CA2857798A1 - Use of ulipristal for treating uterine fibroids - Google Patents
Use of ulipristal for treating uterine fibroids Download PDFInfo
- Publication number
- CA2857798A1 CA2857798A1 CA 2857798 CA2857798A CA2857798A1 CA 2857798 A1 CA2857798 A1 CA 2857798A1 CA 2857798 CA2857798 CA 2857798 CA 2857798 A CA2857798 A CA 2857798A CA 2857798 A1 CA2857798 A1 CA 2857798A1
- Authority
- CA
- Canada
- Prior art keywords
- ulipristal
- metabolite
- pharmaceutical composition
- ulipristal acetate
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P15/18—Feminine contraceptives
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Diabetes (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Nutrition Science (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US12/021,610 US8299050B2 (en) | 2008-01-29 | 2008-01-29 | Method for treating uterine fibroids |
| US12/021,610 | 2008-01-29 | ||
| CA 2713254 CA2713254C (en) | 2008-01-29 | 2009-01-28 | Use of ulipristal for treating uterine fibroids |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2713254 Division CA2713254C (en) | 2008-01-29 | 2009-01-28 | Use of ulipristal for treating uterine fibroids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2857798A1 true CA2857798A1 (en) | 2009-09-06 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2857798 Abandoned CA2857798A1 (en) | 2008-01-29 | 2009-01-28 | Use of ulipristal for treating uterine fibroids |
| CA 2713254 Expired - Fee Related CA2713254C (en) | 2008-01-29 | 2009-01-28 | Use of ulipristal for treating uterine fibroids |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2713254 Expired - Fee Related CA2713254C (en) | 2008-01-29 | 2009-01-28 | Use of ulipristal for treating uterine fibroids |
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| US (5) | US8299050B2 (enExample) |
| EP (2) | EP2684565B1 (enExample) |
| JP (2) | JP5906016B2 (enExample) |
| KR (2) | KR20150055626A (enExample) |
| AU (1) | AU2009209652B2 (enExample) |
| BR (1) | BRPI0907028B8 (enExample) |
| CA (2) | CA2857798A1 (enExample) |
| CY (1) | CY1116485T1 (enExample) |
| DK (1) | DK2252301T3 (enExample) |
| ES (1) | ES2450592T3 (enExample) |
| HR (1) | HRP20140132T1 (enExample) |
| IL (2) | IL207182A (enExample) |
| MX (1) | MX2010008270A (enExample) |
| NZ (1) | NZ587439A (enExample) |
| PL (1) | PL2252301T3 (enExample) |
| PT (1) | PT2252301E (enExample) |
| SI (1) | SI2252301T1 (enExample) |
| TW (1) | TWI445537B (enExample) |
| WO (1) | WO2009095418A1 (enExample) |
| ZA (1) | ZA201006049B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8299050B2 (en) * | 2008-01-29 | 2012-10-30 | Laboratoire Hra-Pharma | Method for treating uterine fibroids |
| PH12012501812A1 (en) * | 2010-03-22 | 2012-12-10 | Allergan Pharmaceuticals Int Ltd | Compositions and methods for non-toxic delivery of antiprogestins |
| EP2471537A1 (en) * | 2010-12-30 | 2012-07-04 | PregLem S.A. | Treatment of pain associated with dislocation of basal endometrium |
| EP2545922A1 (en) * | 2011-07-12 | 2013-01-16 | PregLem S.A. | Treatment of excessive menstrual bleeding associated with uterine fibroids |
| EP2641602A1 (en) * | 2012-03-23 | 2013-09-25 | PregLem S.A. | Method for treating gynecological diseases |
| WO2014050105A1 (en) * | 2012-09-28 | 2014-04-03 | Aska Pharmaceutical Co., Ltd. | Amorphous ulipristal acetate |
