CA2875718A1 - Macrocyclic inhibitors of flaviviridae viruses - Google Patents

Macrocyclic inhibitors of flaviviridae viruses Download PDF

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Publication number
CA2875718A1
CA2875718A1 CA2875718A CA2875718A CA2875718A1 CA 2875718 A1 CA2875718 A1 CA 2875718A1 CA 2875718 A CA2875718 A CA 2875718A CA 2875718 A CA2875718 A CA 2875718A CA 2875718 A1 CA2875718 A1 CA 2875718A1
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CA
Canada
Prior art keywords
mmol
compound
mixture
alkyl
ethyl acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2875718A
Other languages
English (en)
French (fr)
Inventor
Caroline Aciro
Victoria Alexandra Steadman
Simon Neil Pettit
Karine G. Poullennec
Linos Lazarides
David Kenneth Dean
Neil Andrew Dunbar
Adrian John Highton
Andrew John KEATS
Dustin Scott SIEGEL
Kapil Kumar KARKI
Adam James SCHRIER
Petr Jansa
Richard Mackman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Selcia Ltd
Gilead Sciences Inc
Original Assignee
Selcia Ltd
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Selcia Ltd, Gilead Sciences Inc filed Critical Selcia Ltd
Publication of CA2875718A1 publication Critical patent/CA2875718A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/504—Pyridazines; Hydrogenated pyridazines forming part of bridged ring systems
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    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
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CA2875718A 2012-06-08 2013-06-07 Macrocyclic inhibitors of flaviviridae viruses Abandoned CA2875718A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261657553P 2012-06-08 2012-06-08
US61/657,553 2012-06-08
PCT/US2013/044809 WO2013185090A1 (en) 2012-06-08 2013-06-07 Macrocyclic inhibitors of flaviviridae viruses

Publications (1)

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CA2875718A1 true CA2875718A1 (en) 2013-12-12

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Application Number Title Priority Date Filing Date
CA2875718A Abandoned CA2875718A1 (en) 2012-06-08 2013-06-07 Macrocyclic inhibitors of flaviviridae viruses

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US (3) US9090653B2 (OSRAM)
EP (1) EP2859009B1 (OSRAM)
JP (1) JP6209600B2 (OSRAM)
KR (1) KR20150040266A (OSRAM)
CN (1) CN104662033B (OSRAM)
AU (1) AU2013271413B2 (OSRAM)
BR (1) BR112014030649A2 (OSRAM)
CA (1) CA2875718A1 (OSRAM)
EA (1) EA201492205A1 (OSRAM)
ES (1) ES2656087T3 (OSRAM)
HK (1) HK1210483A1 (OSRAM)
IL (1) IL236006A0 (OSRAM)
IN (1) IN2014MN02658A (OSRAM)
MX (1) MX2014014768A (OSRAM)
NO (1) NO2887898T3 (OSRAM)
NZ (2) NZ703066A (OSRAM)
PL (1) PL2859009T3 (OSRAM)
PT (1) PT2859009T (OSRAM)
SG (1) SG11201408045UA (OSRAM)
SI (1) SI2859009T1 (OSRAM)
WO (1) WO2013185090A1 (OSRAM)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR091279A1 (es) * 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
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