CA2861341A1 - Metalloenzyme inhibitor compounds against fungal infection induced plant diseases and method of use thereof - Google Patents

Metalloenzyme inhibitor compounds against fungal infection induced plant diseases and method of use thereof Download PDF

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Publication number
CA2861341A1
CA2861341A1 CA2861341A CA2861341A CA2861341A1 CA 2861341 A1 CA2861341 A1 CA 2861341A1 CA 2861341 A CA2861341 A CA 2861341A CA 2861341 A CA2861341 A CA 2861341A CA 2861341 A1 CA2861341 A1 CA 2861341A1
Authority
CA
Canada
Prior art keywords
pyridin
tetrazol
difluorophenyl
difluoro
propan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2861341A
Other languages
English (en)
French (fr)
Inventor
William J. Hoekstra
Robert J. Schotzinger
Stephen W. Rafferty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mycovia Pharmaceuticals Inc
Original Assignee
Viamet Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viamet Pharmaceuticals Inc filed Critical Viamet Pharmaceuticals Inc
Publication of CA2861341A1 publication Critical patent/CA2861341A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/713Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with four or more nitrogen atoms as the only ring hetero atoms
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/561,2-Diazoles; Hydrogenated 1,2-diazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647Triazoles; Hydrogenated triazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647Triazoles; Hydrogenated triazoles
    • A01N43/6531,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • A01N57/16Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing heterocyclic radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catching Or Destruction (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA2861341A 2012-01-20 2013-01-18 Metalloenzyme inhibitor compounds against fungal infection induced plant diseases and method of use thereof Abandoned CA2861341A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261589064P 2012-01-20 2012-01-20
US61/589,064 2012-01-20
PCT/US2013/022317 WO2013110002A1 (en) 2012-01-20 2013-01-18 Metalloenzyme inhibitor compounds

Publications (1)

Publication Number Publication Date
CA2861341A1 true CA2861341A1 (en) 2013-07-25

Family

ID=48799720

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2861341A Abandoned CA2861341A1 (en) 2012-01-20 2013-01-18 Metalloenzyme inhibitor compounds against fungal infection induced plant diseases and method of use thereof

Country Status (17)

Country Link
US (1) US9414596B2 (enEXAMPLES)
EP (1) EP2804479A4 (enEXAMPLES)
JP (3) JP2015505538A (enEXAMPLES)
KR (1) KR20140116515A (enEXAMPLES)
CN (1) CN104135861A (enEXAMPLES)
AU (1) AU2013209520A1 (enEXAMPLES)
BR (1) BR112014017799A8 (enEXAMPLES)
CA (1) CA2861341A1 (enEXAMPLES)
CL (1) CL2014001892A1 (enEXAMPLES)
CO (1) CO7111289A2 (enEXAMPLES)
CR (1) CR20140387A (enEXAMPLES)
EA (1) EA201491386A1 (enEXAMPLES)
EC (1) ECSP14014530A (enEXAMPLES)
IN (1) IN2014DN06812A (enEXAMPLES)
MX (1) MX2014008729A (enEXAMPLES)
PH (1) PH12014501653A1 (enEXAMPLES)
WO (1) WO2013110002A1 (enEXAMPLES)