| FR2997627B1 (fr) * | 2012-11-08 | 2015-01-16 | Hra Pharma Lab | Produit de co-micronisation comprenant de l'ulipristal acetate |
| FR2997628B1 (fr) * | 2012-11-08 | 2015-01-16 | Hra Pharma Lab | Produit de co-micronisation comprenant un modulateur selectif des recepteurs a la progesterone |
| HK1213487A1 (zh) * | 2012-12-14 | 2016-07-08 | The Population Council, Inc. | 銅子宮環 |
| CN103006595B (zh) * | 2012-12-25 | 2018-04-06 | 江苏亚邦爱普森药业有限公司 | 制备醋酸优力司特片的方法 |
| CA2941010A1 (en) * | 2013-02-26 | 2014-09-04 | Triact Therapeutics, Inc. | Cancer therapy |
| JP2016516764A (ja) | 2013-04-10 | 2016-06-09 | プレグレム ソシエテ アノニム | 子宮筋腫治療に用いるプロゲステロン受容体調節剤 |
| US10444958B2 (en) * | 2013-09-23 | 2019-10-15 | Adobe Systems Incorporated | Visual example-based user interface for adjusting photos along two dimensions |
| JP2018502061A (ja) * | 2014-11-24 | 2018-01-25 | ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッドＲａｍｏｔ Ａｔ Ｔｅｌ Ａｖｉｖ Ｕｎｉｖｅｒｓｉｔｙ Ｌｔｄ． | 子宮筋腫の治療のための色素上皮由来因子（ｐｅｄｆ） |
| WO2017216637A2 (en) | 2017-08-04 | 2017-12-21 | Alvogen Malta Operations (Row) Ltd | Tablet form including ulipristal acetate and the methods for its preparation |
| KR102086827B1 (ko) * | 2017-12-14 | 2020-03-10 | 경희대학교 산학협력단 | 자궁근육종 치료용 울리프리스탈 아세테이트 |
| KR102043349B1 (ko) * | 2018-01-10 | 2019-11-12 | 경희대학교 산학협력단 | 대장암 치료 용도의 울리프리스탈 아세테이트 |
| WO2021166001A1 (en) | 2020-02-19 | 2021-08-26 | Velfag Ehf. | Device and method for filleting and pin-bone removal |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4954490A (en) | 1988-06-23 | 1990-09-04 | Research Triangle Institute | 11 β-substituted progesterone analogs |
| US5468741A (en) * | 1993-05-28 | 1995-11-21 | The Regents Of The University Of California | Use of low levels of mifepristone to treat leiomyomata |
| DE4426601A1 (de) * | 1994-07-27 | 1996-02-01 | Schering Ag | Verwendung eines Kombinationsproduktes enthaltend einen kompetitiven Progesteronantagonisten und ein Gestagen zur Herstellung eines Arzneimittels zur Behandlung der Endometriose oder des Leiomyomata uteri |
| DK0806952T3 (da) * | 1995-02-02 | 2003-06-16 | Schering Ag | Progesteronantagonister til fremstillingen af lægemidler til behandling af dysfunktionelle uterine blødninger |
| US5929262A (en) | 1995-03-30 | 1999-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Method for preparing 17α-acetoxy-11β-(4-N, N-dimethylaminophyl)-19-Norpregna-4,9-diene-3, 20-dione, intermediates useful in the method, and methods for the preparation of such intermediates |
| WO1997041145A1 (en) * | 1996-05-01 | 1997-11-06 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | 21-substituted progesterone derivatives as new antiprogestational agents |
| AU747710B2 (en) * | 1997-11-14 | 2002-05-23 | Akzo Nobel N.V. | Progestogen-antiprogestogen regimens |
| US6262042B1 (en) * | 1998-05-29 | 2001-07-17 | Research Triangle Institute | 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
| FR2827517B1 (fr) | 2001-07-23 | 2003-10-24 | Bioalliance Pharma | Systemes therapeutiques bioadhesifs a liberation prolongee |
| ES2212912B1 (es) | 2003-01-22 | 2005-10-01 | Crystal Pharma, S.A. | Procedimiento para la obtencion de 17alfa-acetoxi-11beta-(4-n,n-dimetilaminofenil)-19-norpregna-4,9-dien-3,20-diona. |
| US20060111577A1 (en) | 2003-02-28 | 2006-05-25 | Kim Hyun K | Method for preparing 17 alpha-acetoxy-11beta-(4-n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, intermediates thereof, and methods for the preparation of such intermediates |
