CA2871429C - Crystalline microspheres and the process for manufacturing the same - Google Patents

Crystalline microspheres and the process for manufacturing the same Download PDF

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Publication number
CA2871429C
CA2871429C CA2871429A CA2871429A CA2871429C CA 2871429 C CA2871429 C CA 2871429C CA 2871429 A CA2871429 A CA 2871429A CA 2871429 A CA2871429 A CA 2871429A CA 2871429 C CA2871429 C CA 2871429C
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CA
Canada
Prior art keywords
microspheres
composition comprises
microsphere
mannitol
less
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2871429A
Other languages
English (en)
French (fr)
Other versions
CA2871429A1 (en
Inventor
Cecil W. Propst
Marc W. Meadows
Michael S. Todd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SPI Pharma Inc
Original Assignee
SPI Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SPI Pharma Inc filed Critical SPI Pharma Inc
Publication of CA2871429A1 publication Critical patent/CA2871429A1/en
Application granted granted Critical
Publication of CA2871429C publication Critical patent/CA2871429C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2871429A 2012-04-25 2013-04-25 Crystalline microspheres and the process for manufacturing the same Active CA2871429C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261638073P 2012-04-25 2012-04-25
US61/638,073 2012-04-25
US201361783603P 2013-03-14 2013-03-14
US61/783,603 2013-03-14
PCT/US2013/038257 WO2013163453A1 (en) 2012-04-25 2013-04-25 Crystalline microspheres and the process for manufacturing the same

Publications (2)

Publication Number Publication Date
CA2871429A1 CA2871429A1 (en) 2013-10-31
CA2871429C true CA2871429C (en) 2018-07-31

Family

ID=49483900

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2871429A Active CA2871429C (en) 2012-04-25 2013-04-25 Crystalline microspheres and the process for manufacturing the same

Country Status (9)

Country Link
US (5) US9089487B2 (enExample)
EP (2) EP3583935A1 (enExample)
JP (2) JP6577865B2 (enExample)
BR (1) BR112014026351B1 (enExample)
CA (1) CA2871429C (enExample)
ES (1) ES2729035T3 (enExample)
IN (1) IN2014DN09416A (enExample)
MX (1) MX359554B (enExample)
WO (1) WO2013163453A1 (enExample)

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IL219362A (en) 2012-04-23 2017-04-30 Verint Systems Ltd A system and method for predicting threatened points of interest
EP3583935A1 (en) 2012-04-25 2019-12-25 SPI Pharma, INC. Crystalline microspheres and the process for manufacturing the same
US10560842B2 (en) 2015-01-28 2020-02-11 Verint Systems Ltd. System and method for combined network-side and off-air monitoring of wireless networks
IL242354B (en) 2015-10-29 2019-09-26 Verint Systems Ltd System and method for identifying genuine base stations that serve rogue base stations
IL245299B (en) 2016-04-25 2021-05-31 Verint Systems Ltd A system and method for decoding communication transmitted in a wireless local communication network
AU2020214626B2 (en) 2019-01-31 2025-10-16 Halozyme Hypercon, Inc. Particle formation and morphology
AU2020344675B2 (en) 2019-09-13 2026-06-25 Halozyme Hypercon, Inc. Compositions and methods for the delivery of therapeutic biologics for treatment of disease
US10639312B1 (en) * 2019-12-06 2020-05-05 Edenbridge Pharmaceuticals, LLC Finished pharmaceutical dosage form of a methenamine salt such as methenamine mandelate

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FR2670398B1 (fr) * 1990-12-14 1995-02-17 Roquette Freres Composition pulverulente directement compressible et procede d'obtention.
US5573783A (en) 1995-02-13 1996-11-12 Nano Systems L.L.C. Redispersible nanoparticulate film matrices with protective overcoats
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US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
WO2002035991A2 (en) * 2000-10-30 2002-05-10 The Board Of Regents, The University Of Texas System Spherical particles produced by a hot-melt extrusion/spheronization process
US20030129250A1 (en) * 2001-11-20 2003-07-10 Advanced Inhalation Research Inc. Particulate compositions for improving solubility of poorly soluble agents
US7118765B2 (en) 2001-12-17 2006-10-10 Spi Pharma, Inc. Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms
PT1487416E (pt) * 2002-03-26 2010-01-25 Teva Pharma Micropartículas de fármacos
GB0228826D0 (en) * 2002-12-11 2003-01-15 Okpala Joseph Hair technology in creating particles with improved delivery capabilities
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CN103393601A (zh) * 2004-05-12 2013-11-20 巴克斯特国际公司 含有蛋白并在高浓度蛋白下显示可注射性的微球体
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JP2009544812A (ja) 2006-08-01 2009-12-17 ザ プロクター アンド ギャンブル カンパニー 有益剤含有デリバリー粒子
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BRPI0810978B1 (pt) * 2007-05-28 2021-05-25 Mitsubishi Shoji Foodtech Co., Ltd Partícula esférica de manitol cristalino
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Also Published As

Publication number Publication date
BR112014026351B1 (pt) 2022-09-27
IN2014DN09416A (enExample) 2015-07-17
US10245232B2 (en) 2019-04-02
US9089487B2 (en) 2015-07-28
BR112014026351A2 (pt) 2017-06-27
JP6577865B2 (ja) 2019-09-18
EP2841057B1 (en) 2019-03-20
US20150140097A1 (en) 2015-05-21
US20160015640A1 (en) 2016-01-21
MX2014012805A (es) 2015-01-22
EP2841057A1 (en) 2015-03-04
US20140099372A1 (en) 2014-04-10
CA2871429A1 (en) 2013-10-31
MX359554B (es) 2018-10-02
US12233163B2 (en) 2025-02-25
US20220151932A1 (en) 2022-05-19
JP2019112438A (ja) 2019-07-11
US20190224126A1 (en) 2019-07-25
JP2015514809A (ja) 2015-05-21
EP3583935A1 (en) 2019-12-25
ES2729035T3 (es) 2019-10-29
WO2013163453A1 (en) 2013-10-31
EP2841057A4 (en) 2015-09-16
US11278496B2 (en) 2022-03-22

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