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JP6189865B2 (ja) * 2012-01-20 2017-08-30 ヴィアメット ファーマスーティカルズ,インコーポレイテッド 金属酵素阻害薬化合物
CA2894515C (en) 2012-12-28 2021-10-19 Dow Agrosciences Llc Synergistic fungicidal mixtures comprising (3s, 6s, 7r, 8r)-8-benzyl-3-(3-((isobutyryloxy)methoxy)-4-methoxypicolinamido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl isobutyrate and fluxapyroxad for fungal control in cereals
KR20150103175A (ko) 2012-12-31 2015-09-09 다우 아그로사이언시즈 엘엘씨 살진균제로서의 마크로시클릭 피콜린아미드
EP3086640A4 (en) 2013-12-26 2017-06-21 Dow AgroSciences LLC Macrocyclic picolinamides as fungicides
EP3086642A4 (en) 2013-12-26 2017-09-27 Dow Agrosciences LLC Use of macrocyclic picolinamides as fungicides
CA2942936A1 (en) * 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
CA2942979A1 (en) * 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
WO2015143172A1 (en) * 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
EP3119755B1 (en) * 2014-03-19 2019-03-06 Viamet Pharmaceuticals (NC), Inc. Antifungal compound process
WO2015143184A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
US10196375B2 (en) 2014-03-19 2019-02-05 Mycovia Pharmaceuticals, Inc. Antifungal compound process
EP3119771B1 (en) * 2014-03-19 2020-05-06 Mycovia Pharmaceuticals, Inc. Antifungal compound process
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JP6572234B2 (ja) * 2014-03-19 2019-09-04 ヴィアメット ファーマスーティカルズ(エヌシー),インコーポレイテッド 抗真菌化合物の調製方法
CN109678791B (zh) * 2014-03-19 2022-07-01 美国陶氏益农公司 1-(2,4-二氟苯)-2,2-二氟-2-(5-取代吡啶-2-基)乙酮及制备方法
CN106535635A (zh) * 2014-04-15 2017-03-22 美国陶氏益农公司 作为杀真菌剂的金属酶抑制剂化合物
KR20160144410A (ko) 2014-04-15 2016-12-16 다우 아그로사이언시즈 엘엘씨 살진균제로서의 금속효소 억제제 화합물
BR112016025397A2 (pt) 2014-05-06 2017-08-15 Dow Agrosciences Llc picolinamidas macrocíclicas como fungicidas
WO2016007531A1 (en) 2014-07-08 2016-01-14 Dow Agrosciences Llc Macrocyclic picolinamides as fungicides
EP3166936A4 (en) 2014-07-08 2017-11-22 Dow AgroSciences LLC Macrocyclic picolinamides as fungicides
PL3240416T3 (pl) 2014-12-30 2022-12-19 Corteva Agriscience Llc Kompozycje fungicydowe
WO2016109301A1 (en) 2014-12-30 2016-07-07 Dow Agrosciences Llc Picolinamides with fungicidal activity
NZ732569A (en) 2014-12-30 2019-01-25 Dow Agrosciences Llc Picolinamide compounds with fungicidal activity
EP3240419B1 (en) 2014-12-30 2020-05-06 Dow Agrosciences LLC Picolinamide compounds with fungicidal activity
JP6777637B2 (ja) 2014-12-30 2020-10-28 ダウ アグロサイエンシィズ エルエルシー 殺真菌剤としてのピコリンアミド
CN107207414B (zh) 2014-12-30 2021-03-30 美国陶氏益农公司 具有杀真菌活性的吡啶酰胺化合物
EP3271347B1 (en) 2015-03-19 2022-06-22 Mycovia Pharmaceuticals, Inc. Antifungal compounds and processes for making
CN108348511A (zh) 2015-09-18 2018-07-31 Vps-3公司 抗真菌化合物和制备方法
CA3006469C (en) * 2015-12-30 2023-01-10 Vps-3, Inc. Metalloenzyme inhibitor compounds
US10034477B2 (en) 2016-08-30 2018-07-31 Dow Agrosciences Llc Pyrido-1,3-oxazine-2,4-dione compounds with fungicidal activity
US10173982B2 (en) 2016-08-30 2019-01-08 Dow Agrosciences Llc Picolinamides as fungicides
WO2018044987A1 (en) 2016-08-30 2018-03-08 Dow Agrosciences Llc Thiopicolinamide compounds with fungicidal activity
US10244754B2 (en) 2016-08-30 2019-04-02 Dow Agrosciences Llc Picolinamide N-oxide compounds with fungicidal activity
BR102018000183B1 (pt) 2017-01-05 2023-04-25 Dow Agrosciences Llc Picolinamidas, composição para controle de um patógeno fúngico, e método para controle e prevenção de um ataque por fungos em uma planta
US20200045967A1 (en) * 2017-02-08 2020-02-13 Bayer Cropscience Aktiengesellschaft Novel triazole derivatives
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Also Published As

Publication number Publication date
AU2013209520A1 (en) 2014-08-28
CO7111289A2 (es) 2014-11-10
WO2013110002A1 (en) 2013-07-25
CR20140387A (es) 2014-11-27
EA201491386A1 (ru) 2014-11-28
JP2017110004A (ja) 2017-06-22
IN2014DN06812A (enEXAMPLES) 2015-05-22
BR112014017799A8 (pt) 2017-07-11
BR112014017799A2 (enEXAMPLES) 2017-06-20
EP2804479A4 (en) 2015-07-22
KR20140116515A (ko) 2014-10-02
JP2015505538A (ja) 2015-02-23
PH12014501653A1 (en) 2014-10-13
JP2019116476A (ja) 2019-07-18
ECSP14014530A (es) 2015-06-30
US9414596B2 (en) 2016-08-16
CL2014001892A1 (es) 2014-11-14
US20150024938A1 (en) 2015-01-22
CN104135861A (zh) 2014-11-05
EP2804479A1 (en) 2014-11-26
MX2014008729A (es) 2015-02-04

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180109

FZDE Discontinued

Effective date: 20210201