JP2015513919A - 膵癌細胞への治療的送達および診断的送達のためのrnaアプタマー - Google Patents
膵癌細胞への治療的送達および診断的送達のためのrnaアプタマー Download PDFInfo
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- JP2015513919A JP2015513919A JP2015505732A JP2015505732A JP2015513919A JP 2015513919 A JP2015513919 A JP 2015513919A JP 2015505732 A JP2015505732 A JP 2015505732A JP 2015505732 A JP2015505732 A JP 2015505732A JP 2015513919 A JP2015513919 A JP 2015513919A
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- pancreatic cancer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261622375P | 2012-04-10 | 2012-04-10 | |
| US61/622,375 | 2012-04-10 | ||
| PCT/US2013/031074 WO2013154735A1 (en) | 2012-04-10 | 2013-03-13 | Rna aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015513919A true JP2015513919A (ja) | 2015-05-18 |
| JP2015513919A5 JP2015513919A5 (enExample) | 2016-04-28 |
Family
ID=49328023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505732A Pending JP2015513919A (ja) | 2012-04-10 | 2013-03-13 | 膵癌細胞への治療的送達および診断的送達のためのrnaアプタマー |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9464293B2 (enExample) |
| EP (1) | EP2836501B1 (enExample) |
| JP (1) | JP2015513919A (enExample) |
| AU (1) | AU2013246419A1 (enExample) |
| CA (1) | CA2870288A1 (enExample) |
| WO (1) | WO2013154735A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017073535A1 (ja) * | 2015-10-30 | 2017-05-04 | タグシクス・バイオ株式会社 | 癌細胞に結合するdnaアプタマー |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR122019025681B1 (pt) | 2012-11-01 | 2023-04-18 | Factor Bioscience Inc | Método para inserir uma sequência de ácido nucleico em uma localização segura de um genoma de uma célula |
| WO2014144744A1 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of Columbia University In The City Of New York | Aptamer methods and compositions |
| MX373332B (es) * | 2013-07-26 | 2020-05-21 | Univ Iowa Res Found | UNA PARTÍCULA rAAV Y UN AGENTE DE INMUNOSUPRESIÓN PARA USARSE EN EL TRATAMIENTO DE ENFERMEDADES. |
| WO2015184224A1 (en) * | 2014-05-30 | 2015-12-03 | Academia Sinica | Aptamer targeting mage-a3 peptide and uses thereof |
| CN107106697B (zh) * | 2014-10-15 | 2021-06-18 | 希望之城 | Pdgfr rna适体 |
| US10550394B2 (en) | 2015-03-31 | 2020-02-04 | City Of Hope | Anti-cancer RNA aptamers |
| US11219635B2 (en) | 2016-02-19 | 2022-01-11 | City Of Hope | Bi-specific aptamer |
| WO2017173247A1 (en) * | 2016-03-31 | 2017-10-05 | City Of Hope | Aptamer compositions and the use thereof |
| WO2019033050A1 (en) * | 2017-08-11 | 2019-02-14 | City Of Hope | BISPECIFIC MOLECULE FOR BINDING TO ANTIGEN |
| EP3664814A4 (en) | 2017-08-11 | 2021-05-05 | City of Hope | Rna aptamers against transferrin receptor (tfr) |
| ES2925031T3 (es) * | 2017-12-21 | 2022-10-13 | Marelli Automotive Lighting Italy Spa | Faro de vehículo con partes a diferentes niveles de luminancia |
| US11225665B2 (en) | 2019-06-20 | 2022-01-18 | City Of Hope | P38 map kinase inhibitors |
| KR102294694B1 (ko) * | 2019-07-18 | 2021-08-30 | 국립암센터 | 신규한 dna 앱타머 및 이의 용도 |
| JP2024515220A (ja) | 2021-04-26 | 2024-04-05 | セラニーズ・イーブイエイ・パフォーマンス・ポリマーズ・エルエルシー | 高分子薬剤化合物の持続放出用の埋め込み型デバイス |
