CA2889584C - Methods for controlling blood pressure and reducing dyspnea in heart failure - Google Patents

Methods for controlling blood pressure and reducing dyspnea in heart failure Download PDF

Info

Publication number
CA2889584C
CA2889584C CA2889584A CA2889584A CA2889584C CA 2889584 C CA2889584 C CA 2889584C CA 2889584 A CA2889584 A CA 2889584A CA 2889584 A CA2889584 A CA 2889584A CA 2889584 C CA2889584 C CA 2889584C
Authority
CA
Canada
Prior art keywords
clevidipine
blood pressure
patient
mmhg
patients
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2889584A
Other languages
English (en)
French (fr)
Other versions
CA2889584A1 (en
Inventor
Edward C. Spindler, Jr.
Loretta M. Itri
Gregory Charles Williams
Ming-yi HU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiesi Farmaceutici SpA
Original Assignee
Chiesi Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici SpA filed Critical Chiesi Farmaceutici SpA
Publication of CA2889584A1 publication Critical patent/CA2889584A1/en
Application granted granted Critical
Publication of CA2889584C publication Critical patent/CA2889584C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/44221,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2889584A 2012-10-26 2013-10-26 Methods for controlling blood pressure and reducing dyspnea in heart failure Active CA2889584C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261719127P 2012-10-26 2012-10-26
US61/719,127 2012-10-26
PCT/US2013/066990 WO2014066870A1 (en) 2012-10-26 2013-10-26 Methods for controlling blood pressure and reducing dyspnea in heart failure

Publications (2)

Publication Number Publication Date
CA2889584A1 CA2889584A1 (en) 2014-05-01
CA2889584C true CA2889584C (en) 2018-08-14

Family

ID=50545374

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2889584A Active CA2889584C (en) 2012-10-26 2013-10-26 Methods for controlling blood pressure and reducing dyspnea in heart failure

Country Status (18)

Country Link
US (1) US10881645B2 (cg-RX-API-DMAC7.html)
EP (1) EP2925128B1 (cg-RX-API-DMAC7.html)
JP (2) JP6329957B2 (cg-RX-API-DMAC7.html)
KR (1) KR102299073B1 (cg-RX-API-DMAC7.html)
CN (2) CN104968199A (cg-RX-API-DMAC7.html)
AU (1) AU2013334081B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015009291B1 (cg-RX-API-DMAC7.html)
CA (1) CA2889584C (cg-RX-API-DMAC7.html)
EA (1) EA030354B1 (cg-RX-API-DMAC7.html)
ES (1) ES2671639T3 (cg-RX-API-DMAC7.html)
IL (1) IL238462A0 (cg-RX-API-DMAC7.html)
MX (1) MX359768B (cg-RX-API-DMAC7.html)
NZ (1) NZ708511A (cg-RX-API-DMAC7.html)
PL (1) PL2925128T3 (cg-RX-API-DMAC7.html)
TR (1) TR201807636T4 (cg-RX-API-DMAC7.html)
UA (1) UA117571C2 (cg-RX-API-DMAC7.html)
WO (1) WO2014066870A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201503741B (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3145508B1 (en) * 2014-05-19 2023-07-05 Chiesi Farmaceutici S.p.A. Clevidipine nanoparticles and pharmaceutical compositions thereof
KR20210136048A (ko) * 2019-03-05 2021-11-16 윈드트리 세라퓨틱스, 인크. 급성 심부전 (ahf)의 치료를 위한 이스타록심-함유 정맥내 제형
CN114966056B (zh) * 2022-06-08 2024-07-02 四川大学华西医院 筛查急性主动脉夹层的试剂盒和系统

