CA2878640C - Multivalent heteromultimer scaffold design and constructs - Google Patents
Multivalent heteromultimer scaffold design and constructs Download PDFInfo
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- CA2878640C CA2878640C CA2878640A CA2878640A CA2878640C CA 2878640 C CA2878640 C CA 2878640C CA 2878640 A CA2878640 A CA 2878640A CA 2878640 A CA2878640 A CA 2878640A CA 2878640 C CA2878640 C CA 2878640C
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- C07K14/475—Growth factors; Growth regulators
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- C07K14/575—Hormones
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
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Landscapes
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| US201361845945P | 2013-07-12 | 2013-07-12 | |
| US61/845,945 | 2013-07-12 | ||
| PCT/US2013/050408 WO2014012082A2 (en) | 2012-07-13 | 2013-07-12 | Multivalent heteromultimer scaffold design an constructs |
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| WO2012116453A1 (en) | 2011-03-03 | 2012-09-07 | Zymeworks Inc. | Multivalent heteromultimer scaffold design and constructs |
| RU2675319C2 (ru) | 2011-11-04 | 2018-12-18 | Займворкс Инк. | РАЗРАБОТКА СТАБИЛЬНОГО ГЕТЕРОДИМЕРНОГО АНТИТЕЛА С МУТАЦИЯМИ В ДОМЕНЕ Fc |
| US9499634B2 (en) | 2012-06-25 | 2016-11-22 | Zymeworks Inc. | Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells |
| AU2013289881B2 (en) | 2012-07-13 | 2018-01-18 | Zymeworks Bc Inc. | Multivalent heteromultimer scaffold design and constructs |
| US9914785B2 (en) | 2012-11-28 | 2018-03-13 | Zymeworks Inc. | Engineered immunoglobulin heavy chain-light chain pairs and uses thereof |
| JP2016523102A (ja) * | 2013-06-24 | 2016-08-08 | アントフロゲネシス コーポレーション | Ｔ細胞を増殖させるための方法 |
| ES2800674T3 (es) | 2014-03-21 | 2021-01-04 | X Body Inc | Polipéptidos biespecíficos de unión a antígeno |
| AU2015265457B2 (en) | 2014-05-28 | 2021-02-18 | Zymeworks Bc Inc. | Modified antigen binding polypeptide constructs and uses thereof |
| SI3237005T1 (sl) * | 2014-12-22 | 2025-02-28 | Systimmune, Inc. | Bispecifična tetravalentna protitelesa in postopki njihove izdelave in uporabe |
| JP2018524373A (ja) | 2015-07-15 | 2018-08-30 | ザイムワークス，インコーポレイテッド | 薬物がコンジュゲートされた二重特異性抗原結合コンストラクト |
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| JOP20190222A1 (ar) | 2017-04-11 | 2019-09-24 | Zymeworks Inc | الأجسام المضادة ثنائية النوعية المضادة لـ pd-l1 والمضادة لـ tim-3 |
| US11531030B2 (en) | 2017-04-21 | 2022-12-20 | Mayo Foundation For Medical Education And Research | Polypeptide-antibody complexes and uses thereof |
| JP2020521452A (ja) | 2017-05-24 | 2020-07-27 | パンディオン・セラピューティクス・インコーポレイテッド | 標的化免疫寛容 |
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| US10358479B2 (en) | 2019-07-23 |
| WO2014012082A2 (en) | 2014-01-16 |
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