CA2862940C - 1h-pyrrolo[2,3-b] pyridine derivatives and their use as kinase inhibitors - Google Patents

1h-pyrrolo[2,3-b] pyridine derivatives and their use as kinase inhibitors Download PDF

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Publication number
CA2862940C
CA2862940C CA2862940A CA2862940A CA2862940C CA 2862940 C CA2862940 C CA 2862940C CA 2862940 A CA2862940 A CA 2862940A CA 2862940 A CA2862940 A CA 2862940A CA 2862940 C CA2862940 C CA 2862940C
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Prior art keywords
pyridin
pyrazole
carboxylic acid
pyrrolo
amide
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CA2862940A
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English (en)
French (fr)
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CA2862940A1 (en
Inventor
Stephen Stokes
Christoper John GRAHAM
Stuart Christopher RAY
Emma Jayne STEFANIAK
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Vernalis R&D Ltd
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Vernalis R&D Ltd
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Publication of CA2862940A1 publication Critical patent/CA2862940A1/en
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2862940A 2012-01-30 2013-01-30 1h-pyrrolo[2,3-b] pyridine derivatives and their use as kinase inhibitors Active CA2862940C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1201566.5A GB201201566D0 (en) 2012-01-30 2012-01-30 New chemical compounds
GB1201566.5 2012-01-30
PCT/GB2013/050212 WO2013114113A1 (en) 2012-01-30 2013-01-30 1h-pyrrolo[2,3-b] pyridine derivatives and their use as kinase inhibitors

Publications (2)

Publication Number Publication Date
CA2862940A1 CA2862940A1 (en) 2013-08-08
CA2862940C true CA2862940C (en) 2021-09-14

Family

ID=45876325

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2862940A Active CA2862940C (en) 2012-01-30 2013-01-30 1h-pyrrolo[2,3-b] pyridine derivatives and their use as kinase inhibitors

Country Status (21)

