CA2856609C - Process for the preparation of sterol derivatives - Google Patents

Process for the preparation of sterol derivatives Download PDF

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Publication number
CA2856609C
CA2856609C CA2856609A CA2856609A CA2856609C CA 2856609 C CA2856609 C CA 2856609C CA 2856609 A CA2856609 A CA 2856609A CA 2856609 A CA2856609 A CA 2856609A CA 2856609 C CA2856609 C CA 2856609C
Authority
CA
Canada
Prior art keywords
beta
alpha
hydroxy
acetoxy
aminopropylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2856609A
Other languages
English (en)
French (fr)
Other versions
CA2856609A1 (en
Inventor
Marc Poirot
Michael Paillasse
Philippe De Medina
Sandrine Poirot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
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Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Affichem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM, Affichem filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Publication of CA2856609A1 publication Critical patent/CA2856609A1/en
Application granted granted Critical
Publication of CA2856609C publication Critical patent/CA2856609C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA2856609A 2011-11-24 2012-11-23 Process for the preparation of sterol derivatives Active CA2856609C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11306548.6 2011-11-24
EP11306548 2011-11-24
PCT/EP2012/073489 WO2013076257A1 (en) 2011-11-24 2012-11-23 Process for the preparation of sterol derivatives

Publications (2)

Publication Number Publication Date
CA2856609A1 CA2856609A1 (en) 2013-05-30
CA2856609C true CA2856609C (en) 2021-01-12

Family

ID=47216329

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2856609A Active CA2856609C (en) 2011-11-24 2012-11-23 Process for the preparation of sterol derivatives

Country Status (14)

Country Link
US (1) US9447141B2 (2)
EP (1) EP2782923B1 (2)
JP (1) JP6157492B2 (2)
KR (1) KR20140098131A (2)
CN (1) CN104039807B (2)
AU (1) AU2012342460B2 (2)
BR (1) BR112014012458A2 (2)
CA (1) CA2856609C (2)
ES (1) ES2613753T3 (2)
IN (1) IN2014MN00976A (2)
MX (1) MX343787B (2)
RU (1) RU2014125435A (2)
WO (1) WO2013076257A1 (2)
ZA (1) ZA201403736B (2)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10669296B2 (en) 2014-01-10 2020-06-02 Rgenix, Inc. LXR agonists and uses thereof
CA3010883A1 (en) 2016-01-11 2017-07-20 The Rockefeller University Methods for the treatment of myeloid derived suppressor cells related disorders
FR3064470A1 (fr) * 2017-03-31 2018-10-05 Lessonia Masque ou patch prepare a partir d’une composition d’alginate
EP3713575A4 (en) 2017-11-21 2021-08-25 Rgenix, Inc. POLYMORPHS AND THEIR USES
WO2020061317A1 (en) * 2018-09-19 2020-03-26 Modernatx, Inc. Sterol purification
BE1027157B9 (fr) * 2019-08-01 2020-11-03 Dendrogenix Composition de dérivés de stérols pour son utilisationdans le traitement d’une pathologie neuronale liée à une hypoxie et/ou à une hypoglycémie et composition correspondante
HUE067466T2 (hu) 2019-12-13 2024-10-28 Inspirna Inc Fémsók és alkalmazásuk
JP7849051B2 (ja) * 2020-10-29 2026-04-21 デンドロゲニックス 癌の治療に使用するための５α－ヒドロキシ－６β－［２－（１Ｈ－イミダゾール－４－イル）エチルアミノ］－コレスタン－３β－オール類似体およびそれを含む医薬組成物
BE1028852B1 (fr) * 2020-12-03 2022-07-05 Dendrogenix PRODROGUE DU 5α-hydroxy-6β-[2-(1H-imidazol-4-yl) éthylamino]cholestan-3β-ol ET COMPOSITIONS PHARMACEUTIQUES LE COMPRENANT POUR UTILISATION DANS LE TRAITEMENT DU CANCER

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2838741B1 (fr) 2002-04-19 2006-01-27 Inst Nat Sante Rech Med Derives de sterols, leur procede de preparation et medicaments les comportant

Also Published As

Publication number Publication date
CN104039807B (zh) 2018-02-13
JP6157492B2 (ja) 2017-07-05
KR20140098131A (ko) 2014-08-07
JP2015502934A (ja) 2015-01-29
US20140309417A1 (en) 2014-10-16
RU2014125435A (ru) 2015-12-27
WO2013076257A1 (en) 2013-05-30
IN2014MN00976A (2) 2015-04-24
ZA201403736B (en) 2015-11-25
MX343787B (es) 2016-10-31
BR112014012458A2 (pt) 2017-06-06
EP2782923A1 (en) 2014-10-01
CN104039807A (zh) 2014-09-10
ES2613753T3 (es) 2017-05-25
CA2856609A1 (en) 2013-05-30
EP2782923B1 (en) 2016-11-23
MX2014006303A (es) 2014-09-08
AU2012342460A1 (en) 2014-06-12
US9447141B2 (en) 2016-09-20
AU2012342460B2 (en) 2017-06-29

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