおよびその使用方法 |
| DE4435368A1 (de) | 1994-09-22 | 1996-03-28 | Schering Ag | Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann |
| DE69617245T2 (de) | 1995-08-17 | 2002-07-25 | Csir, Pretoria | Produkte mit gesteuerter freisetzung |
| US5773031A (en) | 1996-02-27 | 1998-06-30 | L. Perrigo Company | Acetaminophen sustained-release formulation |
| IL120262A (en) | 1996-02-28 | 2001-01-28 | Pfizer | Droloxifene and derivatives thereof for use in increasing serum testosterone levels |
| CA2269806C (en) | 1996-10-28 | 2006-01-24 | Bernhard H. Van Lengerich | Embedding and encapsulation of controlled release particles |
| DE69826994T2 (de) | 1997-04-03 | 2005-12-08 | Guilford Pharmaceuticals Inc. | Bioabbaubare Terephthalat Polyester-Polyphosphat Polymere, Zusammensetzungen, Gegenstände und Verfahren für ihre Herstellung und Verwendung |
| US6653297B1 (en) | 1997-07-03 | 2003-11-25 | Medical College Of Hampton Roads | Control of selective estrogen receptor modulators |
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| US20040176470A1 (en) | 1998-05-07 | 2004-09-09 | Steiner Mitchell S. | Method for treatment and chemoprevention of prostate cancer |
| US6413533B1 (en) | 1998-05-07 | 2002-07-02 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
| EP1100330A4 (en) | 1998-07-30 | 2004-04-14 | Stoller Ets | TREATMENT OF PLANTS WITH SALICYLIC ACID AND ORGANIC AMINES |
| ATE355279T1 (de) | 1998-08-07 | 2006-03-15 | Novartis Vaccines & Diagnostic | Pyrazole als modulatoren des östrogenrezeptors |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| HUP0301813A2 (hu) | 1999-06-11 | 2003-09-29 | Watson Pharmaceuticals, Inc. | Nem-orális androgén szteroidok |
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| NZ534348A (en) | 2000-01-28 | 2006-06-30 | Endorech Inc | Selective estrogen receptor modulators in combination with estrogens |
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-
2013
- 2013-10-22 WO PCT/US2013/066141 patent/WO2014070523A1/en not_active Ceased
- 2013-10-22 CA CA2889770A patent/CA2889770A1/en not_active Abandoned
- 2013-10-22 EP EP13786580.4A patent/EP2914294A1/en not_active Withdrawn
- 2013-10-22 MX MX2015005160A patent/MX2015005160A/es unknown
- 2013-10-22 CN CN201380057363.2A patent/CN104994877A/zh active Pending
- 2013-10-22 AU AU2013338311A patent/AU2013338311A1/en not_active Abandoned
- 2013-10-22 US US14/440,007 patent/US9687458B2/en not_active Expired - Fee Related
- 2013-10-22 HK HK16104449.1A patent/HK1216502A1/zh unknown
- 2013-10-22 JP JP2015540702A patent/JP2015535283A/ja not_active Withdrawn
-
2015
- 2015-04-26 IL IL238453A patent/IL238453A0/en unknown
-
2018
- 2018-05-16 JP JP2018094685A patent/JP2018123168A/ja active Pending
-
2020
- 2020-12-25 JP JP2020216526A patent/JP2021046448A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017081171A1 (en) | 2015-11-10 | 2017-05-18 | Paracrine Therapeutics Ab | Treatment of er-negative breast cancer with an pdgf-cc inhibitor and an anti estrogen |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014070523A1 (en) | 2014-05-08 |
| MX2015005160A (es) | 2015-07-17 |
| AU2013338311A1 (en) | 2015-05-14 |
| IL238453A0 (en) | 2015-06-30 |
| US9687458B2 (en) | 2017-06-27 |
| HK1216502A1 (zh) | 2016-11-18 |
| JP2018123168A (ja) | 2018-08-09 |
| JP2015535283A (ja) | 2015-12-10 |
| EP2914294A1 (en) | 2015-09-09 |
| CN104994877A (zh) | 2015-10-21 |
| JP2021046448A (ja) | 2021-03-25 |
| US20150283099A1 (en) | 2015-10-08 |
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