CA2884393A1 - Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates - Google Patents

Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates Download PDF

Info

Publication number
CA2884393A1
CA2884393A1 CA2884393A CA2884393A CA2884393A1 CA 2884393 A1 CA2884393 A1 CA 2884393A1 CA 2884393 A CA2884393 A CA 2884393A CA 2884393 A CA2884393 A CA 2884393A CA 2884393 A1 CA2884393 A1 CA 2884393A1
Authority
CA
Canada
Prior art keywords
formula
compound
prot
group
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2884393A
Other languages
English (en)
French (fr)
Inventor
Murat Acemoglu
Heribert Hellstern
Felix Kollmer
Robert Schreiber
Hans Stettler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CA2884393A1 publication Critical patent/CA2884393A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K11/00Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K11/00Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0819Tripeptides with the first amino acid being acidic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2884393A 2012-10-09 2013-10-08 Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates Abandoned CA2884393A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261711284P 2012-10-09 2012-10-09
US61/711,284 2012-10-09
PCT/IB2013/059196 WO2014057418A2 (en) 2012-10-09 2013-10-08 Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates

Publications (1)

Publication Number Publication Date
CA2884393A1 true CA2884393A1 (en) 2014-04-17

Family

ID=49880854

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2884393A Abandoned CA2884393A1 (en) 2012-10-09 2013-10-08 Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates

Country Status (14)

Country Link
US (2) US9067978B2 (instruction)
EP (1) EP2906585A2 (instruction)
JP (1) JP2015533156A (instruction)
KR (1) KR20150065709A (instruction)
CN (1) CN104703997A (instruction)
AR (1) AR092948A1 (instruction)
AU (1) AU2013328284B2 (instruction)
BR (1) BR112015007196A2 (instruction)
CA (1) CA2884393A1 (instruction)
EA (1) EA201590698A1 (instruction)
IN (1) IN2015DN01811A (instruction)
MX (1) MX2015004629A (instruction)
TW (1) TW201418278A (instruction)
WO (1) WO2014057418A2 (instruction)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103298827B (zh) 2007-08-17 2017-05-31 诺华股份有限公司 环状酯肽
US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
US8614289B2 (en) 2011-04-20 2013-12-24 Novartis Ag Processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8987413B2 (en) 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
US10947267B2 (en) 2015-12-21 2021-03-16 Texas Tech University System System and method for solution phase gap peptide synthesis
WO2019217116A1 (en) * 2018-05-06 2019-11-14 Gap Peptides Llc Method for solution-phase peptide synthesis
US12024537B2 (en) 2018-05-31 2024-07-02 Sederma Compositions and methods for chemical synthesis
WO2020018888A1 (en) 2018-07-20 2020-01-23 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use
EP3917937A4 (en) 2019-02-01 2022-11-23 Sederma SYNTHETIC STRATEGY FOR A SPLIT PROTECTION GROUP
JP7162853B1 (ja) * 2021-07-02 2022-10-31 ペプチスター株式会社 液相ペプチド合成用担体結合ペプチドの分析方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3043252C2 (de) 1980-11-15 1982-12-02 Degussa Ag, 6000 Frankfurt Cyclische Acetale von N-Acylglutaminsäure -γ- semialdehyden, Verfahren zu deren Herstellung und ihre Verwendung
US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
DE4421113A1 (de) 1994-06-16 1995-12-21 Biotechnolog Forschung Gmbh Chondramide, Gewinnungsverfahren, Mittel mit Chondramiden und Mischkultur zur Chondramid-Gewinnung
DE19828043A1 (de) 1998-06-24 1999-12-30 Bayer Ag Ektoparasitizide Mittel
JP2000154198A (ja) 1998-11-20 2000-06-06 Nisshin Flour Milling Co Ltd 環状デプシペプチドの固相合成方法及びその中間体
GB0108234D0 (en) 2001-04-02 2001-05-23 Pharma Mar Sa Process for producing trunkamide A compounds
US20040110228A1 (en) 2002-04-01 2004-06-10 Mcalpine Shelli R. Combinatorial organic synthesis of unique biologically active compounds
PL1631295T3 (pl) 2003-06-06 2010-09-30 Arexis Ab Zastosowanie skondensowanych związków heterocyklicznych jako inhibitorów SCCE do leczenia chorób skóry
GB0322140D0 (en) 2003-09-22 2003-10-22 Pfizer Ltd Combinations
EP1716248A1 (en) 2004-02-03 2006-11-02 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with kallikrein 7 (klk7)
JP2009532664A (ja) 2006-02-27 2009-09-10 アリゾナ・ボード・オブ・リージェンツ・フォー・アンド・オン・ビハーフ・オブ・アリゾナ・ステイト・ユニバーシティ 癌の治療のためのノボペプチドの同定および使用
GB0715750D0 (en) 2007-08-13 2007-09-19 Karus Therapeutics Ltd Chemical compounds
CN103298827B (zh) * 2007-08-17 2017-05-31 诺华股份有限公司 环状酯肽
ES2527298T3 (es) 2007-08-17 2015-01-22 Novartis Ag Uso de depsipéptidos cíclicos para inhibir calicreína 7
DE102007052391A1 (de) 2007-10-31 2009-05-07 Henkel Ag & Co. Kgaa Mattwachs
US20110112121A1 (en) 2009-07-06 2011-05-12 Joerg Berghausen Pharmaceutical Compositions and Solid Forms
US20120064013A1 (en) 2010-02-03 2012-03-15 David Marcos Foamable topical composition
KR101004362B1 (ko) 2010-03-19 2010-12-28 가톨릭대학교 산학협력단 자가 면역 질환 예방 및 치료용 TNF-α와 TWEAK 이중 길항제
US20120064136A1 (en) 2010-09-10 2012-03-15 Nanobio Corporation Anti-aging and wrinkle treatment methods using nanoemulsion compositions
KR20240119180A (ko) 2011-01-24 2024-08-06 안테리오스, 인코퍼레이티드 나노입자 조성물, 이의 제형, 및 그의 용도
DK2667854T3 (en) 2011-01-24 2019-04-23 Anterios Inc NANO PARTICLE FORMATIONS
US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
US8614289B2 (en) 2011-04-20 2013-12-24 Novartis Ag Processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8987413B2 (en) 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates

Also Published As

Publication number Publication date
IN2015DN01811A (instruction) 2015-05-29
US9493512B2 (en) 2016-11-15
KR20150065709A (ko) 2015-06-15
EA201590698A1 (ru) 2015-07-30
EP2906585A2 (en) 2015-08-19
US20150218224A1 (en) 2015-08-06
US9067978B2 (en) 2015-06-30
AU2013328284B2 (en) 2016-07-14
BR112015007196A2 (pt) 2017-07-04
JP2015533156A (ja) 2015-11-19
AU2013328284A1 (en) 2015-03-12
US20140100355A1 (en) 2014-04-10
WO2014057418A2 (en) 2014-04-17
AR092948A1 (es) 2015-05-06
CN104703997A (zh) 2015-06-10
TW201418278A (zh) 2014-05-16
MX2015004629A (es) 2015-07-14
WO2014057418A3 (en) 2014-07-10

Similar Documents

Publication Publication Date Title
AU2013328284B2 (en) Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
KR101580729B1 (ko) 거대고리형 뎁시펩티드 및 신규 중간체의 제조 방법
JP6350632B2 (ja) ペプチドの製造方法
AU2013328285B2 (en) Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
WO2015155676A1 (en) Novel aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
WO2017092689A1 (en) Method for preparation of rada-16

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20181010