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9303657D0 (sv) 1993-11-05 1993-11-05 Astra Ab Short-acting dihydropyridines
SE9303744D0 (sv) 1993-11-12 1993-11-12 Astra Ab Pharmaceutical emulsion
SE9804002D0 (sv) 1998-11-23 1998-11-23 Astra Ab New manufacturing process
ES2546287T3 (es) 2008-05-16 2015-09-22 Corthera, Inc. Relaxina para uso en el tratamiento de la disnea asociada con la insuficiencia cardiaca aguda
WO2010014727A1 (en) 2008-08-01 2010-02-04 The Medicines Company Pharmaceutical compositions and methods for producing low impurity concentrations of the same
KR20170051542A (ko) 2008-08-01 2017-05-11 치에시 파마슈티시 에스.피.아. 약제학적 조성물 및 이를 안정화시키는 방법
DK2498731T3 (da) * 2009-11-11 2020-03-02 Chiesi Farm Spa Fremgangsmåder til behandling eller forebyggelse af stenttrombose
TW201215392A (en) 2010-06-16 2012-04-16 Gilead Sciences Inc Use of ranolazine for treating pulmonary hypertension
PL2627173T5 (pl) * 2010-10-12 2019-11-29 Chiesi Farm Spa Formulacje emulsyjne klewidypiny zawierające środki przeciw mikrobom
US20150094344A1 (en) 2011-04-01 2015-04-02 The Medicines Company Short-acting dihydropyridines (clevidipine) for use in reducing stroke damage

Also Published As

Publication number Publication date
IL238462A0 (en) 2015-06-30
KR102299073B1 (ko) 2021-09-09
CN104968199A (zh) 2015-10-07
CA2889584A1 (en) 2014-05-01
EP2925128A4 (en) 2016-06-08
EA201590825A1 (ru) 2015-09-30
BR112015009291A2 (pt) 2017-07-04
WO2014066870A1 (en) 2014-05-01
AU2013334081A1 (en) 2015-06-11
AU2013334081B2 (en) 2017-05-18
EA030354B1 (ru) 2018-07-31
MX2015005341A (es) 2016-05-24
US20140121247A1 (en) 2014-05-01
ZA201503741B (en) 2022-09-28
JP2018065875A (ja) 2018-04-26
EP2925128B1 (en) 2018-04-11
UA117571C2 (uk) 2018-08-27
MX359768B (es) 2018-10-10
ES2671639T3 (es) 2018-06-07
JP2015535258A (ja) 2015-12-10
JP6329957B2 (ja) 2018-05-23
KR20150104084A (ko) 2015-09-14
PL2925128T3 (pl) 2018-10-31
EP2925128A1 (en) 2015-10-07
CN110840890A (zh) 2020-02-28
TR201807636T4 (tr) 2018-06-21
BR112015009291B1 (pt) 2021-03-16
US10881645B2 (en) 2021-01-05
NZ708511A (en) 2018-11-30

Similar Documents

Publication Publication Date Title
US11559559B2 (en) Angiotensin II alone or in combination for the treatment of hypotension
EP2153830A1 (en) Use of dronedarone for the preparation of a medicament intended for the prevention of stroke or transient ischemic attack
CA2889584C (en) Methods for controlling blood pressure and reducing dyspnea in heart failure
Ferguson-Myrthil Novel agents for the treatment of hyponatremia: a review of conivaptan and tolvaptan
BR112013020377A2 (pt) métodos para o tratamento da hipertensão pulmonar
RU2623039C2 (ru) Дигидропиридины (клевидипин) кратковременного действия для применения в восстановлении после инсульта
JP6629850B2 (ja) 汎用心停止液(変種)
HK40020897A (en) Methods for controlling blood pressure and reducing dyspnea in heart failure
WO2025128432A1 (en) Istaroxime and metabolite derivatives thereof for reducing the risk of acute myocardial arrhythmia
Kumar et al. Pharmacological strategies for the treatment of congestive heart failure
Marti et al. Digoxin, Diuretics, and Vasodilators in Patients with Heart Failure
Brampton PrRAN™-LISINOPRIL

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20161026