CA2872154C - Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin-2-amine compounds as inhibitors of app, bace1 and bace2 - Google Patents
Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin-2-amine compounds as inhibitors of app, bace1 and bace2 Download PDFInfo
- Publication number
- CA2872154C CA2872154C CA2872154A CA2872154A CA2872154C CA 2872154 C CA2872154 C CA 2872154C CA 2872154 A CA2872154 A CA 2872154A CA 2872154 A CA2872154 A CA 2872154A CA 2872154 C CA2872154 C CA 2872154C
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- Prior art keywords
- compound
- tautomer
- mmol
- thiazin
- hexahydropyrano
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- 239000003112 inhibitor Substances 0.000 title description 44
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Classifications
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- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261642480P | 2012-05-04 | 2012-05-04 | |
| US61/642,480 | 2012-05-04 | ||
| PCT/IB2013/053178 WO2013164730A1 (en) | 2012-05-04 | 2013-04-22 | Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin- 2 -amine compounds as inhibitors of app, bace1 and bace 2. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2872154A1 CA2872154A1 (en) | 2013-11-07 |
| CA2872154C true CA2872154C (en) | 2016-08-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2872154A Expired - Fee Related CA2872154C (en) | 2012-05-04 | 2013-04-22 | Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin-2-amine compounds as inhibitors of app, bace1 and bace2 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8962616B2 (enExample) |
| EP (1) | EP2852597B1 (enExample) |
| JP (1) | JP6110937B2 (enExample) |
| AR (1) | AR090928A1 (enExample) |
| CA (1) | CA2872154C (enExample) |
| ES (1) | ES2585262T3 (enExample) |
| TW (1) | TW201406765A (enExample) |
| UY (1) | UY34778A (enExample) |
| WO (1) | WO2013164730A1 (enExample) |
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| WO2013030713A1 (en) * | 2011-08-31 | 2013-03-07 | Pfizer Inc. | Hexahydropyrano [3,4-d][1,3] thiazin-2-amine compounds |
| CA2872154C (en) | 2012-05-04 | 2016-08-23 | Pfizer Inc. | Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin-2-amine compounds as inhibitors of app, bace1 and bace2 |
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| EP2852597A1 (en) | 2015-04-01 |
| CA2872154A1 (en) | 2013-11-07 |
| AR090928A1 (es) | 2014-12-17 |
| WO2013164730A1 (en) | 2013-11-07 |
| TW201406765A (zh) | 2014-02-16 |
| US20130296308A1 (en) | 2013-11-07 |
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