Country Link
US (3) US10000481B2 (OSRAM)
EP (1) EP2809670B1 (OSRAM)
JP (1) JP6199316B2 (OSRAM)
CN (4) CN107011341A (OSRAM)
AU (1) AU2013213954B2 (OSRAM)
BR (1) BR112014018795B1 (OSRAM)
CA (1) CA2862940C (OSRAM)
DK (1) DK2809670T3 (OSRAM)
EA (1) EA026657B1 (OSRAM)
ES (1) ES2637340T3 (OSRAM)
GB (1) GB201201566D0 (OSRAM)
HK (1) HK1200447A1 (OSRAM)
HU (1) HUE035332T2 (OSRAM)
IL (1) IL233595B (OSRAM)
IN (1) IN2014DN06104A (OSRAM)
MX (1) MX352927B (OSRAM)
NZ (1) NZ627361A (OSRAM)
PL (1) PL2809670T3 (OSRAM)
PT (1) PT2809670T (OSRAM)
WO (1) WO2013114113A1 (OSRAM)
ZA (1) ZA201405070B (OSRAM)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201201566D0 (en) 2012-01-30 2012-03-14 Vernalis R&D Ltd New chemical compounds
JP6370772B2 (ja) * 2012-04-23 2018-08-08 ジェネンテック, インコーポレイテッド 化合物の調製のための中間体及び方法
RU2672725C2 (ru) 2013-08-22 2018-11-19 Дженентек, Инк. Способ получения соединения
CN104829609B (zh) * 2014-02-11 2016-08-03 北大方正集团有限公司 取代的吡啶并嘧啶化合物及其制备方法和应用
MA41559A (fr) * 2015-09-08 2017-12-26 Taiho Pharmaceutical Co Ltd Composé de pyrimidine condensé ou un sel de celui-ci
US10032914B2 (en) * 2015-10-20 2018-07-24 Taiwan Semiconductor Manufacturing Co., Ltd. Semiconductor device and manufacturing method thereof
SI3269370T1 (sl) 2016-02-23 2020-07-31 Taiho Pharmaceutical Co., Ltd. Nova spojina kondenziranega pirimida ali njegove soli
US12258376B2 (en) 2017-08-21 2025-03-25 Taiho Pharmaceutical Co., Ltd. Fusion protein of DCTN1 protein with RET protein
WO2020150417A2 (en) 2019-01-17 2020-07-23 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
CN111518096B (zh) 2019-02-02 2022-02-11 江苏威凯尔医药科技有限公司 两面神激酶jak家族抑制剂及其制备和应用
EP4007757B1 (en) 2019-08-01 2025-09-10 Sperogenix Therapeutics Limited Heterocyclic compounds as kinase inhibitor and uses thereof
IT202000005527A1 (it) * 2020-03-16 2021-09-16 Univ Degli Studi Di Trento Trattamento terapeutico di cromatinopatie
US20230271941A1 (en) 2020-07-15 2023-08-31 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
CN116261452A (zh) * 2020-07-15 2023-06-13 艾福姆德尤股份有限公司 用于治疗与sting活性有关的疾病的化合物和组合物
TW202216685A (zh) * 2020-07-15 2022-05-01 美商Ifm Due有限公司 用於治療與sting活性相關的病狀之化合物及組合物
US12152018B2 (en) 2021-01-08 2024-11-26 Ifm Due, Inc. Compounds and compositions for treating conditions associated with STING activity
WO2023137034A1 (en) * 2022-01-12 2023-07-20 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
CN116554170A (zh) * 2023-04-26 2023-08-08 上海大学 4-氟-7-氮杂吲哚的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1012976A (en) * 1909-03-25 1911-12-26 Adolf Bordt Adding-machine.
WO2003028724A1 (en) * 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
US7531553B2 (en) * 2003-03-21 2009-05-12 Amgen Inc. Heterocyclic compounds and methods of use
BRPI0416852A (pt) * 2003-11-21 2007-02-27 Array Biopharma Inc inibidores da quinase akt
EP2242755B1 (en) 2008-01-08 2012-09-12 Array Biopharma, Inc. Pyrrolopyridines as kinase inhibitors
PT2294065E (pt) 2008-01-22 2014-05-15 Vernalis R&D Ltd Derivados de indolil-piridona com actividade inibidora de quinase 1 de ponto de controlo
AR071717A1 (es) 2008-05-13 2010-07-07 Array Biopharma Inc Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer.
KR20110015699A (ko) 2008-06-11 2011-02-16 제넨테크, 인크. 디아자카르바졸 및 사용 방법
US8569295B2 (en) * 2009-08-06 2013-10-29 Merck Patent Gmbh Bicyclic urea compounds
EP2571361A4 (en) * 2010-05-19 2013-11-13 Univ North Carolina PYRAZOLOPYRIMIDINE COMPOUNDS FOR CANCER TREATMENT
GB201201566D0 (en) * 2012-01-30 2012-03-14 Vernalis R&D Ltd New chemical compounds

Also Published As

Publication number Publication date
JP6199316B2 (ja) 2017-09-20
ES2637340T3 (es) 2017-10-11
BR112014018795B1 (pt) 2020-09-29
CN106866658B (zh) 2021-04-27
EP2809670A1 (en) 2014-12-10
PT2809670T (pt) 2017-08-23
ZA201405070B (en) 2016-03-30
US20150011533A1 (en) 2015-01-08
GB201201566D0 (en) 2012-03-14
US20210206762A1 (en) 2021-07-08
MX352927B (es) 2017-12-14
JP2015505555A (ja) 2015-02-23
CN104203948A (zh) 2014-12-10
CN111484493A (zh) 2020-08-04
BR112014018795A2 (pt) 2017-07-04
CN107011341A (zh) 2017-08-04
CN106866658A (zh) 2017-06-20
PL2809670T3 (pl) 2017-10-31
WO2013114113A1 (en) 2013-08-08
IL233595A0 (en) 2014-08-31
US10889582B2 (en) 2021-01-12
AU2013213954A1 (en) 2014-08-07
EP2809670B1 (en) 2017-05-17
US10000481B2 (en) 2018-06-19
MX2014009112A (es) 2014-11-10
HK1200447A1 (en) 2015-08-07
IN2014DN06104A (OSRAM) 2015-08-14
DK2809670T3 (en) 2017-08-28
AU2013213954B2 (en) 2016-02-25
HUE035332T2 (en) 2018-05-02
EA201491376A1 (ru) 2015-01-30
US20180362526A1 (en) 2018-12-20
CA2862940A1 (en) 2013-08-08
NZ627361A (en) 2016-07-29
EA026657B1 (ru) 2017-05-31
IL233595B (en) 2018-05-31

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Effective date: 20171019