CA2879252C - Combination therapies for melanoma comprising administering cobimetinib and vemurafinib - Google Patents
Combination therapies for melanoma comprising administering cobimetinib and vemurafinib Download PDFInfo
- Publication number
- CA2879252C CA2879252C CA2879252A CA2879252A CA2879252C CA 2879252 C CA2879252 C CA 2879252C CA 2879252 A CA2879252 A CA 2879252A CA 2879252 A CA2879252 A CA 2879252A CA 2879252 C CA2879252 C CA 2879252C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q30/00—Commerce
- G06Q30/02—Marketing; Price estimation or determination; Fundraising
- G06Q30/0241—Advertisements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Business, Economics & Management (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Finance (AREA)
- Strategic Management (AREA)
- Development Economics (AREA)
- Accounting & Taxation (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Business, Economics & Management (AREA)
- Marketing (AREA)
- Theoretical Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Economics (AREA)
- Game Theory and Decision Science (AREA)
- Entrepreneurship & Innovation (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2928396A CA2928396A1 (en) | 2012-08-17 | 2013-08-15 | Combination therapies for melanoma comprising administering cobimetinib and vemurafinib |
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261684673P | 2012-08-17 | 2012-08-17 | |
US61/684,673 | 2012-08-17 | ||
US201261705575P | 2012-09-25 | 2012-09-25 | |
US61/705,575 | 2012-09-25 | ||
US201261706026P | 2012-09-26 | 2012-09-26 | |
US61/706,026 | 2012-09-26 | ||
US201261722725P | 2012-11-05 | 2012-11-05 | |
US61/722,725 | 2012-11-05 | ||
US201361780708P | 2013-03-13 | 2013-03-13 | |
US61/780,708 | 2013-03-13 | ||
PCT/EP2013/067050 WO2014027056A1 (en) | 2012-08-17 | 2013-08-15 | Combination therapies for melanoma comprising administering cobimetinib and vemurafinib |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2928396A Division CA2928396A1 (en) | 2012-08-17 | 2013-08-15 | Combination therapies for melanoma comprising administering cobimetinib and vemurafinib |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2879252A1 CA2879252A1 (en) | 2014-02-20 |
CA2879252C true CA2879252C (en) | 2017-10-10 |
Family
ID=49035547
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2879252A Active CA2879252C (en) | 2012-08-17 | 2013-08-15 | Combination therapies for melanoma comprising administering cobimetinib and vemurafinib |
CA2928396A Abandoned CA2928396A1 (en) | 2012-08-17 | 2013-08-15 | Combination therapies for melanoma comprising administering cobimetinib and vemurafinib |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2928396A Abandoned CA2928396A1 (en) | 2012-08-17 | 2013-08-15 | Combination therapies for melanoma comprising administering cobimetinib and vemurafinib |
Country Status (31)
Country | Link |
---|---|
US (3) | US11087354B2 (sl) |
EP (1) | EP2884979B1 (sl) |
JP (2) | JP6335169B2 (sl) |
KR (5) | KR20190057421A (sl) |
CN (2) | CN104640545A (sl) |
AU (1) | AU2013304021B2 (sl) |
BR (1) | BR112015003418A2 (sl) |
CA (2) | CA2879252C (sl) |
CL (1) | CL2015000345A1 (sl) |
CO (1) | CO7180225A2 (sl) |
DK (1) | DK2884979T3 (sl) |
EA (1) | EA033573B1 (sl) |
ES (1) | ES2743427T3 (sl) |
HK (1) | HK1206605A1 (sl) |
HR (1) | HRP20191533T1 (sl) |
HU (1) | HUE044789T2 (sl) |
IL (1) | IL237065B (sl) |
LT (1) | LT2884979T (sl) |
MX (1) | MX367970B (sl) |
MY (1) | MY180613A (sl) |
NZ (1) | NZ744862A (sl) |
PE (1) | PE20151156A1 (sl) |
PH (1) | PH12015500186A1 (sl) |
PL (1) | PL2884979T3 (sl) |
PT (1) | PT2884979T (sl) |
RS (1) | RS59113B1 (sl) |
SG (3) | SG11201500582UA (sl) |
SI (1) | SI2884979T1 (sl) |
UA (1) | UA114923C2 (sl) |
WO (1) | WO2014027056A1 (sl) |
ZA (1) | ZA201500348B (sl) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2884979T (pt) * | 2012-08-17 | 2019-09-04 | Hoffmann La Roche | Terapêuticas combinadas para o melanoma, compreendendo a administração de cobimetinib e vemurafinib |
US9532987B2 (en) | 2013-09-05 | 2017-01-03 | Genentech, Inc. | Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases |
WO2015095842A2 (en) * | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Methods and compositions for treating non-erk mapk pathway inhibitor-resistant cancers |
WO2015191986A1 (en) * | 2014-06-13 | 2015-12-17 | Genentech, Inc. | Methods of treating and preventing cancer drug resistance |
CZ2015250A3 (cs) * | 2015-04-14 | 2016-10-26 | Zentiva, K.S. | Amorfní formy vemurafenibu |
TWI812581B (zh) * | 2015-05-22 | 2023-08-21 | 美商普雷辛肯公司 | 激酶調節及其適應症 |
SI3881833T1 (sl) * | 2015-06-30 | 2024-03-29 | Genentech, Inc., | Tablete s takojšnjim sproščanjem, ki vsebujejo zdravilo in postopek za oblikovanje tablet |
MA43170A (fr) | 2015-11-03 | 2018-09-12 | Univ Texas | Association d'un inhibiteur de bcl-2 et d'un inhibiteur de mek pour le traitement du cancer |
