AU2013246419A1 - RNA aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells - Google Patents

RNA aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells Download PDF

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Publication number
AU2013246419A1
AU2013246419A1 AU2013246419A AU2013246419A AU2013246419A1 AU 2013246419 A1 AU2013246419 A1 AU 2013246419A1 AU 2013246419 A AU2013246419 A AU 2013246419A AU 2013246419 A AU2013246419 A AU 2013246419A AU 2013246419 A1 AU2013246419 A1 AU 2013246419A1
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Prior art keywords
pancreatic cancer
seq
aptamer
molecule
pancreatic
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Abandoned
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AU2013246419A
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English (en)
Inventor
John J. Rossi
Sorah YOON
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City of Hope
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City of Hope
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Publication of AU2013246419A1 publication Critical patent/AU2013246419A1/en
Assigned to CITY OF HOPE reassignment CITY OF HOPE Request for Assignment Assignors: ROSSI, JOHN, YOON, Sorah
Abandoned legal-status Critical Current

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549Sugars, nucleosides, nucleotides or nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111General methods applicable to biologically active non-coding nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/16Aptamers
    • CCHEMISTRY; METALLURGY
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3222'-R Modification
    • CCHEMISTRY; METALLURGY
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate
    • CCHEMISTRY; METALLURGY
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate
    • C12N2310/3519Fusion with another nucleic acid
    • CCHEMISTRY; METALLURGY
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    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications
    • C12N2320/32Special delivery means, e.g. tissue-specific

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2013246419A 2012-04-10 2013-03-13 RNA aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells Abandoned AU2013246419A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261622375P 2012-04-10 2012-04-10
US61/622,375 2012-04-10
PCT/US2013/031074 WO2013154735A1 (en) 2012-04-10 2013-03-13 Rna aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells

Publications (1)

Publication Number Publication Date
AU2013246419A1 true AU2013246419A1 (en) 2014-10-30

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Family Applications (1)

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AU2013246419A Abandoned AU2013246419A1 (en) 2012-04-10 2013-03-13 RNA aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells

Country Status (6)

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US (2) US9464293B2 (enExample)
EP (1) EP2836501B1 (enExample)
JP (1) JP2015513919A (enExample)
AU (1) AU2013246419A1 (enExample)
CA (1) CA2870288A1 (enExample)
WO (1) WO2013154735A1 (enExample)

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KR102315098B1 (ko) 2012-11-01 2021-10-21 팩터 바이오사이언스 인크. 세포에서 단백질을 발현시키는 방법들과 생성물들
WO2014144744A1 (en) * 2013-03-15 2014-09-18 The Trustees Of Columbia University In The City Of New York Aptamer methods and compositions
DK3024497T3 (da) * 2013-07-26 2021-04-12 Univ Iowa Res Found Fremgangsmåder og præparater til behandling af hjernesygdomme
EP3149167B1 (en) * 2014-05-30 2019-09-04 Academia Sinica Aptamer targeting mage-a3 peptide and uses thereof
WO2016061401A1 (en) * 2014-10-15 2016-04-21 City Of Hope Pdgfr rna aptamers
US10550394B2 (en) 2015-03-31 2020-02-04 City Of Hope Anti-cancer RNA aptamers
SG11201803600PA (en) * 2015-10-30 2018-05-30 Tagcyx Biotechnologies Dna aptamer binding to cancer cell
CN109312347A (zh) * 2016-02-19 2019-02-05 希望之城 双特异性适配子
WO2017173247A1 (en) * 2016-03-31 2017-10-05 City Of Hope Aptamer compositions and the use thereof
KR20200068647A (ko) 2017-08-11 2020-06-15 시티 오브 호프 트랜스페린 수용체 (TfR)에 대한 RNA 앱타머
WO2019033050A1 (en) * 2017-08-11 2019-02-14 City Of Hope BISPECIFIC MOLECULE FOR BINDING TO ANTIGEN
EP3502552B1 (en) * 2017-12-21 2022-05-25 Marelli Automotive Lighting Italy S.p.A. Vehicle light with portions at different luminance levels
US11225665B2 (en) 2019-06-20 2022-01-18 City Of Hope P38 map kinase inhibitors
KR102294694B1 (ko) * 2019-07-18 2021-08-30 국립암센터 신규한 dna 앱타머 및 이의 용도
US12472148B2 (en) 2021-04-26 2025-11-18 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
JP2025521912A (ja) 2022-07-06 2025-07-10 モレキュラー アクシオム エルエルシー 膵臓癌を治療するための組成物及び方法

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US20030073207A1 (en) * 1997-01-31 2003-04-17 Saghir Akhtar Enzymatic nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors
WO1999065928A2 (en) * 1998-06-19 1999-12-23 Genzyme Corporation Polynucleotide population isolated from non-metastatic and metastatic breast tumor tissues
US20030064946A1 (en) * 2000-08-09 2003-04-03 Mcswiggen James Method and reagent for the inhibition of calcium activated chloride channel-1 (CLCA-1)
JP4381826B2 (ja) 2002-04-22 2009-12-09 ユニヴァーシティ オヴ フロリダ 機能化されたナノ粒子及びその使用方法
EP3241915B1 (en) * 2002-10-16 2021-06-23 Gen-Probe Incorporated Compositions and methods for detecting west nile virus
US7655785B1 (en) * 2002-11-14 2010-02-02 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
US20100254901A1 (en) * 2005-07-28 2010-10-07 Smith Cassandra L Compositions comprising nucleic acid aptamers
GB2437727B (en) 2006-05-04 2011-04-20 Univ Open Aptamers directed to MUC1
WO2007128109A1 (en) * 2006-05-04 2007-11-15 University Health Network Aptamers that recognize the carbohydrate n-acetylgalactosamine (galnac)
WO2007137117A2 (en) * 2006-05-17 2007-11-29 Massachusetts Institute Of Technology Aptamer-directed drug delivery
US20090169613A1 (en) * 2007-11-09 2009-07-02 Reznik Boris N Targeting of tumor stem cells through selective silencing of boris expression
WO2009129465A2 (en) * 2008-04-17 2009-10-22 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of xbp-1 gene
CN102498211B (zh) * 2009-06-01 2014-12-10 成均馆大学校产学协力团 特异结合胰腺癌细胞或组织的核酸适体及其用途

Also Published As

Publication number Publication date
EP2836501B1 (en) 2018-03-07
CA2870288A1 (en) 2013-10-17
US20150197752A1 (en) 2015-07-16
EP2836501A4 (en) 2016-03-09
US20160201059A1 (en) 2016-07-14
EP2836501A1 (en) 2015-02-18
JP2015513919A (ja) 2015-05-18
WO2013154735A1 (en) 2013-10-17
US9464293B2 (en) 2016-10-11

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PC1 Assignment before grant (sect. 113)

Owner name: CITY OF HOPE

Free format text: FORMER APPLICANT(S): YOON, SORAH; ROSSI, JOHN

MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period