| KR101229701B1 (ko) | 2004-07-09 | 2013-02-05 | 라보라토이레 에이치알에이 파르마 | 프로게스테론 수용체 조절제를 함유하는 서방형 조성물 |
| US20060251581A1 (en) * | 2005-05-09 | 2006-11-09 | Mcintyre Jon T | Method for treatment of uterine fibroid tumors |
| WO2007038796A1 (en) | 2005-09-29 | 2007-04-05 | Repros Therapeutics Inc. | Formulations with improved bioavailability, comprising a steroid derivative and a polyglycolysed glyceride |
| WO2007103510A2 (en) | 2006-03-08 | 2007-09-13 | Danco Laboratories Llc | Methods, dosing regimens & medications using anti-progestational agents for the treatment of disorders |
| AU2007339820A1 (en) | 2006-12-28 | 2008-07-10 | Repros Therapeutics Inc. | Methods and formulations for improved bioavailability of antiprogestins |
| US8569274B2 (en) | 2007-04-20 | 2013-10-29 | Preglem S.A. | Progesterone antagonist and selective progesterone modulator in the treatment of excessive uterine bleeding |
| US8299050B2 (en) * | 2008-01-29 | 2012-10-30 | Laboratoire Hra-Pharma | Method for treating uterine fibroids |
-
2008
- 2008-01-29 US US12/021,610 patent/US8299050B2/en not_active Expired - Fee Related
-
2009
- 2009-01-28 DK DK09706347.3T patent/DK2252301T3/en active
- 2009-01-28 PL PL09706347T patent/PL2252301T3/pl unknown
- 2009-01-28 HR HRP20140132AT patent/HRP20140132T1/hr unknown
- 2009-01-28 WO PCT/EP2009/050961 patent/WO2009095418A1/en not_active Ceased
- 2009-01-28 KR KR1020157011511A patent/KR20150055626A/ko not_active Ceased
- 2009-01-28 CA CA 2857798 patent/CA2857798A1/en not_active Abandoned
- 2009-01-28 PT PT97063473T patent/PT2252301E/pt unknown
- 2009-01-28 CA CA 2713254 patent/CA2713254C/en not_active Expired - Fee Related
- 2009-01-28 JP JP2010544688A patent/JP5906016B2/ja not_active Expired - Fee Related
- 2009-01-28 BR BRPI0907028A patent/BRPI0907028B8/pt active Search and Examination
- 2009-01-28 EP EP13187859.7A patent/EP2684565B1/en not_active Revoked
- 2009-01-28 AU AU2009209652A patent/AU2009209652B2/en not_active Ceased
- 2009-01-28 NZ NZ587439A patent/NZ587439A/en not_active IP Right Cessation
- 2009-01-28 MX MX2010008270A patent/MX2010008270A/es active IP Right Grant
- 2009-01-28 ES ES09706347.3T patent/ES2450592T3/es active Active
- 2009-01-28 KR KR1020107019181A patent/KR101571400B1/ko not_active Expired - Fee Related
- 2009-01-28 EP EP09706347.3A patent/EP2252301B1/en not_active Revoked
- 2009-01-28 SI SI200930850T patent/SI2252301T1/sl unknown
- 2009-02-02 TW TW098103314A patent/TWI445537B/zh not_active IP Right Cessation
-
2010
- 2010-07-25 IL IL207182A patent/IL207182A/en active IP Right Grant
- 2010-08-26 ZA ZA2010/06049A patent/ZA201006049B/en unknown
-
2012
- 2012-09-19 US US13/622,892 patent/US8722653B2/en not_active Expired - Fee Related
-
2014
- 2014-02-27 CY CY20141100158T patent/CY1116485T1/el unknown
- 2014-03-07 US US14/200,100 patent/US9180133B2/en not_active Expired - Fee Related
- 2014-08-17 IL IL234149A patent/IL234149B/en active IP Right Grant
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2015
- 2015-01-14 JP JP2015004978A patent/JP6138838B2/ja not_active Expired - Fee Related
- 2015-10-01 US US14/872,320 patent/US9682088B2/en not_active Expired - Fee Related
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2017
- 2017-05-16 US US15/596,746 patent/US20170246189A1/en not_active Abandoned
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