EP3377107B1 (en) * | 2015-11-19 | 2020-08-12 | H. Hoffnabb-La Roche Ag | Methods of treating cancer using b-raf inhibitors and immune checkpoint inhibitors |
WO2017095826A1 (en) * | 2015-11-30 | 2017-06-08 | The Regents Of The University Of California | Combination therapy for treatment of melanoma |
BR112019002036A2 (pt) | 2016-08-12 | 2019-05-14 | Genentech Inc | métodos de tratamento de um sujeito com câncer colorretal, kit para tratamento do câncer colorretal em um sujeito humano e combinação de fármacos para a terapia do câncer colorretal |
JP2019534251A (ja) | 2016-09-29 | 2019-11-28 | ジェネンテック, インコーポレイテッド | Mek阻害剤、pd−1軸阻害剤、及びタキサンを用いた併用療法 |
WO2018134254A1 (en) | 2017-01-17 | 2018-07-26 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
HRP20240069T1 (hr) | 2017-03-02 | 2024-03-29 | Genentech, Inc. | Adjuvantno liječenje her2-pozitivnog raka dojke |
WO2019139970A1 (en) * | 2018-01-09 | 2019-07-18 | Duke University | Topical administration of mek inhibiting agents for the treatment of skin disorders |
CN109879855B (zh) * | 2019-03-26 | 2021-01-05 | 中国医学科学院医药生物技术研究所 | 靶向肿瘤细胞表面pd-l1分子的抑制剂及其应用 |
CN115551509A (zh) * | 2020-05-12 | 2022-12-30 | 诺华股份有限公司 | 包含craf抑制剂的治疗组合 |
EP4304592A1 (en) | 2021-03-09 | 2024-01-17 | Genentech, Inc. | Belvarafenib for use in treatment of brain cancers |
WO2022216719A1 (en) | 2021-04-06 | 2022-10-13 | Genentech, Inc. | Combination therapy with belvarafenib and cobimetinib or with belvarafenib, cobimetinib, and atezolizumab |
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EP1578346A4 (en) | 2001-12-04 | 2007-11-28 | Onyx Pharma Inc | INHIBITORS OF THE RAF-MEK-ERK PATHWAY TO TREAT CANCER |
EP2275102B1 (en) | 2002-03-13 | 2015-07-29 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
US7144907B2 (en) | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
AU2003286447A1 (en) | 2003-10-16 | 2004-06-06 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Treatments for inhibiting development and progression of nevi and melanoma having braf mutations |
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US7517994B2 (en) | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
US7732616B2 (en) | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
PT1696920E (pt) | 2003-12-19 | 2015-01-14 | Plexxikon Inc | Compostos e métodos para o desenvolvimento de moduladores de ret |
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EP1934174B1 (en) | 2005-10-07 | 2011-04-06 | Exelixis, Inc. | Azetidines as mek inhibitors for the treatment of proliferative diseases |
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RU2009114745A (ru) | 2006-09-19 | 2010-10-27 | Новартис АГ (CH) | Биомаркеры, предназначенные для выявления направленной модуляции, эффективности ингибиторов raf, применения с целью диагностики и/или прогнозирования |
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US20120214828A1 (en) | 2009-08-24 | 2012-08-23 | Georgia Hatzivassiliou | Determining sensitivity of cells to b-raf inhibitor treatment by detecting kras mutation and rtk expression levels |
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MX345155B (es) * | 2009-10-12 | 2017-01-18 | F Hoffmann-La Roche Ag * | Combinaciones de un inhibidor de pi3k y un inhibidor de mek. |
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KR20130116291A (ko) | 2010-11-19 | 2013-10-23 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | Braf 억제제를 이용한 치료 방법 |
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WO2012145503A1 (en) | 2011-04-21 | 2012-10-26 | Novartis Ag | Pharmaceutical combinations |
US20130172375A1 (en) | 2011-12-13 | 2013-07-04 | Hoffmann-La Roche Inc. | Pharmaceutical composition |
US9216170B2 (en) | 2012-03-19 | 2015-12-22 | Hoffmann-La Roche Inc. | Combination therapy for proliferative disorders |
PT2884979T (pt) * | 2012-08-17 | 2019-09-04 | Hoffmann La Roche | Terapêuticas combinadas para o melanoma, compreendendo a administração de cobimetinib e vemurafinib |
KR20150118159A (ko) | 2013-02-22 | 2015-10-21 | 에프. 호프만-라 로슈 아게 | 암의 치료 방법 및 약물 내성의 예방 방법 |
-
2013
- 2013-08-15 PT PT13753131T patent/PT2884979T/pt unknown
- 2013-08-15 SI SI201331565T patent/SI2884979T1/sl unknown
- 2013-08-15 KR KR1020197014117A patent/KR20190057421A/ko active Application Filing
- 2013-08-15 KR KR1020177009790A patent/KR20170044759A/ko active Search and Examination
- 2013-08-15 CA CA2879252A patent/CA2879252C/en active Active
- 2013-08-15 PE PE2015000215A patent/PE20151156A1/es not_active Application Discontinuation
- 2013-08-15 CN CN201380042815.XA patent/CN104640545A/zh active Pending
- 2013-08-15 MY MYPI2015700457A patent/MY180613A/en unknown
- 2013-08-15 JP JP2015526987A patent/JP6335169B2/ja active Active
- 2013-08-15 SG SG11201500582UA patent/SG11201500582UA/en unknown
- 2013-08-15 KR KR1020157003834A patent/KR20150038068A/ko active Search and Examination
- 2013-08-15 US US13/967,782 patent/US11087354B2/en active Active
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