CA2884393A1 - Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates - Google Patents
Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates Download PDFInfo
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- CA2884393A1 CA2884393A1 CA2884393A CA2884393A CA2884393A1 CA 2884393 A1 CA2884393 A1 CA 2884393A1 CA 2884393 A CA2884393 A CA 2884393A CA 2884393 A CA2884393 A CA 2884393A CA 2884393 A1 CA2884393 A1 CA 2884393A1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Analytical Chemistry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261711284P | 2012-10-09 | 2012-10-09 | |
| US61/711,284 | 2012-10-09 | ||
| PCT/IB2013/059196 WO2014057418A2 (en) | 2012-10-09 | 2013-10-08 | Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2884393A1 true CA2884393A1 (en) | 2014-04-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2884393A Abandoned CA2884393A1 (en) | 2012-10-09 | 2013-10-08 | Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9067978B2 (instruction) |
| EP (1) | EP2906585A2 (instruction) |
| JP (1) | JP2015533156A (instruction) |
| KR (1) | KR20150065709A (instruction) |
| CN (1) | CN104703997A (instruction) |
| AR (1) | AR092948A1 (instruction) |
| AU (1) | AU2013328284B2 (instruction) |
| BR (1) | BR112015007196A2 (instruction) |
| CA (1) | CA2884393A1 (instruction) |
| EA (1) | EA201590698A1 (instruction) |
| IN (1) | IN2015DN01811A (instruction) |
| MX (1) | MX2015004629A (instruction) |
| TW (1) | TW201418278A (instruction) |
| WO (1) | WO2014057418A2 (instruction) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2008002394A1 (es) | 2007-08-17 | 2009-05-15 | Novartis Ag | Depsipeptido ciclico, o derivados, inhibidores de calicreína 7, obtenidos desde chondromyces crocatus, metodo de obtencion y usos terapeuticos. |
| AR086168A1 (es) | 2011-04-20 | 2013-11-27 | Novartis Ag | Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios |
| US8680054B2 (en) | 2011-04-20 | 2014-03-25 | Novartis Ag | Suspension type topical formulations comprising cyclic depsipeptide |
| US8987413B2 (en) * | 2012-10-09 | 2015-03-24 | Novartis Ag | Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates |
| US9067978B2 (en) | 2012-10-09 | 2015-06-30 | Novartis Ag | Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates |
| EP3393499B1 (en) | 2015-12-21 | 2022-05-11 | Texas Tech University System | System and method for solution phase gap peptide synthesis |
| WO2019217116A1 (en) * | 2018-05-06 | 2019-11-14 | Gap Peptides Llc | Method for solution-phase peptide synthesis |
| US12024537B2 (en) | 2018-05-31 | 2024-07-02 | Sederma | Compositions and methods for chemical synthesis |
| US11643438B2 (en) | 2018-07-20 | 2023-05-09 | The Board Of Regents Of The University Of Oklahoma | Antimicrobial peptides and methods of use |
| CA3126705A1 (en) | 2019-02-01 | 2020-08-06 | Gap Peptides Llc | Synthesis strategy for gap protecting group |
| JP7162853B1 (ja) * | 2021-07-02 | 2022-10-31 | ペプチスター株式会社 | 液相ペプチド合成用担体結合ペプチドの分析方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3043252C2 (de) | 1980-11-15 | 1982-12-02 | Degussa Ag, 6000 Frankfurt | Cyclische Acetale von N-Acylglutaminsäure -γ- semialdehyden, Verfahren zu deren Herstellung und ihre Verwendung |
| US5595756A (en) | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| DE4421113A1 (de) | 1994-06-16 | 1995-12-21 | Biotechnolog Forschung Gmbh | Chondramide, Gewinnungsverfahren, Mittel mit Chondramiden und Mischkultur zur Chondramid-Gewinnung |
| DE19828043A1 (de) | 1998-06-24 | 1999-12-30 | Bayer Ag | Ektoparasitizide Mittel |
| JP2000154198A (ja) | 1998-11-20 | 2000-06-06 | Nisshin Flour Milling Co Ltd | 環状デプシペプチドの固相合成方法及びその中間体 |
| GB0108234D0 (en) | 2001-04-02 | 2001-05-23 | Pharma Mar Sa | Process for producing trunkamide A compounds |
| US20040110228A1 (en) | 2002-04-01 | 2004-06-10 | Mcalpine Shelli R. | Combinatorial organic synthesis of unique biologically active compounds |
