CA2870288A1 - Rna aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells - Google Patents
Rna aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells Download PDFInfo
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- CA2870288A1 CA2870288A1 CA2870288A CA2870288A CA2870288A1 CA 2870288 A1 CA2870288 A1 CA 2870288A1 CA 2870288 A CA2870288 A CA 2870288A CA 2870288 A CA2870288 A CA 2870288A CA 2870288 A1 CA2870288 A1 CA 2870288A1
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- pancreatic cancer
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- aptamer
- molecule
- pancreatic
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261622375P | 2012-04-10 | 2012-04-10 | |
| US61/622,375 | 2012-04-10 | ||
| PCT/US2013/031074 WO2013154735A1 (en) | 2012-04-10 | 2013-03-13 | Rna aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2870288A1 true CA2870288A1 (en) | 2013-10-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA2870288A Abandoned CA2870288A1 (en) | 2012-04-10 | 2013-03-13 | Rna aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells |
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| Country | Link |
|---|---|
| US (2) | US9464293B2 (enExample) |
| EP (1) | EP2836501B1 (enExample) |
| JP (1) | JP2015513919A (enExample) |
| AU (1) | AU2013246419A1 (enExample) |
| CA (1) | CA2870288A1 (enExample) |
| WO (1) | WO2013154735A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107106697A (zh) * | 2014-10-15 | 2017-08-29 | 希望之城 | Pdgfr rna适体 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR122019025681B1 (pt) | 2012-11-01 | 2023-04-18 | Factor Bioscience Inc | Método para inserir uma sequência de ácido nucleico em uma localização segura de um genoma de uma célula |
| WO2014144744A1 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of Columbia University In The City Of New York | Aptamer methods and compositions |
| MX373332B (es) * | 2013-07-26 | 2020-05-21 | Univ Iowa Res Found | UNA PARTÍCULA rAAV Y UN AGENTE DE INMUNOSUPRESIÓN PARA USARSE EN EL TRATAMIENTO DE ENFERMEDADES. |
| WO2015184224A1 (en) * | 2014-05-30 | 2015-12-03 | Academia Sinica | Aptamer targeting mage-a3 peptide and uses thereof |
| US10550394B2 (en) | 2015-03-31 | 2020-02-04 | City Of Hope | Anti-cancer RNA aptamers |
| CN108350459B (zh) * | 2015-10-30 | 2022-05-27 | 新加坡科技研究局 | 结合癌细胞的dna适配体 |
| US11219635B2 (en) | 2016-02-19 | 2022-01-11 | City Of Hope | Bi-specific aptamer |
| WO2017173247A1 (en) * | 2016-03-31 | 2017-10-05 | City Of Hope | Aptamer compositions and the use thereof |
| WO2019033050A1 (en) * | 2017-08-11 | 2019-02-14 | City Of Hope | BISPECIFIC MOLECULE FOR BINDING TO ANTIGEN |
| EP3664814A4 (en) | 2017-08-11 | 2021-05-05 | City of Hope | Rna aptamers against transferrin receptor (tfr) |
| ES2925031T3 (es) * | 2017-12-21 | 2022-10-13 | Marelli Automotive Lighting Italy Spa | Faro de vehículo con partes a diferentes niveles de luminancia |
| US11225665B2 (en) | 2019-06-20 | 2022-01-18 | City Of Hope | P38 map kinase inhibitors |
| KR102294694B1 (ko) * | 2019-07-18 | 2021-08-30 | 국립암센터 | 신규한 dna 앱타머 및 이의 용도 |
| JP2024515220A (ja) | 2021-04-26 | 2024-04-05 | セラニーズ・イーブイエイ・パフォーマンス・ポリマーズ・エルエルシー | 高分子薬剤化合物の持続放出用の埋め込み型デバイス |
| EP4551705A2 (en) | 2022-07-06 | 2025-05-14 | Molecular Axiom, Llc | Compositions and methods for treating pancreatic cancer |
Family Cites Families (13)
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| US20030073207A1 (en) * | 1997-01-31 | 2003-04-17 | Saghir Akhtar | Enzymatic nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors |
| WO1999065928A2 (en) | 1998-06-19 | 1999-12-23 | Genzyme Corporation | Polynucleotide population isolated from non-metastatic and metastatic breast tumor tissues |
| US20030064946A1 (en) * | 2000-08-09 | 2003-04-03 | Mcswiggen James | Method and reagent for the inhibition of calcium activated chloride channel-1 (CLCA-1) |
| CN100419426C (zh) | 2002-04-22 | 2008-09-17 | 佛罗里达州立大学 | 功能化纳米微粒及其使用方法 |
| EP2977470B1 (en) * | 2002-10-16 | 2018-01-03 | Gen-Probe Incorporated | Compositions and methods for detecting west nile virus |
| US7655785B1 (en) * | 2002-11-14 | 2010-02-02 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof |
| US20100254901A1 (en) * | 2005-07-28 | 2010-10-07 | Smith Cassandra L | Compositions comprising nucleic acid aptamers |
| GB2437727B (en) | 2006-05-04 | 2011-04-20 | Univ Open | Aptamers directed to MUC1 |
| WO2007128109A1 (en) * | 2006-05-04 | 2007-11-15 | University Health Network | Aptamers that recognize the carbohydrate n-acetylgalactosamine (galnac) |
| US20110052697A1 (en) * | 2006-05-17 | 2011-03-03 | Gwangju Institute Of Science & Technology | Aptamer-Directed Drug Delivery |
| US20090169613A1 (en) * | 2007-11-09 | 2009-07-02 | Reznik Boris N | Targeting of tumor stem cells through selective silencing of boris expression |
| WO2009129465A2 (en) * | 2008-04-17 | 2009-10-22 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of xbp-1 gene |
| US8563711B2 (en) * | 2009-06-01 | 2013-10-22 | Sungkyunkwan University Foundation For Corporate Collaboration | Nucleic acid aptamer capable of binding specifically to pancreatic cancer cells or tissues and use thereof |
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2013
- 2013-03-13 CA CA2870288A patent/CA2870288A1/en not_active Abandoned
- 2013-03-13 AU AU2013246419A patent/AU2013246419A1/en not_active Abandoned
- 2013-03-13 US US14/391,997 patent/US9464293B2/en active Active
- 2013-03-13 JP JP2015505732A patent/JP2015513919A/ja active Pending
- 2013-03-13 WO PCT/US2013/031074 patent/WO2013154735A1/en not_active Ceased
- 2013-03-13 EP EP13775956.9A patent/EP2836501B1/en not_active Not-in-force
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2016
- 2016-03-28 US US15/082,621 patent/US20160201059A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107106697A (zh) * | 2014-10-15 | 2017-08-29 | 希望之城 | Pdgfr rna适体 |
| CN107106697B (zh) * | 2014-10-15 | 2021-06-18 | 希望之城 | Pdgfr rna适体 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2836501A4 (en) | 2016-03-09 |
| US20160201059A1 (en) | 2016-07-14 |
| AU2013246419A1 (en) | 2014-10-30 |
| US9464293B2 (en) | 2016-10-11 |
| WO2013154735A1 (en) | 2013-10-17 |
| US20150197752A1 (en) | 2015-07-16 |
| EP2836501B1 (en) | 2018-03-07 |
| EP2836501A1 (en) | 2015-02-18 |
| JP2015513919A (ja) | 2015-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20170314 |