| EP4551705A2 (en) | 2022-07-06 | 2025-05-14 | Molecular Axiom, Llc | Compositions and methods for treating pancreatic cancer |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010140834A2 (ko) * | 2009-06-01 | 2010-12-09 | 성균관대학교산학협력단 | 췌장암 세포 또는 조직에 특이적으로 결합할 수 있는 핵산 압타머 및 그 용도 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030073207A1 (en) * | 1997-01-31 | 2003-04-17 | Saghir Akhtar | Enzymatic nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors |
| WO1999065928A2 (en) | 1998-06-19 | 1999-12-23 | Genzyme Corporation | Polynucleotide population isolated from non-metastatic and metastatic breast tumor tissues |
| US20030064946A1 (en) * | 2000-08-09 | 2003-04-03 | Mcswiggen James | Method and reagent for the inhibition of calcium activated chloride channel-1 (CLCA-1) |
| CN100419426C (zh) | 2002-04-22 | 2008-09-17 | 佛罗里达州立大学 | 功能化纳米微粒及其使用方法 |
| EP2977470B1 (en) * | 2002-10-16 | 2018-01-03 | Gen-Probe Incorporated | Compositions and methods for detecting west nile virus |
| US7655785B1 (en) * | 2002-11-14 | 2010-02-02 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof |
| US20100254901A1 (en) * | 2005-07-28 | 2010-10-07 | Smith Cassandra L | Compositions comprising nucleic acid aptamers |
| GB2437727B (en) | 2006-05-04 | 2011-04-20 | Univ Open | Aptamers directed to MUC1 |
| WO2007128109A1 (en) * | 2006-05-04 | 2007-11-15 | University Health Network | Aptamers that recognize the carbohydrate n-acetylgalactosamine (galnac) |
| US20110052697A1 (en) * | 2006-05-17 | 2011-03-03 | Gwangju Institute Of Science & Technology | Aptamer-Directed Drug Delivery |
| US20090169613A1 (en) * | 2007-11-09 | 2009-07-02 | Reznik Boris N | Targeting of tumor stem cells through selective silencing of boris expression |
| WO2009129465A2 (en) * | 2008-04-17 | 2009-10-22 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of xbp-1 gene |
-
2013
- 2013-03-13 CA CA2870288A patent/CA2870288A1/en not_active Abandoned
- 2013-03-13 AU AU2013246419A patent/AU2013246419A1/en not_active Abandoned
- 2013-03-13 US US14/391,997 patent/US9464293B2/en active Active
- 2013-03-13 JP JP2015505732A patent/JP2015513919A/ja active Pending
- 2013-03-13 WO PCT/US2013/031074 patent/WO2013154735A1/en not_active Ceased
- 2013-03-13 EP EP13775956.9A patent/EP2836501B1/en not_active Not-in-force
-
2016
- 2016-03-28 US US15/082,621 patent/US20160201059A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010140834A2 (ko) * | 2009-06-01 | 2010-12-09 | 성균관대학교산학협력단 | 췌장암 세포 또는 조직에 특이적으로 결합할 수 있는 핵산 압타머 및 그 용도 |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017073535A1 (ja) * | 2015-10-30 | 2017-05-04 | タグシクス・バイオ株式会社 | 癌細胞に結合するdnaアプタマー |
| JPWO2017073535A1 (ja) * | 2015-10-30 | 2018-08-16 | タグシクス・バイオ株式会社 | 癌細胞に結合するdnaアプタマー |
| JP7041517B2 (ja) | 2015-10-30 | 2022-03-24 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | 癌細胞に結合するdnaアプタマー |
| JP2022061987A (ja) * | 2015-10-30 | 2022-04-19 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | 癌細胞に結合するdnaアプタマー |
| JP7391074B2 (ja) | 2015-10-30 | 2023-12-04 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | 癌細胞に結合するdnaアプタマー |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2836501A4 (en) | 2016-03-09 |
| CA2870288A1 (en) | 2013-10-17 |
| US20160201059A1 (en) | 2016-07-14 |
| AU2013246419A1 (en) | 2014-10-30 |
| US9464293B2 (en) | 2016-10-11 |
| WO2013154735A1 (en) | 2013-10-17 |
| US20150197752A1 (en) | 2015-07-16 |
| EP2836501B1 (en) | 2018-03-07 |
| EP2836501A1 (en) | 2015-02-18 |
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