| CN101152185B (zh) | 2003-06-06 | 2010-12-08 | 阿里克斯股份公司 | 杂环化合物作为scce抑制剂的用途 |
| GB0322140D0 (en) | 2003-09-22 | 2003-10-22 | Pfizer Ltd | Combinations |
| EP1716248A1 (en) | 2004-02-03 | 2006-11-02 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with kallikrein 7 (klk7) |
| JP2009532664A (ja) | 2006-02-27 | 2009-09-10 | アリゾナ・ボード・オブ・リージェンツ・フォー・アンド・オン・ビハーフ・オブ・アリゾナ・ステイト・ユニバーシティ | 癌の治療のためのノボペプチドの同定および使用 |
| GB0715750D0 (en) | 2007-08-13 | 2007-09-19 | Karus Therapeutics Ltd | Chemical compounds |
| ES2527298T3 (es) | 2007-08-17 | 2015-01-22 | Novartis Ag | Uso de depsipéptidos cíclicos para inhibir calicreína 7 |
| CL2008002394A1 (es) * | 2007-08-17 | 2009-05-15 | Novartis Ag | Depsipeptido ciclico, o derivados, inhibidores de calicreína 7, obtenidos desde chondromyces crocatus, metodo de obtencion y usos terapeuticos. |
| DE102007052391A1 (de) | 2007-10-31 | 2009-05-07 | Henkel Ag & Co. Kgaa | Mattwachs |
| US20110112121A1 (en) | 2009-07-06 | 2011-05-12 | Joerg Berghausen | Pharmaceutical Compositions and Solid Forms |
| KR101004362B1 (ko) | 2010-03-19 | 2010-12-28 | 가톨릭대학교 산학협력단 | 자가 면역 질환 예방 및 치료용 ＴＮＦ－α와 ＴＷＥＡＫ 이중 길항제 |
| US20120064136A1 (en) | 2010-09-10 | 2012-03-15 | Nanobio Corporation | Anti-aging and wrinkle treatment methods using nanoemulsion compositions |
| EP2616037A2 (en) | 2010-09-14 | 2013-07-24 | Trima - Israel Phramaceutical Products Maabarot Ltd. | Foamable topical composition |
| SG193972A1 (en) | 2011-01-24 | 2013-11-29 | Anterios Inc | Nanoparticle compositions, formulations thereof, and uses therefor |
| US20120328702A1 (en) | 2011-01-24 | 2012-12-27 | Anterios, Inc. | Nanoparticle compositions |
| AR086168A1 (es) * | 2011-04-20 | 2013-11-27 | Novartis Ag | Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios |
| US8680054B2 (en) | 2011-04-20 | 2014-03-25 | Novartis Ag | Suspension type topical formulations comprising cyclic depsipeptide |
| US8987413B2 (en) * | 2012-10-09 | 2015-03-24 | Novartis Ag | Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates |
| US9067978B2 (en) | 2012-10-09 | 2015-06-30 | Novartis Ag | Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates |
-
2013
- 2013-10-04 US US14/045,844 patent/US9067978B2/en active Active
- 2013-10-08 AU AU2013328284A patent/AU2013328284B2/en not_active Ceased
- 2013-10-08 IN IN1811DEN2015 patent/IN2015DN01811A/en unknown
- 2013-10-08 CA CA2884393A patent/CA2884393A1/en not_active Abandoned
- 2013-10-08 CN CN201380051965.7A patent/CN104703997A/zh active Pending
- 2013-10-08 JP JP2015536260A patent/JP2015533156A/ja active Pending
- 2013-10-08 WO PCT/IB2013/059196 patent/WO2014057418A2/en active Application Filing
- 2013-10-08 EA EA201590698A patent/EA201590698A1/ru unknown
- 2013-10-08 MX MX2015004629A patent/MX2015004629A/es unknown
- 2013-10-08 TW TW102136392A patent/TW201418278A/zh unknown
- 2013-10-08 KR KR1020157008834A patent/KR20150065709A/ko not_active Withdrawn
- 2013-10-08 EP EP13812092.8A patent/EP2906585A2/en not_active Withdrawn
- 2013-10-08 BR BR112015007196A patent/BR112015007196A2/pt not_active IP Right Cessation
- 2013-10-09 AR ARP130103654A patent/AR092948A1/es unknown
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2015
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2014057418A2 (en) | 2014-04-17 |
| US9493512B2 (en) | 2016-11-15 |
| AR092948A1 (es) | 2015-05-06 |
| US20140100355A1 (en) | 2014-04-10 |
| JP2015533156A (ja) | 2015-11-19 |
| AU2013328284B2 (en) | 2016-07-14 |
| TW201418278A (zh) | 2014-05-16 |
| MX2015004629A (es) | 2015-07-14 |
| KR20150065709A (ko) | 2015-06-15 |
| BR112015007196A2 (pt) | 2017-07-04 |
| WO2014057418A3 (en) | 2014-07-10 |
| IN2015DN01811A (instruction) | 2015-05-29 |
| EP2906585A2 (en) | 2015-08-19 |
| AU2013328284A1 (en) | 2015-03-12 |
| EA201590698A1 (ru) | 2015-07-30 |
| US20150218224A1 (en) | 2015-08-06 |
| US9067978B2 (en) | 2015-06-30 |
| CN104703997A (zh) | 2015-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20181010 |